23 research outputs found

    The Fifteenth Data Release of the Sloan Digital Sky Surveys: First Release of MaNGA-derived Quantities, Data Visualization Tools, and Stellar Library

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    Twenty years have passed since first light for the Sloan Digital Sky Survey (SDSS). Here, we release data taken by the fourth phase of SDSS (SDSS-IV) across its first three years of operation (2014 July–2017 July). This is the third data release for SDSS-IV, and the 15th from SDSS (Data Release Fifteen; DR15). New data come from MaNGA—we release 4824 data cubes, as well as the first stellar spectra in the MaNGA Stellar Library (MaStar), the first set of survey-supported analysis products (e.g., stellar and gas kinematics, emission-line and other maps) from the MaNGA Data Analysis Pipeline, and a new data visualization and access tool we call "Marvin." The next data release, DR16, will include new data from both APOGEE-2 and eBOSS; those surveys release no new data here, but we document updates and corrections to their data processing pipelines. The release is cumulative; it also includes the most recent reductions and calibrations of all data taken by SDSS since first light. In this paper, we describe the location and format of the data and tools and cite technical references describing how it was obtained and processed. The SDSS website (www.sdss.org) has also been updated, providing links to data downloads, tutorials, and examples of data use. Although SDSS-IV will continue to collect astronomical data until 2020, and will be followed by SDSS-V (2020–2025), we end this paper by describing plans to ensure the sustainability of the SDSS data archive for many years beyond the collection of data

    Histone H3.3 beyond cancer: Germline mutations in Histone 3 Family 3A and 3B cause a previously unidentified neurodegenerative disorder in 46 patients

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    Although somatic mutations in Histone 3.3 (H3.3) are well-studied drivers of oncogenesis, the role of germline mutations remains unreported. We analyze 46 patients bearing de novo germline mutations in histone 3 family 3A (H3F3A) or H3F3B with progressive neurologic dysfunction and congenital anomalies without malignancies. Molecular modeling of all 37 variants demonstrated clear disruptions in interactions with DNA, other histones, and histone chaperone proteins. Patient histone posttranslational modifications (PTMs) analysis revealed notably aberrant local PTM patterns distinct from the somatic lysine mutations that cause global PTM dysregulation. RNA sequencing on patient cells demonstrated up-regulated gene expression related to mitosis and cell division, and cellular assays confirmed an increased proliferative capacity. A zebrafish model showed craniofacial anomalies and a defect in Foxd3-derived glia. These data suggest that the mechanism of germline mutations are distinct from cancer-associated somatic histone mutations but may converge on control of cell proliferation

    The fifteenth data release of the Sloan Digital Sky Surveys : first release of MaNGA derived quantities, data visualization tools and stellar library

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    Twenty years have passed since first light for the Sloan Digital SkySurvey (SDSS). Here, we release data taken by the fourth phase of SDSS(SDSS-IV) across its first three years of operation (July 2014-July2017). This is the third data release for SDSS-IV, and the fifteenth from SDSS (Data Release Fifteen; DR15). New data come from MaNGA - we release 4824 datacubes, as well as the first stellar spectra in the MaNGA Stellar Library (MaStar), the first set of survey-supported analysis products (e.g. stellar and gas kinematics, emission line, andother maps) from the MaNGA Data Analysis Pipeline (DAP), and a new data visualisation and access tool we call "Marvin". The next data release, DR16, will include new data from both APOGEE-2 and eBOSS; those surveys release no new data here, but we document updates and corrections to their data processing pipelines. The release is cumulative; it also includes the most recent reductions and calibrations of all data taken by SDSS since first light. In this paper we describe the location and format of the data and tools and cite technical references describing how it was obtained and processed. The SDSS website (www.sdss.org) has also been updated, providing links to data downloads, tutorials and examples of data use. While SDSS-IV will continue to collect astronomical data until 2020, and will be followed by SDSS-V(2020-2025), we end this paper by describing plans to ensure the sustainability of the SDSS data archive for many years beyond the collection of data.Publisher PDFPeer reviewe

    THE ABSORPTION SPECTRUM OF VAPORIZED CuO: A REASSESSMENT OF THE ORANGE-RED SYSTEM

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    1^{1} A. Guntsch, Arkiv Mat. Astron. Fysik 33A, no. 2 (1945).""Author Institution: Department of Chemistry, Drexel UniversityThe vapor phase absorption spectrum of CuO (produced by flash heating powdered Cu2Cu_{2}O) has been photographed at high resolution (\sim 0.645 \AA/mm dispersion) between 6000 and 6200 {\AA}. The measurements for the observed rotational lines agree well (\leq 0.04cm10.04 cm^{-1} deviation) with those presently in the literature.1literature.^{1} Nevertheless, an improved least squares fit to a Fortrat parabola (the rms deviation is reduced from 0.200 to 0.018cm10.018 cm^{-1}) is obtained if lines previously assigned to the observed band with a head at 6161.9 {\AA} (16 224 cm1cm^{-1}) are assumed to form, instead, the band whose head appears at 6162.8 {\AA} (16.222cm116.222 cm^{-1})

    REVISED VIBRATIONAL ANALYSIS FOR METHANETHIOL

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    1^{1}J. Travert, O. Saur, A. Janin,and J. C. Lavalley, J. Mol. Struct., 1976, 33, 265; O. Saur, J. Travert, J.-C. Lavalley, and M. Chabanel, C.R. Acad. Sci. Paris, 1980, c, 291, 227. 2^{2}I.W. May and E.L. Pace, Spectrochim. Acta, 1968, 24A, 1605.Vibrational data for C-deuterated methanethiols are now available1available^{1} to supplement those previously reported for CH3SHCH_{3}SH and CH3SD.2CH_{3}SD.^{2} In addition 13CH3SH(90^{13}CH_{3}SH (90% ^{13}C)hasbeenprepared,anditsvaporphaseinfraredspectrumobtained.Onthebasisofthisinformation,anewnormalcoordinateanalysisofmethanethiolwasundertaken.Thecalculationsusedamodifiedvalenceforcefieldinwhicheightdiagonal(thetorsionalmodewasneglected)andfourinteractionconstantsweresimultaneouslyrefined.This12parameterforcefieldreproduced50observedfrequencieswithisaverageerroroflessthan has been prepared, and its vapor-phase infrared spectrum obtained. On the basis of this information, a new normal coordinate analysis of methanethiol was undertaken. The calculations used a modified valence force field in which eight diagonal (the torsional mode was neglected) and four interaction constants were simultaneously refined. This 12 parameter force field reproduced 50 observed frequencies with is average error of less than 9 cm^{-1}(<0.8 (< 0.8%). One consequence of these calculations is the revision of certain published assignments for several bands involving the CD_{3}$ and CSH deformations of the C-deuterated species

    High-level adaptive program optimization with ADAPT

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