ПУТИ ПОВЫШЕНИЯ РОЛИ ИННОВАЦИОННЫХ ЯРМАРОК В АКТИВИЗАЦИИ ИННОВАЦИОННЫХ ПРОЦЕССОВ В УЗБЕКИСТАНЕ

This article is devoted to revealing the role of innovative trade fairs in encouraging the innovation process in Uzbekistan and analysis of their effect for the economy. The article represents correlation - regression analysis of the impact of the volume of trade fair transactions and a number of innovations implemented in the real sector of the economy on the volume of the innovative products manufactured in the economy. Moreover, the article provides recommendations aimed at using venture capital funds as the source of financing innovation projects as well as a trade fair mechanism of initiating cooperation between innovative beneficiaries and donors of venture funds.Статья посвящена выявлению роли проводимых ежегодных инновационных ярмарок в стимулировании инновационных процессов в Узбекистане и анализу соответствующего эффекта для экономики. В работе проведен корреляционно-регрессионный анализ влияния объема ярмарочных сделок и количества внедренных инноваций в реальный сектор, на объем выпускаемой инновационной продукции в экономике. Даны рекомендации по использованию венчурного капитала как источника финансирования инновационных проектов, а также ярмарочного механизма инициирования сотрудничества инновационных бенефициаров и венчурных доноров

Design and technological scheme of a multifunctional seeding unit

Currently, the vast majority of agricultural producers in the Southern Federal District with a total area of arable land up to 50-70 hectares cultivate three main crops, namely grain ears, usually winter wheat, and row crops – corn for grain and sunflower. Grain ear crops are sown in the usual ordinary way, and row crops use the dotted method. These key agrotechnological features lead to the need to use different sowing machines equipped with different types of sowing units. Since the vast majority of agricultural producers of the Southern Federal district with a total area of arable land up to 50-70 hectares do not use monoculture in the structure of crops, this leads to a low annual load of these seeders. This is through deductions for depreciation, maintenance service and repairs inevitably affect the final cost of production. It should also be noted that often, due to the high cost of sowing machines, small agricultural producers are not able to purchase the required agricultural machinery, in addition, this is most often not economically feasible. The use of hired units does not allow sowing in the specified agrotechnical terms, which significantly reduces their productivity and quality parameters. The use of specialized seeders leads to an increase in metal consumption and multi-marking on the farm. This problem can be solved by using a multifunctional seeding machine (MSU). This will make it possible to abandon the use of specialized seeders and perform sowing of grain and row crops with the same machine by carrying out conversion for a specific crop. We have de-scribed the design scheme of the MSU and the principle of its operation. The technical result of the development is also presented and the way to achieve is described

The results of the study of the qualitative parameters of the multifunctional seeding machine

The article presents a constructive scheme of a multifunctional seeding apparatus and substantiates the relevance of its use for agricultural producers of the Southern Federal district with a total area of arable land up to 50-70 hectares. This multifunctional seeding machine allows sowing in various ways for each crop. To assess the qualitative performance of the multifunctional seeding machine in Kuban State University named after I. T. Trubilin, a private methodology and experimental setup were developed at the PriMa department. A mathematical model of the frequency of a single seed supply by a multifunctional seeding machine for sowing corn and wheat has been developed. The parameters for the rational mode of operation of the multifunctional sowing machine for sowing wheat and corn have been determined: the rotation frequency of the disk n, the pressure in the seed chamber P and the frequency of a single seed supply is M for sowing wheat and corn. It was found that the frequency of a single seed supply during wheat sowing is more influenced by the value of excess pressure in the seed chamber. The frequency of a single seed supply during corn sowing is greatly influenced by the value of excess pressure in the seed chamber

Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study

PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

PERSONNEL TRAINING FOR THE CONSTRUCTION INDUSTRY OF THE REGION

The article substantiates the need to increase the efficiency of interaction of higher education institution with employers for solution of the problem of training high-quality personnel. The authors show the role of practical work in development of students’professional competences and skills

Interaction of rotary working body of roller type with the object of processing

There was presented the constructive-technological scheme of leaf-separating apparatus for harvesting tobacco leaves in the article. There was conducted the theoretical analysis of the process of tobacco leaf separation from a stalk. There were obtained the dependencies characterizing the trajectory and speed of arbitrary point of the cutting edge of a small drum

Interaction of rotary working body of roller type with the object of processing

There was presented the constructive-technological scheme of leaf-separating apparatus for harvesting tobacco leaves in the article. There was conducted the theoretical analysis of the process of tobacco leaf separation from a stalk. There were obtained the dependencies characterizing the trajectory and speed of arbitrary point of the cutting edge of a small drum

The GEM-GECO Calcium Indicator Is Useable in <i>Ogataea parapolymorpha</i> Yeast, but Aggravates Effects of Increased Cytosolic Calcium Levels

Ca2+ is a ubiquitous second messenger, which allows eukaryotic cells to respond to external stimuli. The use of genetically encoded Ca2+ indicators allows real-time monitoring of cytosolic Ca2+ levels to study such responses. Here we explored the possibility of using the ratiometric Ca2+ indicator GEM-GECO for monitoring cytosolic Ca2+ concentration ([Ca2+]cyt) in the yeast Ogataea parapolymorpha. High-level production of GEM-GECO led to a severe growth defect in cells lacking the vacuolar Ca2+ ATPase Pmc1, which is involved in [Ca2+]cyt control, and prompted a phenotype resembling that of Pmc1 deficiency, in a strain with wild-type PMC1. This was likely due to the presence of the calmodulin domain in GEM-GECO. In contrast to previous studies of genetically-encoded calcium indicators in neuronal cells, our results suggest that physiological effects of GEM-GECO expression in yeast cells are due not to Ca2+ depletion, but to excessive Ca2+ signaling. Despite these drawbacks, study of fluorescence in individual cells revealed switching of GEM-GECO from the Ca2+-free to Ca2+-bound state minutes after external addition of CaCl2. This was followed by gradual return of GEM-GECO to a Ca2+-free-state that was impaired in the pmc1-Δ mutant. These results demonstrate GEM-GECO usability for [Ca2+]cyt monitoring in budding yeast