Prospectus, January 20, 1975

STUDENTS RESPOND TO BOYCOTT; CU Mass Transit Increases Service; Few Support Canteen, Hate Food And Prices; A Separate Reality?; Dental Hygiene Gives Students Free Care; Trustees Approve Funding For New (Yellow Bricj?) Road; Amateur Radio Class To Begin; String Club To Present Music Festival; Sangamon State Rep. Here Feb. 4; Handicapped Left Out In Parking Lot Cold; Walker Blasts Fed Agencies, Refuses State-Level Tax Cut; \u27Sorry, Wrong Number\u27 Is PC Players\u27 Hit; Mighty Joe Young Sings Blues With Style; Right To Life To Meet; \u27Front Page\u27 A Flat Disappointing Comedy; what happens after boycott?; The Kaleidoscope; letters; PSA President Answers Day Care Questions; Monroe Doctrine Plays Bluegrass at PC Friday; New Student Privacy Law In Effect; The People\u27s Choice; Lit One: The Obscure Poet, Laying play dreaming..., Li Po..., Snow on the high Mountains..., Survival, Ode to you, O School!; Milhouse & Outhouse; Christmas Reprise; Classified Ads; Jack Ruby: Cubans And Strippers; File Petition For Graduation; Cobras Meet Top-Ranked Lakeland Tonight; Oliver Nets 40 Points As Cagers Rebound To Dump Springfield; Parkland No. 2 In Basketball; New Fencing Club Strives To Gain Members, Recognition; Women Cobras Open Season; Intramural Basketball; Parkland Events; Bouncing Bob\u27s Basketball Bonanzahttps://spark.parkland.edu/prospectus_1975/1018/thumbnail.jp

Blended learning in refugee education:An interim report on the Foundations for All project in Kampala and Kiryandongo, Uganda

This paper presents interim findings from the Foundations for All pilot. Foundations for All is a blended learning bridging program aimed at supporting refugee students and disadvantaged members of the host community in two Ugandan locations to access higher education. Through discussing the Foundations for All pilot’s teaching and learning design, multi-partner collaboration, use of technology, emphasis on a psychosocial support model, and learner-centred curriculum, we offer relevant practical perspectives applicable to using blended learning in teaching in emergency contexts like the Covid-19 global pandemic, as well as situations of conflict and displacement. Our interim findings contribute to practice through making concrete recommendations for other institutions wishing to embark on a similar model. We contribute to research by proposing a distinction between ‘thick’ models of refugee access programmes which offer blended or online content along with substantial psychosocial and other support, interaction with specialist tutors, contextually-relevant learning design and content, accessible technology and learning centres and financial support, along with meaningful exit pathways for students, against ‘thin’ models which offer curated online content for free to refugees without the additional support. A further contribution outlined in the paper is the role which expert psychosocial support can play in enhancing refugee learners’ engagement with teaching

Prospectus, April 21, 1975

ORGANIZED STRUGGLE,\u27 DAVIS; Bomb Scare????; StuGo: Wegner Made Secretary Get Budget; Hot Meals; Albin, Barnes, Hood Win Trustee Election; StuGo Elections May 7-8; editorials; letters; The Short Circuit; The Kaleidoscope; Special Feature: Women In Art; Women Work Of Art; Who\u27s Afraid Of ERA??; The Poison Pen Tongue; Chess Talk; EIU At PC; Photography 35; L.T.D.s Corner: Pure Music: by Chase; Skylines; This And That; Sports Views; Cobras Drop Twin Bill; E. St. Louis Track Meet; Bio-Field Course; Walk For The Bald Eagles Week; Track To Kansas; Classified Ads; Moon Lake; Cat Ballou; L.R.C. Hires New Staff Member; Parkland Events; Suggestion Box; New PC Staffhttps://spark.parkland.edu/prospectus_1975/1012/thumbnail.jp

Exploring the patient experience of remote hypertension management in Scotland during COVID-19: a qualitative study

ObjectivesThe aim of this study was to understand how patients experienced hypertension management, with or without BP telemonitoring, during the COVID-19 pandemic. Design, Methods, participants, and settingThis qualitative study conducted between April and November 2022 consisted of 43 semi-structured telephone interviews (23 men and 20 women) from six primary care practices in one area of Scotland. Results From the views of 25 participants with experience of using the Connect Me telemonitoring service and 18 participants without such experience, five themes were developed. These were: (1) Navigating access to services. There were challenges to gaining timely and/or in-person access to services and a reluctance to attend clinical settings because participants were aware of their increased risk of contracting the COVID-19 virus. (2) Adapting NHS services. All six practices had adapted care provision in response to potential COVID-19 transmission, however, these adaptations disrupted routine management of in-person primary care hypertension, diabetes and/or asthma checks. (3) Telemonitoring feedback. Telemonitoring reduced the need to attend in-person primary care practices and supported access to remote healthcare monitoring and feedback. (4) Self-management. Many non-telemonitoring participants were motivated to use self-management strategies to track their blood pressure using home monitoring equipment. Also, participants were empowered to self-manage lifestyle and hypertension medication. (5) Experience of having COVID-19. Some participants contracting the COVID-19 virus experienced an immediate increase in their BP whilst a few experienced ongoing increased BP readings. ConclusionsThe COVID-19 pandemic disrupted routine in-person care for hypertension patients. Both telemonitoring and some non-telemonitoring patients were motivated to self-manage hypertension, including self-adjusting medication, however only those with access to telemonitoring had increased access to hypertension monitoring and feedback. Blood pressure telemonitoring permitted routine care to continue for participants in this study and may offer a service useful in pandemic proofing hypertension healthcare in the future

Effectiveness of the cardiac-diabetes transcare program: protocol for a randomised controlled trial (Protocol)

Background This paper presents a protocol for a randomised controlled trial of the Cardiac-Diabetes Transcare program which is a transitional care, multi-modal self-management program for patients with acute coronary syndrome comorbid with type 2 diabetes. Prior research has indicated people hospitalised with dual cardiac and diabetes diagnoses are at an elevated risk of hospital readmissions, morbidity and mortality. The primary aim of this study is to evaluate the effectiveness (and cost-effectiveness) of a Cardiac-Diabetes Transcare intervention program on 6-month readmission rate in comparison to usual care. Methods/Design A two-armed, randomised controlled trial with blinded outcome assessment will be conducted to evaluate the comparative effectiveness of two modes of care, including a Usual Care Group and a Cardiac-Diabetes Transcare Intervention (in addition to usual care) Group. The primary outcome is 6-month readmission rate, although a range of secondary outcomes will be collected (including self-efficacy) at baseline, 1, 3 and 6 month reassessments. The intervention group will receive in-hospital education tailored for people recovering from an acute coronary syndrome-related hospital admission who have comorbid diabetes, and they will also receive home visits and telephone follow-up by a trained Research Nurse to reinforce and facilitate disease-management-related behaviour change. Both groups will receive usual care interventions offered or referred from participating hospital facilities. A sample size of 432 participants from participating hospitals in the Australian states of Queensland and Victoria will be recruited for 90% power based on the most conservative scenarios modelled for sample size estimates. Discussion The study outlined in this protocol will provide valuable insight into the effectiveness of a transitional care intervention targeted for people admitted to hospital with cardiac-related presentations commencing in the inpatient hospital setting and transition to the home environment. The purpose of theory-based intervention comprising face-to-face sessions and telephone follow up for patients with acute coronary syndrome and type 2 diabetes is to increase self-efficacy to enhance self-management behaviours and thus improve health outcomes and reduce hospital readmissions

Host-dependent Lewis (Le) antigen expression in Helicobacter pylori cells recovered from Leb-transgenic mice

Variation of surface antigen expression is a mechanism used by microbes to adapt to and persist within their host habitats. Helicobacter pylori, a persistent bacterial colonizer of the human stomach, can alter its surface Lewis (Le) antigen expression. We examined H. pylori colonization in mice to test the hypothesis that host phenotype selects for H. pylori (Le) phenotypes. When wild-type and Leb-expressing transgenic FVB/N mice were challenged with H. pylori strain HP1, expressing Lex and Ley, we found that bacterial populations recovered after 8 mo from Leb-transgenic, but not wild-type, mice expressed Leb. Changes in Le phenotype were linked to variation of a putative galactosyltransferase gene (β-(1,3)galT); mutagenesis and complementation revealed its essential role in type I antigen expression. These studies indicate that H. pylori evolves to resemble the host's gastric Le phenotype, and reveal a bacterial genetic locus that is subject to host-driven selection pressure

Contact heat evoked potentials using simultaneous EEG and fMRI and their correlation with evoked pain

BACKGROUND: The Contact Heat Evoked Potential Stimulator (CHEPS) utilises rapidly delivered heat pulses with adjustable peak temperatures to stimulate the differential warm/heat thresholds of receptors expressed by Adelta and C fibres. The resulting evoked potentials can be recorded and measured, providing a useful clinical tool for the study of thermal and nociceptive pathways. Concurrent recording of contact heat evoked potentials using electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) has not previously been reported with CHEPS. Developing simultaneous EEG and fMRI with CHEPS is highly desirable, as it provides an opportunity to exploit the high temporal resolution of EEG and the high spatial resolution of fMRI to study the reaction of the human brain to thermal and nociceptive stimuli. METHODS: In this study we have recorded evoked potentials stimulated by 51° C contact heat pulses from CHEPS using EEG, under normal conditions (baseline), and during continuous and simultaneous acquisition of fMRI images in ten healthy volunteers, during two sessions. The pain evoked by CHEPS was recorded on a Visual Analogue Scale (VAS). RESULTS: Analysis of EEG data revealed that the latencies and amplitudes of evoked potentials recorded during continuous fMRI did not differ significantly from baseline recordings. fMRI results were consistent with previous thermal pain studies, and showed Blood Oxygen Level Dependent (BOLD) changes in the insula, post-central gyrus, supplementary motor area (SMA), middle cingulate cortex and pre-central gyrus. There was a significant positive correlation between the evoked potential amplitude (EEG) and the psychophysical perception of pain on the VAS. CONCLUSION: The results of this study demonstrate the feasibility of recording contact heat evoked potentials with EEG during continuous and simultaneous fMRI. The combined use of the two methods can lead to identification of distinct patterns of brain activity indicative of pain and pro-nociceptive sensitisation in healthy subjects and chronic pain patients. Further studies are required for the technique to progress as a useful tool in clinical trials of novel analgesics

What Is the Evidence to Support the Use of Therapeutic Gardens for the Elderly?

Horticulture therapy employs plants and gardening activities in therapeutic and rehabilitation activities and could be utilized to improve the quality of life of the worldwide aging population, possibly reducing costs for long-term, assisted living and dementia unit residents. Preliminary studies have reported the benefits of horticultural therapy and garden settings in reduction of pain, improvement in attention, lessening of stress, modulation of agitation, lowering of as needed medications, antipsychotics and reduction of falls. This is especially relevant for both the United States and the Republic of Korea since aging is occurring at an unprecedented rate, with Korea experiencing some of the world's greatest increases in elderly populations. In support of the role of nature as a therapeutic modality in geriatrics, most of the existing studies of garden settings have utilized views of nature or indoor plants with sparse studies employing therapeutic gardens and rehabilitation greenhouses. With few controlled clinical trials demonstrating the positive or negative effects of the use of garden settings for the rehabilitation of the aging populations, a more vigorous quantitative analysis of the benefits is long overdue. This literature review presents the data supporting future studies of the effects of natural settings for the long term care and rehabilitation of the elderly having the medical and mental health problems frequently occurring with aging

Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis.

Common birthmarks can be an indicator of underlying genetic disease but are often overlooked. Mongolian blue spots (dermal melanocytosis) are usually localized and transient, but they can be extensive, permanent, and associated with extracutaneous abnormalities. Co-occurrence with vascular birthmarks defines a subtype of phakomatosis pigmentovascularis, a group of syndromes associated with neurovascular, ophthalmological, overgrowth, and malignant complications. Here, we discover that extensive dermal melanocytosis and phakomatosis pigmentovascularis are associated with activating mutations in GNA11 and GNAQ, genes that encode Gα subunits of heterotrimeric G proteins. The mutations were detected at very low levels in affected tissues but were undetectable in the blood, indicating that these conditions are postzygotic mosaic disorders. In vitro expression of mutant GNA11(R183C) and GNA11(Q209L) in human cell lines demonstrated activation of the downstream p38 MAPK signaling pathway and the p38, JNK, and ERK pathways, respectively. Transgenic mosaic zebrafish models expressing mutant GNA11(R183C) under promoter mitfa developed extensive dermal melanocytosis recapitulating the human phenotype. Phakomatosis pigmentovascularis and extensive dermal melanocytosis are therefore diagnoses in the group of mosaic heterotrimeric G-protein disorders, joining McCune-Albright and Sturge-Weber syndromes. These findings will allow accurate clinical and molecular diagnosis of this subset of common birthmarks, thereby identifying infants at risk for serious complications, and provide novel therapeutic opportunities

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely