263 research outputs found
Recommended from our members
Geologic and geotechnical assessment RFETS Building 371, Rocky Flats, Colorado
This report describes the review and evaluation of the geological, geotechnical and geophysical data supporting the design basis analysis for the Rocky Flats Environmental Test Site (RFETS) Building 371. The primary purpose of the geologic and geotechnical reviews and assessments described herein are to assess the adequacy of the crustal and near surface rock and soil model used in the seismic analysis of Building 371. This review was requested by the RFETS Seismic Evaluation Program. The purpose was to determine the adequacy of data to support the design basis for Building 371, with respect to seismic loading. The objectives required to meet this goal were to: (1) review techniques used to gather data (2) review analysis and interpretations of the data; and (3) make recommendations to gather additional data if required. Where there were questions or inadequacies in data or interpretation, recommendations were made for new data that will support the design basis analysis and operation of Building 371. In addition, recommendations are provided for a geologic and geophysical assessment for a new facility at the Rocky Flats Site
Exemestane in the Adjuvant Treatment of Breast Cancer in Postmenopausal Women
Exemestane is an irreversible inhibitor of the aromatase enzyme, which is a key component in the production of estrogen. The majority of breast cancers are sensitive to the proliferative effects of estrogen. Exemestane is approved for the adjuvant treatment of postmenopausal women with breast cancer after 2 to 3 years of tamoxifen therapy, based on a 32% improvement in disease-free survival compared with 5 years of tamoxifen alone (P < 0.001). Exemestane has also shown clinical benefits as an upfront therapy. The safety profile of exemestane shares some side effects with tamoxifen (hot flashes and arthralgia), but is not associated with an increased risk of endometrial cancer or thromboembolic events. This review will discuss in detail the efficacy and safety of exemestane in early breast cancer
Свободные аминокислоты и их азотсодержащие метаболиты в гипоталамусе крыс при острой интоксикации динилом и их корреляция с аминокислотным спектром плазмы крови
аминокислотыгипоталамусдинилотравлениеплазм
Sustainability assessment of electrokinetic bioremediation compared with alternative remediation options for a petroleum release site
Sustainable management practices can be applied to the remediation of contaminated land to maximise
the economic, environmental and social benefits of the process. The Sustainable Remediation Forum UK
(SuRF-UK) have developed a framework to support the implementation of sustainable practices within
contaminated land management and decision making. This study applies the framework, including
qualitative (Tier 1) and semi-quantitative (Tier 2) sustainability assessments, to a complex site where the
principal contaminant source is unleaded gasoline, giving rise to a dissolved phase BTEX and MTBE
plume. The pathway is groundwater migration through a chalk aquifer and the receptor is a water supply
borehole. A hydraulic containment system (HCS) has been installed to manage the MTBE plume
migration. The options considered to remediate the MTBE source include monitored natural attenuation
(MNA), air sparging/soil vapour extraction (AS/SVE), pump and treat (PT) and electrokinetic-enhanced
bioremediation (EK-BIO). A sustainability indictor set from the SuRF-UK framework, including priority
indicator categories selected during a stakeholder engagement workshop, was used to frame the assessments.
At Tier 1 the options are ranked based on qualitative supporting information, whereas in Tier
2 a multi-criteria analysis is applied. Furthermore, the multi-criteria analysis was refined for scenarios
where photovoltaics (PVs) are included and amendments are excluded from the EK-BIO option. Overall,
the analysis identified AS/SVE and EK-BIO as more sustainable remediation options at this site than either
PT or MNA. The wider implications of this study include: (1) an appraisal of the management decision
from each Tier of the assessment with the aim to highlight areas for time and cost savings for similar
assessments in the future; (2) the observation that EK-BIO performed well against key indicator categories
compared to the other intensive treatments; and (3) introducing methods to improve the sustainability
of the EK-BIO treatment design (such as PVs) did not have a significant effect in this instance
Search for Higgs bosons decaying to tautau pairs in ppbar collisions at sqrt(s) = 1.96 TeV
We present a search for the production of neutral Higgs bosons decaying into
tautau pairs in ppbar collisions at a center-of-mass energy of 1.96 TeV. The
data, corresponding to an integrated luminosity of 5.4 fb-1, were collected by
the D0 experiment at the Fermilab Tevatron Collider. We set upper limits at the
95% C.L. on the product of production cross section and branching ratio for a
scalar resonance decaying into tautau pairs, and we then interpret these limits
as limits on the production of Higgs bosons in the minimal supersymmetric
standard model (MSSM) and as constraints in the MSSM parameter space.Comment: 7 pages, 5 figures, submitted to PL
Measurement of three-jet differential cross sections d sigma-3jet / d M-3jet in p anti-p collisions at sqrt(s)=1.96 TeV
We present the first measurement of the inclusive three-jet differential
cross section as a function of the invariant mass of the three jets with the
largest transverse momenta in an event in p anti-p collisions at sqrt(s) = 1.96
TeV. The measurement is made in different rapidity regions and for different
jet transverse momentum requirements and is based on a data set corresponding
to an integrated luminosity of 0.7 fb^{-1} collected with the D0 detector at
the Fermilab Tevatron Collider. The results are used to test the three-jet
matrix elements in perturbative QCD calculations at next-to-leading order in
the strong coupling constant. The data allow discrimination between
parametrizations of the parton distribution functions of the proton.Comment: 10 pages, 4 figures, 2 tables, submitted to Phys. Lett. B, corrected
chi2 values for NNPD
Search for pair production of the scalar top quark in muon+tau final states
We present a search for the pair production of scalar top quarks
(), the lightest supersymmetric partners of the top quarks, in
collisions at a center-of-mass energy of 1.96 TeV, using data
corresponding to an integrated luminosity of {7.3 } collected with the
\dzero experiment at the Fermilab Tevatron Collider. Each scalar top quark is
assumed to decay into a quark, a charged lepton, and a scalar neutrino
(). We investigate final states arising from and
. With no significant excess of events observed above the
background expected from the standard model, we set exclusion limits on this
production process in the (,) plane.Comment: Submitted to Phys. Lett.
Measurements of inclusive W+jets production rates as a function of jet transverse momentum in ppbar collisions at sqrt{s}=1.96 TeV
This Letter describes measurements of inclusive W (--> e nu) + n jet cross
sections (n = 1-4), presented as total inclusive cross sections and
differentially in the nth jet transverse momentum. The measurements are made
using data corresponding to an integrated luminosity of 4.2 fb-1 collected by
the D0 detector at the Fermilab Tevatron Collider, and achieve considerably
smaller uncertainties on W +jets production cross sections than previous
measurements. The measurements are compared to next-to-leading order
perturbative QCD (pQCD) calculations in the n =1-3 jet multiplicity bins and to
leading order pQCD calculations in the 4-jet bin. The measurements are
generally in agreement with pQCD predictions, although certain regions of phase
space are identified where the calculations could be improved
Measurement of spin correlation in ttbar production using dilepton final states
We measure the correlation between the spin of the top quark and the spin of
the anti-top quark in (ttbar -> W+ W- b bbar -> l+ nu b l- nubar bbar) final
states produced in ppbar collisions at a center of mass energy sqrt(s)=1.96
TeV, where l is an electron or muon. The data correspond to an integrated
luminosity of 5.4 fb-1 and were collected with the D0 detector at the Fermilab
Tevatron collider. The correlation is extracted from the angles of the two
leptons in the t and tbar rest frames, yielding a correlation strength C=
0.10^{+0.45}_{-0.45}, in agreement with the NLO QCD prediction within two
standard deviations, but also in agreement with the no correlation hypothesis.Comment: 10 pages, 3 figures, submitted to PL
Measurement of the ttbar production cross section using dilepton events in ppbar collisions
We present a measurement of the ttbar production cross section sigma(ttbar)
in ppbar collisions at sqrt{s} = 1.96 TeV using 5.4 fb-1 of integrated
luminosity collected with the D0 detector. We consider final states with at
least two jets and two leptons (ee, emu, mumu), and events with one jet for the
the emu final state as well. The measured cross section is sigma(ttbar)= 7.36
+0.90-0.79 (stat + syst) pb. This result combined with the cross section
measurement in the lepton + jets final state yields sigma(ttbar)=7.56
+0.63-0.56 (stat + syst) pb, which agrees with the standard model expectation.
The relative precision of 8% of this measurement is comparable to the latest
theoretical calculations.Comment: 9 pages, published in Phys. Lett.
- …