Just don\u27t call it boot camp : Implementing intensive dissertation writing experiences

This roundtable presentation explored intensive writing programs for dissertation writers conducted at two R1 institutions. Evaluations indicated the programs encouraged dissertation progress, provided relational support, and taught skills. The materials here share contextual and curricular information and discuss aspects like group dynamics and timing that can affect program success

Genetic diversity, structure and gene flow of migratory barren-ground caribou (Rangifer tarandus groenlandicus) in Canada

Migratory barren-ground caribou (Rangifer tarandus groenlandicus) provide an opportunity to examine the genetic population structure of a migratory large mammal whose movements and distribution, in some instances, have not been heavily influenced by human activities that result in habitat loss or fragmentation. These caribou have likely reached large effective population sizes since their rapid radiation during the early Holocene despite cyclic changes in abundance. Migratory barren-ground caribou are managed as discrete subpopulations. We investigated genetic variation among those subpopulations to determine the patterns of genetic diversity within and among them, and the implications for long-term persistence of caribou. We identified three distinct genetic clusters across the Canadian arctic tundra: the first cluster consisted of all fully-continental migratory barren-ground subpopulations; the second cluster was the Dolphin and Union caribou; and the third cluster was caribou from Southampton Island. The Southampton Island caribou are especially genetically distinct from the other barren-ground type caribou. Gene flow among subpopulations varied across the range. Occasional gene flow across the sea-ice is likely the reason for high levels of genetic variation in the Dolphin and Union subpopulation, which experienced very low numbers in the past. These results suggest that for most migratory caribou subpopulations, connectivity among subpopulations plays an important role in maintaining natural genetic diversity. Our analyses provide insight into the levels of microsatellite genetic diversity and patterns of gene flow that may be common to large subpopulations that historically had a continuous distribution across a large continental range. These data can also be used as a benchmark to compare the effects of habitat fragmentation and bottlenecks on other large caribou populations

On-Orbit Polymer Degradation Results from MakerSat-1: First Satellite Designed to be Additively Manufactured in Space

MakerSat-1, a 1U cubesat, is a proof-of-concept mission from Northwest Nazarene University (NNU) and Made In Space (MIS). It demonstrates microgravity additive manufacturing of a cubesat aboard the International Space Station (ISS). It is the first satellite specifically designed to be 3D printed and easily snap-assembled in microgravity. Its structural frame was 3D printed on the ISS AMF printer in August 2017. In late 2019, MakerSat-1 was loaded in a SEOPS Hypergiant Slingshot deployer and then launched to the ISS aboard SpaceX CRS-19 Dragon on Dec. 5, 2019. On Jan. 31, 2020, this deployer was mounted on the hatchdoor of the Cygnus NG-12 spacecraft, unberthed from ISS, and raised to a 300 mile high orbit. MakerSat-1 and other cubesats were deployed from Slingshot into orbit on Feb. 1, 2020. In the four months following deployment, MakerSat-1 has been carrying out research on the durability of 3D printed polymer samples in the orbital space environment. The results of this science data are reported here

Technology, organisation and productivity performance in services : lessons from Britain and the United States since 1870

This paper documents the comparative productivity performance of the United States and Britain since 1870, showing the importance of developments in services. We identify the transition in market services from customised, low-volume, high-margin business organised on a network basis to standardised, high-volume, low-margin business with hierarchical management, as a key factor. A model of the interaction between technology, organisation and economic performance is then provided, focusing on the transition from networks to hierarchies. Four general lessons are drawn: (1) developments in services must be analysed if the major changes in comparative productivity performance among nations are to be understood fully; (2) different technologies and organisational forms can co-exist efficiently; (3) technological change can cause difficulties of adjustment in technology-using sectors if it is not suited to the social capabilities of the society; (4) reversal of technological trends can lead to reversal of comparative productivity performance

2003 Manifesto on the California Electricity Crisis

The authors, an ad-hocgroup of professionals with experience in regulatory and energy economics, share a common concern with the continuing turmoil facing the electricity industry ("the industry") in California. Most ofthe authorsendorsed the first California Electricity Manifesto issued on January 25, 2001. Almost two years have passed since that first Manifesto. While wholesale electric prices have moderated and California no longer faces the risk of blackouts, in many ways the industry is in worse shape now than it was at the start of 2001. As a result, the group of signatories continues to have a deep concern with the conflicting policy directions being pursued for the industry at both the State and Federal levels of government and the impact the uncertainties associated with these conflicting policies will have, long term, on the economy of California. Theauthorshave once again convened under the auspices of the Institute of Management, Innovation and Organization at the University of California, Berkeley, to put forward ourtheir ideas on a basic set of necessary policies to move the industry forward for the benefit of all Californians and the nation. The authors point out that theydo not pretend to be "representative." They do bring, however, a very diverse range of backgrounds and expertise.Technology and Industry, Regulatory Reform

A rapid, non-invasive population assessment technique for marine burrowing macrofauna inhabiting soft sediments

Population assessment techniques for soft-sediment infauna (invertebrates within the substrate) requires excavation of specimens, damaging or killing the specimen and surrounding habitat, while being time-consuming and costly. Rapid population assessments of some marine burrowing decapods have been possible by counting burrow openings to estimate abundance, and while they may be used as indicator species, these decapods are not ubiquitous to environments requiring monitoring. Additionally, the presence of other burrowing macrofauna (invertebrates living in the sediment and retained on 1mm mesh such as clams or large worms) may reduce the efficacy of burrow openings in estimating macrofauna abundance. As such, we assessed mudflats along the north coast of British Columbia, Canada, during summer 2017 to determine if macrofauna abundances could be estimated from burrow openings on the sediment surface in regions of low (n = 1 species) and high (n = 8 species) biodiversity. Abundance could not be estimated at the low diversity sites where only one macrofaunal species created burrows. At the high diversity site, species-specific models estimating abundance from burrow openings could not be constructed; however, the total number of burrow openings observed was useful in estimating total infaunal community abundance. As such, burrow openings may not be an effective tool in assessing species-specific abundances, but may be appropriate to estimate overall community changes

The human capital transition and the role of policy

Along with information and communication technology, infrastructure, and the innovation system, human capital is a key pillar of the knowledge economy with its scope for increasing returns. With this in mind, the purpose of this chapter is to investigate how industrialized economies managed to achieve the transition from low to high levels of human capital. The first phase of the human capital transition was the result of the interaction of supply and demand, triggered by technological change and boosted by the demands for (immaterial) services. The second phase of the human capital transition (i.e., mass education) resulted from enforced legislation and major public investment. The state’s aim to influence children’s beliefs appears to have been a key driver in public investment. Nevertheless, the roles governments played differed according to the developmental status and inherent socioeconomic and political characteristics of their countries. These features of the human capital transition highlight the importance of understanding governments’ incentives and roles in transitions

Cardio-renal cachexia syndromes (CRCS): pathophysiological foundations of a vicious pathological circle

Cardio-renal syndromes (CRS) are defined as disorders of the heart and kidney whereby acute or chronic dysfunction in one organ may induce acute or chronic dysfunction of the other. CRS have been classified into five categories, where types 2 and 4 represent respectively chronic cardio-renal and chronic reno-cardiac syndromes. In these conditions, the chronic disorder of either the heart or kidney has been shown to induce some degree of cachexia. At the same time, cachexia has been proposed as a possible mechanism contributing to the worsening of such pathological organ cross talk. Common pathogenetic mechanisms underlie body wasting in cachectic states of different chronic heart and kidney diseases. In these circumstances, a vicious circle could arise, in which cachexia associated with either heart failure or chronic kidney disease may contribute to further damage of the other organ. In chronic CRS, activation of the immune and neuroendocrine systems contributes to the genesis of cachexia, which in turn can negatively affect the heart and kidney function. In patients with cardiac sustained activation of the immune and neuroendocrine systems and oxidative stress, renal vascular resistance can increase and therefore impair renal perfusion, leading to worsening kidney function. Similarly, in renal cachexia, increased levels of pro-inflammatory cytokines can cause progressive left ventricular systolic dysfunction, myocardial cell death, endothelial dysfunction and increased myocardial fibrosis, with consequent impairment of the chronic reno-cardiac syndrome type 4. Thus, we speculate that the occurrence of different types of chronic CRS could represent a fundamental step in the genesis of cachexia, being renal and cardiac dysfunction closely related to the occurrence of systemic disorders leading to a final common pathway. Therefore, the heart and kidney and cachexia represent a triad causing a vicious circle that increases mortality and morbidity: In such circumstances, we may plausibly talk about cardio-renal cachexia syndrome. Complex interrelations may explain the transition from CRS to cachexia and from cachexia to CRS. Identification of the exact mechanisms occurring in these conditions could potentially help in preventing and treating this deadly combination

Assessing Physicochemical Properties of Drug Molecules via Microsolvation Measurements with Differential Mobility Spectrometry

Definitive version is available here: Liu, C., Le Blanc, J. C. Y., Schneider, B. B., Shields, J., Federico, J. J., Zhang, H., … Campbell, J. L. (2017). Assessing Physicochemical Properties of Drug Molecules via Microsolvation Measurements with Differential Mobility Spectrometry. ACS Central Science, 3(2), 101–109. https://doi.org/10.1021/acscentsci.6b00297. This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.http://pubs.acs.org/page/policy/authorchoice_termsofuse.htmlThe microsolvated state of a molecule, represented by its interactions with only a small number of solvent molecules, can play a key role in determining the observable bulk properties of the molecule. This is especially true in cases where strong local hydrogen bonding exists between the molecule and the solvent. One method that can probe the microsolvated states of charged molecules is differential mobility spectrometry (DMS), which rapidly interrogates an ion’s transitions between a solvated and desolvated state in the gas phase (i.e., few solvent molecules present). However, can the results of DMS analyses of a class of molecules reveal information about the bulk physicochemical properties of those species? Our findings presented here show that DMS behaviors correlate strongly with the measured solution phase pKa and pKb values, and cell permeabilities of a set of structurally related drug molecules, even yielding high-resolution discrimination between isomeric forms of these drugs. This is due to DMS’s ability to separate species based upon only subtle (yet predictable) changes in structure: the same subtle changes that can influence isomers’ different bulk properties. Using 2-methylquinolin-8-ol as the core structure, we demonstrate how DMS shows promise for rapidly and sensitively probing the physicochemical properties of molecules, with particular attention paid to drug candidates at the early stage of drug development. This study serves as a foundation upon which future drug molecules of different structural classes could be examined.Natural Sciences and Engineering Research Council of Canada || ENGAGE grant (EGP No. 449354-13) ENGAGE Plus grant || (EGP No.463974-14) Collaborative Research and Development grant || (490885). Ontario Centres of Excellence(OCE) || Voucher for Innovation and Productivity II grant (25050

EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA); Scientific Opinion on Dietary Reference Values for protein

This opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) deals with the setting of Dietary Reference Values (DRVs) for protein. The Panel concludes that a Population Reference Intake (PRI) can be derived from nitrogen balance studies. Several health outcomes possibly associated with protein intake were also considered but data were found to be insufficient to establish DRVs. For healthy adults of both sexes, the average requirement (AR) is 0.66 g protein/kg body weight per day based on nitrogen balance data. Considering the 97.5th percentile of the distribution of the requirement and assuming an efficiency of utilisation of dietary protein for maintenance of 47 %, the PRI for adults of all ages was estimated to be 0.83 g protein/kg body weight per day and is applicable both to high quality protein and to protein in mixed diets. For children from six months onwards, age-dependent requirements for growth estimated from average daily rates of protein deposition and adjusted by a protein efficiency for growth of 58 % were added to the requirement for maintenance of 0.66 g/kg body weight per day. The PRI was estimated based on the average requirement plus 1.96 SD using a combined SD for growth and maintenance.For pregnancy, an intake of 1, 9 and 28 g/d in the first, second and third trimesters, respectively, is proposed in addition to the PRI for non-pregnant women. For lactation, a protein intake of 19 g/d during the first six months, and of 13 g/d after six months, is proposed in addition to the PRI for non-lactating women. Data are insufficient to establish a Tolerable Upper Intake Level (UL) for protein. Intakes up to twice the PRI are regularly consumed from mixed diets by some physically active and healthy adults in Europe and are considered safe