30 research outputs found
Adipose tissue concentrations of non-persistent environmental phenols and local redox balance in adults from Southern Spain
The aim was to evaluate the associations of environmental phenol and paraben concentrations with the oxidative
microenvironment in adipose tissue. This study was conducted in a subsample (n=144) of the GraMo cohort
(Southern Spain). Concentrations of 9 phenols and 7 parabens, and levels of oxidative stress biomarkers were
quantified in adipose tissue. Associations were estimated using multivariable linear regression analyses adjusted
for potential confounders.
Benzophenone-3 (BP-3) concentration was borderline associated with enhanced glutathione peroxidase (GPx)
activity [exp(β)=1.20, p=0.060] and decreased levels of reduced glutathione (GSH) [exp(β)=0.55,
p=0.070]. Concentrations of bisphenol A (BPA) and methylparaben (MeP) were associated to lower glutathione
reductase (GRd) activity [exp(β)=0.83, exp(β)=0.72, respectively], and BPA was borderline associated
to increased levels of oxidized glutathione (GSSG) [exp(β)=1.73, p-value=0.062]. MeP was inversely
associated to both hemeoxygenase-1 (HO-1) and superoxide dismustase (SOD) activity, as well as to the levels of
thiobarbituric acid reactive substances (TBARS) [0.75 < exp(β) < 0.79].
Our results suggest that some specific non-persistent pollutants may be associated with a disruption of the
activity of relevant antioxidant enzymes, in addition to the depletion of the glutathione stock. They might act as
a tissue-specific source of free radicals, contributing to the oxidative microenvironment in the adipose tissue.This research was supported
in part by research grants from the European Union Commission
(H2020-EJP-HBM4EU and SOE1/P1/F0082), Biomedical Research
Networking Center-CIBER de EpidemiologÃa y Salud Pública
(CIBERESP), from the Institute of Health Carlos III, supported by
European Regional Development Fund/FEDER (FIS-PI13/02406, FISPI14/
00067, FIS-PI16/01820, FIS-PI16/01812, FIS-PI16/01858 and
FIS-PI17/01743), and from the ConsejerÃa de Salud, Junta de AndalucÃa
(PS-0506-2016). Funding for the equipment used was provided by
Velux Fonden, Augustinus Fonden and Svend Andersen Fonden. The
authors thank Kirsten og Freddy Johansens Fond and the International
Centre for Research and Research Training in Endocrine Disruption of
Male Reproduction and Child Health (EDMaRC, Rigshospitalet,
Copenhagen University) for economic support. Dr. Juan Pedro Arrebola
is under contract within Ramón y Cajal Program (Ministerio de
EconomÃa, Industria y Competitividad de España, RYC-2016-20155)
Osteoprotegerin secreted by inflammatory and invasive breast cancer cells induces aneuploidy, cell proliferation and angiogenesis
Plantamajoside, a potential anti-tumor herbal medicine inhibits breast cancer growth and pulmonary metastasis by decreasing the activity of matrix metalloproteinase-9 and -2
Influence of polychlorinated biphenyls and organochlorine pesticides on the inflammatory milieu. A systematic review of in vitro, in vivo and epidemiological studies
Adipose Tissue Redox Microenvironment as a Potential Link between Persistent Organic Pollutants and the 16-Year Incidence of Non-hormone-Dependent Cancer
[Image: see text] We aimed to assess the relationships among the adipose tissue’s (AT) oxidative microenvironment, in situ accumulated persistent organic pollutant (POP) concentrations, and cancer development. POP and oxidative stress levels were quantified in AT samples from 382 adults recruited within the GraMo cohort (2003–2004) in Granada (Spain). The 16-year cancer incidence was ascertained by reviewing health/administrative databases. Cox-regression models and mediation analyses were performed. The enzymes superoxide dismutase (SOD) and glutathione reductase (GRd) were positively associated with the risk of non-hormone-dependent (NHD) cancer [adjusted hazard ratio (HR) 1.76; 95% confidence interval (CI): 1.17, 2.64 and HR 2.35; 95% CI: 1.41, 3.94, respectively]. After adjustment for covariates, polychlorinated biphenyl-138 (PCB-138) (HR 1.78; 95% CI: 1.03, 3.09), β-hexachlorocyclohexane (β-HCH) (HR 1.70; 95% CI: 1.09, 2.64), and hexachlorobenzene (HR 1.54; 95% CI: 1.02, 2.33) were also positively associated with the risk of NHD cancer. Although confidence intervals included the null value, probably because of the modest number of cancer cases, we observed a potential mediation effect of SOD and GRd on the associations between β-HCH and the risk of NHD tumors (percent mediated = 33 and 47%, respectively). Our results highlight the relevance of human AT’s oxidative microenvironment as a predictor of future cancer risk as well as its potential mediating role on POP-related carcinogenesis. Given their novelty, these findings should be interpreted with caution and confirmed in future studies