Disc galaxies are still settling: The discovery of the smallest nuclear discs and their young stellar bars

When galactic discs settle and become massive enough, they are able to form stellar bars. These non-axisymmetric structures induce shocks in the gas, causing it to flow to the centre where nuclear structures, such as nuclear discs and rings, are formed. Previous theoretical and observational studies have hinted at the co-evolution of bars and nuclear discs, suggesting that nuclear discs grow "inside-out", thereby proposing that smaller discs live in younger bars. Nevertheless, it remains unclear how the bar and the nuclear structures form and evolve with time. The smallest nuclear discs discovered to date tend to be larger than $\sim200~\rm{pc}$, even though some theoretical studies find that when nuclear discs form they can be much smaller. Using MUSE archival data, we report for the first time two extragalactic nuclear discs with radius sizes below $100~\rm{pc}$. Additionally, our estimations reveal the youngest bars found to date. We estimate that the bars in these galaxies formed $4.50^{+1.60}_{-1.10}\rm{(sys)}^{+1.00}_{-0.75}\rm{(stat)}$ and $0.7^{+2.60}\rm{(sys)}^{+0.05}_{-0.05}\rm{(stat)}~\rm{Gyr}$ ago, for NGC\,289 and NGC\,1566, respectively. This suggests that at least some disc galaxies in the Local Universe may still be dynamically settling. By adding these results to previous findings in the literature, we retrieve a stronger correlation between nuclear disc size and bar length and we derive a tentative exponential growth scenario for nuclear discs.Comment: Accepted in A&A (in press), 13 pages, 5 figures, 2 tabel

CALIFA, the Calar Alto Legacy Integral Field Area survey: I. Survey presentation

We present here the Calar Alto Legacy Integral Field Area (CALIFA) survey, which has been designed to provide a first step in this direction.We summarize the survey goals and design, including sample selection and observational strategy.We also showcase the data taken during the first observing runs (June/July 2010) and outline the reduction pipeline, quality control schemes and general characteristics of the reduced data. This survey is obtaining spatially resolved spectroscopic information of a diameter selected sample of $\sim600$ galaxies in the Local Universe (0.005< z <0.03). CALIFA has been designed to allow the building of two-dimensional maps of the following quantities: (a) stellar populations: ages and metallicities; (b) ionized gas: distribution, excitation mechanism and chemical abundances; and (c) kinematic properties: both from stellar and ionized gas components. CALIFA uses the PPAK Integral Field Unit (IFU), with a hexagonal field-of-view of \sim1.3\sq\arcmin', with a 100% covering factor by adopting a three-pointing dithering scheme. The optical wavelength range is covered from 3700 to 7000 {\AA}, using two overlapping setups (V500 and V1200), with different resolutions: R\sim850 and R\sim1650, respectively. CALIFA is a legacy survey, intended for the community. The reduced data will be released, once the quality has been guaranteed. The analyzed data fulfill the expectations of the original observing proposal, on the basis of a set of quality checks and exploratory analysis. We conclude from this first look at the data that CALIFA will be an important resource for archaeological studies of galaxies in the Local Universe.Comment: 32 pages, 29 figures, Accepted for publishing in Astronomy and Astrophysic

Dyskeratosis congenita: natural history of the disease through the study of a cohort of patients diagnosed in childhood

BackgroundDyskeratosis congenita (DC) is a multisystem and ultra-rare hereditary disease characterized by somatic involvement, bone marrow failure, and predisposition to cancer. The main objective of this study is to describe the natural history of DC through a cohort of patients diagnosed in childhood and followed up for a long period of time.Material and methodsMulticenter, retrospective, longitudinal study conducted in patients followed up to 24 years since being diagnosed in childhood (between 1998 and 2020).ResultsFourteen patients were diagnosed with DC between the ages of 3 and 17 years (median, 8.5 years). They all had hematologic manifestations at diagnosis, and nine developed mucocutaneous manifestations during the first decade of life. Seven presented severe DC variants. All developed non-hematologic manifestations during follow-up. Mutations were identified in 12 patients. Thirteen progressed to bone marrow failure at a median age of 8 years [range, 3–18 years], and eight received a hematopoietic stem cell transplant. Median follow-up time was 9 years [range, 2–24 years]. Six patients died, the median age was 13 years [range, 6–24 years]. As of November 2022, eight patients were still alive, with a median age of 18 years [range, 6–32 years]. None of them have developed myeloblastic syndrome or cancer.ConclusionsDC was associated with high morbidity and mortality in our series. Hematologic manifestations appeared early and consistently. Non-hematologic manifestations developed progressively. No patient developed cancer possibly due to their young age. Due to the complexity of the disease multidisciplinary follow-up and adequate transition to adult care are essential

Uso de compuestos nutracéuticos en nuevas formulaciones de piensos acuícolas

Trabajo presentado en las X Jornadas de Acuicultura en el Litoral Suratlántico: Nuevos retos y perspectivas para la sostenibilidad de la acuicultura, celebrado entre el 22 y 23 de noviembre de 2023 en Huelva.[EN] Different strategies have been followed to improve the aquaculture of main European farmed fish, such as genetic selection, refinements in culture conditions or enhanced feed formulation and management. However, more knowledge is required to exploit fish phenotypic plasticity to obtain those that better match aquaculture or market conditions. The overall objective of this mini-review is to identify the latest productive traits recently performed, mainly in commercial carnivorous species, and underlying biological processes that would be susceptible to improve the competitivity of aquaculture sector through nutritional issues. Thus, this work is framed within the concepts of Circular Economy and Blue Growth, where it is intended to point out the use of natural compounds extracted from seaweeds, microalgae and by-products of the industry for their inclusion in aquafeeds, allowing a more efficient use of more sustainable vegetable protein sources, and also to evaluate if these nutraceutical compounds counteract detrimental effects observed by nutritional interventions or environmentally challenged.[ES] La producción acuícola ha seguido diferentes estrategias para su optimización a lo largo de las últimas décadas, como el desarrollo de la selección genética, la mejora de las condiciones de cultivo, o el avance en la formulación y gestión de los piensos. Sin embargo, se requiere más conocimiento para explotar la plasticidad fenotípica de los peces para obtener aquellos que se ajusten mejor a las condiciones de la acuicultura o del mercado. El objetivo general de esta mini-revisión es identificar los últimos avances realizados recientemente, principalmente en especies carnívoras comerciales, y los procesos biológicos subyacentes que serían susceptibles de mejorar la competitividad del sector acuícola a través de intervenciones nutricionales. Así, este trabajo se enmarca dentro de los conceptos de Economía Circular y Crecimiento Azul, donde se pretende señalar el uso de compuestos naturales extraídos de algas, microalgas y subproductos de la industria para su inclusión en alimentos acuícolas, permitiendo un uso más eficiente de fuentes de proteínas vegetales más sostenibles, y también evaluar si estos compuestos nutracéuticos son capaces de contrarrestar los efectos perjudiciales observados por las formulaciones inadecuadas o desafiados por factores ambientales estresantes.This work was supported by the Projects “FEDER-UCA18-107182”, “FisioBream-II Call for Young Researchers CEI⋅MAR 2019”, “ALGAE4FISH-CEI·MAR Empresa 2018”, “VALINVA-CEI·MAR Empresa 2019”, “SeriBlue-CEI·MAR Empresa 2020”, and co-financed by the spin-off LifeBioencapsulation S.L. (Almería) and Biotechnology Biopolym S.A. (Granada)

Height and timing of growth spurt during puberty in young people living with vertically acquired HIV in Europe and Thailand.

OBJECTIVE: The aim of this study was to describe growth during puberty in young people with vertically acquired HIV. DESIGN: Pooled data from 12 paediatric HIV cohorts in Europe and Thailand. METHODS: One thousand and ninety-four children initiating a nonnucleoside reverse transcriptase inhibitor or boosted protease inhibitor based regimen aged 1-10 years were included. Super Imposition by Translation And Rotation (SITAR) models described growth from age 8 years using three parameters (average height, timing and shape of the growth spurt), dependent on age and height-for-age z-score (HAZ) (WHO references) at antiretroviral therapy (ART) initiation. Multivariate regression explored characteristics associated with these three parameters. RESULTS: At ART initiation, median age and HAZ was 6.4 [interquartile range (IQR): 2.8, 9.0] years and -1.2 (IQR: -2.3 to -0.2), respectively. Median follow-up was 9.1 (IQR: 6.9, 11.4) years. In girls, older age and lower HAZ at ART initiation were independently associated with a growth spurt which occurred 0.41 (95% confidence interval 0.20-0.62) years later in children starting ART age 6 to 10 years compared with 1 to 2 years and 1.50 (1.21-1.78) years later in those starting with HAZ less than -3 compared with HAZ at least -1. Later growth spurts in girls resulted in continued height growth into later adolescence. In boys starting ART with HAZ less than -1, growth spurts were later in children starting ART in the oldest age group, but for HAZ at least -1, there was no association with age. Girls and boys who initiated ART with HAZ at least -1 maintained a similar height to the WHO reference mean. CONCLUSION: Stunting at ART initiation was associated with later growth spurts in girls. Children with HAZ at least -1 at ART initiation grew in height at the level expected in HIV negative children of a comparable age

The kinematics of young and old stellar populations in nuclear rings of MUSE TIMER galaxies

Context. Studying the stellar kinematics of galaxies is a key tool in the reconstruction of their evolution. However, the current measurements of the stellar kinematics are complicated by several factors, including dust extinction and the presence of multiple stellar populations. Aims. We use integral field spectroscopic data of four galaxies from the Time Inference with MUSE in Extragalactic Rings (TIMER) survey to explore and compare the kinematics measured in different spectral regions that are sensitive to distinct stellar populations. Methods. We derive the line-of-sight velocity and velocity dispersion of both a young (≲2 Gyr) and an old stellar population from the spectral regions around the Hβ line and the Ca II Triplet. In addition, we determine colour excess, mean age, and metallicity. Results. We report a correlation of the colour excess with the difference in the kinematic parameters of the Hβ line and the Ca II Triplet range, which are dominated by young and old stellar populations, respectively. Young stellar populations, located primarily in nuclear rings, have higher velocity dispersions than old ones. These differences in the rings are typically ∼10 km s−1 in velocity dispersion but can have a mean value as high as ∼24 km s−1 in the most extreme case. Trends with age exist in the nuclear rings but are less significant than those with dust extinction. We report different degrees of correlation for these trends among the galaxies in the sample, which are related to the size of the Voronoi bins in their rings. No clear trends for the line-of-sight velocity differences are observed. The absence of these trends can be explained as a consequence of the Hβ line masking process during the kinematic extraction, as confirmed by dedicated simulations. Conclusions. Our study demonstrates that kinematic differences caused by different stellar populations can be identified in the central regions of nearby galaxies, even from intermediate resolution spectroscopy. This opens the door to future detailed chemo-kinematic studies of galaxies, but also serves as a warning against deriving kinematics from full-spectrum fitting across very wide wavelength ranges when intense star formation is taking place

Disc galaxies are still settling: Discovery of the smallest nuclear discs and their young stellar bars

When galactic discs settle and become massive enough, they are able to form stellar bars. These non-axisymmetric structures induce shocks in the gas, causing it to flow to the centre where nuclear structures, such as nuclear discs and rings, are formed. Previous theoretical and observational studies have hinted at the co-evolution of bars and nuclear discs, suggesting that nuclear discs grow 'inside-out' and thereby proposing that smaller discs reside in younger bars. Nevertheless, it remains unclear how the bar and the nuclear structures form and evolve over time. The smallest nuclear discs discovered to date tend to be larger than ∼200 pc, even though some theoretical studies have reported that when nuclear discs form, they can be much smaller. Using MUSE archival data, we report, for the first time, two extragalactic nuclear discs with radius measurements below 100 pc. Additionally, our estimations reveal the youngest bars found to date. We estimate that the bars in these galaxies formed 4.50-1.10+1.60(sys)-0.75+1.00(stat) and 0.7+2.60(sys)-0.05+0.05(stat) Gyr ago, for NGC 289 and NGC 1566, respectively. This suggests that at least some disc galaxies in the Local Universe may still be dynamically settling. By adding these results to previous findings in the literature, we are able to retrieve a stronger correlation between nuclear disc size and bar length. We also derive a tentative exponential growth scenario for nuclear discs

Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum

The dorsal striatum is a key node for many neurobiological processes such as motor activity, cognitive functions, and affective processes. The proper functioning of striatal neurons relies critically on metabotropic receptors. Specifically, the main adenosine and endocannabinoid receptors present in the striatum, ie, adenosine A2A receptor (A2AR) and cannabinoid CB1 receptor (CB1R), are of pivotal importance in the control of neuronal excitability. Facilitatory and inhibitory functional interactions between striatal A2AR and CB1R have been reported, and evidence supports that this cross-talk may rely, at least in part, on the formation of A2AR-CB1R heteromeric complexes. However, the specific location and properties of these heteromers have remained largely unknown. Here, by using techniques that allowed a precise visualization of the heteromers in situ in combination with sophisticated genetically-modified animal models, together with biochemical and pharmacological approaches, we provide a high resolution expression map and a detailed functional characterization of A2AR-CB1R heteromers in the dorsal striatum. Specifically, our data unveil that the A2AR-CB1R heteromer (i) is essentially absent from corticostriatal projections and striatonigral neurons, and, instead, is largely present in striatopallidal neurons, (ii) displays a striking G protein-coupled signaling profile, where co-stimulation of both receptors leads to strongly reduced downstream signaling, and (iii) undergoes an unprecedented dysfunction in Huntington’s disease, an archetypal disease that affects striatal neurons. Altogether, our findings may open a new conceptual framework to understand the role of coordinated adenosine-endocannabinoid signaling in the indirect striatal pathway, which may be relevant in motor function and neurodegenerative diseases

Metabolic and miRNA Profiling of TMV Infected Plants Reveals Biphasic Temporal Changes

Plant viral infections induce changes including gene expression and metabolic components. Identification of metabolites and microRNAs (miRNAs) differing in abundance along infection may provide a broad view of the pathways involved in signaling and defense that orchestrate and execute the response in plant-pathogen interactions. We used a systemic approach by applying both liquid and gas chromatography coupled to mass spectrometry to determine the relative level of metabolites across the viral infection, together with a miRs profiling using a micro-array based procedure. Systemic changes in metabolites were characterized by a biphasic response after infection. The first phase, detected at one dpi, evidenced the action of a systemic signal since no virus was detected systemically. Several of the metabolites increased at this stage were hormone-related. miRs profiling after infection also revealed a biphasic alteration, showing miRs alteration at 5 dpi where no virus was detected systemically and a late phase correlating with virus accumulation. Correlation analyses revealed a massive increase in the density of correlation networks after infection indicating a complex reprogramming of the regulatory pathways, either in response to the plant defense mechanism or to the virus infection itself. Our data propose the involvement of a systemic signaling on early miRs alteration