Labelling of

In spite of the hazard due to the radiation exposure, preparation of 90Y- and 177Lu-labelled radiopharmaceuticals is still mainly performed using manual procedures. In the present study the performance of a commercial automatic synthesizer based on disposable cassettes for the labelling of 177Lu- and 90Y-DOTA-conjugated biomolecules (namely, DOTATOC and PSMA-617) was evaluated and compared to a manual and a semiautomated approach. The dose exposure of the operators was evaluated as well. More than 300 clinical preparations of both 90Y- and 177Lu-labelled radiopharmaceuticals have been performed using the three different methods. The mean radiochemical yields for 90Y-DOTATOC were 96.2±4.9%, 90.3±5.6%, and 82.0±8.4%, while for 177Lu-DOTATOC they were 98.3%  ± 0.6, 90.8%  ± 8.3, and 83.1±5.7% when manual, semiautomated, and automated approaches were used, respectively. The mean doses on the whole hands for yttrium-90 preparations were 0.15±0.4 mSv/GBq, 0.04±0.1 mSv/GBq, and 0.11±0.3 mSv/GBq for manual, semiautomated, and automated synthesis, respectively, and for lutetium-177 preparations, they were 0.02±0.008 mSv/GBq, 0.01±0.03 mSv/GBq, and 0.01±0.02 mSv/GBq, respectively. In conclusion, the automated approach guaranteed reliable and reproducible preparations of pharmaceutical grade therapeutic radiopharmaceuticals in a decent RCY. The radiation exposure of the operators remained comparable to the manual approach mainly due to the fact that a dedicated shielding was still not available for the system

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Role of the late Variscan inheritance on the Mesozoic evolution of the Iberia/Eurasia plate boundary

National audienc

Role of the late Variscan inheritance on the Mesozoic evolution of the Iberia/Eurasia plate boundary

National audienc

Space-time partitioning of the Mesozoic deformation along the Iberia/Eurasia diffuse plate boundary

International audienc

Space-time partitioning of the Mesozoic deformation alongthe Iberia/Eurasia diffuse plate boundary

National audienceSince the 1970s, the Mesozoic kinematic evolution of the Iberian plate has been largelydebated. In particular, no consensus exists on the timing, kinematics and partitioningof the deformation along the Iberia/Eurasia plate boundary during the Late Jurassic-Early Cretaceous. Most of the plate kinematics models suggest that this plate boundarymust have accommodated ~400 km of left-lateral displacement between the two platesin this time lapse. However, no field evidence exists for a narrow transform plateboundary that could have accommodated such displacement. In the last decade, severalauthors have tried to partition this deformation between two/three transtensionalcorridors centered in the Pyrenean realm, but still without resolving the discrepancybetween postulated and observed displacement. In this work, we propose a reappraisalof the Mesozoic Iberia/Eurasia plate boundary by reviewing the tectonic and kinematicevolution of the numerous rift basins located between the Iberian Chains System (to theS) and the Armorican Shelf/Northern Aquitaine System (to the N). This allows todefine the transition between the two plates as a~400 wide NW-SE trending diffuse plate boundary across which the deformation ispartitioned. Its polyphased evolution consists of four main steps: i) a Late Jurassicphase of left-lateral transtension localized at the northern and southern boundaries ofthe system, while the rest of the rift basins underwent orthogonal rifting; ii) aNeocomian phase of tectonic quiescence; iii) a Barremian-Aptian phase of diffuse leftlateraltranstensional rifting, while the North Pyrenean Rift System underwentorthogonal rifting; iv) an Albian- Cenomanian phase of transtension localized along theBasque-Cantabrian/North Pyrenean corridor, following the onset of oceanic spreadingin the Bay of Biscay margins, while the rest of the rift basins underwent post-rift stage.Finally, we discuss the role of structural inheritance and pre-rift salt in favoringdistributed rather than localized deformation at the plate boundary. This review allowsto make inferences on the timing of rotation of Iberia during the Mesozoic and tohighlight the contribution to the evolution of the plate boundary of some domainswithin the Cenozoic foreland basins of the Pyrenees which have been often disregarded

The Mesozoic Iberia-Eurasia diffuse plate boundary: A wide domain of distributed transtensional deformation progressively focusing along the North Pyrenean Zone

International audiencePlate kinematic reconstructions available for the Late Jurassic-Early Cretaceous eastward drift and counterclockwise rotation of the Iberian plate imply a major left-lateral motion of Iberia with respect to Eurasia. According to most authors, this displacement has been accommodated along the transform North Pyrenean Zone. However, no relevant field evidence exists for the proposed >400 km of horizontal displacement along the North Pyrenean Fault. Several Permian-Mesozoic basins are distributed around the Iberia/Eurasia plate boundary and have been more or less inverted during the Cenozoic Pyrenean Orogeny (i.e. Iberian Chain basins, North and South Pyrenean basins, Basque-Cantabrian Basin, Parentis Basin, Bay of Biscay/Asturian margins). All of these basins experienced a complex kinematic history and shared the same tectono-stratigraphic evolution, with two successive rifting stages: (i) Permian-Triassic rifting following the dismantling of the Variscan belt and recording the early breakup of Pangea and (ii) Late Jurassic-Early Cretaceous rifting developing after a Jurassic post-rift thermal cooling stage. Depending on the different techniques of investigation and on the interpretation of controversial datasets, authors proposed either opening by orthogonal rifting or by transtensional/pull-apart tectonics for these basins.In this work, we propose a reappraisal of the processes responsible for the Mesozoic Iberia/Eurasia plate boundary compartmentalization by reviewing the tectono-sedimentary history and the kinematic evolution of the sedimentary basins involved in this domain. We shed light on the fact that the Cretaceous left-lateral movement within the plate boundary was not accommodated by localized deformation along the single North Pyrenean Fault wrench structure, but rather by a distributed zone of deformation in which the transtensional regime was recorded by the sedimentary basins therein. We also suggest that other Permian-Mesozoic depocenters located below the Cenozoic foreland basins of the Pyrenean belt (i.e. the Ebro and Aquitaine basins) may have been active segments of this rift system. We then propose that the real extent of the Mesozoic plate boundary is roughly defined by two NW-SE trending lineaments corresponding to the southwestern margin of the Iberian Chain, on the Iberian side, and to the southern Armorican margin and the southwestern border of the French Central Massif, on the Eurasian side. The complex pre-Cretaceous tectono-sedimentary history of this region determined its peculiar pre-rift structure. Such structural inheritance may have favored a distributed rather than a localized mode of deformation at the Iberia/Eurasia diffuse plate boundary during the Late Jurassic-Early Cretaceous, whilst mechanisms related to the eastward propagation of the Bay of Biscay system might have been responsible for the final localization of the plate boundary along the Basque-Cantabrian/North Pyrenean corridor

Space-time partitioning of the Mesozoic deformation along the Iberia/Eurasia diffuse plate boundary

International audienc

Space-time partitioning of the Mesozoic deformation alongthe Iberia/Eurasia diffuse plate boundary

National audienceSince the 1970s, the Mesozoic kinematic evolution of the Iberian plate has been largelydebated. In particular, no consensus exists on the timing, kinematics and partitioningof the deformation along the Iberia/Eurasia plate boundary during the Late Jurassic-Early Cretaceous. Most of the plate kinematics models suggest that this plate boundarymust have accommodated ~400 km of left-lateral displacement between the two platesin this time lapse. However, no field evidence exists for a narrow transform plateboundary that could have accommodated such displacement. In the last decade, severalauthors have tried to partition this deformation between two/three transtensionalcorridors centered in the Pyrenean realm, but still without resolving the discrepancybetween postulated and observed displacement. In this work, we propose a reappraisalof the Mesozoic Iberia/Eurasia plate boundary by reviewing the tectonic and kinematicevolution of the numerous rift basins located between the Iberian Chains System (to theS) and the Armorican Shelf/Northern Aquitaine System (to the N). This allows todefine the transition between the two plates as a~400 wide NW-SE trending diffuse plate boundary across which the deformation ispartitioned. Its polyphased evolution consists of four main steps: i) a Late Jurassicphase of left-lateral transtension localized at the northern and southern boundaries ofthe system, while the rest of the rift basins underwent orthogonal rifting; ii) aNeocomian phase of tectonic quiescence; iii) a Barremian-Aptian phase of diffuse leftlateraltranstensional rifting, while the North Pyrenean Rift System underwentorthogonal rifting; iv) an Albian- Cenomanian phase of transtension localized along theBasque-Cantabrian/North Pyrenean corridor, following the onset of oceanic spreadingin the Bay of Biscay margins, while the rest of the rift basins underwent post-rift stage.Finally, we discuss the role of structural inheritance and pre-rift salt in favoringdistributed rather than localized deformation at the plate boundary. This review allowsto make inferences on the timing of rotation of Iberia during the Mesozoic and tohighlight the contribution to the evolution of the plate boundary of some domainswithin the Cenozoic foreland basins of the Pyrenees which have been often disregarded

SOURCE-TO-SINK EVOLUTION OF A SUPRADETACHMENT BASIN UNRAVELED BY DETRITAL APATITE FISSION TRACK ANALYSIS: THE GEDIZ GRABEN (MENDERES MASSIF, WESTERN TURKEY)

International audienceThe Menderes Massif (Western Turkey) is a Tertiary continental metamorphic core complexexhumed in the upper Oligocene – Miocene time, during the deposition of a series of E-Wtrending basins. Several studies addressed the exhumation history of the massif, but the depositionalhistory of these basins is still poorly defined. Moreover, the full potential of supradetachmentbasins in recording major tectonic events is often unexploited. In this work, weuse the Gediz Graben supradetachment basin as a case study to illustrate the benefits of acomprehensive approach to detrital fission track dating that combines analysis of modern riversediments, analysis of fossil sedimentary successions, and mineral fertility determinations. Thisapproach allowed us i) to reconstruct the modern short-term erosion pattern, ii) to constrainthe long-term exhumation history of the margins of the basin highlighting relevant alongstrikevariations and deciphering the spatial relevance of the main exhumation events, iii) toidentify major exhumation event recorded in the sedimentary sequence of the basin and iv)to constrain the maximum age for the onset of sedimentation in the basin and for the mainsedimentary units. Here we illustrate how to reconcile our detrital apatite fission track datasetwith field evidences in order to build a coherent 4D model for the evolution of this supradetachmentbasin, which is eventually discussed within the framework of the Cenozoic evolutionof the Menderes Massi