560 research outputs found
Two physical characteristics of numerical apparent horizons
This article translates some recent results on quasilocal horizons into the
language of general relativity so as to make them more useful to
numerical relativists. In particular quantities are described which
characterize how quickly an apparent horizon is evolving and how close it is to
either equilibrium or extremality.Comment: 6 pages, 2 figures, conference proceedings loosely based on talk
given at Theory Canada III (Edmonton, Alberta, 2007). V2: Minor changes in
response to referees comments to improve clarity and fix typos. One reference
adde
Implications of the Top Quark Mass Measurement for the CKM Parameters, and CP Asymmetries
Motivated by the recent determination of the top quark mass by the CDF
collaboration, \mt =174 \pm 10 ^{+13}_{-12} GeV, we review and update the
constraints on the parameters of the quark flavour mixing matrix in
the standard model. In performing our fits, we use inputs from the measurements
of the following quantities: (i) \abseps, the CP-violating parameter in
decays, (ii) \delmd, the mass difference due to the \bdbdbar\ mixing, (iii)
the matrix elements \absvcb and \absvub, and (iv) -hadron lifetimes. We
find that the allowed region of the unitarity triangle is very large, mostly
due to theoretical uncertainties. (This emphasizes the importance of
measurements of CP-violating rate asymmetries in the system.) Nevertheless,
the present data do somewhat restrict the allowed values of the coupling
constant product and the renormalization-scale
invariant bag constant . With the updated CKM matrix we present the
currently-allowed range of the ratio , as well as
the standard model predictions for the \bsbsbar\ mixing parameter \xs and the
quantities , and , which characterize
the CP-asymmetries in -decays. The ALEPH collaboration has recently reported
a significant improvement on the lower limit on the \bs-\bsb mass
difference, (95\% C.L.). This has interesting
consequences for the CKM parameters which are also worked out.
NOTE: this is a revised and updated version of our previous paper.Comment: LaTeX, 27 pages, 16 uuencoded figures (enclosed), CERN-TH.7398/94,
UdeM-GPP-TH-94-0
Cell-mediated transfer of catalase nanoparticles from macrophages to brain endothelial, glial and neuronal cells
Background: Our laboratories forged the concept of macrophage delivery of protein antioxidants to attenuate neuroinflammation and nigrostriatal neurodegeneration in Parkinsons disease. Notably, the delivery of the redox enzyme, catalase, incorporated into a polyion complex micelle ('nanozyme) by bone marrow-derived macrophages protected nigrostriatum against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxication. Nonetheless, how macrophage delivery of nanozyme increases the efficacy of catalase remains unknown. Methods: In this study, we examined the transfer of nanozyme from macrophages to brain microvessel endothelial cells, neurons and astrocytes. Results: Facilitated transport of the nanozyme from macrophages to endothelial, neuronal and glial target cells occurred through endocytosis-independent mechanisms that involved fusion of cellular membranes, macrophage bridging conduits and nanozyme lipid coatings. Nanozyme transfer was operative across an artificial blood-brain barrier and showed efficient reactive oxygen species decomposition. Conclusion: This is the first demonstration, to our knowledge, that drug-loaded macrophages discharge particles to contiguous target cells for therapeutic brain enzyme delivery. The data shown are of potential value for the treatment of neurodegenerative disorders and notably, Parkinsons disease
Polyelectrolyte complex optimization for macrophage delivery of redox enzyme nanoparticles
Background: We posit that cell-mediated drug delivery can improve transport of therapeutic enzymes to the brain and decrease inflammation and neurodegeneration seen during Parkinsons disease. Our prior works demonstrated that macrophages loaded with nanoformulated catalase ('nanozyme) then parenterally injected protect the nigrostriatum in a murine model of Parkinsons disease. Packaging of catalase into block ionomer complex with a synthetic polyelectrolyte block copolymer precludes enzyme degradation in macrophages. Methods: We examined relationships between the composition and structure of block ionomer complexes with a range of block copolymers, their physicochemical characteristics, and loading, release and catalase enzymatic activity in bone marrow-derived macrophages. Results: Formation of block ionomer complexes resulted in improved aggregation stability. Block ionomer complexes with -polylysine and poly(L-glutamic acid)-poly(ethylene glycol) demonstrated the least cytotoxicity and high loading and release rates. However, these formulations did not efficiently protect catalase inside macrophages. Conclusion: Nanozymes with polyethyleneimine- and poly(L-lysine) 10-poly(ethylene glycol) provided the best protection of enzymatic activity for cell-mediated drug delivery
Running Coupling and the Lambda-Parameter from SU(3) Lattice Simulations
We present new results on the static qq-potential from high statistics
simulations on 32^4 and smaller lattices, using the standard Wilson beta = 6.0,
6.4, and 6.8. Within our statistical errors we do not observe any finite size
effects affecting the potential values, on varying the spatial lattice extent
from 0.9fm up to 3.3fm. We are able to see and quantify the running of the
coupling from the Coulomb behaviour of the interquark force. From this we
extract the ratio \sqrt{sigma}/Lambda_L. We demonstrate that scaling violations
on the string tension can be considerably reduced by introducing effective
coupling schemes, which allow for a safe extrapolation of \Lambda_L to its
continuum value. Both methods yield consistent values for Lambda: Lambda_MSbar
= 0.558_{-0.007}^{+0.017}\sqrt{sigma} = 246_{-3}^{+7}MeV. At the highest energy
scale attainable to us we find alpha(5 GeV) = 0.150(3)Comment: 19 pages (LaTex), +6 pages with figures (Postscript, 432K), WUB
92--2
Search for supersymmetry with a dominant R-parity violating LQDbar couplings in e+e- collisions at centre-of-mass energies of 130GeV to 172 GeV
A search for pair-production of supersymmetric particles under the assumption
that R-parity is violated via a dominant LQDbar coupling has been performed
using the data collected by ALEPH at centre-of-mass energies of 130-172 GeV.
The observed candidate events in the data are in agreement with the Standard
Model expectation. This result is translated into lower limits on the masses of
charginos, neutralinos, sleptons, sneutrinos and squarks. For instance, for
m_0=500 GeV/c^2 and tan(beta)=sqrt(2) charginos with masses smaller than 81
GeV/c^2 and neutralinos with masses smaller than 29 GeV/c^2 are excluded at the
95% confidence level for any generation structure of the LQDbar coupling.Comment: 32 pages, 30 figure
The effectiveness of Theraplay for children under 12 – a systematic literature review
Background
Theraplay is a relationship‐focused model of treatment based on attachment theory involving both adult and child. The study aims to review the quality of Theraplay research and Theraplay’s effectiveness for children aged 12 years and under with a range of presenting difficulties, to inform future practice and identify areas for further research.
Methods
A systematic literature search was conducted using PsycINFO, CINAHL, MEDLINE and Web of Science. Quantitative studies using Theraplay only as a treatment for children aged 12 years and under with any presenting difficulty were identified. Additional manual searching was conducted, including eligible studies’ reference lists. Critical appraisal tools were used to provide a narrative synthesis of Theraplay’s effectiveness and research quality.
Results
Only six eligible articles were identified, meaning there was a lack of rigorous evidence eligible to offer conclusions into Theraplay’s effectiveness. The review highlighted the small evidence base, mixed quality research methodology and high levels of heterogeneity in how Theraplay is practiced and evaluated. Of the eligible studies, Theraplay was found promising in its effectiveness when used with internalising and externalising difficulties, dual diagnoses and developmental disabilities.
Conclusions
Theraplay is regularly practiced across the world; however, the evidence base of rigorous research to inform Theraplay’s effectiveness and mechanisms of change is lacking. Firm conclusions could not be offered, although Theraplay was shown to be promising intervention for some presentations. Further research into Theraplay’s effectiveness and key mechanisms of change are recommended to enhance the quality and depth of Theraplay literature
Search for displaced vertices arising from decays of new heavy particles in 7 TeV pp collisions at ATLAS
We present the results of a search for new, heavy particles that decay at a
significant distance from their production point into a final state containing
charged hadrons in association with a high-momentum muon. The search is
conducted in a pp-collision data sample with a center-of-mass energy of 7 TeV
and an integrated luminosity of 33 pb^-1 collected in 2010 by the ATLAS
detector operating at the Large Hadron Collider. Production of such particles
is expected in various scenarios of physics beyond the standard model. We
observe no signal and place limits on the production cross-section of
supersymmetric particles in an R-parity-violating scenario as a function of the
neutralino lifetime. Limits are presented for different squark and neutralino
masses, enabling extension of the limits to a variety of other models.Comment: 8 pages plus author list (20 pages total), 8 figures, 1 table, final
version to appear in Physics Letters
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