The Cyclisation of l-Aryl-2-Benzamidoalkan-l-Ols to 4,5-DihydroOxazoles or Isoquinolines

The cyclisation of several N-benzoyl derivatives of 2-amino-l-phenylpropan-l-ol w~e carried out employing the Pictet-Cams modification ofthe BischlerNapieralski reaction. The formation of4, 5-dihydro-oxazoles orisoquinolines depends on the substituents on the N-benzoyl group. The mode of formation of the products is discussed

Political and Institutional Determinants of Fiscal Policy Persistence in West Africa

This study investigates the political economy of fiscal policy making in West Africa by relying on a two-fold estimation technique, namely – the Instrumental variable regression model which accounts for potential endogeneity issue in the data and the Generalized Least Square regression model. The analysis covered 14 West African countries and spans over the period 1980 to 2016. The key results are as follows. First, we find evidence that fiscal policy has been more persistence in the region. This suggests that the governments of West African economies are either unwilling or just unable to adequately implement counter-cyclical fiscal policy. Second, fiscal policymaking has generally been drivenby political and institutional factor rather than on the basis of sound economic considerations. And third, the core politico-institutional factors determining fiscal persistence include corruption, government effectiveness and rule of law

Bandit framework for systematic learning in wireless video-based face recognition

Video-based object or face recognition services on mobile devices have recently garnered significant attention, given that video cameras are now ubiquitous in all mobile communication devices. In one of the most typical scenarios for such services, each mobile device captures and transmits video frames over wireless to a remote computing cluster (a.k.a. “cloud” computing infrastructure) that performs the heavy-duty video feature extraction and recognition tasks for a large number of mobile devices. A major challenge of such scenarios stems from the highly-varying contention levels in the wireless transmission, as well as the variation in the task-scheduling congestion in the cloud. In order for each device to adapt the transmission, feature extraction and search parameters and maximize its object or face recognition rate under such contention and congestion variability, we propose a systematic learning framework based on multi-user multi-armed bandits. The performance loss under two instantiations of the proposed framework is characterized by the derivation of upper bounds for the achievable shortterm and long-term loss in the expected recognition rate per face recognition attempt against the “oracle” solution that assumes a-priori knowledge of the system performance under every possible setting. Unlike well-known reinforcement learning techniques that exhibit very slow convergence when operating in highly-dynamic environments, the proposed bandit-based systematic learning quickly approaches the optimal transmission and cloud resource allocation policies based on feedback on the experienced dynamics (contention and congestion levels). To validate our approach, time-constrained simulation results are presented via: (i) contention-based H.264/AVC video streaming over IEEE 802.11 WLANs and (ii) principal-component based face recognition algorithms running under varying congestion levels of a cloud-computing infrastructure. Against state- of-theart reinforcement learning methods, our framework is shown to provide 17:8% 44:5% reduction of the number of video frames that must be processed by the cloud for recognition and 11:5% 36:5% reduction in the video traffic over the WLAN

Autoimmune and autoinflammatory mechanisms in uveitis

The eye, as currently viewed, is neither immunologically ignorant nor sequestered from the systemic environment. The eye utilises distinct immunoregulatory mechanisms to preserve tissue and cellular function in the face of immune-mediated insult; clinically, inflammation following such an insult is termed uveitis. The intra-ocular inflammation in uveitis may be clinically obvious as a result of infection (e.g. toxoplasma, herpes), but in the main infection, if any, remains covert. We now recognise that healthy tissues including the retina have regulatory mechanisms imparted by control of myeloid cells through receptors (e.g. CD200R) and soluble inhibitory factors (e.g. alpha-MSH), regulation of the blood retinal barrier, and active immune surveillance. Once homoeostasis has been disrupted and inflammation ensues, the mechanisms to regulate inflammation, including T cell apoptosis, generation of Treg cells, and myeloid cell suppression in situ, are less successful. Why inflammation becomes persistent remains unknown, but extrapolating from animal models, possibilities include differential trafficking of T cells from the retina, residency of CD8(+) T cells, and alterations of myeloid cell phenotype and function. Translating lessons learned from animal models to humans has been helped by system biology approaches and informatics, which suggest that diseased animals and people share similar changes in T cell phenotypes and monocyte function to date. Together the data infer a possible cryptic infectious drive in uveitis that unlocks and drives persistent autoimmune responses, or promotes further innate immune responses. Thus there may be many mechanisms in common with those observed in autoinflammatory disorders

Dynamic Modeling of Hydrogen Production from Photo-Fermentation in Microbial Electrolysis Cell using Sago Waste

Hydrogen has a great potential as an alternative energy and produces zero emissions, but most of hydrogen is produced from non-renewable fossil fuels via reforming. Thus, biomass is a promising replacement to fossil fuels where hydrogen can be sourced from. In this project, sago waste is chosen as raw material in a microbial electrolysis cell (MEC) to produce hydrogen fuel. A mathematical model with the integration of MEC with photo-fermentation has been developed and modified by using sago effluent as a substrate in a batch process. The main parameter such as concentration of microbial community has been observed in this project as it gives a huge influence on the gas product of MEC. In conclusion, the develop model was to observe the behavior of the microbial electrolysis cell where a maximum of 3.8 L/day (t = 4 days) of hydrogen production and 0.38A of MEC current were obtained

Renal replacement therapy in acute kidney injury: controversy and consensus

Renal replacement therapies (RRTs) represent a cornerstone in the management of severe acute kidney injury. This area of intensive care and nephrology has undergone significant improvement and evolution in recent years. Continuous RRTs have been a major focus of new technological and treatment strategies. RRT is being used increasingly in the intensive care unit, not only for renal indications but also for other organ-supportive strategies. Several aspects related to RRT are now well established, but others remain controversial. In this review, we review the available RRT modalities, covering technical and clinical aspects. We discuss several controversial issues, provide some practical recommendations, and where possible suggest a research agenda for the future

Palaeozoic-Recent geological development and uplift of the Amanos Mountains (S Turkey) in the critically located northwesternmost corner of the Arabian continent

<p>We have carried out a several-year-long study of the Amanos Mountains, on the basis of which we present new sedimentary and structural evidence, which we combine with existing data, to produce the first comprehensive synthesis in the regional geological setting. The ca. N-S-trending Amanos Mountains are located at the northwesternmost edge of the Arabian plate, near the intersection of the African and Eurasian plates. Mixed siliciclastic-carbonate sediments accumulated on the north-Gondwana margin during the Palaeozoic. Triassic rift-related sedimentation was followed by platform carbonate deposition during Jurassic-Cretaceous. Late Cretaceous was characterised by platform collapse and southward emplacement of melanges and a supra-subduction zone ophiolite. Latest Cretaceous transgressive shallow-water carbonates gave way to deeper-water deposits during Palaeocene-Eocene. Eocene southward compression, reflecting initial collision, resulted in open folding, reverse faulting and duplexing. Fluvial, lagoonal and shallow-marine carbonates accumulated during Late Oligocene(?)-Early Miocene, associated with basaltic magmatism. Intensifying collision during Mid-Miocene initiated a foreland basin that then infilled with deep-water siliciclastic gravity flows. Late Miocene-Early Pliocene compression created mountain-sized folds and thrusts, verging E in the north but SE in the south. The resulting surface uplift triggered deposition of huge alluvial outwash fans in the west. Smaller alluvial fans formed along both mountain flanks during the Pleistocene after major surface uplift ended. Pliocene-Pleistocene alluvium was tilted towards the mountain front in the west. Strike-slip/transtension along the East Anatolian Transform Fault and localised sub-horizontal Quaternary basaltic volcanism in the region reflect regional transtension during Late Pliocene-Pleistocene (<4 Ma).</p

The Relationship Between Ambient Atmospheric Fine Particulate Matter (PM2.5) and Glaucoma in a Large Community Cohort.

Purpose: Glaucoma is more common in urban populations than in others. Ninety percent of the world's population are exposed to air pollution above World Health Organization (WHO) recommended limits. Few studies have examined the association between air pollution and glaucoma. Methods: Questionnaire data, ophthalmic measures, and ambient residential area air quality data for 111,370 UK Biobank participants were analyzed. Particulate matter with an aerodynamic diameter < 2.5 μm (PM2.5) was selected as the air quality exposure of interest. Eye measures included self-reported glaucoma, intraocular pressure (IOP), and average thickness of macular ganglion cell-inner plexiform layer (GCIPL) across nine Early Treatment Diabetic Retinopathy Study (ETDRS) retinal subfields as obtained from spectral-domain optical coherence tomography. We examined the associations of PM2.5 concentration with self-reported glaucoma, IOP, and GCIPL. Results: Participants resident in areas with higher PM2.5 concentration were more likely to report a diagnosis of glaucoma (odds ratio = 1.06, 95% confidence interval [CI] = 1.01-1.12, per interquartile range [IQR] increase P = 0.02). Higher PM2.5 concentration was also associated with thinner GCIPL (β = -0.56 μm, 95% CI = -0.63 to -0.49, per IQR increase, P = 1.2 × 10-53). A dose-response relationship was observed between higher levels of PM2.5 and thinner GCIPL (P < 0.001). There was no clinically relevant relationship between PM2.5 concentration and IOP. Conclusions: Greater exposure to PM2.5 is associated with both self-reported glaucoma and adverse structural characteristics of the disease. The absence of an association between PM2.5 and IOP suggests the relationship may occur through a non-pressure-dependent mechanism, possibly neurotoxic and/or vascular effects

Regional and experiential differences in surgeon preference for the treatment of cervical facet injuries: a case study survey with the AO Spine Cervical Classification Validation Group

Purpose: The management of cervical facet dislocation injuries remains controversial. The main purpose of this investigation was to identify whether a surgeon’s geographic location or years in practice influences their preferred management of traumatic cervical facet dislocation injuries. Methods: A survey was sent to 272 AO Spine members across all geographic regions and with a variety of practice experience. The survey included clinical case scenarios of cervical facet dislocation injuries and asked responders to select preferences among various diagnostic and management options. Results: A total of 189 complete responses were received. Over 50% of responding surgeons in each region elected to initiate management of cervical facet dislocation injuries with an MRI, with 6 case exceptions. Overall, there was considerable agreement between American and European responders regarding management of these injuries, with only 3 cases exhibiting a significant difference. Additionally, results also exhibited considerable management agreement between those with ≤ 10 and &gt; 10&nbsp;years of practice experience, with only 2 case exceptions noted. Conclusion: More than half of responders, regardless of geographical location or practice experience, identified MRI as a screening imaging modality when managing cervical facet dislocation injuries, regardless of the status of the spinal cord and prior to any additional intervention. Additionally, a majority of surgeons would elect an anterior approach for the surgical management of these injuries. The study found overall agreement in management preferences of cervical facet dislocation injuries around the globe

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field