Tissue Expression of ETS-Related Gene in Gastric Carcinomas

INTRODUCTION: The ETS-related gene (ERG) encodes a member of the erythroblast transformation-specific (ETS) transcription factor family that has been implicated in both tumor invasion and neovascularization. In this retrospective study, we have aimed to investigate the clinical significance of ERG tissue expressions in gastric cancer. METHODS: We examined the expression of ERG protein by immunohistochemical staining in tissue specimens harvested from 172 primary gastric cancer cases. RESULTS: ERG was expressed in normal vascular endothelium. ERG staining was defined as positive in 9.9 % (17 /172) of gastric cancer cases. According to clinicopathological characteristics, statistically significant differences were not observed between ERG expression and tumor invasion, lymph node and distant metastases, increased tumor stage, histological lymphatic and neural invasion. There were no significant differences in age, gender, or histopathological grading as for ERG expression. DISCUSSION AND CONCLUSION: ERT expression in gastric cancers is not correlated with histological prognostic indicators

Superficial (Cervicovaginal) Myofibroblastoma: A Rare Soft Tissue Tumor of the Female Genital Tract

Yüzeyel (servikovajinal ) miyofibroblastom, nadir görülen ve klinikopatolojik özellikleri yeni tanımlanmış bir yumuşak doku tümörüdür. Alt kadın genital sistemin, hormona duyarlı özelleşmiş subepitelyal stromasından köken aldığı düşünülmektedir. Orta-ileri yaştaki kadınlarda serviks, vajen ve vulvada polipoid veya nodüler kitleler oluşturmaktadırlar. Benign davranışa sahip bu lezyonların tanısında en önemli tuzak, belirsiz veya malign davranış gösteren diğer yumuşak doku lezyonları ile karışabilmesidir. Histopatolojik olarak fibromiksoid stromada yer alan iğsi-yıldız şekilli tümör hücrelerinde CD34, östrojen ve progesteron reseptörü immünpozitivitesinin gösterilmesi tanı için gereklidir. Bu çalışmada, 49 yaşındaki kadın olguda servikal leiomiyomu taklit eden yüzeyel (servikovajinal) miyofibroblastom, bu tümörlerin histogenezi ve klinikopatolojik ayırıcı tanısı açısından literatür bilgileri eşliğinde tartışılmıştır.Superficial (cervicovaginal) myofibroblastoma is a rare soft tissue tumor whose clinicopathological properties have been newly defined. It is considered to originate from the hormonesensitive specialized subepithelial stroma of the lower female genital system. It forms polypoid or nodular mass lesions in the cervix, vagina, and vulva of middle-aged or elderly women. The main obstacle in the diagnosis of this benignly behaving lesion is that it may be confused with other soft Superficial (cervicovaginal) myofibroblastoma is a rare soft tissue tumor whose clinicopathological properties have been newly defined. It is considered to originate from the hormonesensitive specialized subepithelial stroma of the lower female genital system. It forms polypoid or nodular mass lesions in the cervix, vagina, and vulva of middle-aged or elderly women. The main obstacle in the diagnosis of this benignly behaving lesion is that it may be confused with other soft tissue lesions with indeterminate or malignant behavior. It is necessary to demonstrate CD34, estrogen, and progesterone receptor positivity in spindle- or star- shaped tumor cells found in a fibromyxoid stroma for a histopathological diagnosis. Herein, we report a case of a superficial (cervicovaginal) myofibroblastoma mimicking cervical leiomyoma in a 49-years-old woman under the light of the existing literature to provide a detailed discussion about the histogenesis and clinicopathological differential diagnosis of this lesion. tissue lesions with indeterminate or malignant behavior. It is necessary to demonstrate CD34, estrogen, and progesterone receptor positivity in spindle- or star- shaped tumor cells found in a fibromyxoid stroma for a histopathological diagnosis. Herein, we report a case of a superficial (cervicovaginal) myofibroblastoma mimicking cervical leiomyoma in a 49-years-old woman under the light of the existing literature to provide a detailed discussion about the histogenesis and clinicopathological differential diagnosis of this lesion

Evaluation of Immunhistochemical ERG Tissue Expression in Wilms Tumor

Objective: The ETS-related gene (ERG) is an oncogene that encodes one of the erythroblast transformation specific (ETS) transcription factors. Although there are many studies on their effects on the development of different malignancies, mainly prostate cancer, Ewing sarcoma and acute myeloid leukemia, its association with Wilms tumor has never been investigated. The aim of this study was to evaluate ERG tissue expression in Wilms tumors

Classic Kaposi's Sarcoma Showing Multiple Organ Involvement: A Case Report and Brief Review of Literature

WOS: 000424788200006Kaposi's sarcoma (KS) is a vascular tumor with different epidemiological, clinical, and morphologic features, and KS-associated herpes virus plays role in its etiology. In the pathogenesis of these tumors, inflammatory, immunological, and oncogenic factors are closely related to each other. Classic KS is characterized by cutaneous lesions and mild clinical course. However, with the addition of various factors to the disease process, KS lesions can occur in unusual locations and cause unexpected clinical symptoms. In this study, we present a case of gastrointestinal system involvement in KS and lymphadenopathic KS following interstitial lung disease and steroid treatment in a 72-year-old male patient who was treated for cutaneous classic KS for 10 years. Histopathologic differential diagnosis of KS lesions seen in unusual localizations is discussed in the context of literature

Classic Kaposi’s Sarcoma Showing Multiple Organ Involvement: A Case Report and Brief Review of Literature

Kaposi’s sarcoma (KS) is a vascular tumor with different epidemiological, clinical, and morphologic features, and KS-associated herpes virus plays role in its etiology. In the pathogenesis of these tumors, inflammatory, immunological, and oncogenic factors are closely related to each other. Classic KS is characterized by cutaneous lesions and mild clinical course. However, with the addition of various factors to the disease process, KS lesions can occur in unusual locations and cause unexpected clinical symptoms. In this study, we present a case of gastrointestinal system involvement in KS and lymphadenopathic KS following interstitial lung disease and steroid treatment in a 72-year-old male patient who was treated for cutaneous classic KS for 10 years. Histopathologic differential diagnosis of KS lesions seen in unusual localizations is discussed in the context of literatureKaposi’s sarcoma (KS) is a vascular tumor with different epidemiological, clinical, and morphologic features, and KS-associated herpes virus plays role in its etiology. In the pathogenesis of these tumors, inflammatory, immunological, and oncogenic factors are closely related to each other. Classic KS is characterized by cutaneous lesions and mild clinical course. However, with the addition of various factors to the disease process, KS lesions can occur in unusual locations and cause unexpected clinical symptoms. In this study, we present a case of gastrointestinal system involvement in KS and lymphadenopathic KS following interstitial lung disease and steroid treatment in a 72-year-old male patient who was treated for cutaneous classic KS for 10 years. Histopathologic differential diagnosis of KS lesions seen in unusual localizations is discussed in the context of literatur

Evaluation of 2015-2016 MOTAKK HBV DNA and HCV RNA External Quality Assessment National Program Results

MOTAKK, as a national external quality control program has been launched to evaluate the molecular detection of viral infections including HBV DNA and HCV RNA in molecular microbiology diagnostic laboratories in Turkey. This program is prepared in compliance with ISO 17043:2010 (Conformity assessment general requirements for proficiency testing) standards, and aims to take the place of external quality control programs from abroad, contributing to standardization and accuracy of molecular diagnostic tests in our country. The aim of this study was to evaluate 2015 and 2016 results of the MOTAKK External Quality Control Program for HBV DNA and HCV RNA viral load. The calls were announced on the web page of MOTAKK (www.motakk.org). The quality control samples were sent to participating laboratories in 2015 and 2016. Main stocks were prepared from patients with chronic hepatitis B and C who had viral load detection with reference methods according to WHO reference materials for viral load studies to improve quality control sera. From these main stocks, samples with different viral loads were prepared from dilutions of plasma with HBV, HCV, HAV, HIV, Parvovirus B19 and CMV negative serologic markers. Quality control samples were sent to the participating laboratories along with the negative samples in the cold chain. The laboratories accomplished the related tests within 2-3 weeks and entered their results on the MOTAKK web page. These results were analysed according to ISO 13528 (Statistical methods for use in proficiency testing by interlaboratory comparison) and scoring reports were created by a software developed by MOTAKK and sent to participating labs. Each laboratory evaluated their own results in comparison with the other laboratory results, reassessed the tests via observing the distance from the mean result and the reference values. The number of laboratories participating in the HBV DNA and HCV RNA external quality control program was 70-73 in 2015-2016. Participants were able to comply with the program tools, registering, entering results and receiving the results reports problem. In HBV panel, 72.6-89.1% and 84.7-90.3% of the participant laboratories were in 1 standard deviation (SD) in 2015-2016, respectively. In HCV panel, 70.8-89.1% and 84.7-90.3% of the participant laboratories were in 1 SD in 2015-2016, respectively. A national external quality control program for HBV DNA and HCV RNA in Turkey has been prepared for the first time with this project and implemented successfully. All the data provided in the MOTAKK external quality control program final report, compensate all the data provided by the quality control program final reports from abroad; additionally, the report allows comparison of used technologies and commercial products