Teto da Igreja do Carmo de Itú: original ou apenas diferente?

Mário de Andrade consagrou sua crítica à composição da pintura do teto da igreja do Carmo de Itu: avaliou-a como inédita, popular e brasileira. A seu ver, Padre Jesuíno do Monte Carmelo inovava por desconhecer as regras acadêmicas. Proponho inverter esse ponto de vista: pode-se concluir que, pelo contrário, o teto do Carmo de Itu representava uma tendência geral de simplificação e introdução de guirlandas. Essa tendência era veiculada pelas publicações leigas ou religiosas portuguesas.Mário de Andrade consecrated his criticism about the composition of the painting on the ceiling of the Church of Carmo, Itu. He estimated it as unusual, popular and Brazilian. In his opinion, Padre Jesuíno do Monte Carmelo innovated because he ignored the academic rules. My propose is to reverse this point of view: on the contrary, it may be argued that the painting on the ceiling of the Church of Carmo in Itu represented a general tendency towards simplification and introduction of festoons. This tendency was vehiculated by religious and laic portuguese publications

La imagen Top of Mind de un Destino Turístico durante un Mega-evento. El Caso de Viana do Castelo y el Festival Vodafone Paredes de Coura

El presente artículo tiene como objetivo principal evaluar la imagen top of mind del destino (ciudad) Viana do Castelo durante el Festival Vodafone Paredes de Coura, así como la imagen del propio festival. A través de un cuestionario (n=395) de preguntas abiertas a los festivaleros se recogen las palabras evocadas sobre 11 criterios y se perfila la percepción de la imagen del destino por parte de este colectivo. Las respuestas de la evocación espontánea de los recuerdos adquiridos reflejan que el Festival Vodafone Paredes de Coura es el festival top of mind del país, seguido del festital NOS Alive y el Festival Super Bock Super Rock, caracterizándolo con atributos como “música”, “naturaleza” y “río”

A Sociedade Escravocrata no Teatro de Martins Pena

Este trabalho analisa a situação do negro em duas peças teatrais de Martins Pena - Os dois ou o inglês maquinista e O juiz de paz da roça. Vemos representadas, nestas peças, as mazelas da sociedade brasileira, as relações patriarcais, a ilegalidade do tráfico negreiro e a omissão do Estado. A independência conquistada em 1822 possibilita o término da aliança política entre Brasil e Portugal. O acordo estabelecido com a Inglaterra em 1826 e a lei regencial de 7 de novembro de 1831 que tornava formalmente ilegal o transporte de novos escravos em território brasileiro não conseguiram banir as contravenções. Desta forma, tem-se uma grande disparidade entre os ideais liberais da Europa e a sociedade brasileira, escravista e imperial, que temia, com as intervenções inglesas, o fim da escravidão. Nas peças de Martins Pena, sob a pena do humor, o escritor satiriza os projetos nacionais e a fragilidade do sistema político-social brasileiro do século XIX

Inhibitory effect of combinations of digoxin and endogenous cardiotonic steroids on Na+/K+-ATPase activity in human kidney membrane preparation

AbstractAimsCardiac glycosides have been extensively used in the treatment of congestive heart failure for more than 200years. Recently, cardenolides and bufadienolides were isolated from mammalian tissue and are considered as a new class of steroidal hormones. The aim of the present work was to characterize the interaction between the most clinical used cardiac glycoside digoxin and the cardiac glycosides known to exist endogenously, i.e., ouabain, marinobufagin and telocinobufagin, on human kidney Na+/K+-ATPase.Main methodsInhibition of Na+/K+-ATPase activity from crude membrane preparations of human kidney was performed using increasing concentrations of the drugs alone or mixtures of ouabain:digoxin, telocinobufagin:digoxin and marinobufagin:digoxin in a fixed ratio 1:4, 2:3 and 3:2, respectively. The colorimetric method of Fiske and Subbarow was used to measure the inorganic phosphate released.Key findingsAnalyses of inhibition curves showed that the experimental curves for all combinations were superimposed on the theoretical additive curves indicating that an additive effect occurs among distinct cardenolides and bufadienolides combinations on the human α1β1 Na+/K+-ATPase protomer.SignificanceConsidering the extensive use of digoxin in the treatment of heart failure and the recent findings that endogenous cardiac glycosides may have altered levels in many diseases, including heart failure, the demonstration of additive effect between cardiac glycosides can help in the understanding of recent clinical observations, including that lower than usual doses of cardiac glycosides are necessary for decreasing mortality in these patients

Music festivals as promoters of tourism destination image. The case of the Vodafone Paredes de Coura Festival

Turismo y eventos no son un fenómeno reciente, lo que es novedoso es la importancia y la influencia de los eventos en la imagen del destino. Los eventos estimulan el desarrollo de los destinos, son instrumentos de construcción de imagen de un territorio, aumentan la visibilidad turística y complementan la promoción turística. En la oferta de eventos de tipo turístico, destacan los festivales de música y entre ellos el Festival Vodafone de Paredes de Coura (con más de 100.000 asistentes), que se celebra en la villa de Paredes de Coura en el destino turístico Porto y Norte (Portugal). La presente comunicación tiene como objetivo principal verificar si la imagen del festival afecta positivamente a la imagen del destino turístico. Para ello, se ha diseñado una encuesta y se ha recogido de modo aleatorio a 395 asistentes al festival, en la que se valoran un total de 24 ítems sobre la imagen del festival y del destino y se analiza el perfil del festivalero.Tourism and events are not a recent phenomenon. What is new and important is the influence that events have on a destination’s image. Events stimulate the development of destinations, they are image-building instruments of a territory, they increase the visibility of destinations and they complement tourism promotion. In the portfolio of events as tourist products, we can highlight music festivals, including the Vodafone Festival of Paredes de Coura (with more than 100,000 attendees), which takes place in the town of Paredes de Coura in the tourist destination of Porto-North (Portugal). The main objective of this article is to determine whether the image of the festival positively affects the image of the tourist destination. For this purpose, a questionnaire has been randomly administered among 395 individuals attending the festival, in which a total of 24 items of the festival and destination image are evaluated. The profile of the festival is also analyzed

The Development of the Hospitality Sector Facing the Digital Challenge

[Abstract] The widespread use of the Internet has changed consumer buying behavior, especially among tourists, considering the intangibility of the tourist product. Although globally the modern tourist is a consumer of the new online market, there is a lack of studies addressing the level of development of the hotel business in relation to online bookings by residents of tourist destinations. Furthermore, this article analyzes the factors that impact the use of e-commerce by these residents in the acquisition of tourist accommodation services. A conceptual model was adopted, using the constructs “social influence” and “price” of the unified theory of acceptance and use of technology 2 (UTAUT2), also including “trust” and “perceived risk”. An electronic questionnaire was used to collect data from a sample of 195 residents of Fortaleza, Ceará, Brazil. Data analysis included descriptive statistics, exploratory factor analysis, Fisher’s exact test, and multiple linear regression. The results show that price and social influence are the most significant constructs associated with booking a hotel online, while trust does not influence the use of the Internet. As practical implications, the findings of this study provide important information for hotel managers, as they allow a better understanding of the profile of respondents who book online, as well as which factors influence online behaviors, contributing to increasing the knowledge of digital platforms in the consumer market and, consequently, the development of the hospitality sector

SOBREVIVÊNCIA INICIAL DE SEIS ESPÉCIES USADAS NA RECUPERAÇÃO DE UMA ÁREA DEGRADADA NA CAATINGA

Este estudo teve como objetivo avaliar a sobrevivência de seis espécies da Caatinga utilizadas na recuperação de uma área degradada no Nordeste do Brasil. O plantio foi realizado no Alto do Aratikum, na cidade de Paulo Afonso, Bahia, área indígena Truká-Tupã. O clima é semiárido, com precipitação pluviométrica entre 700 a 850 mm anuais. Em março de 2014 foi realizado o plantio de 432 mudas de seis espécies arbóreas nativas da caatinga: Anadenthera colubrina (Vell.) Brenan (angico-de-caroço), Caesalpinia ferrea Mart. (pau-ferro), Poincianella pyramidalis (Tul.) L.P.Queiroz (catingueira), Hymenaea courbaril L. (jatobá), Schinopsis brasiliensis Engl.(braúna), Myracrodruon urundeuva (Allemão)  Engl.  (aroeira-do-sertão).   Após um ano, a porcentagem de sobrevivência foi de 46,5% para o total de mudas plantadas. A maior taxa de sobrevivência foi verificada em M. urundeuva (82,5%)a. Já as espécies H. courbaril e A. macrocarpa apresentaram menor sobrevivência (20,5% e 36,9%, respectivamente). Semelhantes taxas de sobrevivência foram verificadas em S. brasiliensis, P. pyramidalis e C. ferrea, (55,5%; 51,2% e 48,8%). M. urundeuva foi a que apresentou a melhor taxa de sobrevivência, demonstrando maior resistência as condições locais. A baixa sobrevivência da maioria das espécies reforça a necessidade de se buscar estratégias mais eficientes para aumentar a resistência de mudas em projetos de recuperação na caatinga.

SOBREVIVÊNCIA INICIAL DE SEIS ESPÉCIES USADAS NA RECUPERAÇÃO DE UMA ÁREA DEGRADADA NA CAATINGA

Este estudo teve como objetivo avaliar a sobrevivência de seis espécies da Caatinga utilizadas na recuperação de uma área degradada no Nordeste do Brasil. O plantio foi realizado no Alto do Aratikum, na cidade de Paulo Afonso, Bahia, área indígena Truká-Tupã. O clima é semiárido, com precipitação pluviométrica entre 700 a 850 mm anuais. Em março de 2014 foi realizado o plantio de 432 mudas de seis espécies arbóreas nativas da caatinga: Anadenthera colubrina (Vell.) Brenan (angico-de-caroço), Caesalpinia ferrea Mart. (pau-ferro), Poincianella pyramidalis (Tul.) L.P.Queiroz (catingueira), Hymenaea courbaril L. (jatobá), Schinopsis brasiliensis Engl.(braúna), Myracrodruon urundeuva (Allemão)  Engl.  (aroeira-do-sertão).   Após um ano, a porcentagem de sobrevivência foi de 46,5% para o total de mudas plantadas. A maior taxa de sobrevivência foi verificada em M. urundeuva (82,5%)a. Já as espécies H. courbaril e A. macrocarpa apresentaram menor sobrevivência (20,5% e 36,9%, respectivamente). Semelhantes taxas de sobrevivência foram verificadas em S. brasiliensis, P. pyramidalis e C. ferrea, (55,5%; 51,2% e 48,8%). M. urundeuva foi a que apresentou a melhor taxa de sobrevivência, demonstrando maior resistência as condições locais. A baixa sobrevivência da maioria das espécies reforça a necessidade de se buscar estratégias mais eficientes para aumentar a resistência de mudas em projetos de recuperação na caatinga.

a hospital-based cohort study

Publisher Copyright: © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.OBJECTIVES: Healthcare workers (HCWs) were the first to be prioritised for COVID-19 vaccination. This study aims to estimate the COVID-19 vaccine effectiveness (VE) against SARS-CoV-2 symptomatic infection among HCWs in Portuguese hospitals. DESIGN: Prospective cohort study. SETTING AND PARTICIPANTS: We analysed data from HCWs (all professional categories) from three central hospitals: one in the Lisbon and Tagus Valley region and two in the central region of mainland Portugal, between December 2020 and March 2022. VE against symptomatic SARS-CoV-2 infection was estimated as one minus the confounder adjusted HRs by Cox models considering age group, sex, self-reported chronic disease and occupational exposure to patients diagnosed with COVID-19 as adjustment variables. RESULTS: During the 15 months of follow-up, the 3034 HCWs contributed a total of 3054 person-years at risk, and 581 SARS-CoV-2 events occurred. Most participants were already vaccinated with a booster dose (n=2653, 87%), some are vaccinated with only the primary scheme (n=369, 12.6%) and a few remained unvaccinated (n=12, 0.4%) at the end of the study period. VE against symptomatic infection was 63.6% (95% CI 22.6% to 82.9%) for HCWs vaccinated with two doses and 55.9% (95% CI -1.3% to 80.8%) for HCWs vaccinated with one booster dose. Point estimate VE was higher for individuals with two doses taken between 14 days and 98 days (VE=71.9%; 95% CI 32.3% to 88.3%). CONCLUSION: This cohort study found a high COVID-19 VE against symptomatic SARS-CoV-2 infection in Portuguese HCWs after vaccination with one booster dose, even after Omicron variant occurrence. The small sample size, the high vaccine coverage, the very low number of unvaccinated individuals and the few events observed during the study period contributed to the low precision of the estimates.publishersversionpublishe

Novel ultraviolet absorbers derived from cashew nut shell liquid: spectrophotometric, in silico and in vitro assays

The cashew nut shell liquid (CNSL) constituents were isolated by our group leading to four mixtures and seventeen pure compounds, which had chromophoric groups similar to organic ultraviolet (UV) absorbers. In addition, C15 and C8 CNSL-derivatives molecules were rationally planned as UV absorbers. Mixtures and isolated CNSL compounds were demonstrated to be non-phototoxic when evaluated in a phototoxicity assay using the yeast Saccharomyces cerevisiae. Considering the absorption values on the UV range, 6 compounds showed appropriate SPF values regarding the spectrophotometric test. Additionally, in silico and in vitro evaluations were performed, showing non-oral bioavailability, as well as non-mutagenic, non-genotoxic and non-phototoxic properties for the tested compounds. These results contribute favorably to the aimed use of the compounds under analysis as novel organic UV absorbers that have as precursor the phenolic lipid component of CNSL, a waste product obtained as the by-product of cashew nut food processing