Increased urine IgM excretion predicts cardiovascular events in patients with type 1 diabetes nephropathy

<p>Abstract</p> <p>Background</p> <p>Diabetic nephropathy, a major complication of diabetes, is characterized by progressive renal injury and increased cardiovascular mortality. An increased urinary albumin excretion due dysfunction of the glomerular barrier is an early sign of diabetic nephropathy. An increased urinary excretion of higher molecular weight proteins such as IgM appears with progression of glomerular injury. We aim here to study the prognostic significance of urine IgM excretion in patients with type 1 diabetes mellitus (type 1 diabetic nephropathy).</p> <p>Methods</p> <p>This is an observational study of 139 patients with type1 diabetes mellitus (79 males and 60 females) under routine care at the diabetic outpatient clinic at the Lund University Hospital. The median follow-up time was 18 years (1 to 22) years. Urine albumin and urine IgM concentration were measured at time of recruitment.</p> <p>Results</p> <p>Overall 32 (14 male and 18 female) patients died in a cardiovascular event and 20 (11 male and 9 female) patients reached end-stage renal disease. Univariate analysis indicated that patient survival and renal survival were inversely associated with urine albumin excretion (RR = 2.9 and 5.8, respectively) and urine IgM excretion (RR = 4.6 and 5.7, respectively). Stratified analysis demonstrated that in patients with different degrees of albuminuria, the cardiovascular mortality rate and the incidence of end-stage renal disease was approximately three times higher in patients with increased urine IgM excretion.</p> <p>Conclusion</p> <p>An increase in urinary IgM excretion in patients with type 1 diabetes is associated with an increased risk for cardiovascular mortality and renal failure, regardless of the degree of albuminuria.</p

Separation of Oligosaccharides from Lotus Seeds via Medium-pressure Liquid Chromatography Coupled with ELSD and DAD

peer-reviewedLotus seeds were identified by the Ministry of Public Health of China as both food and medicine. One general function of lotus seeds is to improve intestinal health. However, to date, studies evaluating the relationship between bioactive compounds in lotus seeds and the physiological activity of the intestine are limited. In the present study, by using medium pressure liquid chromatography coupled with evaporative light-scattering detector and diode-array detector, five oligosaccharides were isolated and their structures were further characterized by electrospray ionization-mass spectrometry and gas chromatography-mass spectrometry. In vitro testing determined that LOS3-1 and LOS4 elicited relatively good proliferative effects on Lactobacillus delbrueckii subsp. bulgaricus. These results indicated a structure-function relationship between the physiological activity of oligosaccharides in lotus seeds and the number of probiotics applied, thus providing room for improvement of this particular feature. Intestinal probiotics may potentially become a new effective drug target for the regulation of immunity

Homocysteine Levels in Chronic Gastritis and Other Conditions: Relations to Incident Cardiovascular Disease and Dementia

Background Homocysteine levels in circulation are determined by several factors and hyperhomocysteinemia is reportedly associated with cardiovascular diseases and dementia. The aim of this study is to determine the relation of chronic gastritis and other conditions to homocysteine levels and their relation to incident cardiovascular diseases and dementia. Methods An adult population-based cohort (N = 488) was screened for H. pylori infection, gastro-duodenitis (endoscopic biopsies), disease history, and lifestyle factors. Blood samples were analyzed for pepsinogen I and II (gastric function), vitamin B12, folate, homocysteine, and cystatin C (renal function). The methylenetetrahydrofolate reductase C677T polymorphism reportedly associated with hyperhomocysteinemia was analyzed by pyrosequencing. Incident cardiovascular diseases and dementia were monitored during a median follow-up interval of 10 years. Results At baseline, there was a positive relation of S-homocysteine to male gender, age, S-cystatin C, methylenetetrahydrofolate reductase 677TT genotype and atrophic gastritis. During follow-up, cardiovascular diseases occurred in 101/438 and dementia in 25/488 participants, respectively. Logistic regression analysis (adjusting for gender, age at baseline, follow-up interval, BMI, smoking, alcohol consumption, NSAID use, P-cholesterol, and P-triglycerides) showed an association of S-homocysteine higher than 14.5 μmol/l to cardiovascular diseases (OR 2.05 [95% c.i. 1.14–3.70]), but not to dementia overall. Conclusions Gender, age, vitamin B12, folate, renal function, atrophic gastritis and the methylenetetrahydrofolate 677TT genotype were significant determinants of homocysteine levels, which were positively related to incident cardiovascular diseases

Variants Near MC4R Are Associated With Obesity and Influence Obesity-Related Quantitative Traits in a Population of Middle-Aged People: Studies of 14,940 Danes

OBJECTIVE— Variants downstream of the melanocortin-4 receptor gene (MC4R) have been reported to associate with obesity. We examined rs17782313, rs17700633, rs12970134, rs477181, rs502933, and rs4450508 near MC4R for association with obesity-related quantitative traits, obesity, and type 2 diabetes in Danish individuals

The evolution of quiescent galaxies at high redshift (z > 1.4)

We have studied the evolution of high redshift quiescent galaxies over an effective area of ~1.7 deg^2 in the COSMOS field. Galaxies have been divided according to their star-formation activity and the evolution of the different populations has been investigated in detail. We have studied an IRAC (mag_3.6 < 22.0) selected sample of ~18000 galaxies at z > 1.4 with multi-wavelength coverage. We have derived accurate photometric redshifts (sigma=0.06) and other important physical parameters through a SED-fitting procedure. We have divided our sample into actively star-forming, intermediate and quiescent galaxies depending on their specific star formation rate. We have computed the galaxy stellar mass function of the total sample and the different populations at z=1.4-3.0. We have studied the properties of high redshift quiescent galaxies finding that they are old (1-4 Gyr), massive (log(M/M_sun)~10.65), weakly star forming stellar populations with low dust extinction (E(B-V) < 0.15) and small e-folding time scales (tau ~ 0.1-0.3 Gyr). We observe a significant evolution of the quiescent stellar mass function from 2.5 < z < 3.0 to 1.4 < z < 1.6, increasing by ~ 1 dex in this redshift interval. We find that z ~ 1.5 is an epoch of transition of the GSMF. The fraction of star-forming galaxies decreases from 60% to 20% from z ~ 2.5-3.0 to z ~ 1.4-1.6 for log(M/M_sun) > 11, while the quiescent population increases from 10% to 50% at the same redshift and mass intervals. We compare the fraction of quiescent galaxies derived with that predicted by theoretical models and find that the Kitzbichler & White (2007) model is the one that better reproduces the data. Finally, we calculate the stellar mass density of the star-forming and quiescent populations finding that there is already a significant number of quiescent galaxies at z > 2.5 (rho~6.0 MsunMpc^-3).Comment: 17 pages, 20 figures, 5 tables. Accepted for publication in MNRA

The SWIRE-VVDS-CFHTLS surveys: stellar mass assembly over the last 10 Gyears. Evidence for a major build up of the red sequence between z=2 and z=1

(abridged abstract) We present an analysis of the stellar mass growth over the last 10 Gyrs using a large 3.6$\mu$ selected sample. We split our sample into active (blue) and quiescent (red) galaxies. Our measurements of the K-LFs and LD evolution support the idea that a large fraction of galaxies is already assembled at $z\sim 1.2$. Based on the analysis of the evolution of the stellar mass-to-light ratio (in K-band) for the spectroscopic sub-sample, we derive the stellar mass density for the entire sample. We find that the global evolution of the stellar mass density is well reproduced by the star formation rate derived from UV dust corrected measurements. Over the last 8Gyrs, we observe that the stellar mass density of the active population remains approximately constant while it gradually increases for the quiescent population over the same timescale. As a consequence, the growth of the stellar mass in the quiescent population must be due to the shutoff of star formation in active galaxies that migrate into the quiescent population. From $z=2$ to $z=1.2$, we observe a major build-up of the quiescent population with an increase by a factor of 10 in stellar mass, suggesting that we are observing the epoch when an increasing fraction of galaxies are ending their star formation activity and start to build up the red sequence.Comment: Accepted to A&A with major changes. 1 table and 13 figure

The VIMOS VLT Deep Survey. The Assembly History of the Stellar Mass in Galaxies: from the Young to the Old Universe

We present a detailed analysis of the Galaxy Stellar Mass Function of galaxies up to z=2.5 as obtained from the VVDS. We estimate the stellar mass from broad-band photometry using 2 different assumptions on the galaxy star formation history and show that the addition of secondary bursts to a continuous star formation history produces systematically higher (up to 40%) stellar masses. At low redshift (z=0.2) we find a substantial population of low-mass galaxies (<10^9 Msun) composed by faint blue galaxies (M_I-M_K=0.3). In general the stellar mass function evolves slowly up to z=0.9 and more significantly above this redshift. Conversely, a massive tail is present up to z=2.5 and have extremely red colours (M_I-M_K=0.7-0.8). We find a decline with redshift of the overall number density of galaxies for all masses (59+-5% for M>10^8 Msun at z=1), and a mild mass-dependent average evolution (`mass-downsizing'). In particular our data are consistent with mild/negligible (6x10^10 Msun). For less massive systems the no-evolution scenario is excluded. A large fraction (>=50%) of massive galaxies have been already assembled and converted most of their gas into stars at z=1, ruling out the `dry mergers' as the major mechanism of their assembly history below z=1. This fraction decreases to 33% at z=2. Low-mass systems have decreased continuously in number and mass density (by a factor up to 4) from the present age to z=2, consistently with a prolonged mass assembly also at z<1.Comment: 20 pages with 12 encapsulated figures. Version accepted by A&

The VIMOS VLT Deep Survey: Tracing the galaxy stellar mass assembly history over the last 8Gyr

We selected a mass-limited sample of 4048 objects from the VIMOS VLT Deep Survey in the redshift interval 0.5<z<1.3. We used the amplitude of the 4000 Balmer break (Dn4000) to separate the galaxy population and the EW[OII]3727 line as proxy for the star formation activity. We discuss to what extent stellar mass drives galaxy evolution, showing for the first time the interplay between stellar ages and stellar masses over the past 8Gyr. Low-mass galaxies have small Dn4000 and at increasing stellar mass, the galaxy distribution moves to higher Dn4000 values as observed in the local Universe. As cosmic time goes by, we witness an increasing abundance of massive spectroscopically ET systems at the expense of the LT systems. This spectral transformation is a process started at early epochs and continuing efficiently down to the local Universe. This is confirmed by the evolution of our type-dependent stellar mass function. The underlying stellar ages of LT galaxies apparently do not show evolution, likely as a result of a continuous formation of new stars. All star formation activity indicators consistently point towards a star formation history peaked in the past for massive galaxies, with little or no residual star formation taking place in the most recent epochs. The activity and efficiency of forming stars are mechanisms that depend on stellar mass, and the mass assembly becomes progressively less efficient in massive systems as time elapses. The concepts of star formation downsizing and mass assembly downsizing describe a single scenario that has a top-down evolutionary pattern. The role of (dry) merging events seems to be only marginal at z<1.3, as our estimated efficiency in stellar mass assembly can possibly account for the progressive accumulation of passively evolving galaxies.Comment: Accepted for pubblication in A&A, 14 pages, 5 figure

Effect of Parental Type 2 Diabetes on Offspring With Type 1 Diabetes

OBJECTIVE—The purpose of this study was to study the association between a parental history of type 2 diabetes and the metabolic profile as well as the presence of the metabolic syndrome and diabetes complications in patients with type 1 diabetes