Active Care - Building Design for Habilitation Centers

This paper explores the building design of a Habilitation Center that promotes healthy lifestyles of people with diverse abilities. Habilitation care moves the focus of healthcare from a disease curing approach to lifelong health development. Studies show that the design of healthcare buildings can contribute to improving care and by extension, it is expected that building design can contribute to improving habilitation care. However, in practice, there is limited experience in designing habilitation facilities, particularly concerning emerging healthcare approaches such as health promotion. This paper describes the outcomes of a master thesis that was part of a pre-study for a habilitation center that focused on design strategies and solutions that stimulate physical activity for diverse users. The main research question was: In what way can building design promote active behavior for all types of building users? The study adopted a research by design approach focused on (1) understanding user needs, (2) developing design strategies, and (3) proposing a design solution. The results list several design strategies for habilitation buildings and propose how these can be implemented. These guidelines include strategies for physical movement such as indoor and outdoor exercise areas, climbing walls and access to nature. These results may support the development of the new habilitation center, while also introducing theoretical ideas and design guidelines regarding active design. The study can be used to inspire and discuss the design and development of habilitation centers specifically, and more generally healthcare buildings that adopt new care approaches such as health promotion

Characteristics of Social Sciences and Health Sciences Degrees: self-concept , motivation and learning strategies

[EN] Current university context is experiencing many changes and in order to achieve a better adaptation of students to this new context it is important to identify university students’ characteristics. Among students characteristics’ we emphasise the relevance of self-concept, or the perception that we have about ourselves, motivation and learning strategies that students use to acquire knowledge. In this study a total of 155 students from the University of Granada took part (143 female and 12 men; mean age=22.48, SD=4.11), of whom 65 were taking a degree that belongs to the Social Science disciplines (Preschool Education Degree) and 90 were taking a degree that belongs to the Health Sciences discipline (Speech Therapy degree). Results show that, in general, participants from this study obtain high scores in self-concept. More specifically they score high on family and social self-concept and low on emotional self-concept. Students from both degrees show high to moderate levels of motivation, particularly of intrinsic motivation, high levels of self-efficacy beliefs and intermediate levels of anxiety. The most frequently used learning strategy was the elaboration strategy. To conclude, despite belonging to two different disciplines, there are many similarities between students from both degrees. The implication of results is discussed.[ES] La universidad actual está experimentando diversos cambios, dentro de este contexto es relevante conocer las características del alumnado universitario para lograr una adaptación más óptima. Entre las características más relevantes a analizar destacamos la relevancia del autoconcepto, o la percepción que las personas tenemos de nosotras mismas, la motivación y las estrategias que emplean los estudiantes para el aprendizaje en el ámbito universitario.En este estudio han participado un total de 155 estudiantes de Grado de la Universidad de Granada (143 mujeres y 12 hombres; edad media = 22.48, DT= 4.11), de éstos 65 pertenecen al área de Ciencias Sociales (Grado de Educación Infantil) y 90 al área de Ciencias de la Salud (Grado de Logopedia). Los resultados revelan que en general presentan puntuaciones altas en autoconcepto. En concreto destaca el autoconcepto familiar y social con los valores más altos, mientras que el emocional se revela con valores más bajos.En ambos grados presentan unos niveles de motivación medio-altos, destacando una orientación motivacional intrínseca, mientras que la ansiedad revela puntuaciones intermedias. La estrategia de aprendizaje de elaboración se revela como la más utilizada entre los estudiantes. A modo de conclusión se observan bastantes similitudes entre las características de autoconcepto, motivación y estrategias de aprendizaje a pesar de pertenecer a áreas diferentes. No obstante cabe destacar en ambas áreas presentan rasgos parecidos. Se discute la implicación de los resultados encontrados.Calet, N.; Dumitrache, CG. (2016). Características de los Estudiantes de Grado de las áreas Ciencias Sociales y Salud: autoconcepto, motivación y estrategias de aprendizaje. REDU. Revista de Docencia Universitaria. 14(2):245-260. doi:10.4995/redu.2016.5951.SWORD24526014

Aligned carbon nanotubes catalytically grown on iron-based nanoparticles obtained by laser-induced CVD

International audienceIron-based nanoparticles are prepared by a laser-induced chemical vapor deposition (CVD) process. They are characterized as body-centered Fe and Fe2O3 (maghemite/magnetite) particles with sizes ::;5 and 10 nm, respectively. The Fe particles are embedded in a protective carbon matrix. Both kind of particles are dispersed by spin-coating on SiO2/Si(1 0 0) flat substrates. They are used as catalyst to grow carbon nanotubes by a plasma- and filaments-assisted catalytic CVD process (PE-HF-CCVD). Vertically oriented and thin carbon nanotubes (CNTs) were grown with few differences between the two samples, except the diameter in relation to the initial size of the iron particles, and the density. The electron field emission of these samples exhibit quite interesting behavior with a low turn-on voltage at around 1 V/mm

Transgenic miR156 Switchgrass in the Field: Growth, Recalcitrance and Rust Susceptibility

Sustainable utilization of lignocellulosic perennial grass feedstocks will be enabled by high biomass production and optimized cell wall chemistry for efficient conversion into biofuels. MicroRNAs are regulatory elements that modulate the expression of genes involved in various biological functions in plants, including growth and development. In greenhouse studies, overexpressing a microRNA (miR156) gene in switchgrass had dramatic effects on plant architecture and flowering, which appeared to be driven by transgene expression levels. Highexpressing lines were extremely dwarfed, whereas low and moderate-expressing lines had higher biomass yields, improved sugar release and delayed flowering. Four lines with moderate or low miR156 overexpression from the prior greenhouse study were selected for a field experiment to assess the relationship between miR156 expression and biomass production over three years. We also analysed important bioenergy feedstock traits such as flowering, disease resistance, cell wall chemistry and biofuel production. Phenotypes of the transgenic lines were inconsistent between the greenhouse and the field as well as among different field growing seasons. One low expressing transgenic line consistently produced more biomass (25%–56%) than the control across all three seasons, which translated to the production of 30% more biofuel per plant during the final season. The other three transgenic lines produced less biomass than the control by the final season, and the two lines with moderate expression levels also exhibited altered disease susceptibilities. Results of this study emphasize the importance of performing multiyear field studies for plants with altered regulatory transgenes that target plant growth and development

53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination.

53BP1 activity drives genome instability and lethality in BRCA1-deficient mice by inhibiting homologous recombination (HR). The anti-recombinogenic functions of 53BP1 require phosphorylation-dependent interactions with PTIP and RIF1/shieldin effector complexes. While RIF1/shieldin blocks 5'-3' nucleolytic processing of DNA ends, it remains unclear how PTIP antagonizes HR. Here, we show that mutation of the PTIP interaction site in 53BP1 (S25A) allows sufficient DNA2-dependent end resection to rescue the lethality of BRCA1Δ11 mice, despite increasing RIF1 "end-blocking" at DNA damage sites. However, double-mutant cells fail to complete HR, as excessive shieldin activity also inhibits RNF168-mediated loading of PALB2/RAD51. As a result, BRCA1Δ1153BP1S25A mice exhibit hallmark features of HR insufficiency, including premature aging and hypersensitivity to PARPi. Disruption of shieldin or forced targeting of PALB2 to ssDNA in BRCA1D1153BP1S25A cells restores RNF168 recruitment, RAD51 nucleofilament formation, and PARPi resistance. Our study therefore reveals a critical function of shieldin post-resection that limits the loading of RAD51.We thank Anthony Tubbs for comments on the paper; Jennifer Mehalko and Dom Esposito (Protein Expression Laboratory, Frederick National Laboratory for Cancer Research) for transgenic constructs; Karim Baktiar, Diana Haines, and Elijah Edmonson (Pathology/Histotechnology Laboratory, Frederick National Laboratory for Cancer Research) for rodent necropsy, pathology analysis, and imaging; Joseph Kalen and Nimit Patel (Small Animal Imaging Program, Frederick National Laboratory for Cancer Research) for X-ray computed tomography (CT) scan imaging; Jennifer Wise and Kelly Smith for assistance with animal work; Davide Robbiani and Kai Ge for antibodies; Dan Durocher for shieldin constructs; David Goldstein and the CCR Genomics core for sequencing support; and Neil Johnson for discussions. Research in the J.M.S. laboratory is supported by NIH grant R01CA197506. Research in the N.M. laboratory is supported by NIH grant R01 227001. The A.N. laboratory is supported by the Intramural Research Program of the NIH, an Ellison Medical Foundation Senior Scholar in Aging Award (AG-SS-2633-11), the Department of Defense Idea Expansion (W81XWH-15-2-006) and Breakthrough (W81XWH-16-1-599) Awards, the Alex's Lemonade Stand Foundation Award, and an NIH Intramural FLEX Award.S

Performance of the CMS Cathode Strip Chambers with Cosmic Rays

The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device in the CMS endcaps. Their performance has been evaluated using data taken during a cosmic ray run in fall 2008. Measured noise levels are low, with the number of noisy channels well below 1%. Coordinate resolution was measured for all types of chambers, and fall in the range 47 microns to 243 microns. The efficiencies for local charged track triggers, for hit and for segments reconstruction were measured, and are above 99%. The timing resolution per layer is approximately 5 ns

Performance and Operation of the CMS Electromagnetic Calorimeter

The operation and general performance of the CMS electromagnetic calorimeter using cosmic-ray muons are described. These muons were recorded after the closure of the CMS detector in late 2008. The calorimeter is made of lead tungstate crystals and the overall status of the 75848 channels corresponding to the barrel and endcap detectors is reported. The stability of crucial operational parameters, such as high voltage, temperature and electronic noise, is summarised and the performance of the light monitoring system is presented