Miocardiopatia de Takotsubo e suas variáveis: uma revisão integrativa

In post-modern society, changes in people's lifestyle have triggered both professional and personal problems. In this context, encouraging the biopsychosocial look at the patient, there is a concern to research more about Takotsubo Cardiomyopathy. The objective of this research is to identify studies that address the factors that can trigger Takotsubo myocardiopathy. This is an integrative literature review. The evidence found through the retrieved articles indicates the association of CMT with stressors, this being the most likely variable, it is an underdiagnosed pathology because its findings are confused with Acute Coronary Syndrome. The results of the present study demonstrate the association of stressors with the development of Takotsubo Cardiomyopathy, clarifying possible relationships between them.Na sociedade pós-moderna, as mudanças no estilo de vida das pessoas desencadearam problemas tanto profissionais, quanto pessoais. Nesse contexto, incentivando o olhar biopsicossocial para o paciente, surge a inquietação de se pesquisar mais sobre a Cardiomiopatia de Takotsubo. O objetivo dessa pesquisa é identificar estudos que abordem os fatores que podem desencadear a mio cardiopatia de Takotsubo. Trata-se de uma revisão integrativa da literatura.  As evidências encontradas através dos artigos recuperados indicam a associação da CMT com fatores estressores, sendo essa a variável mais provável, é uma patologia sub diagnosticada pois seus achados se confundem com a Síndrome Coronariana Aguda. Os resultados do presente estudo demonstram a associação dos fatores estressores com o desenvolvimento da Cardiomiopatia de Takotsubo esclarecendo possíveis relações entre eles

Miocardiopatia de Takotsubo e suas variáveis: uma revisão integrativa

In post-modern society, changes in people's lifestyle have triggered both professional and personal problems. In this context, encouraging the biopsychosocial look at the patient, there is a concern to research more about Takotsubo Cardiomyopathy. The objective of this research is to identify studies that address the factors that can trigger Takotsubo myocardiopathy. This is an integrative literature review. The evidence found through the retrieved articles indicates the association of CMT with stressors, this being the most likely variable, it is an underdiagnosed pathology because its findings are confused with Acute Coronary Syndrome. The results of the present study demonstrate the association of stressors with the development of Takotsubo Cardiomyopathy, clarifying possible relationships between them.Na sociedade pós-moderna, as mudanças no estilo de vida das pessoas desencadearam problemas tanto profissionais, quanto pessoais. Nesse contexto, incentivando o olhar biopsicossocial para o paciente, surge a inquietação de se pesquisar mais sobre a Cardiomiopatia de Takotsubo. O objetivo dessa pesquisa é identificar estudos que abordem os fatores que podem desencadear a mio cardiopatia de Takotsubo. Trata-se de uma revisão integrativa da literatura.  As evidências encontradas através dos artigos recuperados indicam a associação da CMT com fatores estressores, sendo essa a variável mais provável, é uma patologia sub diagnosticada pois seus achados se confundem com a Síndrome Coronariana Aguda. Os resultados do presente estudo demonstram a associação dos fatores estressores com o desenvolvimento da Cardiomiopatia de Takotsubo esclarecendo possíveis relações entre eles

A influência da respiração oral na qualidade de vida infantil

A respiração bucal na infância, frequentemente associada à obstrução das vias aéreas superiores, impacta significativamente a qualidade de vida das crianças. Originada por fatores como hipertrofia de adenoides e desvio de septo nasal, esse padrão respiratório influencia não apenas o desenvolvimento orofacial, mas também aspectos cognitivos e emocionais. Com efeitos sutis, mas abrangentes, compreender e abordar precocemente esse fenômeno torna-se crucial para promover o pleno bem-estar infantil. Sendo assim, o objetivo desse estudo foi compreender o impacto que a respiração oral na qualidade de vida das crianças. Foi conduzida uma revisão narrativa da literatura utilizando as bases de dados bibliográficos Lilacs, SciELO e PubMed. As estratégias de busca empregaram os termos em inglês: “Mouth breathing”, “quality of life” e “Child”. A delimitação da pesquisa ocorreu por meio do cruzamento desses termos utilizando o operador booleano AND. Os resultados e discussões demostram que as alterações faciais e dentárias evidenciadas necessitam de intervenção multidisciplinar nesses pacientes. Além disso, foi verificado a importância da intervenção desde a infância até a idade adulta. A faixa etária e identificação precoce são cruciais para influenciar positivamente a qualidade de vida. Em conclusão, é notável o impacto negativo que a respiração oral exerce na qualidade de vida das crianças, podendo perdurar ao longo de sua vida. Desta forma, é necessário uma abordagem mais abrangente para melhorar a qualidade de vida desses pacientes.    

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Nasal, Oral and Ear Swabs for Canine Visceral Leishmaniasis Diagnosis: New Practical Approaches for Detection of <i>Leishmania infantum</i> DNA

<div><p>Background</p><p>The aim of this study was to evaluate the potential use of nasal, oral, and ear swabs for molecular diagnosis of canine visceral leishmaniasis (CVL) in an endemic urban area in Brazil.</p> <p>Methodology/Principal Findings</p><p>Sixty-two naturally infected and ten healthy dogs were enrolled in this study. Bone marrow aspirates, peripheral blood, skin biopsy, and conjunctival, nasal, oral, and ear swabs were collected. All samples, except blood, were submitted to conventional PCR (cPCR) and quantitative real time PCR (qPCR) to detect and quantify <i>Leishmania infantum</i> DNA, respectively. All dogs were submitted to thorough clinical analysis and were included based on a combination of serological (ELISA immunoassay and immunofluorescent antibody test) and parasitological methods. The cPCR positivity obtained from nasal swab samples was 87% (54/62), equivalent to those from other samples (P>0.05). Positive results were obtained for 79% (22/28) in oral swabs and 43% (12/28) in ear swab samples. A significant difference was observed between these data (P = 0.013), and the frequency of positive results from oral swab was equivalent to those from other samples (P>0.05). The use of ear swab samples for cPCR assays is promising because its result was equivalent to skin biopsy data (P>0.05). The qPCR data revealed that parasite loads in mucosal tissues were similar (P>0.05), but significantly lower than the parasite burden observed in bone marrow and skin samples (P<0.05).</p> <p>Conclusions</p><p>Nasal and oral swab samples showed a high potential for the qualitative molecular diagnosis of CVL because their results were equivalent to those observed in samples collected invasively. Considering that mucosae swab collections are painless, noninvasive, fast and practical, the combination of these samples would be useful in massive screening of dogs. This work highlights the potential of practical approaches for molecular diagnosis of CVL and human leishmaniasis infections.</p> </div

El Compostelano : diario independiente: Ano XIX Número 5478 - 1938 agosto 26

*<p>Only the left nostril was considered;</p>**<p>Only the left conjunctiva was considered.</p><p>The <i>P</i> values were calculated using the chi square test.</p

Estimated parasite loads in different clinical samples from 28 naturally infected dogs.

<p>Data distributions with distinct letters are significantly different according to the Mann-Whitney <i>U</i> test. Nasal swab and bone marrow (P = 0.0024); Nasal swab and skin biopsy (P = 0.019); Oral swab and bone marrow (P = 0.0013); Oral swab and skin biopsy (P = 0.0058); Conjunctival swab and bone marrow (P = 0.0009); Conjunctival swab and skin biopsy (P = 0.0057) *Only the left nostril was considered. **Only the left conjunctiva was considered.</p

Estimated parasite loads in different clinical samples from 62 naturally infected dogs.

<p>Data distributions with distinct letters are significantly different according to the Mann-Whitney <i>U</i> test. Nasal swab and bone marrow (P = 0.0004); nasal swab and skin biopsy (P = 0.0074); conjunctival swab and bone marrow (P = 0.0076); conjunctival swab and skin biopsy (P = 0.04). *Only the left nostril was considered. **Only the left conjunctiva was considered.</p

Frequency of clinical signs detected in ear, eyes, mouth and nose in naturally infected dogs.

<p>Frequency of clinical signs detected in ear, eyes, mouth and nose in naturally infected dogs.</p