On the use of polynomial models in multiobjective directional direct search

FCT - Fundacao para a Ciencia e a Tecnologia PTDC/MAT-APL/28400/2017; UIDB/00297/2020.Polynomial interpolation or regression models are an important tool in Derivative-free Optimization, acting as surrogates of the real function. In this work, we propose the use of these models in the multiobjective framework of directional direct search, namely the one of Direct Multisearch. Previously evaluated points are used to build quadratic polynomial models, which are minimized in an attempt of generating nondominated points of the true function, defining a search step for the algorithm. Numerical results state the competitiveness of the proposed approach.authorsversionpublishe

Blunted Coronary Flow Velocity Reserve is Associated With Impairment in Systolic Function and Functional Capacity in Hypertrophic Cardiomyopathy

Background Coronary microvascular dysfunction constitutes an important pathophysiological feature in hypertrophic cardiomyopathy (HCM). We aimed to assess the association between impaired coronary flow velocity reserve (CFVR) and ventricular systolic function and functional capacity. Methods Eighty-three patients with HCM were enrolled in this prospective cohort study. Patients underwent echocardiogram to evaluate ventricular performance and CFVR in the left anterior descending artery (LAD) and posterior descending artery (PD). Diastolic coronary flow velocity was measured in basal conditions and in hyperemia. CFVR was calculated as the ratio of hyperemic and basal peak diastolic flow velocities. Functional capacity was evaluated by cardiopulmonary exercise testing (CPET). The link between CFVR and biventricular systolic function and peak VO2 was studied. Results Age was 55.0(14.4)years, 50 patients (60%) were male; 59 patients (71%) had nonobstructive HCM. Mean CFVR LAD was 1.81(0.49) and CFVR PD was 1.73(0.55). Lower CFVR PD was associated with impaired global longitudinal strain (GLS) 2D (β-estimate:-3.240,95%CI:-4.634;-1.846, p < 0.001), GLS 3D (β-estimate:-2.559,95%CI:-3.932;-1.186, p < 0.001) and area strain (β-estimate:-3.044,95%CI:-5.373;-0.716, p = 0.011). Lower values of CFVR PD related to worse global work index (β-estimate:267.824,95%CI:75.964;459.683, p = 0.007), global constructive work (β-estimate:217.300,95%CI:38.750;395.850, p = 0.018) and global work efficiency (β-estimate:5.656,95%CI:2.229;9.084, p = 0.002). Impaired CFVR LAD (β-estimate:2.826, 95%CI:0.913;4.739, p = 0.004) and CFVR PD (β-estimate:2.801,95%CI:0.657;4.945, p = 0.011) were associated with lower TAPSE. Lower values of CFVR LAD (β-estimate:2.580, 95%CI:0.169;4.991, p = 0.036) and CFVR PD (β-estimate:3.163, 95%CI: 0.721;5.606, p = 0.012) were associated with worse peak VO2. Conclusion Lower CFVR was associated with impairment in biventricular systolic function parameters and functional capacity assessed by pVO2.info:eu-repo/semantics/publishedVersio

Assessment of Indoor Environmental Quality in Elderly Care Centers

The aim of this study was to characterize indoor environmental quality in a representative sample of Elderly Care Centers (ECC) in order to associate it with ventilation, health and comfort of elderly people. Indoor air quality (IAQ) parameters and thermal comfort were measured twice, during winter and spring/summer seasons, from 18 Elderly Care Centers (ECC) located in Lisbon, with a total of 116 rooms evaluated. Carbon dioxide and carbon monoxide were monitored during occupation periods using the Indoor Air Quality Meter (TSI, model 7545, USA). Formaldehyde was collected by active sampling on impingers, using personal pumps at an airflow of 1L/min and analyzed according to NIOSH 3500 method, using visible spectrometry (UV4, UNICAM). PM10 and PM2,5 were collected by active sampling on pre-weighted PTFE filters mounted on PM10 and PM2,5 collectors (PEM, SKC), using personal pumps operating at 2L/min, followed by gravimetric analysis for particle mass according to the method IP-10A by SKC (2004). Duplicate samples of total volatile organic compounds were collected on TENAX Tubes (Ref. 25054, Supelco) using SKC personal pumps calibrated to 0.05 L/min and analyzed after thermal desorption according to ISO 16000-part 6 using gas chromatography. Duplicate samples of viable airborne bacteria and fungi were collected using the Microbiological Air Sampler (Merck) and TSA, McK and MEA for total bacteria, Gram-negative bacteria and fungi, respectively. Whole-body thermal comfort evaluation was based on PMV (Predicted Mean Vote) and PPD (Predicted Percentage of Dissatisfied) indices, according to the ISO 7730:2005. Considering the obtained results for environmental indoor quality it is possible to conclude that thermal comfort was not reached in more than 30% of the rooms. In winter, carbon dioxide concentrations were above the reference in 20% of the rooms. PM10 and PM2,5 mean concentrations were above the reference levels in approximately 25% and 30% of the rooms, respectively. Microbiological contamination (total bacteria and fungi) was above the reference levels in more than 35% of the rooms. Indoor environmental quality should be improved by controlling contamination sources, ventilation and thermal parameters (or clothing) in order to obtain healthier environments for the elderly.Fundação para a Ciência e TecnologiaN/

Characterisation of microbial attack on archaeological bone

As part of an EU funded project to investigate the factors influencing bone preservation in the archaeological record, more than 250 bones from 41 archaeological sites in five countries spanning four climatic regions were studied for diagenetic alteration. Sites were selected to cover a range of environmental conditions and archaeological contexts. Microscopic and physical (mercury intrusion porosimetry) analyses of these bones revealed that the majority (68%) had suffered microbial attack. Furthermore, significant differences were found between animal and human bone in both the state of preservation and the type of microbial attack present. These differences in preservation might result from differences in early taphonomy of the bones. © 2003 Elsevier Science Ltd. All rights reserved