Virtual Library Matthäus Daniel Pöppelmann

The „Virtual Library Matthäus Daniel Pöppelmann“ is planned as a book index with attached weblinks to digitized historical printed works and reflects the former, in original lost private library of the famous baroque architect in Dresden. The index was developed in 2013/14 by the subproject-team of the TU Dresden within the European Network of Baroque Cultural Heritage (ENBaCH). In 2017 the virtual library has been brought up-to-date with regard to the transcribed book titles and the additional weblinks within the context of the Project Matthäus Daniel Pöppelmann (1662-1736): Die Schloss- und Zwingerplanungen für Dresden. Planen und Bauen im “modus romanus” of the TU Dresden, supported by the Fritz-Thyssen-Stiftung

Complex interaction of sensory and motor signs and symptoms in chronic CRPS.

Spontaneous pain, hyperalgesia as well as sensory abnormalities, autonomic, trophic, and motor disturbances are key features of Complex Regional Pain Syndrome (CRPS). This study was conceived to comprehensively characterize the interaction of these symptoms in 118 patients with chronic upper limb CRPS (duration of disease: 43±23 months). Disease-related stress, depression, and the degree of accompanying motor disability were likewise assessed. Stress and depression were measured by Posttraumatic Stress Symptoms Score and Center for Epidemiological Studies Depression Test. Motor disability of the affected hand was determined by Sequential Occupational Dexterity Assessment and Michigan Hand Questionnaire. Sensory changes were assessed by Quantitative Sensory Testing according to the standards of the German Research Network on Neuropathic Pain. Almost two-thirds of all patients exhibited spontaneous pain at rest. Hand force as well as hand motor function were found to be substantially impaired. Results of Quantitative Sensory Testing revealed a distinct pattern of generalized bilateral sensory loss and hyperalgesia, most prominently to blunt pressure. Patients reported substantial motor complaints confirmed by the objective motor disability testings. Interestingly, patients displayed clinically relevant levels of stress and depression. We conclude that chronic CRPS is characterized by a combination of ongoing pain, pain-related disability, stress and depression, potentially triggered by peripheral nerve/tissue damage and ensuing sensory loss. In order to consolidate the different dimensions of disturbances in chronic CRPS, we developed a model based on interaction analysis suggesting a complex hierarchical interaction of peripheral (injury/sensory loss) and central factors (pain/disability/stress/depression) predicting motor dysfunction and hyperalgesia

Virtuelle Bibliothek Matthäus Daniel Pöppelmann

Die „Virtuelle Bibliothek Matthäus Daniel Pöppelmann“ ist als Bücherverzeichnis mit beigefügten Weblinks zu digitalisierten historischen Druckwerken konzipiert und spiegelt die einstige, im Original verlorene Privatbibliothek des bekannten Dresdner Barockbaumeisters wieder. Die Erarbeitung erfolgte 2013/14 im Teilprojekt-Team der TU Dresden innerhalb des European Network of Baroque Cultural Heritage (ENBaCH). 2017 ist die Virtuelle Bibliothek im Rahmen des an der TU Dresden angesiedelten Fritz-Thyssen-Forschungsprojekts Matthäus Daniel Pöppelmann (1662-1736): Die Schloss- und Zwingerplanungen für Dresden. Planen und Bauen im „modus Romanus“ hinsichtlich der transkribierten Buchtitel und der weiterführenden Verlinkungen aktualisiert worden

Interaction of hyperalgesia and sensory loss in complex regional pain syndrome type I (CRPS I)

Sensory abnormalities are a key feature of Complex Regional Pain Syndrome (CRPS). In order to characterise these changes in patients suffering from acute or chronic CRPS I, we used Quantitative Sensory Testing (QST) in comparison to an age and gender matched control group

Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume

The volume of the lateral ventricles (LV) increases with age and their abnormal enlargement is a key feature of several neurological and psychiatric diseases. Although lateral ventricular volume is heritable, a comprehensive investigation of its genetic determinants is lacking. In this meta-analysis of genome-wide association studies of 23,533 healthy middle-aged to elderly individuals from 26 population-based cohorts, we identify 7 genetic loci associated with LV volume. These loci map to chromosomes 3q28, 7p22.3, 10p12.31, 11q23.1, 12q23.3, 16q24.2, and 22q13.1 and implicate pathways related to tau pathology, S1P signaling, and cytoskeleton organization. We also report a significant genetic overlap between the thalamus and LV volumes (ρgenetic = -0.59, p-value = 3.14 × 10-6), suggesting that these brain structures may share a common biology. These genetic associations of LV volume provide insights into brain morphology

Genetic correlations and genome-wide associations of cortical structure in general population samples of 22824 adults

Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging

Genetic Variants For Head Size Share Genes and Pathways With Cancer

The size of the human head is highly heritable, but genetic drivers of its variation within the general population remain unmapped. We perform a genome-wide association study on head size (N = 80,890) and identify 67 genetic loci, of which 50 are novel. Neuroimaging studies show that 17 variants affect specific brain areas, but most have widespread effects. Gene set enrichment is observed for various cancers and the p53, Wnt, and ErbB signaling pathways. Genes harboring lead variants are enriched for macrocephaly syndrome genes (37-fold) and high-fidelity cancer genes (9-fold), which is not seen for human height variants. Head size variants are also near genes preferentially expressed in intermediate progenitor cells, neural cells linked to evolutionary brain expansion. Our results indicate that genes regulating early brain and cranial growth incline to neoplasia later in life, irrespective of height. This warrants investigation of clinical implications of the link between head size and cancer

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

Virtual Library Matthäus Daniel Pöppelmann

The „Virtual Library Matthäus Daniel Pöppelmann“ is planned as a book index with attached weblinks to digitized historical printed works and reflects the former, in original lost private library of the famous baroque architect in Dresden. The index was developed in 2013/14 by the subproject-team of the TU Dresden within the European Network of Baroque Cultural Heritage (ENBaCH). In 2017 the virtual library has been brought up-to-date with regard to the transcribed book titles and the additional weblinks within the context of the Project Matthäus Daniel Pöppelmann (1662-1736): Die Schloss- und Zwingerplanungen für Dresden. Planen und Bauen im “modus romanus” of the TU Dresden, supported by the Fritz-Thyssen-Stiftung