7 research outputs found
Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic
- Author
- 14 | COVIDSurg COllabOratIVe Tzovaras G. (General University Hospital of Larissa)
- Aawsaj Y.
- Abad Gurumeta A.
- Abad-Motos A.
- Abate E.
- Abbott D.
- Abdalla M.
- Abdeldayem H.
- Abdelkader Salama I.
- Abdelkarim M.
- Abdur-Rahman L.
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- Alma Mater Studiorum University of Bologna)
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- Argentina: Alurralde C.
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- COVIDSurg COllabOratIVe | 15 Violante T. (IRCCS Azienda Ospedaliero â Universitaria di Bologna
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- Department of Biomedical Sciences
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- Government Medical College). Ireland: Aremu M.
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- TU Dresden)
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- Universiti Sains Malaysia)
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- Vassiliu P. (Attikon University General Hospital)
- Vaz Pereira R.
- Vaz S. (Centro Hospitalar e UniversitĂĄrio de SĂŁo JoĂŁo)
- Velchuru V.
- Velickovic D. (Clinic for Digestive Surgery
- Velidedeoglu M.
- Venn M. (Royal London Hospital)
- Venskutonis D. (Lithuanian University of Health Sciences Kaunas Clinical Hospital). Madagascar: Rasoaherinomenjanahary F.
- Vera Mansilla C. (Hospital Universitario Principe de Asturias)
- Verberne C. (John Radcliffe Hospital)
- Vergari R. (Ospedali Riuniti di Ancona)
- Vernon L. (Cork University Hospital)
- Vervoort D.
- Vescio G. (University âMagna Graeciaâ of Catanzaro)
- Vezakis A. (Aretaieion Hospital)
- Videira J. F. (IPO Porto). RĂ©union: Kassir R.
- Vieira B. (Centro Hospitalar de TrĂĄs-Os-Montes e Alto Douro
- Vieira Caroço T. (IPO Coimbra)
- Vieira Paiva Lopes A. C. (Hospital de Torres Vedras â Centro Hospitalar do Oeste)
- Vignali A. (San Raffaele Scientific Institute
- Vigorita V. (Ălvaro Cunqueiro Hospital)
- Vijayan D. (Queen Elizabeth Hospital Birmingham)
- Villalabeitia Ateca I. (Hospital Universitario Cruces)
- Vimalachandran D. (Countess of Chester Hospital)
- Viswanath Y. K. S. (James Cook University Hospital)
- Vitali A. (Ospedale San Giovanni di Dio)
- Vitone L. (Royal Blackburn Hospital)
- Vives R. V. (Bellvitge University Hospital)
- Vo U. G. (Fiona Stanley Hospital)
- Von Papen M.
- Vovola F. (Ospedali Riuniti Azienda Ospedaliera Universitaria Foggia)
- Vucic N.
- VĂĄzquez FernĂĄndez A. (Hospital ClĂnico Universitario de Valladolid)
- Wadham B. (The University Hospital of South Manchester)
- Walkes K. (Queen Elizabeth Hospital). Belgium: Flamey N.
- Wani R. (Sher-I-Kashmir Institute of Medical Sciences)
- Waqar S. H. (Pakistan Institute of Medical Sciences). Poland: Major P. (Jagiellonian University Medical College). Portugal: Azevedo C.
- Warren O. (Chelsea and Westminster Hospital)
- Watson L. J. (Sunderland Royal Hospital)
- Watson N. (Kingâs Mill Hospital)
- Weitz J.
- Welsch T. (Carl-Gustav-Carus University Hospital
- Werner J. (LMU Klinikum Campus Innenstadt)
- Westwood E. (James Paget University NHS Foundation Trust Hospital)
- Whelan M. (Tallaght University Hospital)
- Whitmore H. (Torbay and South Devon NHS Trust)
- Wilkin R. J. W. (South Warwickshire NHS Foundation Trust)
- Wilkins A. (Hull University Teaching Hospitals NHS Trust)
- Williams G. (Royal Gwent Hospital)
- Williams K. (St Georgeâs Hospital)
- Wilson M. (Forth Valley Royal Hospital)
- Wimmer A. (Paracelsus Medical University Salzburg). Barbados: Barker D.
- Wong M.
- Worku D. (Queens Medical Centre)
- Wullschleger M. (Gold Coast University Hospital)
- Xavier R. G.
- Xenaki S.
- Xynos E. (University Hospital of Heraklion Crete and Interclinic Hospital of Crete). Hong Kong: Futaba K.
- Yang W.
- Yassin N. (Royal Wolverhampton NHS Trust)
- Ye G.
- Yesantharao P.
- Yetkin S. G. (Sisli Hamidiye Etfal Training and Research Hospital)
- YeĆilyurt D. (University of Health Sciences Tepecik Training and Research Hospital)
- Yiallourou A. (Nicosia General Hospital). Czechia: Martinek L.
- Yıldırım A.
- Yildiz A. (Yildirim Beyazit University Yenimahalle Training and Research Hospital). Uganda: Lule H.
- Young R. (York Teaching Hospitals NHS Trust)
- Yousof E. A. (Assiut University Hospital)
- Youssef M. (Norfolk and Norwich University Hospital)
- Yurttas C. (University Hospital Tuebingen)
- YĂĄnez C. (Royo Villanova)
- YĂŒksel E. (Kocaeli University Teaching Hospital)
- Zafar S. N. (University of Wisconsin)
- Zakaria A. D.
- Zakaria Z. (School of Medical Sciences and Hospital
- Zambon M. (Policlinico Umberto I Sapienza University of Rome)
- Zanus G. (Caâ Foncello Treviso â DISCOG â UniversitĂ di Padova)
- Zegarac M. (Institute for Oncology and Radiology of Serbia)
- ZeliÄ M. (University Hospital Center Rijeka)
- Zengin A. K. (Istanbul Universty â CerrahpaĆa Medical Faculty)
- Zerbib P. (CHU Lille)
- Zervas K.
- Zese M. (Santa Maria degli Angeli Hospital ULSS 5 â Adria)
- Zhang H. (Concord Repatriation General Hospital)
- Zizzo M. (Azienda UnitĂ Sanitaria Locale â IRCCS di Reggio Emilia)
- Zografos C. (Laiko University Hospital)
- Zorrilla OrtĂșzar J. (Hospital General Universitario Gregorio Marañón)
- Zourntou S. (General Hospital of Larissa âKoutlimpaneio and Triantafylleioâ)
- Zubaidi A. M. (King Saud University). Serbia: AleksiÄ L.
- Ăngelo M.
- Ăelebi F.
- Ăolak E.
- Ăfner D. (Medical University of Innsbruck)
- Ăhlberger L.
- Ăzçelık M. F.
- ĂÄĂŒcĂŒ H.
- ĂberrĂŒck L.
- Äoza I.
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
Get PDFThis study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic
Impact of methodological choices in comparative effectiveness studies: application in natalizumab versus fingolimod comparison among patients with multiple sclerosis
- Author
- Aalborg University
- Aalborg University Hospital
- Aarhus University
- Al-Amiri Hospital
- Al-Khedr A.
- Alfred Health
- Alroughani R.
- American University of Beirut
- Andersen J.B.
- Assistance publique - HĂŽpitaux de Marseille
- Assistance publique â HĂŽpitaux de Paris
- Azienda Ospedaliera Di Rilievo Nazionale San Giuseppe Moscati Avellino
- Ben Nasr Nasr H.
- Berger E.
- Bourre B.
- Boz C.
- Bramow S.
- Butzkueven H.
- Buzzard K.
- Cabre P.
- Camdessanché J.P.
- Casey R.
- Casez O.
- Centre Hospitalier de Pontoise
- Centre Hospitalier de Saint-Denis
- Centre Hospitalier de Versailles
- Centre Hospitalier RĂ©gional Universitaire de Tours
- Centre Hospitalier Sud Francilien
- Centre Hospitalier Universitaire d'Amiens Picardie
- Centre Hospitalier Universitaire de Fort de France
- Charles University
- CHI de Poissy-St-Germain-en-Laye
- CHU de Limoges
- CHU de Nancy
- CHU de Nantes
- CHU de Nice
- CHU de NĂźmes
- CHU de Poitiers
- CHU de Rennes
- CHU de Toulouse
- CHU HĂŽpitaux de Rouen
- Ciron J.
- CISSS Chaudiere-Appalache
- Clavelou P.
- CNRS
- Csepany T.
- CSSS Saint-JĂ©rĂŽme
- De SĂšze Seze J.
- Debouverie M.
- Defer G.
- Dimitri-Boulos D.
- Dokuz Eylul University
- Duquette P.
- Edan G.
- Eichau S.
- Eugene Devic EDMUS Foundation
- Ferraro D.
- Flinders University
- Frederiksen J.L.
- Gabriele d'Annunzio University
- Girard M.
- Gout O.
- Grammond P.
- GrandâMaison F.
- Granella F.
- Groupe hospitalier Pellegrin
- Hacettepe University
- Hankiewicz K.
- Hasselt University
- Havrdova E.K.
- HaydarpaĆa Numune Training and Research Hospital
- Heinzlef O.
- Hilt Christensen Christensen C.C.
- Horakova D.
- Hospices civils de Lyon
- Hospital Universitario Virgen Macarena
- Hunter New England Health
- HĂŽpital du Bocage CHU Dijon Bourgogne
- HĂŽpital Fondation Adolphe de Rothschild
- HĂŽpital Gabriel Montpied
- HĂŽpital Gui de Chauliac
- HĂŽpital Henri Mondor
- HĂŽpital Jean Minjoz
- HĂŽpital Nord CHU de Saint-Ătienne
- HĂŽpital Pontchaillou
- Institut national de la santé et de la recherche médicale
- IRCCS Istituto delle Scienze Neurologiche di Bologna
- Isfahan University of Medical Sciences
- Izquierdo G.
- Jensen M.B.
- Kalincik T.
- Karabudak R.
- Karadeniz Technical University
- Koch-Henriksen N.
- Labauge P.
- Laplaud D.A.
- Lebrun-Frenay C.
- Lechner-Scott J.
- Lefort M.
- Leray E.
- Lugaresi A.
- Magyari M.
- Maillart E.
- Maimone D.
- Mathiesen H.K.
- Maubeuge N.
- Maurousset A.
- McCombe P.
- Monash University
- Montcuquet A.
- Moreau T.
- Neuro Rive-Sud
- Nifle C.
- Ondokuz Mayis University
- Onofrj M.
- Ospedale Garibaldi
- Ozakbas S.
- Patti F.
- Pelletier J.
- Policlinico G Rodolico
- Pottier C.
- Prat A.
- Prevost J.
- Rasmussen P.V.
- Royal Brisbane & Women's Hospital
- Royal Melbourne Hospital
- Ruet A.
- Schreiber K.I.
- Sellebjerg F.
- Sharmin S.
- Shaygannejad V.
- Skibina O.
- Slee M.
- Soerensen P.S.
- Sola P.
- Sorbonne Université
- Spitaleri D.
- Stankoff B.
- Terzi M.
- Thouvenot E.
- Trojano M.
- Turkoglu R.
- Universite Claude Bernard Lyon 1
- Universite Joseph Fourier
- University Hospital of Northern Sealand
- University of Bari
- University of Bologna
- University of Catania
- University of Copenhagen
- University of Debrecen
- University of Melbourne
- University of Modena and Reggio Emilia
- University of Montreal
- University of Newcastle
- University of Parma
- University of Queensland
- Université de Caen
- Université de Lille
- Université de Strasbourg
- Van der Walt der Walt A.
- Van Wijmeersch Wijmeersch B.
- Vucic S.
- Vukusic S.
- Wahab A.
- Westmead Hospital
- Yamout B.
- Zephir H.
- Publication venue
- Figshare
- Publication date
- 01/01/2022
- Field of study
No full textAbstract Background Natalizumab and fingolimod are used as high-efficacy treatments in relapsingâremitting multiple sclerosis. Several observational studies comparing these two drugs have shown variable results, using different methods to control treatment indication bias and manage censoring. The objective of this empirical study was to elucidate the impact of methods of causal inference on the results of comparative effectiveness studies. Methods Data from three observational multiple sclerosis registries (MSBase, the Danish MS Registry and French OFSEP registry) were combined. Four clinical outcomes were studied. Propensity scores were used to match or weigh the compared groups, allowing for estimating average treatment effect for treated or average treatment effect for the entire population. Analyses were conducted both in intention-to-treat and per-protocol frameworks. The impact of the positivity assumption was also assessed. Results Overall, 5,148 relapsingâremitting multiple sclerosis patients were included. In this well-powered sample, the 95% confidence intervals of the estimates overlapped widely. Propensity scores weighting and propensity scores matching procedures led to consistent results. Some differences were observed between average treatment effect for the entire population and average treatment effect for treated estimates. Intention-to-treat analyses were more conservative than per-protocol analyses. The most pronounced irregularities in outcomes and propensity scores were introduced by violation of the positivity assumption. Conclusions This applied study elucidates the influence of methodological decisions on the results of comparative effectiveness studies of treatments for multiple sclerosis. According to our results, there are no material differences between conclusions obtained with propensity scores matching or propensity scores weighting given that a study is sufficiently powered, models are correctly specified and positivity assumption is fulfilled
Data_Sheet_1.PDF
- Author
- Association
- Assogna
- Badawy
- Badawy
- Badawy
- Badawy
- Badawy
- Badawy
- Badawy
- Badawy
- Badawy
- Badawy
- Balzekas
- Barbin
- Bares
- Barker
- Basavaraju
- Basavaraju
- Basavaraju
- Bauer
- Benes
- Benussi
- Benussi
- Benussi
- Benussi
- Benussi
- Benussi
- Berardelli
- Bernardo
- Boecker
- Bolden
- Bolden
- Brady RO
- Brebner
- Brem
- Brodtmann
- Buchmann
- Canafoglia
- Cantello
- Cantello
- Cash
- Chen
- Chen
- Chu
- Cloud
- Cosentino
- Creamer
- Croarkin
- Croarkin
- Cunic
- Daskalakis
- Daskalakis
- Daskalakis
- Davalos
- De Beaumont
- De Beaumont
- DeFelipe
- Doruk Camsari
- Edden
- Enticott
- Espay
- Farzan
- Feldman
- Fierro
- Fitzgerald
- Fitzgerald
- Fitzgerald
- Florian
- Frankowska
- Fried
- Gao
- Gjini
- Goodman
- Hoeppner
- Hoppenbrouwers
- Huang
- Jeng
- Joshi
- Kalueff
- Kang
- King
- Kobori
- Kokinovic
- Krnjevic
- Krystal
- Kujirai
- Kuppuswamy
- Kushner
- Lang
- Latorre
- Leland Albright
- Lett
- Lewis
- Lewis
- Lewis
- Li
- Li
- Lissemore
- Lu
- Luscher
- Manganotti
- McCormick
- McDonnell
- Mehta
- Mehta
- Meunier
- Moher
- Molnar
- Mooney
- Mooney
- Mori
- Morin-Parent
- Naim-Feil
- Nakamura
- Nantes
- Noda
- Oberman
- Opie
- Page
- Pan
- Pawley
- Pearce
- Pearce
- Pearce
- Philpott
- Pierantozzi
- Pierantozzi
- Potkin
- Powers
- Priori
- Priori
- Radhu
- Radhu
- Radhu
- Romeo
- Rona
- Ruiz-Veguilla
- Sailer
- Salas
- Salerno
- Sanacora
- Sanger
- Schambra
- Schambra
- SchĂŒr
- Seeger
- Silbert
- Siniatchkin
- Sofuoglu
- Squintani
- Sun
- Sun
- Sundaresan
- Swayne
- Tamburin
- Tegenthoff
- Treiman
- Tremblay
- Tremblay
- Valls-Solé
- Valzania
- Valzania
- van der Kamp
- Werhahn
- Zanette
- Zhao
- Publication venue
- 'Frontiers Media SA'
- Publication date
- Field of study
No full textPotential therapeutic targets for combating SARS-CoV-2: Drug repurposing, clinical trials and recent advancements
- Author
- Abdallah
- Abhjieet Pandey
- Ajinkya Nitin Nikam
- Ajjappla Basavaraj Shreya
- Alhazzani
- Amanat
- Anguiano
- Ashburn
- Barlow
- Basta
- Behrens
- Benjamin
- Bernareggi
- Bharath Singh Padya
- Biot
- Blaising
- Bloch
- BĂĄrcena
- C. for B.E. and Research
- Cai
- Caly
- Campoli-Richards
- Cascella
- Centenario Hospital Miguel Hidalgo
- Cha
- Chan
- Chan
- Chan-Yeung
- Chaturvedi
- Chen
- Cheng
- Chighizola
- Chu
- Colson
- Coutard
- Cui
- Cure
- Damle
- de Wilde
- de Wilde
- Deng
- Divya Gopalan
- Dong
- Duan
- Falzarano
- Faulds
- Fohner
- Gabutti
- Gao
- Gasper Fernandes
- Gautret
- Gautret
- Gielen
- Graci
- Griffin
- Gupta
- Henehan
- Hensley
- Hoenen
- Hoffmann
- Hsu
- Huang
- Hulseberg
- Hussain
- Irigoyen
- Jakimovski
- Jin
- K. K.
- Kadam
- Keizer
- Kindrachuk
- Knowles
- Kongsaengdao
- Kraft
- Kupferschmidt
- Kuriya
- Lai
- Lei
- Li
- Li
- Li
- Li
- Li
- Lim
- Liu
- Liu
- Liu
- Lo
- Lu
- Lu
- Lutz
- Madelain
- Marmor
- Mathias
- Mehta
- Mousavizadeh
- Nantes University Hospital
- National Cancer Institute Naples
- Omrani
- Oprea
- Pannu
- Parenti
- Parenti
- Peiris
- Perrier
- Phillips
- Pushpakom
- PĂ©cheur
- Richman
- Rojas
- Ruan
- Russell
- Ruth Prassl
- Sadhana P. Mutalik
- Sanjay Kulkarni
- Santos
- Savarino
- Sawicki
- Schneider
- Schoeman
- Shang
- Sheahan
- Sheahan
- Shen
- Singh
- Sola
- Somma
- Song
- Srinivas Mutalik
- Subissi
- Talevi
- Tan
- Te
- te Velthuis
- Teissier
- The Lancet Infectious Diseases
- Totura
- Tseng
- Tyteca
- Uyeki
- Vashist
- Vellingiri
- Vincent
- W.H. Organization
- W.H. Organization
- Wagstaff
- Walls
- Walls
- Wan
- Wang
- Wang
- Wang
- Wang
- Warren
- Wrapp
- Wu
- Wu
- Xia
- Xia
- Xia
- Xu
- Yan
- Yang
- Yang
- Yang
- Yin
- Yu
- Yuen
- Zeng
- Zhang
- Zhang
- Zhang
- Zhong
- Zhou
- Zhou
- Zhou
- Zhou
- Zhu
- Zou
- Zumla
- ĂlschlĂ€ger
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
No full textIntravenous immunoglobulin treatment for mild Guillain-Barré syndrome. An international observational study
- Author
- 2. Erasmus MC
- 2. KU Leuven
- 2. National and Kapodistrian University of Athens
- A. Davidson
- A. Doets
- A. Echaniz-Laguna
- A. J. van der Kooi
- A. Kohler
- A. Magot
- A. Pardal
- A. Savransky
- A. Schenone
- A. Spyropoulos (Royal Victoria Infirmary
- Aarhus Denmark)
- Aarhus Denmark)
- Allentown USA)
- Amsterdam
- Amsterdam
- Argentina)
- Argentina)
- Argentina)
- Argentina)
- Argentina)
- Argentina)
- Argentina)
- Asturias Spain)
- Athens Greece)
- b) Dhaka
- b) Dhaka
- b) Dhaka
- B. Islam
- B. Stein
- B. van den Berg
- Baltimore USA)
- Bangladesh (icddr
- Bangladesh (icddr
- Bangladesh (icddr
- Bangladesh)
- Bangladesh)
- Bangladesh)
- Barcelona Spain)
- Barcelona Spain)
- Barcelona Spain)
- Barcelona Spain)
- Barcelona Spain)
- Barcelona Spain)
- Barroso F.
- Binda D.
- Bradford UK)
- Buenos Aires
- Buenos Aires
- Buenos Aires
- Buenos Aires
- Buenos Aires
- Buenos Aires
- Buenos Aires
- Burlington
- Burlington VT
- C. Briani
- C. Bunschoten
- C. C. Chao
- C. Casasnovas
- C. Dornonville de la Cour
- C. Fokke
- C. G. Faber
- C. Homedes
- C. J. Gijsbers
- C. J. McDermott
- C. L. Sommer
- C. MĂĄrquez Infante
- C. Nascimbene
- C. Y. Tan
- Calgary Canada)
- Cambridge UK)
- Canada)
- Cape Town
- Cape Town
- Cavaletti G.
- Center
- Charlottesville USA)
- Chiba Japan)
- Chicago USA)
- Columbus USA)
- Copenhagen Denmark)
- Cordoba Spain)
- Cornblath D. R.
- Delft
- Department of Medicine
- Department of Medicine
- Dhaka Bangladesh)
- DO (Lehigh Valley Health Network
- DO (Spectrum Health System
- Dordrecht
- Dordrecht
- E. Dardiotis
- E. H. Niks
- E. Lee Pan
- E. Martinez Hernandez
- E. Nobile Orazio
- F. Eftimov
- F. Vermeij
- Faculty of Medicine
- Faculty of Medicine
- Fayetteville USA)
- FLENI
- France)
- France)
- FRCP (Ipswich Hospital
- FRCP (The Walton Centre
- G. A. Marfia
- G. Antonini
- G. Chavada
- G. Gutiérrez-Gutiérrez
- G. M. Sachs
- G. Mataluni
- G. Meekins
- G. MorĂs de la Tassa
- G. W. van Dijk
- Galassi G.
- Genetics and Maternal and Infantile Sciences (DINOGMI)
- Genova
- Genova Italy)
- Glasgow UK)
- Glasgow UK)
- Glasgow UK)
- Glostrup Denmark)
- Gorson K. C.
- Grand Rapids
- H. D. Katzberg
- H. J. Willison
- H. Kerkhoff
- H. Manji
- H. Tankisi
- Harbo T.
- Helmond and Deurne
- Homburg Germany)
- Homburg Germany)
- Hoorn
- Hospital Clinic
- Hospital of Larissa
- Houston USA)
- Hughes R. A. C.
- Humanitas Clinicala and Research Institute Milan
- Humanitas Clinicala and Research Institute Milan
- I. Illa
- I. Jahan
- I. JericĂł Pascual
- I. R. Bella
- I. Rojas-Marcos
- Indianapolis USA)
- Ipswich UK)
- Irvine USA)
- Italy 2. IRCCS Policlinico San Martino
- Italy)
- Italy)
- Italy)
- Italy)
- J. A. L. Miller
- J. BuÌrmann
- J. D. Varrato
- J. Fehmi (University of Oxford E. A. Fulgenzi
- J. Gilhuis
- J. K. L. Holt
- J. M. Gilchrist
- J. M. Goldstein
- J. Pardo Fernandez (Hospital ClĂnico de Santiago
- J. Roodbol
- J. S. Cosgrove
- J. V. Holbech
- J. Y. Kwan
- Jacksonville USA)
- Jacobs B. C. H. Andersen
- K. Bateman
- K. G. Claeys
- K. Jellema
- K. Kaida
- K. Kimpinski
- K. Kuitwaard
- K. Sheikh
- Kansas City
- Kusunoki S.
- Kuwabara S.
- L. Benedetti
- L. H. Visser
- L. Kiers
- L. Landschoff Lassen
- L. MartĂn-Aguilar
- L. Querol Gutierrez
- L. Santoro
- L. Schwindling
- L. Zhou
- La Spezia
- La Spezia
- Larissa Greece)
- Leeds UK)
- Lehmann H. C.
- Leiden
- Leiden
- Leuven Belgium
- Leuven Belgium)
- Leuven Belgium)
- Leuven Belgium)
- LHSC London-Ontario
- Liverpool UK)
- London UK)
- London UK)
- Lunn M. P.
- M. Bianco (Milan University
- M. Busby
- M. C. Dalakas
- M. Derejko
- M. E. Conti
- M. G. Mattiazzi
- M. Htut
- M. J. Sedano Tous
- M. Kuwahara
- M. M. Dimachkie
- M. Mandarakas
- M. Osei-Bonsu
- M. P. J. Garssen
- M. Pulley
- M. S. Monges
- M. Samukawa
- M. V. Vytopil
- M. van Woerkom (Erasmus MC
- Maastricht
- Malaya)
- Malaya)
- Marseille France)
- MBChB
- MBChB (Groote Schuur Hospital
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
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- MD
- MD
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- MD
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- MD
- MD
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- MD
- MD
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- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD
- MD (1. Thomas Jefferson University
- MD (Addenbrookeâs Hospital Cambridge
- MD (Barrow Neurology Clinics
- MD (Bellvitge University Hospital - IDIBELL Neurometabolic Diseases Group. CIBERER
- MD (BicĂȘtre University Hospital
- MD (Buffalo Jacobs School of Medicine S. Sindrup
- MD (Canisius Wilhelmina Hospital
- MD (Columbia University
- MD (Dokkyo Medical University
- MD (Franciscus Gasthuis
- MD (Franciscus Gasthuis
- MD (Gelre Hospital
- MD (Glostrup Hospital
- MD (Hospital Britanico
- MD (Hospital Cesar Milstein Buenos Aires
- MD (Hospital ClĂnico de Santiago
- MD (Hospital de la Santa Creu i Sant Pau
- MD (Hospital de PediatrĂa J. P. Garrahan
- MD (Hospital Militar Central
- MD (Hospital Universitario Infanta Sofia
- MD (Hospital Universitario Marques de Valdecilla
- MD (Hospital Universitario Virgen del Rocio
- MD (Hospital UniversitarioCentral de Asturias
- MD (Hospital Univesitario Reina Sofia
- MD (Institut dâInvestigacions BiomĂšdiques August Pi i Sunyer (IDIBAPS)
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- MD (Leeds General Infirmary
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- MD (Soulthern Illinois University School of Medicine
- MD (St. Georgeâs Hospital
- MD (St. Josephâs Regional Medical Center
- MD (The University of Tennessee Health Science Center (UTHSC)
- MD (Toho University Medical Center
- MD (University Hospital
- MD (University Hospital Clinicas
- MD (University Hospital/ University of Texas Health Science Center
- MD (University of Arkansas
- MD (University of Calgary
- MD (University of California
- MD (University of Florida
- MD (University of Glasgow
- MD (University of Indiana School of Medicine
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- MD (University of Maryland School of Medicine
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- MD (University of Melbourne
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- MD (University of Padova
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- MD (University of Thessaly
- MD (University of Toronto
- MD (University of Utah School of Medicine
- MD (University of Vermont
- MD (University of Vermont Medical Center
- MD (University of Virginia
- MD (UniversitÀtsklinikum des Saarlandes
- MD (UniversitÀtsklinikum des Saarlandes
- MD (UniversitĂ€tsklinikum WuÌrzburg
- MD (Vlietland Hospital
- MD (Westfriesgasthuis
- MD (Wexner Medical Center at The Ohio State University
- MD (Yale University School of Medicine
- MD (Yale University School of Medicine
- Memphis USA)
- Middlesbrough UK)
- Milan Italy)
- Milan Italy)
- MRCP (Neurology Unit
- N. A. Goyal
- N. J. Silvestri
- N. Kokubun
- N. Kolb
- N. Shahrizaila
- Nantes University Hospital
- Nantes University Hospital
- Napels Italy)
- New Brunswick
- New Haven
- New Haven
- New York
- New York City
- Newcastle UK)
- Newcastle UK)
- NIHR Clinical
- Nijmegen
- Odense Denmark)
- Odense Denmark)
- Odense Denmark)
- Osaka Japan)
- Osaka Japan)
- P. Twydell
- P. Van Damme
- P. Van den Bergh
- Padova Italy)
- Pamplona Spain)
- Paris France)
- Parkville Australia)
- Paterson USA)
- PhD
- PhD (1. Albert Schweitzer Hospital
- PhD (1. Department of Neurosciences
- PhD (1. University Hospitals Leuven
- PhD (Aarhus University Hospital
- PhD (Aarhus University Hospital
- PhD (Albert Schweitzer Hospital
- PhD (Amsterdam University Medical Centre
- PhD (Amsterdam University Medical Centre
- PhD (Bellvitge University Hospital - IDIBELL Neurometabolic Diseases Group. CIBERER
- PhD (Chiba University
- PhD (CHU Timone
- PhD (Complejo Hospitalario de Navarra
- PhD (Concord Repatriation General Hospital
- PhD (Elisabeth-TweeSteden Hospital
- PhD (Elkerliek Hospital
- PhD (Erasmus University Medical Centre
- PhD (Glasgow University
- PhD (Groote Schuur Hospital
- PhD (Haaglanden Medisch Centrum
- PhD (HagaZiekenhuis
- PhD (Hospital de la Santa Creu i Sant Pau
- PhD (Hospital de la Santa Creu i Sant Pau
- PhD (Hospital de PediatrĂa J. P. Garrahan
- PhD (Icahn School
- PhD (International Centre for Diarrhoeal Disease Research
- PhD (International Centre for Diarrhoeal Disease Research
- PhD (James Cook University Hospital
- PhD (Jeroen Bosch Hospital
- PhD (Kindai University
- PhD (Kindai University
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- PhD (Royal Victoria Infirmary
- PhD (Rutgers
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- PhD (Tufts University School of Medicine Lahey Hospital P. W. Wirtz
- PhD (University Clinic St. Luc
- PhD (University Federico II
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- PhD (University of Glasgow
- PhD (University of Oxford J. P. A. Samijn
- PhD candidate (Erasmus University Medical Centre
- PhD candidate (Erasmus University Medical Centre
- PhD candidate (Erasmus University Medical Centre
- PhD candidate (Erasmus University Medical Centre
- PhD candidate (International Centre for Diarrhoeal Disease Research
- Philadelphia USA
- Phoenix Arizona
- Policlinico Tor Vergata
- Policlinico Tor Vergata
- Providence USA)
- Q. D. Mohammad
- R. Bhavaraju-Sanka
- R. C. Roberts
- R. D. M. Hadden
- R. Fazio
- R. J. Nowak
- R. M. Pascuzzi
- R. van Koningsveld
- Rehabilitation Ophthalmology
- Reisin R. C.
- Robert Wood Johnson University Hospital
- Rome Italy)
- Rome Italy)
- Rome Italy)
- Rotterdam
- Rotterdam
- Rotterdam
- Rotterdam
- Rotterdam
- Rotterdam
- Rotterdam
- Rotterdam
- Rotterdam
- Rotterdam
- Royal Melbourne Hospital
- S. A. Rudnicki
- S. Ajroud-Driss
- S. Attarian
- S. Butterworth
- S. Chen
- S. E. Leonhard
- S. Grisanti
- S. Karafiath
- S. Rinaldi
- S. S. Ladha
- S. T. Hsieh
- S. W. Reddel
- Saitama Japan)
- Salt Lake City
- San Antonio Texas
- San Sebastian
- Santander Cantabria
- Santiago de Compostela (A Coruña)
- Santiago de Compostela (A Coruña)
- SantâAndrea Hospital
- Sapienza University
- Schiedam
- Seville Spain)
- Sheffield UK)
- South-Africa)
- South-Africa)
- Spain)
- Spain)
- Spain)
- Spain)
- Springfield USA)
- Sydney Australia)
- T. E. Bertorini
- T. E. Feasby
- T. Fujioka
- T. GarcĂa-Sobrino
- T. H. Brannagan
- T. van der Ree
- Taipei Taiwan)
- Taipei Taiwan)
- The Hague
- The Hague
- The Netherlands)
- The Netherlands)
- The Netherlands)
- The Netherlands)
- The Netherlands)
- The Netherlands)
- The Netherlands)
- The Netherlands)
- The Netherlands)
- The Netherlands)
- The Netherlands)
- The Netherlands)
- The Netherlands)
- the Netherlands)
- The Netherlands)
- The Netherlands)
- The Netherlands)
- The Netherlands)
- The Netherlands)
- The Netherlands)
- the Netherlands)
- the Netherlands)
- The Netherlands)
- the Netherlands)
- The Netherlands)
- the Netherlands)
- Tilburg and Waalwijk
- Tochigi Japan)
- Tokyo Japan)
- Toronto Canada)
- U. A. Badrising
- Universitat AutĂČnoma de Barcelona
- Universitat AutĂČnoma de Barcelona
- Universitat AutĂČnoma de Barcelona
- University of Genova
- University of Malaya
- University of Malaya
- USA)
- USA)
- USA)
- USA)
- USA)
- USA)
- USA)
- USA)
- USA)
- USA)
- USA)
- USA)
- USA). Other collaborators were:J. M. Addington
- V. Granit
- V. Lawson
- Van Doorn P. A.
- Verboon C.
- W. Waheed
- Wakefield UK)
- Worcester USA)
- WuÌrzburg Germany)
- Y. Péréon
- Y. Sekiguchi
- Z. Islam
- Zutphen and Apeldoorn
- âs Hertogenbosch
- Publication venue
- 'BMJ'
- Publication date
- 01/01/2021
- Field of study
No full textObjective: To compare the disease course in patients with mild Guillain-Barré syndrome (GBS) who were treated with intravenous immunoglobulin (IVIg) or supportive care only. Methods: We selected patients from the prospective observational International GBS Outcome Study (IGOS) who were able to walk independently at study entry (mild GBS), treated with one IVIg course or supportive care. The primary endpoint was the GBS disability score four weeks after study entry, assessed by multivariable ordinal regression analysis. Results: Of 188 eligible patients, 148 (79%) were treated with IVIg and 40 (21%) with supportive care. The IVIg group was more disabled at baseline. IVIg treatment was not associated with lower GBS disability scores at 4 weeks (adjusted OR (aOR) 1.62, 95% CI 0.63 to 4.13). Nearly all secondary endpoints showed no benefit from IVIg, although the time to regain full muscle strength was shorter (28 vs 56 days, p=0.03) and reported pain at 26 weeks was lower (n=26/121, 22% vs n=12/30, 40%, p=0.04) in the IVIg treated patients. In the subanalysis with persistent mild GBS in the first 2 weeks, the aOR for a lower GBS disability score at 4 weeks was 2.32 (95% CI 0.76 to 7.13). At 1 year, 40% of all patients had residual symptoms. Conclusion: In patients with mild GBS, one course of IVIg did not improve the overall disease course. The certainty of this conclusion is limited by confounding factors, selection bias and wide confidence limits. Residual symptoms were often present after one year, indicating the need for better treatments in mild GBS
