25 research outputs found
COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study
Background:
The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms.
Methods:
International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms.
Results:
‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country.
Interpretation:
This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men
L'homme et le temps en Suisse 1291-1991
L'ouvrage, également disponible en allemand, a été réalisé à l'occasion du 700e anniversaire de la Confédération helvétique.International audienceRéunissant les contributions d'une quarantaine d'auteurs, l'ouvrage offre la première recherche pluridisciplinaire sur le temps en Suisse, sa mesure et sa perception du Moyen Age jusqu'à la période contemporaine. Cerner l'usage du temps distribué par les horloges et les montres, évoquer sa notion dans la vie quotidienne sont les sujets des premiers chapitres. Ensuite, des historiens ont élaboré un panorama de l'horlogerie suisse de ses origines au XXe siècle , canton par canton. Des aspects particuliers, relatifs à l'économie, au droit du travail, à l'évolution de l'art et de la technique sont mis en lumière grâce à une suite d'études prenant parfois la forme de témoignages. Le catalogue de quelque cent-cinquante pièces, provenant de huit musées suisses et de collections privées, complète les études de cette volumineuse monographie
Erratum to 'Predominance of healthcare-associated cases among episodes of community-onset bacteraemia due to extended-spectrum β-lactamase-producing Enterobacteriaceae' [International Journal of Antimicrobial Agents 49/1 67-73]
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