Laurence Cadet, De Proust à Simon: le miroitement des textes

Il lavoro di Laurence Cadet si fonda su un preciso asserto: Proust, e in particolare la Recherche, sono un punto di riferimento per Claude Simon, tanto che la Recherche può essere usata per illuminare l’opera dello scrittore di Tananarive. Prendendo le distanze dai lavori scritti in precedenza sul rapporto tra i due, Laurence Cadet analizza l’evolvere della filiation, come lei la definisce, da Proust a Simon, distinguendo nell’avventura letteraria di quest’ultimo tre momenti, cui corrispondon..

La Lettre et l’œuvre. Correspondances de Marguerite Yourcenar, textes réunis par André-Alain Morello

Questo volume, come scrive il suo curatore André-Alain Morello, è «le prolongement» del Colloquio internazionale tenutosi il 9 e 10 dicembre 2004 presso l’Université du Sud Toulon-Var. Gli esperti, intervenuti al dibattito, sono stati chiamati a riflettere sul vasto corpus di lettere conservato maniacalmente da Marguerite Yourcenar e, in parte, già pubblicato: Lettres à ses amis et quelques autres (1995), D’Hadrien à Zénon. Correspondance 1951-1956 (2004) e «Une volonté sans fléchissement». C..

Marguerite Yourcenar, «Persévérer dans l’être». Correspondance 1961-1963 (D’Hadrien à Zénon, III)

Continua il lavoro degli abituali curatori sulla corrispondenza della grande scrittrice belga iniziato nei tre volumi precedenti: Lettres à ses amis et quelques autres (1995), D’Hadrien à Zénon, Correspondance 1951-1956 (2004) e «Une volonté sans fléchissement». Correspondance 1957-1960 (2007). Questo quarto volume è dedicato all’analisi delle lettere scritte da Marguerite Yourcenar tra il 1961 e il 1963. Il materiale di partenza è sempre lo stesso: le copie, dattiloscritte o manoscritte, del..

Renée Camou, Marguerite Yourcenar et «Les Songes & les Sorts»

Il sogno come momento di eternità, come comunione con il mondo e con gli altri uomini, come tensione verso la perfezione: è questo il punto di partenza dell’analisi di Renée Camou, volta a conoscere meglio Marguerite Yourcenar e la sua opera, cogliendo altresì la presenza del mito, che serpeggia ovunque negli scritti e nella vita della grande autrice. Secondo R. Camou tre sono le chiavi di lettura che permettono di accedere all’essenza dell’opera della Yourcenar: la biografia dell’autrice, il..

Renaud de Portzamparc, La Folie d’Artaud

Renaud de Portzamparc, psichiatra e psicanalista, sonda, in questo volume, la natura della follia di Antonin Artaud, a lungo internato in istituti psichiatrici; individua così alcuni elementi della storia personale dello scrittore che, secondo l’A., ne hanno scatenato i deliri. Prima di tutto la sua nascita, che per Artaud è strettamente legata alla morte: secondo lui, infatti, egli avrebbe dovuto morire, come molti altri dei suoi fratelli, in quanto frutto del rapporto sessuale tra i suoi ge..

Brisk walking can be a maximal effort in heart failure patients: a comparison of cardiopulmonary exercise and 6 min walking test cardiorespiratory data

Aims Cardiopulmonary exercise test (CPET) and 6 min walking test (6MWT) are frequently used in heart failure (HF). CPET is a maximal exercise, whereas 6MWT is a self-selected constant load test usually considered a submaximal, and therefore safer, exercise, but this has not been tested previously. The aim of this study was to compare the cardiorespiratory parameters collected during CPET and 6MWT in a large group of healthy subjects and patients with HF of different severity.Methods and results Subjects performed a standard maximal CPET and a 6MWT wearing a portable device allowing breath-by-breath measurement of cardiorespiratory parameters. HF patients were grouped according to their CPET peak oxygen uptake (peak(V) over-dotO(2)). One hundred and fifty-five subjects were enrolled, of whom 40 were healthy (59 +/- 8 years; male 67%) and 115 were HF patients (69 +/- 10 years; male 80%; left ventricular ejection fraction 34.6 +/- 12.0%). CPET peak(V) over-dotO(2) was 13.5 +/- 3.5 ml/kg/min in HF patients and 28.1 +/- 7.4 mL/kg/min in healthy subjects (P < 0.001). 6MWT-(V) over-dotO(2) was 98 +/- 20% of the CPET peak(V) over-dotO(2) values in HF patients, while 72 +/- 20% in healthy subjects (P < 0.001). 6MWT-(V) over-dot was >110% of CPET peak(V) over-dotO(2) in 42% of more severe HF patients (peak(V) over-dotO(2) < 12 mL/kg/min). Similar results have been found for ventilation and heart rate. Of note, the slope of the relationship between (V) over-dotO(2) at 6MWT, reported as a percentage of CPET peak(V) over-dotO(2) vs. 6MWT (V) over-dotO(2) reported as the absolute value, progressively increased as exercise limitation did.Conclusions In conclusion, the last minute of 6MWT must be perceived as a maximal or even supramaximal exercise activity in patients with more severe HF. Our findings should influence the safety procedures needed for the 6MWT in HF

Production of He-4 and (4) in Pb-Pb collisions at root(NN)-N-S=2.76 TeV at the LHC

Results on the production of He-4 and (4) nuclei in Pb-Pb collisions at root(NN)-N-S = 2.76 TeV in the rapidity range vertical bar y vertical bar <1, using the ALICE detector, are presented in this paper. The rapidity densities corresponding to 0-10% central events are found to be dN/dy4(He) = (0.8 +/- 0.4 (stat) +/- 0.3 (syst)) x 10(-6) and dN/dy4 = (1.1 +/- 0.4 (stat) +/- 0.2 (syst)) x 10(-6), respectively. This is in agreement with the statistical thermal model expectation assuming the same chemical freeze-out temperature (T-chem = 156 MeV) as for light hadrons. The measured ratio of (4)/He-4 is 1.4 +/- 0.8 (stat) +/- 0.5 (syst). (C) 2018 Published by Elsevier B.V.Peer reviewe

12(S)-Hydroxyeicosatetraenoic acid downregulates monocyte-derived-macrophage efferocytosis: new insights in atherosclerosis

The involvement of 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE), a 12-lipooxygenase product of arachidonic acid, has been suggested in atherosclerosis. However, its effect on macrophage functions is not completely understood, so far. The uptake of apoptotic cells (efferocytosis) by macrophages is an anti-inflammatory process, impaired in advanced atherosclerotic lesions. This process induces the release of the anti-inflammatory cytokine interleukin-10 (IL-10), and it is regulated by Rho-GTPases, whose activation involves the isoprenylation, a modification inhibited by statins. We assessed 12-HETE levels in serum of coronary artery disease (CAD) patients, and explored 12(S)-HETE in vitro effect on monocyte-derived macrophage (MDM) efferocytosis. Sixty-four CAD patients and 24 healthy subjects (HS) were enrolled. Serum 12-HETE levels were measured using a tandem mass spectrometry method. MDMs, obtained from a spontaneous differentiation of adherent monocytes, were treated with 12(S)-HETE (10-50 ng/mL). Efferocytosis and RhoA activation were evaluated by flow cytometry. IL-10 was measured by ELISA. CAD patients showed increased 12-HETE serum levels compared to HS (665.2 [438.1-896.2] ng/mL and 525.1 [380.1-750.1] ng/mL, respectively, p < 0.05) and reduced levels of IL-10. MDMs expressed the 12(S)-HETE cognate receptor GPR31. CAD-derived MDMs displayed defective efferocytosis vs HS-MDMs (9.4 [7.7-11.3]% and 11.1 [9.6-14.1]% of MDMs that have engulfed apoptotic cells, respectively, p < 0.01). This reduction is marked in MDMs obtained from patients not treated with statin (9.3 [7.4-10.6]% statin-free CAD vs HS, p = 0.01; and 9.9 [8.6-11.6]% statin-treated CAD vs HS, p = 0.07). The in vitro treatment of MDMs with 12(S)-HETE (20 ng/mL) induced 20% decrease of efferocytosis (p < 0.01) and 71% increase of RhoA activated form (p < 0.05). Atorvastatin (0.1 μM) counteracted these 12(S)-HETE-mediated effects.These results show a 12(S)-HETE pro-inflammatory effect and suggest a new potential contribution of this mediator in the development of atherosclerosis