205 research outputs found
The production of metal-organic frameworks by microfluidic synthesis
Metal-Organic Frameworks (MOFs), particularly Zirconium based UiO type MOFs, have been developed for a wide variety of applications in the past, such as gas storage and supporting catalysts. However, they are limited by traditionally being synthesised in long batch reactions, leading to high energy cost and potential batch to batch variations. Microfluidic synthesis can address these issues, as continuous flow reactors with increased mass/heat transfer, leading to reduced synthesis times and greater reaction control. Microfluidic synthesis has been used in this thesis to synthesise, modify, and investigate MOFs/UiO-67 in varying ways, presented in a papers format.
The first paper was published in MethodsX and describes the microfluidic synthesis of UiO-67 using a coiled flow inverter reactor. The second paper, published in the Journal of Porous Materials, describes how the crystal phase of UiO-67 can be controlled using water in the microfluidic reactor, resulting in a new product, HCP/FCC-UiO-67-Benzoic acid, being formed for the first time. The third paper, which has been submitted to the Journal of Porous Materials, describes the attempted microfluidic synthesis of Pd(0)-UiO-67-BPYDC and the several insights made on the complications present within this attempted synthesis. The final paper, which was published in the Journal of Chemical Information and Modelling, describes the formation of a machine learning model to predict the gravimetric uptake of several gasses (CO2, CH4 and H2) in MOF materials at varying pressures and temperatures. This model was fitted using experimental literature uptake data and descriptors that could be acquired without pre done modelling, to form an accurate, flexible and easy to use model for a new researcher.
This project was a success, with novel research into MOF materials through a lens of microfluidics being produced and resulting in several publications. Specific results and conclusions have been formed in each publication alongside more overarching deductions on the effects of microfluidic synthesis on MOF materials. The insights formed within this thesis may be used in future research into MOF materials and the use of microfluidics for their synthesis
Bostonia: 1993-1994, no. 2-3
Founded in 1900, Bostonia magazine is Boston University's main alumni publication, which covers alumni and student life, as well as university activities, events, and programs
Disparities in registration and use of an online patient portal among older adults: findings from the LitCog cohort
(C) The Author 2015. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved.Financial disclosure: This project was supported by the
National Institute on Aging (R01 AG030611), the National
Center for Research Resources (5UL1RR025741), and the
National Center for Advancing Translational Sciences (Grant
8UL1TR000150). The content is solely the responsibility of the
authors and does not necessarily represent the official views of
the National Institutes of Health. Smith is currently supported
by a Cancer Research UK Fellowship
Prospectus, December 16, 1981
CHRISTMAS GREETINGS; Parkland offers workshop on real estate Jan. 16; Student bids farewell to Parkland; Attention Accounting students; Students should let state know feelings; News In Brief; Cleaning holiday messes; Bookstores having a prosperous gift season; W.I.R.E. celebrates fifth year; Spring semester classes begin Jan. 18; Greetings from the President...; Don\u27t want to complain, but...: Mother wants to avoid hassles; She enjoys atmosphere; Second annual video competition is underway; Students help with layout; Sistercelebration plans winter ritual; Uni High could get aid; Area offerings; 3 sides involved in radio issue; County eligible for grant; Com Club donates money; Stay on diet with sensible foods; \u27Sugar Babies\u27 rescheduled; Poinsettia: sign of season; Tree trimming becomes an art; Christmas cards start in England; He shares a gift of love; Christmas signifies something for everyone; Gift of jewelry never grows old; Boar\u27s head: traditional feast; Day after: throw nuts; Tiny candy shop tempts with treats; Age-old customs make lovely Christmas; Collectibles make memorable Christmas; Joyous carols fill December air; Norwegian Christmas same, yet different from other countries; Christmas garden takes place of tree; Ski club selling candy bars; Good food, drink is large part of Christmas tradition; Sweep bad luck out of house; Spread holiday cheer with goodies from Great Britain; Drive carefully on icy winter days; \u27Tis the season; Santa puts a smile on everyone\u27s face; \u27Buddy Buddy\u27 funny, \u27Rollover\u27 does better; \u27Pennies from Heaven\u27 is touching; Cablevision announces service changes; A tribute to Lennon; Two new books make good Christmas presents; Max? He\u27s a sweetheart; Christmas lives on through years; Burnham offers counsel; LRC adds two new librarians; Movie theatres offer good holiday viewing; Crazy Ozzy coming soon; Santa chooses rug over outdated reindeer; Keep holidays safe, hazard-free; Albums, 45\u27s make great music gifts; Disease killing off pine trees in Illinois; U of I receives 3 grants; Computer model acts like storm; Artificial tree puts a crimp in her tradition; Christmas celebrated in spring?; Guest speaker featured; Students do same things on break as during class; For those who love to skate: Ice arena offers fun for all ages; Parkland\u27s 1981-82 women\u27s basketball; Classifieds; Christmas personals; Post offices keep busy with holiday season; Survey explains degree days; Final Exam Schedule -- Fall \u2781; Prospectus Christmas Hide-A-Word; 1981-1982 College bowl calendar; Women face stern test with Cougars; Women play with balanced attack; B-ballers raise to 5-0; Plenty of upcoming action for football fans; Last Fast Freddy is on Bowls; Fast Freddy Contest; Cobras meet DuPage 19th; Fall semester in reviewhttps://spark.parkland.edu/prospectus_1981/1000/thumbnail.jp
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Pollinator monitoring more than pays for itself
1. Resilient pollination services depend on sufficient abundance of pollinating insects over time. Currently, however, most knowledge about the status and trends of pollinators is based on changes in pollinator species richness and distribution only. 2. Systematic, long‐term monitoring of pollinators is urgently needed to provide baseline information on their status, to identify the drivers of declines and to inform suitable response measures. 3. Power analysis was used to determine the number of sites required to detect a 30% change in pollinator populations over 10 years. We then evaluated the full economic costs of implementing four national monitoring schemes in the UK: (a) professional pollinator monitoring, (b) professional pollination service monitoring, (c) volunteer collected pan traps and (d) volunteer focal floral observations. These costs were compared to (a) the costs of implementing separate, expert‐designed research and monitoring networks and (b) the economic benefits of pollination services threatened by pollinator loss. 4. Estimated scheme costs ranged from £6,159/year for a 75‐site volunteer focal flower observation scheme to £2.7 M/year for an 800‐site professional pollination service monitoring network. The estimated research costs saved using the site network as research infrastructure range from £1.46–4.17 M/year. The economic value of UK crop yield lost following a 30% decline in pollinators was estimated at ~£188 M/year. 5. Synthesis and applications. We evaluated the full costs of running pollinator monitoring schemes against the economic benefits to research and society they provide. The annual costs of monitoring are <0.02% of the economic value of pollination services that would be lost after a 30% decline in pollination services. Furthermore, by providing high‐quality scientific data, monitoring schemes would save at least £1.5 on data collection per £1 spent. Our findings demonstrate that long‐term systematic monitoring can be a cost‐effective tool for both answering key research questions and setting action points for policymakers. Careful consideration must be given to scheme design, the logistics of national‐scale implementation and resulting data quality when selecting the most appropriate combination of surveyors, methods and site networks to deliver a successful scheme
The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the extended Baryon Oscillation Spectroscopic Survey and from the second phase of the Apache Point Observatory Galactic Evolution Experiment
The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in
operation since July 2014. This paper describes the second data release from
this phase, and the fourteenth from SDSS overall (making this, Data Release
Fourteen or DR14). This release makes public data taken by SDSS-IV in its first
two years of operation (July 2014-2016). Like all previous SDSS releases, DR14
is cumulative, including the most recent reductions and calibrations of all
data taken by SDSS since the first phase began operations in 2000. New in DR14
is the first public release of data from the extended Baryon Oscillation
Spectroscopic Survey (eBOSS); the first data from the second phase of the
Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2),
including stellar parameter estimates from an innovative data driven machine
learning algorithm known as "The Cannon"; and almost twice as many data cubes
from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous
release (N = 2812 in total). This paper describes the location and format of
the publicly available data from SDSS-IV surveys. We provide references to the
important technical papers describing how these data have been taken (both
targeting and observation details) and processed for scientific use. The SDSS
website (www.sdss.org) has been updated for this release, and provides links to
data downloads, as well as tutorials and examples of data use. SDSS-IV is
planning to continue to collect astronomical data until 2020, and will be
followed by SDSS-V.Comment: SDSS-IV collaboration alphabetical author data release paper. DR14
happened on 31st July 2017. 19 pages, 5 figures. Accepted by ApJS on 28th Nov
2017 (this is the "post-print" and "post-proofs" version; minor corrections
only from v1, and most of errors found in proofs corrected
Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context
Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts
Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas
Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN
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