Flower-CDN: A hybrid P2P overlay for Efficient Query Processing in CDN

International audienceMany websites with a large user base, e.g., websites of non-profit organizations, do not have the financial means to install large web-servers or use specialized content distribution networks such as Akamai. For those websites, we have developed Flower-CDN, a locality-aware peer-to-peer based content-distribution network in which the users that are interested in a website support the distribution of its content. The idea is that peers keep the web-pages they retrieve and later serve them to other peers that are close to them in locality. Our architecture is a hybrid between structured and unstructured networks. When a node requests a web-page from a website for the first time, a locality-aware DHT quickly finds a peer in its neighborhood that has the web-page available. Additionally, all peers in a given region that maintain content of a particular website build an unstructured content overlay. Within a content overlay peers gossip information about their content allowing the system to maintain accurate information despite failures and churn. In our detailed performance evaluation, we compare Flower-CDN with Squirrel, which is a content distribution network that is strictly based on DHTs and not locality aware. Compared to Squirrel, Flower-CDN reduces lookup latency by a factor of 9 and the transfer distance by a factor of 2. We also show that Flower-CDN's gossiping has low overhead and can be adjusted according to hit ratio requirements and bandwidth availability

A Highly Robust P2P-CDN Under Large-Scale and Dynamic Participation

International audienceBy building a P2P Content Distribution Network (CDN), peers collaborate to distribute the content of under-provisioned websites and to serve queries for larger audiences on behalf of the websites. This can reveal very challenging, given the highly dynamic and autonomous participation of peers. Indeed, the P2P-CDN should adapt to increasing numbers of participants and provide robust algorithms under churn because these issues have a key impact on performance. Also, the distribution of tasks and content over peers should take into account their interests in order to give them proper incentives to cooperate. Finally, the routing of queries should aim peers close in locality and serve content from close-by providers to reduce network overload and achieve scalability. We have previously proposed a locality and interest-aware P2P-CDN, Flower-CDN, that lacks efficient management of robustness and scalability. In this paper, we focus on these crucial shortcomings and propose PetalUp-CDN. The performance evaluation with respect to scalability and churn shows highly significant gains

Flower-CDN: A hybrid P2P overlay for Efficient Query Processing in CDN

International audienceMany websites with a large user base, e.g., websites of non-profit organizations, do not have the financial means to install large web-servers or use specialized content distribution networks such as Akamai. For those websites, we have developed Flower-CDN, a locality-aware peer-to-peer based content-distribution network in which the users that are interested in a website support the distribution of its content. The idea is that peers keep the web-pages they retrieve and later serve them to other peers that are close to them in locality. Our architecture is a hybrid between structured and unstructured networks. When a node requests a web-page from a website for the first time, a locality-aware DHT quickly finds a peer in its neighborhood that has the web-page available. Additionally, all peers in a given region that maintain content of a particular website build an unstructured content overlay. Within a content overlay peers gossip information about their content allowing the system to maintain accurate information despite failures and churn. In our detailed performance evaluation, we compare Flower-CDN with Squirrel, which is a content distribution network that is strictly based on DHTs and not locality aware. Compared to Squirrel, Flower-CDN reduces lookup latency by a factor of 9 and the transfer distance by a factor of 2. We also show that Flower-CDN's gossiping has low overhead and can be adjusted according to hit ratio requirements and bandwidth availability

Cardiovascular magnetic resonance feature tracking derived strain parameters in patients with acute myocarditis and preserved ejection fraction : A validation study

[No abstract available

A Highly Robust P2P-CDN Under Large-Scale and Dynamic Participation

International audienceBy building a P2P Content Distribution Network (CDN), peers collaborate to distribute the content of under-provisioned websites and to serve queries for larger audiences on behalf of the websites. This can reveal very challenging, given the highly dynamic and autonomous participation of peers. Indeed, the P2P-CDN should adapt to increasing numbers of participants and provide robust algorithms under churn because these issues have a key impact on performance. Also, the distribution of tasks and content over peers should take into account their interests in order to give them proper incentives to cooperate. Finally, the routing of queries should aim peers close in locality and serve content from close-by providers to reduce network overload and achieve scalability. We have previously proposed a locality and interest-aware P2P-CDN, Flower-CDN, that lacks efficient management of robustness and scalability. In this paper, we focus on these crucial shortcomings and propose PetalUp-CDN. The performance evaluation with respect to scalability and churn shows highly significant gains

Методы и механизмы геттерирования кремниевых структур в производстве интегральных микросхем

Увеличение степени интеграции элементной базы предъявляет все более жесткие требования к уменьшению концентрации загрязняющих примесей и окислительных дефектов упаковки в исходных кремниевых пластинах с ее сохранением в технологическом цикле изготовления ИМС. Это обуславливает высокую актуальность применения геттерирования в современной технологии микроэлектроники. В статье рассмотрены существующие методы геттерирования кремниевых пластин и механизмы их протекания.Збільшення ступеня інтеграції елементної бази пред'являє все більш жорсткі вимоги до зменшення концентрації забруднюючих домішок та окислювальних дефектів упаковки у вихідних кремнієвих пластинах за її збереження у технологічному циклі виготовлення ІМС. Це обумовлює високу актуальність застосування гетерування в сучасній технології мікроелектроніки. Розглянуто існуючі методи гетерування кремнієвих пластин та розглянуто механізми їх перебігу.Increasing the degree of integration of hardware components imposes more stringent requirements for the reduction of the concentration of contaminants and oxidation stacking faults in the original silicon wafers with its preservation in the IC manufacturing process cycle. This causes high relevance of the application of gettering in modern microelectronic technology. The existing methods of silicon wafers gettering and the mechanisms of their occurrence are considered

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Well being of obstetric patients on minimal blood transfusions (WOMB trial)

Background: Primary postpartum haemorrhage is an obstetrical emergency often causing acute anaemia that may require immediate red blood cell (RBC) transfusion. This anaemia results in symptoms such as fatigue, whic

Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32

Genetic generalized epilepsies (GGEs) have a lifetime prevalence of 0.3% and account for 20-30% of all epilepsies. Despite their high heritability of 80%, the genetic factors predisposing to GGEs remain elusive. To identify susceptibility variants shared across common GGE syndromes, we carried out a two-stage genome-wide association study (GWAS) including 3020 patients with GGEs and 3954 controls of European ancestry. To dissect out syndrome-related variants, we also explored two distinct GGE subgroups comprising 1434 patients with genetic absence epilepsies (GAEs) and 1134 patients with juvenile myoclonic epilepsy (JME). Joint Stage-1 and 2 analyses revealed genome-wide significant associations for GGEs at 2p16.1 (rs13026414, Pmeta = 2.5 × 10−9, OR[T] = 0.81) and 17q21.32 (rs72823592, Pmeta = 9.3 × 10−9, OR[A] = 0.77). The search for syndrome-related susceptibility alleles identified significant associations for GAEs at 2q22.3 (rs10496964, Pmeta = 9.1 × 10−9, OR[T] = 0.68) and at 1q43 for JME (rs12059546, Pmeta = 4.1 × 10−8, OR[G] = 1.42). Suggestive evidence for an association with GGEs was found in the region 2q24.3 (rs11890028, Pmeta = 4.0 × 10−6) nearby the SCN1A gene, which is currently the gene with the largest number of known epilepsy-related mutations. The associated regions harbor high-ranking candidate genes: CHRM3 at 1q43, VRK2 at 2p16.1, ZEB2 at 2q22.3, SCN1A at 2q24.3 and PNPO at 17q21.32. Further replication efforts are necessary to elucidate whether these positional candidate genes contribute to the heritability of the common GGE syndrome