Supporting Parents With Mental Health Needs in Systems of Care

Summary: Community-based systems of care (SOCs) must address both the needs of parents with mental illness and the needs of their children. Learning more about the challenges faced by SOCs in this area, and the strategies they implement to overcome them, provides insights with implications for the broader field. This project was intended to learn more about efforts to assess parents’ mental health needs, effectively engage and support them, and improve system coordination and access to services to inform service delivery and system reform, especially for those involved in both child welfare and mental health. This report presents information gathered from a small sample of federally funded SOC communities between March and October 2010. Project directors, lead family contacts, clinical supervisors, family partners, and other staff , along with representatives of partner organizations, especially child welfare, generously shared information about their approaches to policies and practices designed to support whole families—children, youth, and parents or other caregivers

Mapping the Participatory Process

This presentation explores the use of Practice-Based Evidence methodologies to support social work with Native American youth. It is based on a five-year collaborative effort between the Native American Youth and Family Center, National Indian Child Welfare Association, and the Research and Training Center on Family Support and Children\u27s Mental Health. The researchers aims were to develop strategies for documenting the effectiveness of services, and to develop a process for conducting evaluations based on known outcomes of community based programs

Quantum computing with antiferromagnetic spin clusters

We show that a wide range of spin clusters with antiferromagnetic intracluster exchange interaction allows one to define a qubit. For these spin cluster qubits, initialization, quantum gate operation, and readout are possible using the same techniques as for single spins. Quantum gate operation for the spin cluster qubit does not require control over the intracluster exchange interaction. Electric and magnetic fields necessary to effect quantum gates need only be controlled on the length scale of the spin cluster rather than the scale for a single spin. Here, we calculate the energy gap separating the logical qubit states from the next excited state and the matrix elements which determine quantum gate operation times. We discuss spin cluster qubits formed by one- and two-dimensional arrays of s=1/2 spins as well as clusters formed by spins s>1/2. We illustrate the advantages of spin cluster qubits for various suggested implementations of spin qubits and analyze the scaling of decoherence time with spin cluster size.Comment: 15 pages, 7 figures; minor change

Evolution of Linked Avirulence Effectors in Leptosphaeria maculans Is Affected by Genomic Environment and Exposure to Resistance Genes in Host Plants

Brassica napus (canola) cultivars and isolates of the blackleg fungus, Leptosphaeria maculans interact in a ‘gene for gene’ manner whereby plant resistance (R) genes are complementary to pathogen avirulence (Avr) genes. Avirulence genes encode proteins that belong to a class of pathogen molecules known as effectors, which includes small secreted proteins that play a role in disease. In Australia in 2003 canola cultivars with the Rlm1 resistance gene suffered a breakdown of disease resistance, resulting in severe yield losses. This was associated with a large increase in the frequency of virulence alleles of the complementary avirulence gene, AvrLm1, in fungal populations. Surprisingly, the frequency of virulence alleles of AvrLm6 (complementary to Rlm6) also increased dramatically, even though the cultivars did not contain Rlm6. In the L. maculans genome, AvrLm1 and AvrLm6 are linked along with five other genes in a region interspersed with transposable elements that have been degenerated by Repeat-Induced Point (RIP) mutations. Analyses of 295 Australian isolates showed deletions, RIP mutations and/or non-RIP derived amino acid substitutions in the predicted proteins encoded by these seven genes. The degree of RIP mutations within single copy sequences in this region was proportional to their proximity to the degenerated transposable elements. The RIP alleles were monophyletic and were present only in isolates collected after resistance conferred by Rlm1 broke down, whereas deletion alleles belonged to several polyphyletic lineages and were present before and after the resistance breakdown. Thus, genomic environment and exposure to resistance genes in B. napus has affected the evolution of these linked avirulence genes in L. maculans

PKCδ Sensitizes Neuroblastoma Cells to L-Buthionine-Sulfoximine and Etoposide Inducing Reactive Oxygen Species Overproduction and DNA Damage

Neuroblastoma is a type of pediatric cancer. The sensitivity of neuroblastoma (NB) cancer cells to chemotherapy and radiation is inhibited by the presence of antioxidants, such as glutathione (GSH), which is crucial in counteracting the endogenous production of reactive oxygen species (ROS). We have previously demonstrated that cells depleted of GSH undergo apoptosis via oxidative stress and Protein kinase C (PKC) δ activation. In the present study, we transfected PKCδ in NB cells resistant to oxidative death induced by L-buthionine-S,R-sulfoximine (BSO), a GSH-depleting agent. Cell responses, in terms of ROS production, apoptosis and DNA damage were evaluated. Moreover, PKCδ activation was monitored by analyzing the phosphorylation status of threonine 505 residue, carrying out PKC activity assay and investigating the subcellular localization of the kinase. The cell responses obtained in BSO-resistant cells were also compared with those obtained in BSO-sensitive cells subjected to the same experimental protocol. Our results demonstrate, for the first time, that PKCδ induces DNA oxidation and ROS overproduction leading to apoptosis of BSO-resistant NB cells and potentiates the cytotoxic effects induced by BSO in sensitive cells. Moreover, PKCδ overexpression enhances the sensitivity of NB cells to etoposide, a well-characterised drug, commonly used in neuroblastoma therapy. Altogether our data provide evidence of a pro-oxidant role of PKCδ that might be exploited to design new therapeutic strategies aimed at selective killing of cancer cells and overcoming drug resistance. However, it becomes evident that a more detailed understanding of ROS-mediated signaling in cancer cells is necessary for the development of redox-modulated therapeutic approaches

Justify your alpha

Benjamin et al. proposed changing the conventional “statistical significance” threshold (i.e.,the alpha level) from p ≤ .05 to p ≤ .005 for all novel claims with relatively low prior odds. They provided two arguments for why lowering the significance threshold would “immediately improve the reproducibility of scientific research.” First, a p-value near .05provides weak evidence for the alternative hypothesis. Second, under certain assumptions, an alpha of .05 leads to high false positive report probabilities (FPRP2 ; the probability that a significant finding is a false positive

Justify your alpha

In response to recommendations to redefine statistical significance to p ≤ .005, we propose that researchers should transparently report and justify all choices they make when designing a study, including the alpha level

Changing the Rules: A Guide for Youth and Young Adults with Mental Health Conditions who Want to Change Policy

To some people, “policy” seems like a mysterious and perhaps boring topic, compared to the busyness and intensity of everyday life. However, a growing number of youth- and young adult-led groups have shown how policy issues can influence their choices and their lives in critical ways, and that they can have substantial influence on policy. Policies may be general, and apply to all people in society (e.g., traffic laws), or they may specifically focus on particular groups of people, such as people with a mental health condition or criminal record (e.g., policies about housing or employment). Organizations such as Youth M.O.V.E. and other groups led by young people with mental health concerns have demonstrated that they can have important roles in changing flawed policies to make them better or to put positive policies in place. Examples of policy issues that might need change include rules about eligibility for housing or rent subsidies; increased young adult choice in treatment; greater availability of peer services; or more services, supports, and funding for young people entering college, among others. This guide provides information about policy and policy change in mental health and other human services for young adult groups who want to be directly involved in policy change activities. Some of the many ways that young people can be involved in policy work include serving on advisory committees that consider areas where policy change is needed, participating on groups convened to review contract language about youth-related issues or serving on groups charged with developing rules and regulations to support recent policy change. A number of manuals or handbooks address these important roles, although few of them are specifically focused on mental health. This policy guide is written for youth- and young adult-led groups and organizations that want to make changes in policies that affect them and other transition-age youth. The intended audience for this guide is youth and young adults working together within a group or organization to make specific change, usually in partnership with other agencies, groups, or organizations. In fact, young adults who have been involved in successful policy change efforts often emphasize that their groups were able to accomplish their goals because they had supportive partnerships with other organizations