Vier jaargetijden: archeologisch onderzoek van nederzettingen uit de ijzer- en Romeinse tijd in een leemontginning te Kesselt - Lanaken (Provincie Limburg)

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Survey on time-delay approach to networked control

This paper provides a survey on time-delay approach to networked control systems (NCSs). The survey begins from a brief summary on fundamental network-induced issues in NCSs and the main approaches to the modelling of NCSs. In particular, a comprehensive introduction to time-delay approach to sampled-data and networked control is provided. Then, recent results on time-delay approach to event-triggered control are recalled. The survey highlights time-delay approach developed to modelling, analysis and synthesis of NCSs, under communication constraints, with a particular focus on Round-Robin, Try-once-discard and stochastic protocols. The time-delay approach allows communication delays to be larger than the sampling intervals in the presence of scheduling protocols. Moreover, some results on networked control of distributed parameter systems are surveyed. Finally, conclusions and some future research directions are briefly addressed

Etiology of knee pain in elite cyclists A 14-month consecutive case series

Overuse injuries of the knee are a common cause of missed training and competition days in elite cyclists, however the underlying conditions causing this knee pain are not well defined. We conducted a diagnostic study, investigating a consecutive series of 53 high level cyclists with non-traumatic knee pain over a 14 month period. Demographic data on the participants’ cycling specialty and training level was noted. Clinical information concerning knee pain intensity, location and occurrence were collected using a questionnaire. Our results show 7 different overuse injuries were identified. The prepatellar friction syndrome accounted for the majority of these overuse injuries (46%), while medial plica syndrome (15%), biceps femoris tendinopathy (7.5%), patellar tendinopathy (9.4%), infrapatellar plica friction syndrome (7.5%), infrapatellar fat pad impingement (5.7%) and iliotibial band syndrome (3.7%) were other causes of knee pain in these athletes. In contrast to current belief, our results show that instead of patellofemoral cartilage overload, friction related overuse injuries are the most frequent and underestimated cause of knee pain in high level cyclists

A prospective comparative study between a cooling device and manual cooling after total knee arthroplasty

Background Studies have shown that the use of cryotherapy after a total knee arthroplasty can have beneficial effect on blood loss, pain and medication usage. In this study, the effect of the applied cryotherapy procedure is investigated.Methods 52 patients underwent a total knee arthroplasty. The test group received continuous cooling, whereas the control group received manual conventional cooling with ice dressing. The knee circumference and range of motion, medication use, satisfaction and pain were investigated.Results There is no statistical significant difference in pain and medication usage. A significant difference is observed in the swelling of the knee on the first postoperative day, the range of motion on the 7th, 10th, 11th and 12th postoperative day, and the satisfaction rate.Conclusion This study shows that continuous cooling has a positive effect on the swelling and range of motion of the knee, and on the satisfaction of the treatment

Discovery of a Novel Dual Fungal CYP51/Human 5-Lipoxygenase Inhibitor: Implications for Anti-Fungal Therapy

We report the discovery of a novel dual inhibitor targeting fungal sterol 14α-demethylase (CYP51 or Erg11) and human 5-lipoxygenase (5-LOX) with improved potency against 5-LOX due to its reduction of the iron center by its phenylenediamine core. A series of potent 5-LOX inhibitors containing a phenylenediamine core, were synthesized that exhibit nanomolar potency and >30-fold selectivity against the LOX paralogs, platelet-type 12-human lipoxygenase, reticulocyte 15-human lipoxygenase type-1, and epithelial 15-human lipoxygenase type-2, and >100-fold selectivity against ovine cyclooxygenase-1 and human cyclooxygnease-2. The phenylenediamine core was then translated into the structure of ketoconazole, a highly effective anti-fungal medication for seborrheic dermatitis, to generate a novel compound, ketaminazole. Ketaminazole was found to be a potent dual inhibitor against human 5-LOX (IC50 = 700 nM) and CYP51 (IC50 = 43 nM) in vitro. It was tested in whole blood and found to down-regulate LTB4 synthesis, displaying 45% inhibition at 10 µM. In addition, ketaminazole selectively inhibited yeast CYP51 relative to human CYP51 by 17-fold, which is greater selectivity than that of ketoconazole and could confer a therapeutic advantage. This novel dual anti-fungal/anti-inflammatory inhibitor could potentially have therapeutic uses against fungal infections that have an anti-inflammatory componen