28 research outputs found
Search for light top squark pair production in final states with leptons and b -jets with the ATLAS detector in s=7 TeV proton-proton collisions
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdinov O
- Aben R
- Abi B
- Abolins M
- AbouZeid OS
- Abramowicz H
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- Acharya BS
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- Publication venue
- Publication date
- 01/01/2012
- Field of study
The results of a search for pair production of light top squarks are presented, using 4.7 fb^-1 of sqrt(s) = 7 TeV proton-proton collisions collected with the ATLAS detector at the Large Hadron Collider. This search targets top squarks with masses similar to, or lighter than, the top quark mass. Final states containing exclusively one or two leptons (e, mu), large missing transverse momentum, light-jets and b-jets are used to reconstruct the top squark pair system. Global mass scale variables are used to separate the signal from a large ttbar background. No excess over the Standard Model expectations is found. The results are interpreted in the framework of the Minimal Supersymmetric Standard Model, assuming the top squark decays exclusively to a chargino and a b-quark. Light top squarks with masses between 123-167 GeV are excluded for neutralino masses around 55 GeV
Search for the standard model Higgs boson in the diphoton decay channel with 4.9fb -1 of pp collision data at √s=7TeV with atlas
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- Åkesson TPA
- Åsman B
- Publication venue
- Publication date
- 01/01/2012
- Field of study
A search for the standard model Higgs boson is performed in the diphoton decay channel. The data used correspond to an integrated luminosity of 4.9 fb-1 collected with the ATLAS detector at the Large Hadron Collider in proton-proton collisions at a center-of-mass energy of √s=7 TeV. In the diphoton mass range 110–150 GeV, the largest excess with respect to the background-only hypothesis is observed at 126.5 GeV, with a local significance of 2.8 standard deviations. Taking the look-elsewhere effect into account in the range 110–150 GeV, this significance becomes 1.5 standard deviations. The standard model Higgs boson is excluded at 95% confidence level in the mass ranges of 113–115 GeV and 134.5–136 GeV
Search for the standard model Higgs boson in the diphoton decay channel with 4.9fb -1 of pp collision data at √s=7TeV with atlas
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdel Khalek S
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abouzeid OS
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aenia T
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
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- Vrba V
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- Vukotic I
- Wagner P
- Wagner W
- Wahlen H
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- Walch S
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- Walker R
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- Waller P
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- Wang H
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- Wang JC
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- Warburton A
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- Wasicki C
- Watkins PM
- Watson AT
- Watson IJ
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- Weber MS
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- Weingarten J
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- Whitaker SP
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- Wickens FJ
- Wiedenmann W
- Wielers M
- Wienemann P
- Wiglesworth C
- Wiik LAM
- Wijeratne PA
- Wildauer A
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- Wilhelm I
- Wilkens HG
- Will JZ
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- Williams HH
- Willis W
- Willocq S
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- Wilson MG
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- Winkelmann S
- Winklmeier F
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- Wolter MW
- Wolters H
- Wong WC
- Wooden G
- Wosiek BK
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- Woudstra MJ
- Wozniak KW
- Wraight K
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- Wu Y
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- Wynne BM
- Xella S
- Xiao M
- Xie S
- Xie Y
- Xu C
- Xu D
- Xu G
- Yabsley B
- Yacoob S
- Yamada M
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- Yamanaka T
- Yamaoka J
- Yamazaki T
- Yamazaki Y
- Yan Z
- Yang H
- Yang UK
- Yang Y
- Yang Y
- Yang Z
- Yanush S
- Yao Y
- Yasu Y
- Ybeles Smit GV
- Ye J
- Ye S
- Yilmaz M
- Yoosoofmiya R
- Yorita K
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- Youssef S
- Yu D
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- Zaets VG
- Zaidan R
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- Zeitnitz C
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- Zenz S
- Zerwas D
- Zevi Della Porta G
- Zhan Z
- Zhang D
- Zhang H
- Zhang J
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- Zhang Z
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- Zhao T
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- Zhemchugov A
- Zheng S
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- Zhu H
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- Zhu Y
- Zhuang X
- Zhuravlov V
- Zieminska D
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zitoun R
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zolnierowski Y
- Zsenei A
- Zur Nedden M
- Zutshi V
- Zwalinski L
- Åkesson TPA
- Åsman B
- Publication venue
- Publication date
- 01/01/2012
- Field of study
A search for the standard model Higgs boson is performed in the diphoton decay channel. The data used correspond to an integrated luminosity of 4.9 fb-1 collected with the ATLAS detector at the Large Hadron Collider in proton-proton collisions at a center-of-mass energy of √s=7 TeV. In the diphoton mass range 110–150 GeV, the largest excess with respect to the background-only hypothesis is observed at 126.5 GeV, with a local significance of 2.8 standard deviations. Taking the look-elsewhere effect into account in the range 110–150 GeV, this significance becomes 1.5 standard deviations. The standard model Higgs boson is excluded at 95% confidence level in the mass ranges of 113–115 GeV and 134.5–136 GeV
A Functional Study of Human Inflammatory Arthritis Using Photoacoustic Imaging
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins
- Author
- A Julia
- A Moayyeri
- A Subramanian
- AE Teschendorff
- AE Teschendorff
- AE Teschendorff
- AJ Silman
- AJ Silman
- Amy P. Webster
- Andrew Feber
- Anne Barton
- B Phipson
- BM Javierre
- CM Quinonez-Flores
- D Gomez-Cabrero
- D Plant
- Darren Plant
- Dirk S. Paul
- DS Paul
- EA Houseman
- Flore Zufferey
- Frances M. K. Williams
- G Schett
- GM Silva
- HW van Steenbergen
- J Lotem
- Jane Worthington
- Jordana T. Bell
- JR Glossop
- JT Bell
- K Nakano
- K Nakano
- KD Hansen
- L de la Rica
- LE Reinius
- LP Breitling
- MJ Aryee
- MJ Bonder
- MJ Ziller
- MM Maurice
- P Geeleher
- P Guilhamon
- PC Tsai
- RA Hoovestol
- RT Barfield
- S Klunker
- S Tokuhiro
- S Yoshida
- SE Johnstone
- Simone Ecker
- Stephan Beck
- Y Benjamini
- Y Liu
- Y Okada
- Y Tian
- Z Chen
- Publication venue
- Publication date
- 04/05/2018
- Field of study
Abstract
Background
Rheumatoid arthritis is a common autoimmune disorder influenced by both genetic and environmental factors. Epigenome-wide association studies can identify environmentally mediated epigenetic changes such as altered DNA methylation, which may also be influenced by genetic factors. To investigate possible contributions of DNA methylation to the aetiology of rheumatoid arthritis with minimum confounding genetic heterogeneity, we investigated genome-wide DNA methylation in disease-discordant monozygotic twin pairs.
Methods
Genome-wide DNA methylation was assessed in 79 monozygotic twin pairs discordant for rheumatoid arthritis using the HumanMethylation450 BeadChip array (Illumina). Discordant twins were tested for both differential DNA methylation and methylation variability between rheumatoid arthritis and healthy twins. The methylation variability signature was then compared with methylation variants from studies of other autoimmune diseases and with an independent healthy population.
Results
We have identified a differentially variable DNA methylation signature that suggests multiple stress response pathways may be involved in the aetiology of the disease. This methylation variability signature also highlighted potential epigenetic disruption of multiple RUNX3 transcription factor binding sites as being associated with disease development. Comparison with previously performed epigenome-wide association studies of rheumatoid arthritis and type 1 diabetes identified shared pathways for autoimmune disorders, suggesting that epigenetics plays a role in autoimmunity and offering the possibility of identifying new targets for intervention.
Conclusions
Through genome-wide analysis of DNA methylation in disease-discordant monozygotic twins, we have identified a differentially variable DNA methylation signature, in the absence of differential methylation in rheumatoid arthritis. This finding supports the importance of epigenetic variability as an emerging component in autoimmune disorders
Increased DNA methylation variability in rheumatoid arthritis-discordant monozygotic twins
- Author
- A Julia
- A Moayyeri
- A Subramanian
- AE Teschendorff
- AE Teschendorff
- AE Teschendorff
- AJ Silman
- AJ Silman
- Amy P. Webster
- Andrew Feber
- Anne Barton
- B Phipson
- BM Javierre
- CM Quinonez-Flores
- D Gomez-Cabrero
- D Plant
- Darren Plant
- Dirk S. Paul
- DS Paul
- EA Houseman
- Flore Zufferey
- Frances M. K. Williams
- G Schett
- GM Silva
- HW van Steenbergen
- J Lotem
- Jane Worthington
- Jordana T. Bell
- JR Glossop
- JT Bell
- K Nakano
- K Nakano
- KD Hansen
- L de la Rica
- LE Reinius
- LP Breitling
- MJ Aryee
- MJ Bonder
- MJ Ziller
- MM Maurice
- P Geeleher
- P Guilhamon
- PC Tsai
- RA Hoovestol
- RT Barfield
- S Klunker
- S Tokuhiro
- S Yoshida
- SE Johnstone
- Simone Ecker
- Stephan Beck
- Y Benjamini
- Y Liu
- Y Okada
- Y Tian
- Z Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Potential role of mitochondria in synoviocytes
- Author
- A Mathiessen
- A Meyer
- AC Bulua
- AJ Kowaltowski
- AR Phull
- B Abramoff
- B Bartok
- B Cillero-Pastor
- C Derambure
- C Ospelt
- C Vaamonde-Garcia
- C Vaamonde-Garcia
- CH Woo
- CM Quinonez-Flores
- CY Wang
- DJ Veale
- E Balogh
- E Eerola
- EK Kim
- FJ Blanco
- FJ Blanco
- FM Brennan
- FW Roemer
- H Fahmi
- H Liu
- H Perlman
- H Zhong
- HC Hsu
- HL Hu
- I Shokolenko
- J Karami
- J Lunec
- J Tu
- JA Sparks
- JC Martinou
- JE Chipuk
- K Baker
- L Wu
- LC Harty
- LV Collins
- M Biniecka
- M Biniecka
- M Biniecka
- M Kurowska
- MC Chang
- MN Valcarcel-Ares
- MS Chimenti
- MS Ola
- N Dalbeth
- N Nissanka
- O Firuzi
- P Chalan
- P Coto-Segura
- R Calvani
- R Miesel
- R Pullerits
- R Zhou
- RF Loeser
- S Busteed
- S Mitsunaga
- S Zhou
- SK Chang
- SK Kim
- SY Lee
- T Kumagai
- T McGarry
- T McGarry
- T Wang
- TH Nguyen
- TR Da Sylva
- U Fearon
- U Muller-Ladner
- U Muller-Ladner
- W Droge
- W Kammouni
- Y Gu
- YE Henrotin
- Z Zhao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Sex-Based Differences in Monocytic Lineage Cells Contribute to More Severe Collagen-Induced Arthritis in Female Rats Compared with Male Rats
- Author
- A Andersson
- A Puchner
- AA Patel
- AK Rana
- B De Klerck
- Biljana Bufan
- C Shi
- CA Roberts
- CC Whitacre
- CM Quinonez-Flores
- CT Ritchlin
- DA Chistiakov
- DD Brand
- DH Alamdari
- Duško Kosec
- E Lubberts
- E Lundstrom
- E Segura
- EV Acosta-Rodriguez
- F Benaglio
- F Grassi
- F Stirpe
- FK Swirski
- G An
- G Chabchoub
- G Schett
- G Schett
- Gordana Leposavić
- GS Firestein
- H Fuseini
- H Ha
- H Li
- HG Evans
- IB McInnes
- IE Adamopoulos
- IP Wicks
- Ivan Pilipović
- J Djikic
- J Kotur-Stevuljevic
- Jelena Kotur-Stevuljević
- Jelena Sopta
- JH Kim
- JM Rak
- JR Kiesel
- K Ganesan
- K Palmblad
- L Ibanez
- L Leonavičienė
- L Ziegler-Heitbrock
- Ljubica Simić
- M Cristani
- M Cutolo
- M Dimitrijevic
- M Dimitrijevic
- M Dimitrijevic
- M Gengenbacher
- M Krasselt
- M Robert
- MB Madel
- MD Gunn
- MH Abdel Meguid
- Mirjana Dimitrijević
- Mirjana Nacka-Aleksić
- MJ Girotti
- ML Krause
- MM Bradford
- MM Griffiths
- MM Herenius
- MP Vierboom
- N Fujiwara
- NC Lambert
- Nevena Arsenović-Ranin
- O Erel
- O Erel
- OL Quintero
- P Ancuta
- P D'Amelio
- P Hawkins
- P Matthys
- P Ruiz-Limon
- PJ Egan
- PP Tak
- Q Guo
- Q Luo
- RW Kinne
- RW Kinne
- S Gordon
- S Hirose
- S Kotake
- S Sayegh
- S Shahrara
- S Thornton
- S Umar
- SM Jung
- ST Gal-Oz
- T Dimitroulas
- T Kawabe
- T Sokka
- TK Tarrant
- U Islander
- V Ahuja
- V Witko-Sarsat
- VM Victor
- W Hou
- W Wang
- WJ Kovacs
- Y Chabbi-Achengli
- Y Chung
- Y Nakamichi
- YY Lo
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Monocytes' plasticity has an important role in the development of rheumatoid arthritis (RA), an autoimmune disease exhibiting greater prevalence in women. Contribution of this phenomenon to sex bias in RA severity was investigated in rat collagen-induced arthritis (CIA) model of RA. The greater severity of CIA in females (exhibiting signs of bone resorption) was accompanied by the higher blood level of advanced oxidation protein products and a more pro-oxidant profile. Consistently, in females, the greater density of giant multinuclear cells (monocytes/macrophages and osteoclasts) in inflamed joint tissue was found. This correlated with the higher frequencies of CCR2- and CX3CR1- expressing cells (precursors of inflammatory monocytes/macrophages and osteoclasts) among CD11b+ splenocytes. This in conjunction with the enhanced migratory capacity of CD11b+ monocytic cells in females compared with males could be linked with the higher frequencies of CCR2+CX3CR1-CD43(low)CD11b+ and CCR2-CX3CR1+CD43(hi)CD11b+ cells (corresponding to "classical" and "non-classical" monocytes, respectively) and the greater density of CD68+ cells (monocytes/macrophages and osteoclast precursors/osteoclasts) in blood and inflamed paws from female rats, respectively. Consistently, the higher levels of GM-CSF, TNF-alpha and IL-6, IL-1 beta (driving Th17 cell differentiation), and IL-17 followed by the lower level of IL-10 were measured in inflamed paw cultures from female compared with male rats. To the greater IL-17 production (associated with enhanced monocyte immigration and differentiation into osteoclasts) most likely contributed augmented Th17 cell generation in the lymph nodes draining arthritic joints from female compared with male rats. Overall, the study suggests the sex-specific contribution of monocytic lineage cells to CIA, and possibly RA development
Metabolic reprogramming as a key regulator in the pathogenesis of rheumatoid arthritis
- Author
- A Angajala
- A Camporeale
- A Hoshino
- A Rongvaux
- AD D'Souza
- AHV Remels
- AHV Schapira
- AL Saraiva
- AS Rambold
- B Beltran
- B Carames
- BM Weinstein
- C Karlsson
- C Maria Quinonez-Flores
- C Speirs
- C Stathopoulou
- C-G Miao
- CM Weyand
- CM Weyand
- CM Weyand
- CM Yzafhamsagjaw
- D Alvarez-Errico
- D O'Sullivan
- D Xu
- DC Chan
- DJ Puleston
- DP Narendra
- DR Wise
- E Mills
- EC Lai
- EH Levi
- EJ Goetzl
- EL Mills
- EL Mills
- EL Mills
- EL Pearce
- EN Maldonado
- F Baixauli
- F Michopoulos
- Fang Wei
- G Abboud
- G Song
- GJW van der Windt
- GW Dorn II
- H Diez
- H Sauer
- H Shapiro
- H Yan
- H-Y Yap
- HJ Son
- HM Deng
- HM Rodrigues
- HW Jeong
- IA Udalova
- J Garaude
- J Ho
- J Kim
- J Xu
- J Zhou
- J Zhou
- J-G Wang
- J-S Moon
- JJ Oshea
- JK Ahn
- K Duevel
- K Nakahira
- K Okayyaocahtatyat
- KC Carroll
- KE Wellen
- KM Fracchia
- KY Kang
- L Bird
- L Esteban-Martinez
- L Gai
- L Shervington
- L Tilokani
- L Zhu
- LAJ O'Neill
- LI Filippin
- LS Wilkinson
- LZ Shi
- M Akimoto
- M Biniecka
- M Demaria
- M Guma
- M Kono
- MD Buck
- MD Smith
- ML Balmer
- MM Kaminski
- MM Mehta
- MP Murphy
- N Bottini
- N Sanadgol
- O Warburg
- O Warburg
- P Di Benedetto
- P Kumar
- P Mishra
- P Yang
- P Yang
- PG de Oliveira
- PM Gubser
- PT Schumacker
- Q Kong
- R Acin-Perez
- R Garcia-Carbonell
- R Haas
- R Liu-Bryan
- RD Michalek
- RJ DeBerardinis
- RN Dubois
- RW Taylor
- S Angiari
- S Cogliati
- S De Biasi
- S Hajizadeh
- S Hua
- S Jiang
- S Takahashi
- SE Corcoran
- Shi-ye Zong
- SK Yadav
- SP Young
- SY Park
- T Gridley
- T Iso
- T Iso
- T Iyama
- T Karonitsch
- T McGarry
- T Morita
- T Nishioku
- T Okano
- T Okano
- T Shirai
- T Suto
- TF Liu
- TZ Yu
- U Bruning
- U Fearon
- V Deretic
- V Lampropoulou
- VA Gerriets
- VMC Madeira
- W Gao
- W Gao
- Wei-wei Cai
- X Gao
- X Wang
- X-X Hu
- Y Li
- Y Xia
- Y Yamaguchi
- Y Zhao
- Y Zou
- YH Choi
- YJ Jung
- Yun Yu
- Z Samimi
- Z Wen
- Z Yang
- Z Yang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Smoking under hypoxic conditions: a potent environmental risk factor for inflammatory and autoimmune diseases
- Author
- A Dosek
- A Podlutsky
- AA Bengtsson
- AC Koong
- AF Arechiga
- AJ deRuijter
- AJ Silman
- AL Bluhm
- AR Olsson
- B Sivakumar
- B Winsa
- BB Aggarwal
- C Benoni
- C Nagata
- C Nathan
- C Wu
- CD Mathers
- CE Brown
- CH Jeon
- CJ Hardy
- CL Van Hove
- CL Yauk
- CL Yauk
- CM Quinonez-Flores
- CP Tsai
- CT Ng
- CT Taylor
- D Adenuga
- D Hoffmann
- D Howel
- D Hruba
- D Hutchinson
- D Lando
- D Lando
- D Sugiyama
- D van der Woude
- DF Smelter
- DM Comer
- DM DeMarini
- DM DeMarini
- DP Symmons
- DR Donohoe
- E Fiorillo
- E Krishnan
- E Roemer
- EC Somers
- EP Cummins
- EV Dang
- EW Karlson
- F Hu
- F Pan
- FM Moodie
- G Li
- GL deHeens
- GL Semenza
- GS Cooper
- GS Cooper
- H Ellegren
- H Geng
- H Mahdi
- H Mehta
- H Yao
- H Yao
- HI Afridi
- HS Cha
- IA Holm
- International Agency for Research on Cancer
- J Biddlestone
- J Cao
- J Fujii
- J Karhausen
- J Lee
- J Lengfeld
- J Lunec
- J Pfeilschifter
- J Rius
- J Sanchez-Guerrero
- J Zhang
- JA Jefferson
- JD Imig
- JE Swauger
- JK Ahn
- JM Hazes
- JS Maltzman
- K Husgafvel-Pursiainen
- K Ito
- K Lund-Olesen
- K Yoshiuchi
- KA Byron
- KA Ross
- KA Ross
- KH Costenbader
- KH Falchuk
- L Bartalena
- L Caron
- L Haery
- L Klareskog
- L Menard
- L Padyukov
- L Villard-Mackintosh
- L Zhou
- LA Criswell
- LA Criswell
- LF Voigt
- LJ Robays
- LZ Shi
- M Ezzati
- M Freitas
- M Heliovaara
- M Oberg
- M Ohsawa
- M Oikawa
- M Petri
- M Scortegagna
- M Shan
- M Thorogood
- MA Hernan
- ME Gershwin
- MF Mian
- MF Prummel
- MH Avila
- MJ Benito
- MJ Thun
- MJ Walters
- MK Formica
- ML Handel
- MM Freemer
- MM Reidenberg
- MP Vessey
- N Mercado
- NO Ghaussy
- P Behrens
- P Ghadirian
- P Keohavong
- P Stolt
- P Van Uden
- P Vestergaard
- PC Mahon
- PR Bois
- R Holmes
- R Sternglanz
- R Talhout
- R Talhout
- R Vassallo
- R Zivadinov
- RB Smeltz
- RE Simmonds
- RS Belaiba
- S Karakucuk
- S Rajendrasozhan
- S Rajendrasozhan
- S Shukla
- SA Patel
- SH Lee
- SR Yang
- SR Yang
- T Bakonyi
- T Bollinger
- T Cramer
- T Riise
- T Uhlig
- TH Brix
- U Müller-Ladner
- WA Pryor
- WA Robbins
- WG Kaelin
- X Chang
- XJ Sun
- XJ Yang
- XJ Yang
- Y Nakamura
- Y Renaudineau
- YH Huh
- YL Chen
- YP Li
- YS Ding
- Z Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study