Injecting equipment schemes for injecting drug users : qualitative evidence review

This review of the qualitative literature about needle and syringe programmes (NSPs) for injecting drug users (IDUs) complements the review of effectiveness and cost-effectiveness. It aims to provide a more situated narrative perspective on the overall guidance questions

Under the Radar: Muslims Deported, Detained, and Denied on Unsubstantiated Terrorism Allegations

Through the targeted use of a wide set of immigration and law enforcement policies and actions, the U.S. government has cast Muslims as dangerous threats to national security, leaving Muslim communities across the United States vulnerable to discrimination and discriminatory profiling. This Briefing Paper by the Center for Human Rights and Global Justice (CHRGJ) and the Asian American Legal Defense and Education Fund (AALDEF) documents the U.S. government's deployment of lower evidentiary standards and lack of due process guarantees in the immigration system against Muslims to further marginalize this targeted group in the name of national security and counterterrorism. A number of particular immigration programs and practices -- such as the National Security Entry-Exit Registration System (NSEERS),the Federal Bureau of Investigation (FBI) name-check system in the naturalization process, and racial profiling at U.S. borders have received critical attention for their discriminatory impacts on Muslim communities. This Briefing Paper draws on interviews with immigration and criminal defense attorneys and community-based groups, court documents, and media accounts to identify five key under-documented patterns of government practices that appear to be targeting Muslim communities through the immigration system

Self-consistent theory of turbulent transport in the solar tachocline. III. Gravity waves

To understand the fundamental physical processes important for the evolution of solar rotation and distribution of chemical species, we provide theoretical predictions for particle mixing and momentum transport in the stably stratified tachocline. By envisioning that turbulence is driven externally in the tachocline (e.g. by plume penetration), we compute the amplitude of turbulent flow, turbulent particle diffusivities, and eddy viscosity, by incorporating the effect of a strong radial differential rotation and stable stratification. We identify the different roles that the shear flow and stable stratification play in turbulence regulation and transport. Particle transport is found to be severely quenched due to stable stratification as well as radial differential rotation, especially in the radial direction with an effectively more efficient horizontal transport. The eddy viscosity is shown to become negative for parameter values typical of the tachocline, suggesting that turbulence in the stably stratified tachocline leads to a non-uniform radial differential rotation. Similar results also hold in the radiative interiors of stars, in general

Building on our strengths: a framework to reduce race-based discrimination and support diversity in Victoria : full report

Building on our strengths: a framework to reduce race-based discrimination and support diversity in Victoria has been developed through a partnership between the Victorian Health Promotion Foundation (VicHealth), the Victorian Equal Opportunity and Human Rights Commission, the McCaughey Centre: VicHealth Centre for the Promotion of Mental Health and Community Wellbeing and the Onemda VicHealth Koori Health Unit. The McCaughey Centre and Onemda are both in the School of Population Health at the University of Melbourne. Drawing on the best available evidence in Australia and internationally, this report outlines themes, strategies and priority settings for the development and implementation of activity to reduce race-based discrimination and support diversity. Although recognising that discrimination has a specific meaning in law, this report takes a broader approach, being concerned with behaviours and practices that result in avoidable and unfair inequalities across groups in society based on race, ethnicity, culture or religion. Despite widespread support for diversity among Victorians, the data presented in this report indicate that race-based discrimination remains unacceptably high. The findings of a survey commissioned by VicHealth in 2006–07 (referred to in this report as the VicHealth Survey) showed that 90% of Victorians think it is a good thing for society to be made up of people from different cultures. However, existing side-byside with this apparent tolerance: • nearly 1 in 10 respondents agreed with the statement that not all races are equal; • nearly 1 in 10 respondents said that it is not a good idea for people of different races to marry one another; • more than 1 in 3 respondents believed that ‘Australia is weakened by people of different ethnic origins sticking to their old ways’; and • more than 1 in 3 respondents agreed with the statement that there were groups that did not belong in Australia (VicHealth 2007) These findings are of particular concern given increasing evidence that race-based discrimination impacts negatively on both individuals and the community. This includes evidence of links with ill-health and reduced productivity, social inclusion and community cohesion. Reducing race-based discrimination will be critical if the Victorian and Australian governments are to meet their commitments to achieve equitable health for all Australians and, in particular, to eliminate the gaps in health, social and economic status between people from Indigenous and non-indigenous backgrounds. Building on our strengths is driven by the goal of achieving sustainable reductions in race-based discrimination, with associated medium- and long-term benefits to individuals, organisations, communities and society. It is intended for broad usage across government, corporate, non-government and community sectors as a useful resource in policy and program development, implementation and evaluation

ELM triggering conditions for the integrated modeling of H-mode plasmas

Recent advances in the integrated modeling of ELMy H-mode plasmas are presented. A model for the H-mode pedestal and for the triggering of ELMs predicts the height, width, and shape of the H-mode pedestal and the frequency and width of ELMs. Formation of the pedestal and the L-H transition is the direct result of ExB flow shear suppression of anomalous transport. The periodic ELM crashes are triggered by either the ballooning or peeling MHD instabilities. The BALOO, DCON, and ELITE ideal MHD stability codes are used to derive a new parametric expression for the peeling-ballooning threshold. The new dependence for the peeling-ballooning threshold is implemented in the ASTRA transport code. Results of integrated modeling of DIII-D like discharges are presented and compared with experimental observations. The results from the ideal MHD stability codes are compared with results from the resistive MHD stability code NIMROD.Comment: 12th International Congress on Plasma Physics, 25-29 October 2004, Nice (France

The Paradox of Power in CSR: A Case Study on Implementation

Purpose Although current literature assumes positive outcomes for stakeholders resulting from an increase in power associated with CSR, this research suggests that this increase can lead to conflict within organizations, resulting in almost complete inactivity on CSR. Methods A single in-depth case study, focusing on power as an embedded concept. Results Empirical evidence is used to demonstrate how some actors use CSR to improve their own positions within an organization. Resource dependence theory is used to highlight why this may be a more significant concern for CSR. Conclusions Increasing power for CSR has the potential to offer actors associated with it increased personal power, and thus can attract opportunistic actors with little interest in realizing the benefits of CSR for the company and its stakeholders. Thus power can be an impediment to furthering CSR strategy and activities at the individual and organizational level

Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer.

Although targeted therapies often elicit profound initial patient responses, these effects are transient due to residual disease leading to acquired resistance. How tumors transition between drug responsiveness, tolerance and resistance, especially in the absence of preexisting subclones, remains unclear. In epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma cells, we demonstrate that residual disease and acquired resistance in response to EGFR inhibitors requires Aurora kinase A (AURKA) activity. Nongenetic resistance through the activation of AURKA by its coactivator TPX2 emerges in response to chronic EGFR inhibition where it mitigates drug-induced apoptosis. Aurora kinase inhibitors suppress this adaptive survival program, increasing the magnitude and duration of EGFR inhibitor response in preclinical models. Treatment-induced activation of AURKA is associated with resistance to EGFR inhibitors in vitro, in vivo and in most individuals with EGFR-mutant lung adenocarcinoma. These findings delineate a molecular path whereby drug resistance emerges from drug-tolerant cells and unveils a synthetic lethal strategy for enhancing responses to EGFR inhibitors by suppressing AURKA-driven residual disease and acquired resistance

Ionogel-based light-actuated valves for controlling liquid flow in micro-fluidic manifolds

We present the fabrication, characterisation and performance of four novel ionic liquid polymer gels (ionogels) as photo-actuated valves incorporated into micro-fluidic manifolds. The ionogels incorporate benzospiropyran units and phosphonium-based ionic liquids. Each ionogel is photo-polymerised in situ in the channels of a poly(methyl methacrylate) micro-fluidic device, generating a manifold incorporating four different micro-valves. The valves are actuated by simply applying localised white light irradiation, meaning that no physical contact between the actuation impulse (light) and the valve structure is required. Through variation of the composition of the ionogels, each of the micro-valves can be tuned to open at different times under similar illumination conditions. Therefore, flows through the manifold can be independently controlled by a single light source. At present, the contraction process to open the channel is relatively rapid (seconds) while the recovery (expansion) process to re-close the channel is relatively slow (minutes), meaning that the valve, in its current form, is better suited for single-actuation events

Research into employee trust:epistemological foundations and paradigmatic boundaries

This article explores the epistemological roots and paradigmatic boundaries of research into employee trust, a growing field in human resource management. Drawing on Burrell and Morgan's well-known sociological paradigms and their epistemological foundations, we identify the dominant approaches to employee trust research to examine its strengths and limitations. Our review of the literature on employee trust revealed that the majority of the most cited papers were written from a psychological perspective, characterised by positivistic methodologies, variance theory explanations and quantitative data collection methods. We also found that most of the studies can be located in the functionalist paradigm, and while accepting that functionalism and psychological positivism have their merits, we argue that research in these traditions sometimes constrains our understanding of employee trust in their organisations. We conclude that trust researchers would benefit from a better understanding of the ontological, epistemological and axiological assumptions underlying of HRM research and should embrace greater epistemic reflexivity