85 research outputs found
Human Adipose Stromal Cells Increase Survival and Mesenteric Perfusion Following Intestinal Ischemia and Reperfusion Injury
- Author
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/07/2016
- Field of study
OBJECTIVE:
Intestinal ischemia can quickly escalate to bowel necrosis and perforation. Transplantation of stem cells presents a novel treatment modality for this problem. We hypothesized that: human adipose-derived stromal cells (hASCs) would increase survival and mesenteric perfusion to a greater degree compared with differentiated cellular controls following ischemic intestinal injury, and improved outcomes with hASC therapy would be associated with preservation of intestinal histological and tight junction architecture, and lower levels of systemic inflammation following intestinal injury.
METHODS:
hASCs and keratinocytes (differentiated cellular control) were cultured on polystyrene flasks at 37°C in 5% CO2 in air. Adult male C57Bl6J mice were anesthetized and a midline laparotomy performed. The intestines were eviscerated, the small bowel mesenteric root identified, and intestinal ischemia was established by temporarily occluding the superior mesenteric artery for 60 min with a noncrushing vascular clamp. Following ischemia, the clamp was removed, and the intestines were returned to the abdominal cavity. Before abdominal closure, 2 million hASCs or keratinocytes in 250 μL of phosphate-buffered saline (carrier for cells and control solution) were infused into the peritoneum. Animals were allowed to recover for 12 or 24 h (perfusion, histology, cytokine, and immunofluoresence studies), or 7 days (survival studies). Intestinal perfusion was assessed by laser Doppler imaging. Intestinal tissue segments were stained with hematoxylin and eosin, as well as antibodies for the tight junction protein claudin-1. Separate aliquots of intestine, liver, and lung tissue were homogenized and assessed for inflammatory cytokines via multiplex beaded assay.
RESULTS:
Animals administered hASCs following intestinal ischemia and reperfusion (I/R) injury had significantly greater 7-day survival and better postischemic recovery of mesenteric perfusion compared with vehicle or keratinocyte therapy. hASCs also abated intestinal mucosal destruction, facilitated preservation of intestinal tight junctions, and decreased the systemic inflammatory response to injury.
CONCLUSIONS:
Human adipose-derived stromal cells improved survival and mesenteric perfusion and attenuated the mucosal damage associated with intestinal I/R injury. hASCs should be considered as a plausible cell source for novel cellular treatment plans following intestinal ischemia
Reviews
- Author
- Publication venue
- DigitalCommons@Kennesaw State University
- Publication date
- 01/01/2016
- Field of study
Book review
Development and validation of a targeted gene sequencing panel for application to disparate cancers
- Author
- Aghmesheh Morteza
- Amor David
- Andrews Lesley
- Antill Yoland C.
- Armitage Shane
- Arnold Leanne
- Balleine Rosemary
- Bastik Patricia A.
- Beesley Jonathan
- Beilby John
- Bennett Ian
- Blackburn Anneke C.
- Bogwitz Michael R.
- Botes Leon P.
- Brennan Meagan
- Brown Melissa A.
- Buckley Michael
- Burgess Matthew J.
- Burke Jo
- Butow Phyllis
- Caldon Elizabeth
- Callen David F.
- Campbell Ian G.
- Chan Chialing
- Chauhan Deepa
- Chauhan Manisha
- Chenevix-Trench Georgia
- Christian Alice
- Cipponi Arcadi
- Clarke Christine L.
- Cohen Paul A.
- Colley Alison S.
- Crook Ashley
- Cui James
- Culling Bronwyn
- Cummings Margaret C.
- Dawson Sarah J.
- De Sousa Sunita M.
- DeFazio Anna
- Delatycki Martin B.
- Deng Niantao
- Dickson Rebecca
- Dixon Joanne W.
- Dobrovic Alexander
- Dudding Tracy
- Edkins Ted
- Edwards Stacey L.
- Eisenbruch Maurice
- et al .
- Farshid Gelareh
- Fellows Andrew
- Fenton Georgina
- Field Michael
- Flanagan James M.
- Fong Peter C.
- Forrest Laura
- Fox Stephen B.
- French Juliet D.
- Friedlander Michael
- Gaff Clara
- Gallego-Ortega David
- Gattas Michael R.
- Gauthier Marie-Emilie A.
- Gayevskiy Velimir
- George Peter M.
- Giles Graham G.
- Gill Grantley
- Grady John P.
- Greening Sian
- Haan Eric A.
- Harris Marion T.
- Hart Stewart
- Hayward Nicholas K.
- Heiniger Louise E.
- Hopper John L.
- Hunt Clare E.
- James Paul A.
- Jenkins Mark A.
- Johns Amber L.
- Kefford Rick F.
- Kidd Alexa M.
- Kirk Judy
- Koehler Jessica
- Kohonen-Corish Maija R.
- Kollias James
- Lakhini Sunil R.
- Lindeman Geoffrey J.
- Lipton Lara R.
- Lobb Liz
- Lord Reginald V.
- Mann Graham
- March Deborah J.
- McCabe Mark J.
- McLachaln Sue A.
- Meiser Bettina
- Milne Roger L.
- Nightingale Sophie S.
- O'Connell Shona
- O'Sullivan Sarah
- O'Toole Sandra A. (R17255)
- Pachter Nicholas S.
- Patterson Briony
- Phillips Kelly A.
- Pieper Ellen
- Puttick Clare
- Rickard Edwina
- Robinson Bridget
- Saleh Mona
- Salisbury Elizabeth
- Sambrook Joseph F.
- Saunders Christobel
- Saunus Jodi
- Scott Clare L.
- Scott Elizabeth
- Scott Rodney J.
- Sexton Adrienne C.
- Shelling Andrew N.
- Simpson Peter
- Southey Melissa C.
- Spurdle Amanda B.
- Swarbrick Alexander
- Tao Jiang
- Taylor Jessica A.
- Thomas Melissa L.
- Thompson Tanya J.
- Thorne Heather J.
- Trainer Alison H.
- Tucker Katherine
- Visvader Jane E.
- Walker Logan C.
- Williams Rachel A.
- Winship Ingrid
- Ying Kevin
- Young Mary A.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Next generation sequencing has revolutionised genomic studies of cancer, having facilitated the development of precision oncology treatments based on a tumour’s molecular profile. We aimed to develop a targeted gene sequencing panel for application to disparate cancer types with particular focus on tumours of the head and neck, plus test for utility in liquid biopsy. The final panel designed through Roche/Nimblegen combined 451 cancer-associated genes (2.01 Mb target region). 136 patient DNA samples were collected for performance and application testing. Panel sensitivity and precision were measured using well-characterised DNA controls (n = 47), and specificity by Sanger sequencing of the Aryl Hydrocarbon Receptor Interacting Protein (AIP) gene in 89 patients. Assessment of liquid biopsy application employed a pool of synthetic circulating tumour DNA (ctDNA). Library preparation and sequencing were conducted on Illumina-based platforms prior to analysis with our accredited (ISO15189) bioinformatics pipeline. We achieved a mean coverage of 395x, with sensitivity and specificity of >99% and precision of >97%. Liquid biopsy revealed detection to 1.25% variant allele frequency. Application to head and neck tumours/cancers resulted in detection of mutations aligned to published databases. In conclusion, we have developed an analytically-validated panel for application to cancers of disparate types with utility in liquid biopsy
Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial.
- Author
- A Sarah Walker
- Abid Hussain
- Abiola Alli
- Abraham Gihawi
- Achyut Guleri
- Achyut Guleri
- Adam Jeans
- Adam Lewszuk
- Adam Mohamoodally
- Adam Wolstencroft
- Adele Marshall
- Adetunji Adedayo
- Adrian Lyons
- Agnieszka Skotnicka
- Ahalya Malachira
- Aiden Plant
- Alaric Colville
- Alex Chrdle
- Alex Peel
- Alex Szubert
- Alexander Szubert
- Ali Vaughn
- Alisha Beddoe
- Alison Eyre
- Alison Fair
- Alison Porges
- Alison Potter
- Alison Stolton
- Amanda Fife
- Amanda Moran
- Amandip Sahota
- Amita Patel
- Amy Driffill
- Amy Janvier
- Amy Murray
- Ana de Veciana
- Andrea Boyce
- Andree Evans
- Andrew Conbeer
- Andrew Flatt
- Andrew Potter
- Andrew Rosser
- Angela Cape
- Angela Dunne
- Angela Houston
- Angela King
- Angela McCadden
- Angela Parkin
- Ann Sarah Walker
- Anna L Goodman
- Anna McSkeane
- Anna Reyes
- Anna Sweeney
- Anne Anderson
- Anne Clarke
- Anthony Donnelly
- Antonia Scobie
- Antonio Querol-Rubiera
- Aodhan Breathnach
- Asha Mathews
- Atul Kotecha
- Avril Masdin
- Ayodele Ajayi
- Bala Subramanian
- Belinda Romans
- Ben Marks
- Benjamin Jeffs
- Bernadette Cook
- Bernadette Young
- Bernadette Young
- Bev Warner
- Bijal Patel
- Boingotlo Masake
- Brooke Jackson
- Cariad Evan
- Carlene Rowson
- Carlos Díaz-Montaña
- Carmen Cantell
- Carol Brooks
- Carole McPherson
- Caroline Andrews
- Caroline Bedford
- Caroline Renton
- Carolyn Hemsley
- Carrie Ridley
- Catherine Aldridge
- Charley Higham
- Charlote Armer
- Charlotte Eglinton
- Charlotte Gibbs
- Charlotte Russell
- Cherrelle de Souza
- Cheryl Bailey
- Chi Kai Tam
- Chi Kai Tam
- Chiara Borg
- Chris Brewer
- Chris Smalley
- Christop Lohan
- Christopher Sim
- Claire Keatley
- Claire Williams
- Clare Hamson
- Clare Hutchison
- Clare James
- Clare Tarbotton
- Clive Graham
- Clive Graham
- Colin Brown
- Colin Walker
- Cordelia Watson
- Cressida Auckland
- Cressida Auckland
- Cristina Suarez
- Dai Griffiths
- Dakshika Jeyaratnam
- Dakshika Jeyaratnam
- Damien Mack
- Damilola Otiko
- Daniel Greaves
- Daniela Shackcloth
- Dave Osborne
- David A Price
- David Ashley Price
- David Chadwick
- David Harvey
- David Harvey
- Debbie Johnson
- Deborah Gilliam
- Deepa Nayar
- Denise Ward
- Denise Ward
- Diane Swift
- Dominika Wlazly
- Donna Palmer
- Duncan Wyncoll
- Ed Moran
- Edmund Ong
- Efisia Sais
- Elaine Strachan
- Elen Witness
- Elian Liu
- Elizabeth Foote
- Elizabeth Woodford
- Ella Foncel
- Ellen Adams
- Emily Hetherington
- Emma Folland
- Emma Foreman
- Emma Lawrence
- Emma Moore
- Emmanuel Nsutebu
- Emmanuel Nsutebu
- Faith Okhuoya
- Fiona Walters
- Fleur Hudson
- Fleur Hudson
- Fozia Ahmad
- Gagan Kaler
- Gavin Barlow
- Gavin Barlow
- Gaynor Notcheva
- Gayti Islam
- Gemma Pill
- Geoffrey Howell
- Georgina Shaw
- Giordana Sorrentino
- Gonzalez-Ruiz Armando
- Graham FitzGerald
- Gus Cardoso
- Guy E Thwaites
- Guy Thwaites
- Hannah Allsop
- Hannah Crowther
- Hannah Gott
- Helen Chesterfield
- Helen Fairlamb
- Helen Preedy
- Helen Reynolds
- Helen Vassallo
- Helen Webb
- Helen Wilson
- Helen Winslow
- Helen Wooldridge
- Helena Bond
- Helena White
- Hesther Wilson
- Hezron Greaves
- Hilary Pateman
- Holly Burton
- Ilias Mariolis
- Ines De Abreu
- Ingrid Emmerson
- Isobel Ramsay
- Jack Briggs
- Jackie Westcott
- James Calderwood
- James Fellows
- James Meiring
- James Millard
- James Price
- Jane Cunningham
- Jane Minton
- Jane Minton
- Jane Thompson
- Janet Andrews
- Janet Cairns
- Janet Cairns
- Janet Middle
- Janine Gradwell
- Jason Biswas
- Jason Howard
- Jason Wong
- Jennifer Fitzpatrick
- Jennifer Fitzpatrick
- Jennifer Harrison
- Jess Mandiza
- Jill Deane
- Jill Lyons
- Jim Anson
- Jo Studham
- Joanna Allen
- Joanna Flanagan
- Joanne Gordon
- Joanne Malkin
- Joanne Thorpe
- Joanne Williams
- Joby Cole
- John Humphries
- John Paul
- John Sloss
- John Widdrington
- John Williams
- John Williams
- Jonathan D Edgeworth
- Jonathan D Edgeworth
- Jonathan Folb
- Jonathan Wilson
- Jordan Ewing
- Joseph Lewis
- Josephine Marange
- Judith Chapman
- Judith Platt
- Judy Sercombe
- Julia Greig
- Julia Greig
- Julia Halpin
- Julian Sutton
- Julian Sutton
- Julie Frudd
- Julie Mitchell
- Julie Sorrell
- Karen Bisnauthsing
- Karen Brookes
- Karen Martin
- Kate Ellis
- Kate Maitland
- Kate Maloney
- Kate Ripalda
- Katherine Cullen
- Katherine Curley
- Katherine Pagett
- Kathryn Birchall
- Kathryn Louise Taylor
- Kathryn Potts
- Katie Wilkins
- Katy Marden
- Katy Moore
- Keith Yip
- Kelly Attack
- Kevin Cole
- Kim Cox
- Kim Ryalls
- Kirandip Mandar
- Kirsty Baillie
- Kirsty Gladas
- Kristian Warnes
- Kristine Criste
- Laura Behar
- Laura Butland
- Laura Latter
- Laura Makey
- Laura O'Neil
- Laura Ortiz-Ruiz de Gordoa
- Laura Shewan
- Laura Watson
- Leanne Carwithen
- Leanne Galloway-Browne
- Leila Bahadur
- Lemonia Ftika
- Lenka Strakova
- Leon Peto
- Leona Trainor
- Leona Yabsley
- Lesley Rigden
- Leslie Masters
- Lewis Jones
- Li-An Brown
- Lillian Tsang
- Linda March
- Lindsey Masters
- Lisa Burgess
- Lisa Hurley
- Lizzie Roberts
- Lois Mlemba
- Louise Barrett
- Louise Robinson
- Louise Wright
- Luis Cotter
- Luke Anson
- Luke Bedford
- Lydia Rylance-Knight
- Lynne Smart
- Lynne Whitehead
- Lynsey Goodwin
- Lynsey Stephenson
- M Estee Török
- M Estée Török
- Maggie Cole
- Maggie Kalita
- Manish Pareek
- Manju Joy
- Manuel Fenech
- Maria Edwards
- Maria Hayes
- Maria Nadolski
- Marie-Claire Hoyle
- Marie-Claire West
- Marina Morgan
- Mark Bolton
- Mark Wallis
- Martin J Llewelyn
- Martin Llewelyn
- Martin Wiselka
- Martin Wiselka
- Martyn Cain
- Mary Wands
- Matthew Scarborough
- Matthew Scarborough
- Maxine Hough
- Mazhar Alam
- Mel Baxter
- Melanie Ekani
- Melanie Harrison
- Melanie Hutchings
- Melinda Munang
- Melody Smith
- Michael Ankcorn
- Michelle A Graver
- Michelle Wood
- Mike Marner
- Miranda Kean
- Mirriam Sangombe
- Muge Cevik
- Musa Kamfose
- N Claire Gordon
- Nadine Abberley
- Natalia Waddington
- Naval Vyse
- Neil Jenkins
- Neil Jenkins
- Neil Stone
- Nicholas Beeching
- Nicola Claire Gordon
- Nicola Ridley
- Nicola Smith
- Nicolas Cortes
- Nisa Khan
- Noah Yogo
- Orla Brady
- Pankaj Lal
- Pankaj Lal
- Paul Chadwick
- Paul Jones
- Paul McWhinney
- Paul McWhinney
- Paul R Chadwick
- Paul Roberts
- Paula Harlow
- Paula Sharratt
- Pauline Lambert
- Pavithra Natarajan
- Peter Flegg
- Peter Moss
- Peter Wilson
- Peter Wilson
- Polly Tarrant
- Rachel Abrahams
- Rachel Austin-Hutchison
- Rachel Bousfield
- Rachel Vincent
- Rahul Kurup
- Rajesh Jarghese
- Rakhee Chahuan
- Rasha Said
- Rashmi Sharma
- Rebecca B Saunderson
- Rebecca Palmer
- Rebecca Tagney
- Rebecca Warren
- Reni Jacob
- Richard Bellamy
- Richard Cunningham
- Richard Nendick
- Rob Porter
- Rob Wosley
- Robert Porter
- Robert Reed
- Robert Tilley
- Robert Tilley
- Roderick Balancio-Tolentino
- Rosie Fok
- Rosie Fok
- Ruth Millett
- Ruth Moroney
- Saadia Rahman
- Saba Qaiser
- Sally Batham
- Samantha Crossman
- Sani Aliyu
- Sanuki Perera
- Sara Taiyari
- Sarah A Wyllie
- Sarah Birchall
- Sarah Dyas
- Sarah Glover
- Sarah Meisner
- Sarah Meisner
- Sarah Moll
- Sarah Rippon
- Sarah Stevenson
- Sarah Thornthwaite
- Sarah Wyllie
- Scott Prentice
- Sebastien Martin
- Senait Haile
- Sephora Shaw
- Sergio Muñoz-Villaverde
- Sharon Sheehan
- Shirley Cooper
- Shirley Todd
- Shona Hughes
- Simon Matthews
- Simon Warren
- Sophie Collier
- Sophie Whiteley
- Stacey Donaldson
- Stacey Valentine
- Stephen Booth
- Stephen Coleman
- Stephen K Glass
- Stephen Mepham
- Stephen Morris-Jones
- Sue Kimachia
- Sue Williams
- Suryabrata Banerjee
- Susan Hopkins
- Susan Hopkins
- Susan Lord
- Suzanne Price
- Tamara Mitchell
- Tamika Chapter
- Tat Yam
- Tenessa Sargent
- Teresa Pettifer
- Theodore Gouliouris
- Tim Kemp
- Tim Planche
- Tim Planche
- Tina Burdett
- Tiphanie Clarke
- Tracey Dobson
- Tracey Mynes
- Tracey Platt
- Tracy Matheson-Smith
- Tristan Clark
- Una Poultney
- Veena Raviprakash
- Veenu Kollipara
- Vicki Lowthorpe
- Vicky Chu
- Victoria Dean
- Vusumuzi Shabangu
- Weronika Szypura
- Yvonne Jackson
- Zaheer Islam
- Zoe Martin
- Zoe Prime
- Zoe Swann
- Publication venue
- Lancet
- Publication date
- 14/12/2017
- Field of study
BACKGROUND: Staphylococcus aureus bacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would reduce bacteriologically confirmed treatment failure or disease recurrence, or death, by enhancing early S aureus killing, sterilising infected foci and blood faster, and reducing risks of dissemination and metastatic infection. METHODS: In this multicentre, randomised, double-blind, placebo-controlled trial, adults (≥18 years) with S aureus bacteraemia who had received ≤96 h of active antibiotic therapy were recruited from 29 UK hospitals. Patients were randomly assigned (1:1) via a computer-generated sequential randomisation list to receive 2 weeks of adjunctive rifampicin (600 mg or 900 mg per day according to weight, oral or intravenous) versus identical placebo, together with standard antibiotic therapy. Randomisation was stratified by centre. Patients, investigators, and those caring for the patients were masked to group allocation. The primary outcome was time to bacteriologically confirmed treatment failure or disease recurrence, or death (all-cause), from randomisation to 12 weeks, adjudicated by an independent review committee masked to the treatment. Analysis was intention to treat. This trial was registered, number ISRCTN37666216, and is closed to new participants. FINDINGS: Between Dec 10, 2012, and Oct 25, 2016, 758 eligible participants were randomly assigned: 370 to rifampicin and 388 to placebo. 485 (64%) participants had community-acquired S aureus infections, and 132 (17%) had nosocomial S aureus infections. 47 (6%) had meticillin-resistant infections. 301 (40%) participants had an initial deep infection focus. Standard antibiotics were given for 29 (IQR 18-45) days; 619 (82%) participants received flucloxacillin. By week 12, 62 (17%) of participants who received rifampicin versus 71 (18%) who received placebo experienced treatment failure or disease recurrence, or died (absolute risk difference -1·4%, 95% CI -7·0 to 4·3; hazard ratio 0·96, 0·68-1·35, p=0·81). From randomisation to 12 weeks, no evidence of differences in serious (p=0·17) or grade 3-4 (p=0·36) adverse events were observed; however, 63 (17%) participants in the rifampicin group versus 39 (10%) in the placebo group had antibiotic or trial drug-modifying adverse events (p=0·004), and 24 (6%) versus six (2%) had drug interactions (p=0·0005). INTERPRETATION: Adjunctive rifampicin provided no overall benefit over standard antibiotic therapy in adults with S aureus bacteraemia. FUNDING: UK National Institute for Health Research Health Technology Assessment
Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
- Author
- Abajobir Amanuel Alemu
- Abate Kalkidan Hassen
- Abbafati Cristiana
- Abbas Kaja M.
- Abd-Allah Foad
- Abdulkader Rizwan Suliankatchi
- Abdulle Abdishakur M.
- Abebo Teshome Abuka
- Abera Semaw Ferede
- Aboyans Victor
- Abu-Raddad Laith J.
- Ackerman Ilana N.
- Adedeji Isaac A.
- Adedji
- Adetokunboh Olatunji
- Afshin Ashkan
- Aggarwal Rakesh
- Agrawal Anurag
- Agrawal Sutapa
- Ahmed Muktar Beshir
- Aichour Amani Nidhal
- Aichour Ibtihel
- Aichour Miloud Taki Eddine
- Aiyar Sneha
- Akinyemiju Tomi F.
- Akseer Nadia
- Al Lami Faris Hasan
- Al-Aly Ziyad
- Al-Maskari Fatma
- Al-Raddadi Rajaa
- Alahdab Fares
- Alam Khurshid
- Alam Noore
- Alam Tahiya
- Alasfoor Deena
- Alene Kefyalew Addis
- Ali Raghib
- Alizadeh-Navaei Reza
- Alkaabi Juma M.
- Alkerwi Ala'a
- Alla François
- Allebeck Peter
- Allen Christine
- Almazroa Mohammad Abdulaziz
- Alsharif Ubai
- Alsowaidi Shirina
- Althouse Benjamin M.
- Altirkawi Khalid A.
- Alvis-Guzman Nelson
- Amare Azmeraw T.
- Amini Erfan
- Ammar Walid
- Amoako Yaw Ampem
- Ansha Mustafa Geleto
- Antonio Carl Abelardo T.
- Anwari Palwasha
- Arora Megha
- Artaman Al
- Arthur Avokpaho Euripide Frinel G.
- Aryal Krishna Kumar
- Asgedom Solomon W.
- Atey Tesfay Mehari
- Atnafu Niguse Tadele
- Avila-Burgos Leticia
- Awasthi Ashish
- Awasthi Shally
- Azarpazhooh Mahmoud Reza
- Azzopardi Peter
- Babalola Tesleem Kayode
- Bacha Umar
- Badawi Alaa
- Balakrishnan Kalpana
- Bannick Marlena S.
- Barac Aleksandra
- Barker-Collo Suzanne L.
- Barquera Simon
- Barrero Lope H.
- Basu Sanjay
- Battista Robert
- Battle Katherine E.
- Baune Bernhard T.
- Bazargan-Hejazi Shahrzad
- Beardsley Justin
- Bedi Neeraj
- Bekele Bayu Begashaw
- Bell Michelle L.
- Bennett Derrick A.
- Bennett James R.
- Bensenor Isabela M.
- Benson Jennifer
- Berhane Adugnaw
- Berhe Derbew Fikadu
- Bernabé Eduardo
- Betsu Balem Demtsu
- Beuran Mircea
- Beyene Addisu Shunu
- Bhansali Anil
- Bhatt Samir
- Bhutta Zulfqar A.
- Biadgilign Sibhatu
- Bicer Burcu Kucuk
- Bienhof Kelly
- Bikbov Boris
- Birungi Charles
- Biryukov Stan
- Bisanzio Donal
- Bizuayehu Habtamu Mellie
- Blyth Fiona M.
- Boneya Dube Jara
- Bose Dipan
- Bou-Orm Ibrahim R.
- Bourne Rupert R. A.
- Brainin Michael
- Brayne Carol E. G.
- Brazinova Alexandra
- Breitborde Nicholas J. K.
- Briant Paul S.
- Britton Gabrielle
- Brugha Traolach S.
- Bryane
- Buchbinder Rachelle
- Bulto Lemma Negesa Bulto
- Bumgarner Blair
- Butt Zahid A.
- Bärnighausen Till
- Béjot Yannick
- Cahuana-Hurtado Lucero
- Cameron Ewan
- Campos-Nonato Ismael Ricardo
- Carabin Hélène
- Carpenter David O.
- Carrero Juan Jesus
- Carter Austin
- Carvalho Felix
- Casey Daniel
- Castañeda-Orjuela Carlos A.
- Castle Chris D.
- Catalá-López Ferrán
- Chang Jung-Chen
- Charlson Fiona J.
- Chaturvedi Pankaj
- Chen Honglei
- Chibalabala Mirriam
- Chibueze Chioma Ezinne
- Chisumpa Vesper Hichilombwe
- Chitheer Abdulaal A.
- Chowdhury Rajiv
- Christopher Devasahayam Jesudas
- Ciobanu Liliana G.
- Cirillo Massimo
- Colombara Danny
- Cooper Cyrus
- Cooper Leslie Trumbull
- Cortesi Paolo Angelo
- Cortinovis Monica
- Criqui Michael H.
- Cromwell Elizabeth A.
- Cross Marita
- Crump John A.
- Cárdenas Rosario
- Dadi Abel Fekadu
- Dalal Koustuv
- Damasceno Albertino
- Dandona Lalit
- Dandona Rakhi
- Das Jarlais Don C.
- Das Neves José
- Davitoiu Dragos V.
- Davletov Kairat
- De Courten Barbora
- De Leo Diego
- De Steur Hans
- Defo Barthelemy Kuate
- Degenhardt Louisa
- Deiparine Selina
- Dellavalle Robert P.
- Deribe Kebede
- Deribew Amare
- Dey Subhojit
- Dharmaratne Samath D.
- Dhillon Preet K.
- Dicker Daniel
- Djalalinia Shirin
- Do Huyen Phuc
- Dokova Klara
- Doku David Teye
- Dorsey E. Ray
- Dos Santos Kadine Priscila Bender
- Driscoll Tim R.
- Dubey Manisha
- Duncan Bruce Bartholow
- Ebel Beth E.
- Echko Michelle
- El-Khatib Ziad Ziad
- Enayati Ahmadali
- Endries Aman Yesuf
- Ermakov Sergey Petrovich
- Erskine Holly E.
- Eshetie Setegn
- Eshrati Babak
- Esteghamati Alireza
- Estep Kara
- Fanuel Fanuel Belayneh Bekele
- Farag Tamer
- Farinha Carla Sofa E Sa
- Faro André
- Farzadfar Farshad
- Fazeli Mir Sohail
- Feigin Valery L.
- Feigl Andrea B.
- Fereshtehnejad Seyed-Mohammad
- Fernandes João C.
- Ferrari Alize J.
- Feyissa Tesfaye Regassa
- Filip Irina
- Fischer Florian
- Fitzmaurice Christina
- Flaxman Abraham D.
- Foigt Nataliya
- Foreman Kyle J.
- Franklin Richard C.
- Frostad Joseph J.
- Fullman Nancy
- Furtado Joao M.
- Futran Neal D.
- Fürst Thomas
- Gakidou Emmanuela
- Garcia-Basteiro Alberto L.
- Gebre Teshome
- Gebregergs Gebremedhin Berhe
- Gebrehiwot Tsegaye Tewelde
- Geleijnse Johanna M.
- Geleto Ayele
- Gemechu Bikila Lencha
- Gesesew Hailay Abrha
- Gething Peter W.
- Ghajar Alireza
- Gibney Katherine B.
- Gillum Richard F.
- Ginawi Ibrahim Abdelmageem Mohamed
- Gishu Melkamu Dedefo
- Giussani Giorgia
- Godwin William W.
- Goel Kashish
- Goenka Shifalika
- Goldberg Ellen M.
- Gona Philimon N.
- Goodridge Amador
- Gopalani Sameer Vali
- Gosselin Richard A.
- Gotay Carolyn C.
- Goto Atsushi
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- Woodbrook Rachel
- Woolf Anthony D.
- Workicho Abdulhalik
- Xavier Denis
- Xu Gelin
- Yadgir Simon
- Yaghoubi Mohsen
- Yakob Bereket
- Yan Lijing L.
- Yano Yuichiro
- Ye Pengpeng
- Yihdego Mahari Gidey
- Yimam Hassen Hamid
- Yip Paul
- Yonemoto Naohiro
- Yoon Seok-Jun
- Yotebieng Marcel
- Younis Mustafa Z.
- Yu Chuanhua
- Zaidi Zoubida
- Zaki Maysaa El Sayed
- Zegeye Elias Asfaw
- Zenebe Zerihun Menlkalew
- Zhang Xueying
- Zheng Yingfeng
- Zhou Maigeng
- Zipkin Ben
- Zodpey Sanjay
- Zoeckler Leo
- Zuhlke Liesl Joanna
- Ärnlöv Johan
- Publication venue
- Publication date
- 01/01/2017
- Field of study
BACKGROUND: Measurement of changes in health across locations is useful to compare and contrast changing epidemiological patterns against health system performance and identify specific needs for resource allocation in research, policy development, and programme decision making. Using the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we drew from two widely used summary measures to monitor such changes in population health: disability-adjusted life-years (DALYs) and healthy life expectancy (HALE). We used these measures to track trends and benchmark progress compared with expected trends on the basis of the Socio-demographic Index (SDI).
METHODS: We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 for all-cause mortality, cause-specific mortality, and non-fatal disease burden to derive HALE and DALYs by sex for 195 countries and territories from 1990 to 2016. We calculated DALYs by summing years of life lost and years of life lived with disability for each location, age group, sex, and year. We estimated HALE using age-specific death rates and years of life lived with disability per capita. We explored how DALYs and HALE differed from expected trends when compared with the SDI: the geometric mean of income per person, educational attainment in the population older than age 15 years, and total fertility rate.
FINDINGS: The highest globally observed HALE at birth for both women and men was in Singapore, at 75·2 years (95% uncertainty interval 71·9-78·6) for females and 72·0 years (68·8-75·1) for males. The lowest for females was in the Central African Republic (45·6 years [42·0-49·5]) and for males was in Lesotho (41·5 years [39·0-44·0]). From 1990 to 2016, global HALE increased by an average of 6·24 years (5·97-6·48) for both sexes combined. Global HALE increased by 6·04 years (5·74-6·27) for males and 6·49 years (6·08-6·77) for females, whereas HALE at age 65 years increased by 1·78 years (1·61-1·93) for males and 1·96 years (1·69-2·13) for females. Total global DALYs remained largely unchanged from 1990 to 2016 (-2·3% [-5·9 to 0·9]), with decreases in communicable, maternal, neonatal, and nutritional (CMNN) disease DALYs offset by increased DALYs due to non-communicable diseases (NCDs). The exemplars, calculated as the five lowest ratios of observed to expected age-standardised DALY rates in 2016, were Nicaragua, Costa Rica, the Maldives, Peru, and Israel. The leading three causes of DALYs globally were ischaemic heart disease, cerebrovascular disease, and lower respiratory infections, comprising 16·1% of all DALYs. Total DALYs and age-standardised DALY rates due to most CMNN causes decreased from 1990 to 2016. Conversely, the total DALY burden rose for most NCDs; however, age-standardised DALY rates due to NCDs declined globally.
INTERPRETATION: At a global level, DALYs and HALE continue to show improvements. At the same time, we observe that many populations are facing growing functional health loss. Rising SDI was associated with increases in cumulative years of life lived with disability and decreases in CMNN DALYs offset by increased NCD DALYs. Relative compression of morbidity highlights the importance of continued health interventions, which has changed in most locations in pace with the gross domestic product per person, education, and family planning. The analysis of DALYs and HALE and their relationship to SDI represents a robust framework with which to benchmark location-specific health performance. Country-specific drivers of disease burden, particularly for causes with higher-than-expected DALYs, should inform health policies, health system improvement initiatives, targeted prevention efforts, and development assistance for health, including financial and research investments for all countries, regardless of their level of sociodemographic development. The presence of countries that substantially outperform others suggests the need for increased scrutiny for proven examples of best practices, which can help to extend gains, whereas the presence of underperforming countries suggests the need for devotion of extra attention to health systems that need more robust support.
FUNDING: Bill & Melinda Gates Foundation
Global injury morbidity and mortality from 1990 to 2017 : results from the Global Burden of Disease Study 2017
- Author
- A Mahesh P.
- Abdelalim Ahmed
- Abdeldayem Amer Yasser Sami
- Abdoli Amir
- Abdollahpour Ibrahim
- Abdulkader Rizwan Suliankatchi
- Abedi Aidin
- Abosetugn Akine Eshete
- Abushouk Abdelrahman I.
- Adebayo Oladimeji M.
- Adema Bereket Duko
- Agudelo-Botero Marcela
- Ahmad Tauseef
- Ahmed Muktar Beshir
- Ahmed Rushdia
- Al-Hajj Samar
- Alahdab Fares
- Alamene Genet Melak
- Alanezi Fahad Mashhour
- Alebel Animut
- Alema Niguse Meles
- Alghnam Suliman A.
- Ali Beriwan Abdulqadir
- Ali Saqib
- Alikhani Mahtab
- Alinia Cyrus
- Alipour Vahid
- Aljunid Syed Mohamed
- Almasi-Hashiani Amir
- Almasri Nihad A.
- Altirkawi Khalid
- Amini Saeed
- Andrei Catalina Liliana
- Angga Pribadi Dimas Ria
- Anggraini Ningrum Dina Nur
- Ansari-Moghaddam Alireza
- Arab-Zozani Morteza
- Arabloo Jalal
- Arefi Zohreh
- Aremu Olatunde
- Ariani Filippo
- Arora Amit
- Asaad Malke
- Asante Kwaku Oppong
- Asghari Babak
- awiyyah Babale
- Awoke Nefsu
- Ayala Quintanilla Beatriz Paulina
- Ayano Getinet
- Ayanore Martin Amogre
- Azari Samad
- Azarian Ghasem
- Badawi Alaa
- Badiye Ashish D.
- Bagli Eleni
- Baig Atif Amin
- Bairwa Mohan
- Bakhtiari Ahad
- Balachandran Arun
- Bali Ahmed Omar
- Banach Maciej
- Banerjee Srikanta K.
- Banik Palash Chandra
- Banstola Amrit
- Barker-Collo Suzanne Lyn
- Barrero Lope H.
- Barzegar Akbar
- Bayati Mohsen
- Baye Bayisa Abdissa
- Bedi Neeraj
- Behzadifar Masoud
- Bekuma Tariku Tesfaye
- Belete Habte
- Benjet Corina
- Bennett Derrick A.
- Bensenor Isabela M.
- Berhe Kidanemaryam
- Bhardwaj Pankaj
- Bhat Anusha Ganapati
- Bhattacharyya Krittika
- Bibi Sadia
- Bicer Burcu Kucuk
- Bidgoli Hassan Haghparast
- Bijani Ali
- Bin Sayeed Muhammad Shahdaat
- Borges Guilherme
- Borzì Antonio Maria
- Boufous Soufiane
- Brazinova Alexandra
- Briko Nikolay Ivanovich
- Budhathoki Shyam S.
- Bärnighausen Till Winfried
- Car Josip
- Car Lorainne Tudor
- Carvalho Félix
- Castaldelli-Maia João Mauricio
- Castañeda-Orjuela Carlos A.
- Castelpietra Giulio
- Castle Chris D.
- Catalá-López Ferrán
- Cerin Ester
- Chandan Joht S.
- Chanie Wagaye Fentahun
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- Chaudhary Neha
- Cho Daniel Youngwhan
- Chu Dinh-Toi
- Colquhoun Samantha M.
- Constantin Maria-Magdalena
- Costa Vera M.
- Cárdenas Rosario
- da Silva Diana Dias
- Damiani Giovanni
- Dandona Lalit
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- Darwesh Aso Mohammad
- Daryani Ahmad
- Degenhardt Louisa
- Demeke Feleke Mekonnen
- Demis Asmamaw Bizuneh
- Demoz Gebre Teklemariam
- Demsie Desalegn Getnet
- Derakhshani Afshin
- Deribe Kebede
- Desai Rupak
- Dharmaratne Samath Dhamminda
- Dibaji Forooshani Zahra Sadat
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- Doyle Kerrie E.
- Driscoll Tim Robert
- Dubljanin Eleonora
- Dávila-Cervantes Claudio Alberto
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- Eddine Aichour Miloud Taki
- Eftekhari Aziz
- Ehsani-Chimeh Elham
- El Razek Muhammed Magdy Abd
- El-Jaafary Shaimaa I.
- El-Khatib Ziad
- Elemineh Demelash Abewa
- Ellingsen Christian Lycke
- Emamian Mohammad Hassan
- Endalew Daniel Adane
- Eskandarieh Sharareh
- Faris Pawan Sirwan
- Faro Andre
- Farzadfar Farshad
- Fatahi Yousef
- Fekadu Wubalem
- Ferede Tomas Y.
- Fereshtehnejad Seyed-Mohammad
- Fernandes Eduarda
- Ferrara Pietro
- Feyissa Garumma Tolu
- Filip Irina
- Filipino Pepito Veincent Christian
- Fischer Florian
- Folayan Morenike Oluwatoyin
- Foroutan Masoud
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- Geberemariyam Biniyam Sahiledengle
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- Gebremedhin Ketema Bizuwork
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- Gebremichael Berhe
- Gedefaw Getnet Azeze
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- Ghafourifard Mansour
- Ghamari Farhad
- Ghashghaee Ahmad
- Gholamian Asadollah
- Gholi Mezerji Naser Mohammad
- Gill Tiffany K.
- Goulart Alessandra C.
- Grada Ayman
- Grivna Michal
- Guimarães Rafael Alves
- Guo Yuming
- Gupta Gaurav
- Haagsma Juanita A.
- Hafezi-Nejad Nima
- Hall Brian James
- Hamadeh Randah R.
- Hamidi Samer
- Hamilton Erin B.
- Haro Josep Maria
- Hasan Md Mehedi
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- Hassankhani Hadi
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- Hay Simon I.
- Hayat Khezar
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- Heydarpour Fatemeh
- Ho Hung Chak
- Hoang Chi Linh
- Hole Michael K.
- Holla Ramesh
- Hossain Naznin
- Hosseinzadeh Mehdi
- Hostiuc Sorin
- Hu Guoqing
- Huey Lee Shaun Wen
- Híjar Martha
- Ibitoye Segun Emmanuel
- Ilesanmi Olayinka Stephen
- Ilic Irena
- Ilic Milena D.
- Inbaraj Leeberk Raja
- Indriasih Endang
- Islam M. Mofizul
- Ivers Rebecca Q.
- Jacobsen Kathryn H.
- Jahani Mohammad Ali
- Jahanmehr Nader
- Jakovljevic Mihajlo
- Jalilian Farzad
- James Spencer L.
- Jayaraman Sudha
- Jayatilleke Achala Upendra
- Jha Ravi Prakash
- John-Akinola Yetunde O.
- Jonas Jost B.
- Joseph Nitin
- Joukar Farahnaz
- Jozwiak Jacek Jerzy
- Jungari Suresh Banayya
- Jürisson Mikk
- Kabir Chowdhury Mohiuddin Ahsanul
- Kabir Ali
- Kadel Rajendra
- Kahsay Amaha
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- Kalhor Rohollah
- Kamil Teshome Abegaz
- Kanchan Tanuj
- Kapoor Neeti
- Karami Manoochehr
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- Keiyoro Peter Njenga
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- Mohammad Karzan Abdulmuhsin
- Mohammad Yousef
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- Morawska Lidia
- Morisaki Naho
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- Mustafa Ghulam
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- Nasab Mostafa Dianati
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- Park Eun-Kee
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- Pathak Ashish
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- Patton George C.
- Paulos Kebreab
- Peden Amy E.
- Pereira Jeevan
- Pham Hai Quang
- Phillips Michael R.
- Pinheiro Marina
- Polibin Roman V.
- Polinder Suzanne
- Poustchi Hossein
- Prakash Swayam
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- Rabiee Mohammad
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- Radfar Amir
- Rafay Anwar
- Rafiee Ata
- Rafiei Alireza
- Rahim Fakher
- Rahimi Siavash
- Rahimi-Movaghar Vafa
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- Rezapour Aziz
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- Ronfani Luca
- Roshandel Gholamreza
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- Saad Anas M.
- Sabde Yogesh Damodar
- Sabour Siamak
- Saddik Basema
- Safari Saeed
- Safari-Faramani Roya
- Safarpour Hamid
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- Sajadi S. Mohammad
- Salamati Payman
- Salehi Farkhonde
- Salem Hosni
- Salman Omar
- Salz Inbal
- Samy Abdallah M.
- Sanabria Juan
- Santric Milicevic Milena M.
- Sarker Abdur Razzaque
- Sartorius Benn
- Sarveazad Arash
- Sathian Brijesh
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- Sawyer Susan M.
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- Sayed Zaki Maysaa El
- Sayyah Mehdi
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- Seyedmousavi Seyedmojtaba
- Sha Feng
- Shaahmadi Faramarz
- Shadmani Fatemeh Khosravi
- Shahabi Saeed
- Shaikh Masood Ali
- Shams-Beyranvand Mehran
- Shamsizadeh Morteza
- Sharif-Alhoseini Mahdi
- Sharifi Hamid
- Shariful Islam Sheikh Mohammed
- Sheikh Aziz
- Shigematsu Mika
- Shin Jae Il
- Shiri Rahman
- Siabani Soraya
- Sigfusdottir Inga Dora
- Singh Jasvinder A.
- Singh Pankaj Kumar
- Sinha Dhirendra Narain
- Smarandache Catalin-Gabriel
- Soheili Amin
- Soleymani Bija
- Soltanian Ali Reza
- Soriano Joan B.
- Sorrie Muluken Bekele
- Soyiri Ireneous N.
- Stein Dan J.
- Stokes Mark A.
- Sufiyan Mu
- Syed Zahiruddin Quazi
- Sykes Bryan L.
- Sylte Dillon O.
- T Antonio Carl Abelardo
- Tabarés-Seisdedos Rafael
- Tabb Karen M.
- Taddele Biruk Wogayehu
- Tadesse Degena Bahrey
- Tamiru Animut Tagele
- Tarigan Ingan Ukur
- Tefera Yonatal Mesfin
- Tehrani-Banihashemi Arash
- Tekle Merhawi Gebremedhin
- Tekulu Gebretsadkan Hintsa
- Tesema Ayenew Kassie
- Tesfay Berhe Etsay
- Thapar Rekha
- Thi Nguyen Huong Lan
- Tilahune Asres Bedaso
- Tlaye Kenean Getaneh
- Tohidinik Hamid Reza
- Topor-Madry Roman
- Tran Bach Xuan
- Tran Khanh Bao
- Tripathy Jaya Prasad
- Tsai Alexander C.
- Ullah Irfan
- Ullah Saif
- Umar Maida
- Unnikrishnan Bhaskaran
- Upadhyay Era
- Uthman Olalekan A.
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- Venketasubramanian Narayanaswamy
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- Werdecker Andrea
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- Wolde Haileab Fekadu
- Woldeyes Dawit Habte
- Wondafrash Dawit Zewdu
- Wondmeneh Temesgen Gebeyehu
- Wondmieneh Adam Belay
- Wu Ai-Min
- Yadav Rajaram
- Yadollahpour Ali
- Yano Yuichiro
- Yaw Appiah Seth Christopher
- Yaya Sanni
- Yazdi-Feyzabadi Vahid
- Yip Paul
- Yisma Engida
- Yonemoto Naohiro
- Yoon Seok-Jun
- Youm Yoosik
- Younis Mustafa Z.
- Yousefi Zabihollah
- Yu Chuanhua
- Yu Yong
- Yusefzadeh Hasan
- Zahabi Saleh Salehi
- Zaidi Zoubida
- Zaman Sojib Bin
- Zamani Mohammad
- Zamanian Maryam
- Zandian Hamed
- Zare Fatemeh
- Zarei Ahmad
- Zhang Yunquan
- Zhang Zhi-Jiang
- Zodpey Sanjay
- Publication venue
- Publication date
- 06/12/2019
- Field of study
Correction:Background Past research in population health trends has shown that injuries form a substantial burden of population health loss. Regular updates to injury burden assessments are critical. We report Global Burden of Disease (GBD) 2017 Study estimates on morbidity and mortality for all injuries. Methods We reviewed results for injuries from the GBD 2017 study. GBD 2017 measured injury-specific mortality and years of life lost (YLLs) using the Cause of Death Ensemble model. To measure non-fatal injuries, GBD 2017 modelled injury-specific incidence and converted this to prevalence and years lived with disability (YLDs). YLLs and YLDs were summed to calculate disability-adjusted life years (DALYs). Findings In 1990, there were 4 260 493 (4 085 700 to 4 396 138) injury deaths, which increased to 4 484 722 (4 332 010 to 4 585 554) deaths in 2017, while age-standardised mortality decreased from 1079 (1073 to 1086) to 738 (730 to 745) per 100 000. In 1990, there were 354 064 302 (95% uncertainty interval: 338 174 876 to 371 610 802) new cases of injury globally, which increased to 520 710 288 (493 430 247 to 547 988 635) new cases in 2017. During this time, age-standardised incidence decreased non-significantly from 6824 (6534 to 7147) to 6763 (6412 to 7118) per 100 000. Between 1990 and 2017, age-standardised DALYs decreased from 4947 (4655 to 5233) per 100 000 to 3267 (3058 to 3505). Interpretation Injuries are an important cause of health loss globally, though mortality has declined between 1990 and 2017. Future research in injury burden should focus on prevention in high-burden populations, improving data collection and ensuring access to medical care.Peer reviewe
Histone H3.3 beyond cancer: Germline mutations in Histone 3 Family 3A and 3B cause a previously unidentified neurodegenerative disorder in 46 patients
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- Afenjar A. (Alexandra)
- Barresi S. (Sabina)
- Bend R. (Renee)
- Besnard T. (Thomas)
- Bezieau S. (Stephane)
- Bhoj E.J. (Elizabeth J.)
- Brimble E. (Elise)
- Brokamp E. (Elly)
- Brusco A. (Alfredo)
- Bryant L. (Laura)
- Byler M. (Melissa)
- Carli D. (Diana)
- Catarino C.B. (Claudia B.)
- Cathey S.S. (Sara S.)
- Chitayat D. (David)
- Cho M.T. (Megan T.)
- Chung W. (Wendy)
- Cogne B. (Benjamin)
- Costain G. (Gregory)
- Cox S.G. (Samuel G.)
- Crawford H.P. (Heather P.)
- Crump J.G. (J Gage)
- de la Cruz X. (Xavier)
- Dean J. (John)
- Dean J. (Joy)
- Denecke J. (Jonas)
- Dubbs H. (Holly)
- Fagerberg C. (Christina)
- Ferrero G.B. (Giovanni Battista)
- Fregeau B. (Brieana)
- Garcia B. (Benjamin)
- Gotway G. (Garrett)
- Grebe T. (Theresa)
- Günthner R. (Roman)
- Hakonarson H. (Hakon)
- Helbig K.L. (Katherine L.)
- Hoefele J. (Julia)
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- Innis J.W. (Jeffrey)
- Janssen K. (Kevin)
- Joiner E.F. (Evan F.)
- Kamp J.J.P. (Jacques) van de
- Keren B. (Boris)
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- Kitson H. (Hilary)
- Klopstock T. (Thomas)
- Kury S. (Sebastien)
- Larsen M.J. (Martin J.)
- Laulund L.W. (Lone Walentin)
- Lebel R.R. (Robert Roger)
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- Lee P. (Pearl)
- Lehman A. (Anna)
- Lessel D. (Davor)
- Li D. (Dong)
- Longo N. (Nicola)
- Louie R.J. (Raymond J.)
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- Mancini G.M.S. (Grazia)
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- Norman J. (Jennifer)
- Odent S. (Sylvie)
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- Papp J.C. (Jeanette C.)
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- Powis Z. (Zoe)
- Prescott T. (Trine)
- Radio F.C. (Francesca Clementina)
- Radtke K. (Kelly)
- Redon R. (Richard)
- Reinson K. (Karit)
- Retterer K. (Kyle)
- Reutter H. (Heiko)
- Ross A.J. (Alison)
- Schot R. (Rachel)
- Schrier Vergano S.A. (Samantha A.)
- Schuette J.L. (Jane L.)
- Sellars E. (Elizabeth)
- Sherbini O. (Omar)
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- Stumpel C.T.R.M. (Constance T R M)
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- Umana L. (Luis)
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- Vanderver A. (Adeline)
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- Vøllo A. (Arve)
- Wadley A. (Alexandrea)
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- Wierenga K.J. (Klaas J.)
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- Yuan Z.-F. (Zuo-Fei)
- Zackai E. (Elaine)
- Zheng A. (Allison)
- Õunap K. (Katrin)
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/12/2020
- Field of study
Although somatic mutations in Histone 3.3 (H3.3) are well-studied drivers of oncogenesis, the role of germline mutations remains unreported. We analyze 46 patients bearing de novo germline mutations in histone 3 family 3A (H3F3A) or H3F3B with progressive neurologic dysfunction and congenital anomalies without malignancies. Molecular modeling of all 37 variants demonstrated clear disruptions in interactions with DNA, other histones, and histone chaperone proteins. Patient histone posttranslational modifications (PTMs) analysis revealed notably aberrant local PTM patterns distinct from the somatic lysine mutations that cause global PTM dysregulation. RNA sequencing on patient cells demonstrated up-regulated gene expression related to mitosis and cell division, and cellular assays confirmed an increased proliferative capacity. A zebrafish model showed craniofacial anomalies and a defect in Foxd3-derived glia. These data suggest that the mechanism of germline mutations are distinct from cancer-associated somatic histone mutations but may converge on control of cell proliferation
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study
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- Adamali H.
- Adeloye D
- Adeyemi Oluwaseun
- Adrego Rita
- Aguilar Jimenez Laura A.
- Ahmad Haider N
- Ahmad Shanaz
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- Ainsworth Mark
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- Alamoudi Asma
- Alfaro-Almagro Fidel
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- Allsop Lynne
- Allt Ann Marie
- Almeida Paula
- Altmann Danny
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- Arbane Gill
- Arias Ava Maria
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- Warburton Louise
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- Wyles J.
- Wynter Inez
- Xie Cheng
- Xu M
- Yasmin Najira
- Yasmin S
- Yates Tom
- Yip K P
- Young A.
- Young B.
- Young Susan
- Yousuf A J
- Zawia Amira
- Zeidan Lisa
- Zhao Bang
- Zheng Bang
- Zongo O.
- Publication venue
- Elsevier
- Publication date
- 22/09/2023
- Field of study
Introduction:
The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures.
Methods:
In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025.
Findings:
Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation.
Interpretation:
After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification
Search for single production of vector-like quarks decaying into Wb in pp collisions at s=8 TeV with the ATLAS detector
- Author
- Abbott Brad
- Abdallah Jalal
- Abdinov Ovsat
- Abeloos Baptiste
- Aben Rosemarie
- Abolins Maris
- AbouZeid Ossama
- Abramowicz Halina
- Abreu Henso
- Abreu Ricardo
- Abulaiti Yiming
- Acharya Bobby Sami
- Adamczyk Leszek
- Adams David
- Adelman Jahred
- Adomeit Stefanie
- Adye Tim
- Affolder Tony
- Agatonovic-Jovin Tatjana
- Agricola Johannes
- Aguilar-Saavedra Juan Anton
- Ahlen Steven
- Ahmadov Faig
- Aielli Giulio
- Akerstedt Henrik
- Akimov Andrei
- Alberghi Gian Luigi
- Albert Justin
- Albrand Solveig
- Alconada Verzini Maria Jose
- Aleksa Martin
- Aleksandrov Igor
- Alexa Calin
- Alexander Gideon
- Alexopoulos Theodoros
- Alhroob Muhammad
- Alimonti Gianluca
- Alio Lion
- Alison John
- Alkire Steven Pat
- Allbrooke Benedict
- Allen Benjamin W
- Allport Phillip
- Aloisio Alberto
- Alonso Alejandro
- Alonso Francisco
- Alpigiani Cristiano
- Alvarez Gonzalez Barbara
- Alviggi Mariagrazi
- Amadio Brian Thom
- Amako Katsuya
- Amaral Coutinho Yara
- Amelung Christoph
- Amidei Dante
- Amor Dos Santos Susana Pat
- Amorim Antonio
- Amoroso Simone
- Amram Nir
- Amundsen Glenn
- Anastopoulos Christos
- Ancu Lucian Ste
- Andari Nansi
- Andeen Timothy
- Anders Christoph
- Anders Gabriel
- Anders John Kenne
- Anderson Kelby
- Andreazza Attilio
- Andrei George Vic
- Angelidakis Stylianos
- Angelozzi Ivan
- Anger Philipp
- Angerami Aaron
- Anghinolfi Francis
- Anisenkov Alexey
- Anjos Nuno
- Annovi Alberto
- Antonelli Mario
- Antonov Alexey
- Antos Jaroslav
- Anulli Fabio
- Aoki Masato
- Aperio Bella Ludovica
- Arabidze Giorgi
- Arai Yasuo
- Araque Juan Pedro
- Arce Ayana
- Arduh Francisco
- Arguin Jean-Franc
- Argyropoulos Spyridon
- Arik Metin
- Armbruster Aaron Jame
- Arnaez Olivier
- Arnold Hannah
- Arratia Miguel
- Arslan Ozan
- Artamonov Andrei
- Artoni Giacomo
- Artz Sebastian
- Asai Shoji
- Asbah Nedaa
- Ashkenazi Adi
- Asquith Lily
- Assamagan Ketevi
- Astalos Robert
- Atkinson Markus
- Atlay Naim Bora
- Augsten Kamil
- Avolio Giuseppe
- Axen Bradley
- Ayoub Mohamad Ka
- Azuelos Georges
- Baak Max
- Baas Alessandra
- Baca Matthew Jo
- Bachacou Henri
- Bachas Konstantin
- Backes Moritz
- Backhaus Malte
- Bagiacchi Paolo
- Bagnaia Paolo
- Bai Yu
- Baines John
- Baker Oliver Kei
- Baldin Evgenii
- Balek Petr
- Balestri Thomas
- Balli Fabrice
- Balunas William Ke
- Banas Elzbieta
- Banerjee Swagato
- Bannoura Arwa A E
- Barak Liron
- Barberio Elisabetta
- Barberis Dario
- Barbero Marlon
- Barillari Teresa
- Barisonzi Marcello
- Barklow Timothy
- Barlow Nick
- Barnes Sarah Loui
- Barnett Bruce
- Barnett Michael
- Barnovska Zuzana
- Baroncelli Antonio
- Barone Gaetano
- Barr Alan
- Barranco Navarro Laura
- Barreiro Guimarães da Costa João
- Barreiro Fernando
- Barros do Vale Maria Alin
- Bartoldus Rainer
- Barton Adam Edwar
- Bartos Pavol
- Basalaev Artem
- Bassalat Ahmed
- Basye Austin
- Bates Richard
- Batista Santiago J
- Batley Richard
- Battaglia Marco
- Bauce Matteo
- Bauer Florian
- Bawa Harinder S
- Beacham James Bake
- Beattie Michael Da
- Beau Tristan
- Beauchemin Pierre-Hug
- Beccherle Roberto
- Bechtle Philip
- Beck Hans~Peter
- Becker Kathrin
- Becker Maurice
- Beckingham Matthew
- Becot Cyril
- Beddall Andrew
- Beddall Ayda
- Bednyakov Vadim
- Bedognetti Matteo
- Bee Christophe
- Beemster Lars
- Beermann Thomas
- Begel Michael
- Behr Janna Kath
- Belanger-Champagne Camille
- Bell William
- Bella Gideon
- Bellagamba Lorenzo
- Bellerive Alain
- Bellomo Massimilia
- Belotskiy Konstantin
- Beltramello Olga
- Benary Odette
- Benchekroun Driss
- Bender Michael
- Bendtz Katarina
- Benekos Nektarios
- Benhammou Yan
- Benhar Noccioli Eleonora
- Benitez Garcia Jorge-Arma
- Benjamin Douglas
- Bensinger James
- Bentvelsen Stan
- Beresford Lydia
- Beretta Matteo
- Berge David
- Bergeaas Kuutmann Elin
- Berger Nicolas
- Berghaus Frank
- Beringer Jürg
- Bernard Clare
- Bernard Nathan Rog
- Bernius Catrin
- Bernlochner Florian Ur
- Berry Tracey
- Berta Peter
- Bertella Claudia
- Bertoli Gabriele
- Bertolucci Federico
- Bertsche Carolyn
- Bertsche David
- Besjes Geert-Jan
- Bessidskaia Bylund Olga
- Bessner Martin Flo
- Besson Nathalie
- Betancourt Christophe
- Bethke Siegfried
- Bevan Adrian Joh
- Bhimji Wahid
- Bianchi Riccardo-M
- Bianchini Louis
- Bianco Michele
- Biebel Otmar
- Biedermann Dustin
- Biesuz Nicolo Vla
- Biglietti Michela
- Bilbao De Mendizabal Javier
- Bilokon Halina
- Bindi Marcello
- Binet Sebastien
- Bingul Ahmet
- Bini Cesare
- Biondi Silvia
- Bjergaard David Mart
- Black Curtis
- Black James
- Black Kevin
- Blackburn Daniel
- Blair Robert
- Blanchard Jean-Bapti
- Blanco Jacobo Eze
- Blazek Tomas
- Bloch Ingo
- Blocker Craig
- Blum Walter
- Blumenschein Ulrike
- Blunier Sylvain
- Bobbink Gerjan
- Bobrovnikov Victor
- Bocchetta Simona Ser
- Bocci Andrea
- Bock Christophe
- Boehler Michael
- Boerner Daniela
- Bogaerts Joannes An
- Bogavac Danijela
- Bogdanchikov Alexander
- Bohm Christian
- Boisvert Veronique
- Bold Tomasz
- Boldea Venera
- Boldyrev Alexey
- Bomben Marco
- Bona Marcella
- Boonekamp Maarten
- Borisov Anatoly
- Borissov Guennadi
- Bortfeldt Jonathan
- Bortolotto Valerio
- Bos Kors
- Boscherini Davide
- Bosman Martine
- Boudreau Joseph
- Bouffard Julian
- Bouhova-Thacker Evelina Va
- Boumediene Djamel Edd
- Bourdarios Claire
- Bousson Nicolas
- Boutle Sarah Kate
- Boveia Antonio
- Boyd James
- Boyko Igor
- Bracinik Juraj
- Brandt Andrew
- Brandt Gerhard
- Brandt Oleg
- Bratzler Uwe
- Brau Benjamin
- Brau James
- Braun Helmut
- Breaden Madden William Dm
- Brendlinger Kurt
- Brennan Amelia Jea
- Brenner Lydia
- Brenner Richard
- Bressler Shikma
- Bristow Timothy Mi
- Britton Dave
- Britzger Daniel
- Brochu Frederic
- Brock Ian
- Brock Raymond
- Brooijmans Gustaaf
- Brooks Timothy
- Brooks William
- Brosamer Jacquelyn
- Brost Elizabeth
- Bruckman de Renstrom Pawel
- Bruncko Dusan
- Bruneliere Renaud
- Bruni Alessia
- Bruni Graziano
- Brunt Benjamin
- Bruschi Marco
- Bruscino Nello
- Bryant Patrick
- Bryngemark Lene
- Buanes Trygve
- Buat Quentin
- Buchholz Peter
- Buckley Andrew
- Budagov Ioulian
- Buehrer Felix
- Bugge Lars
- Bugge Magnar Kop
- Bulekov Oleg
- Bullock Daniel
- Burckhart Helfried
- Burdin Sergey
- Burgard Carsten Da
- Burghgrave Blake
- Burke Stephen
- Burmeister Ingo
- Busato Emmanuel
- Bussey Peter
- Butler John
- Butt Aatif Imti
- Buttar Craig
- Butterworth Jonathan
- Butti Pierfrance
- Buttinger William
- Buzatu Adrian
- Buzykaev Aleksey
- Büscher Daniel
- Büscher Volker
- Cabrera Urbán Susana
- Caforio Davide
- Cairo Valentina
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- Hasegawa Yoji
- Hasib A
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- Hawkings Richard Jo
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- Zanzi Daniele
- Zeitnitz Christian
- Zeman Martin
- Zemla Andrzej
- Zeng Jian Cong
- Zeng Qi
- Zengel Keith
- Zenin Oleg
- Zerwas Dirk
- Zhang Dongliang
- Zhang Fangzhou
- Zhang Guangyi
- Zhang Huijun
- Zhang Jinlong
- Zhang Lei
- Zhang Rui
- Zhang Ruiqi
- Zhang Xueyao
- Zhang Zhiqing
- Zhao Xiandong
- Zhao Yongke
- Zhao Zhengguo
- Zhemchugov Alexey
- Zhong Jiahang
- Zhou Bing
- Zhou Chen
- Zhou Lei
- Zhou Li
- Zhou Mingliang
- Zhou Ning
- Zhu Cheng Guan
- Zhu Hongbo
- Zhu Junjie
- Zhu Yingchun
- Zhuang Xuai
- Zhukov Konstantin
- Zibell Andre
- Zieminska Daria
- Zimine Nikolai
- Zimmermann Christoph
- Zimmermann Stephanie
- Zinonos Zinonas
- Zinser Markus
- Ziolkowski Michael
- Zobernig Georg
- Zoccoli Antonio
- zur Nedden Martin
- Zurzolo Giovanni
- Zwalinski Lukasz
- Åkesson Torsten Pa
- Åsman Barbro
- Ženiš Tibor
- Živković Lidija
- Άlvarez Piqueras Damián
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 08/08/2016
- Field of study
Measurement of the charge asymmetry in top-quark pair production in the lepton-plus-jets final state in pp collision data at s=8TeV with the ATLAS detector
- Author
- Abbott Brad
- Abdallah Jalal
- Abdinov Ovsat
- Aben Rosemarie
- Abolins Maris
- AbouZeid Ossama
- Abramowicz Halina
- Abreu Henso
- Abreu Ricardo
- Abulaiti Yiming
- Acharya Bobby Sami
- Adamczyk Leszek
- Adams David
- Adelman Jahred
- Adomeit Stefanie
- Adye Tim
- Affolder Tony
- Agatonovic-Jovin Tatjana
- Agricola Johannes
- Aguilar-Saavedra Juan Anton
- Ahlen Steven
- Ahmadov Faig
- Aielli Giulio
- Akerstedt Henrik
- Akimov Andrei
- Alberghi Gian Luigi
- Albert Justin
- Albrand Solveig
- Alconada Verzini Maria Jose
- Aleksa Martin
- Aleksandrov Igor
- Alexa Calin
- Alexander Gideon
- Alexopoulos Theodoros
- Alhroob Muhammad
- Alimonti Gianluca
- Alio Lion
- Alison John
- Alkire Steven Pat
- Allbrooke Benedict
- Allport Phillip
- Aloisio Alberto
- Alonso Alejandro
- Alonso Francisco
- Alpigiani Cristiano
- Altheimer Andrew Dav
- Alvarez Gonzalez Barbara
- Alviggi Mariagrazi
- Amadio Brian Thom
- Amako Katsuya
- Amaral Coutinho Yara
- Amelung Christoph
- Amidei Dante
- Amor Dos Santos Susana Pat
- Amorim Antonio
- Amoroso Simone
- Amram Nir
- Amundsen Glenn
- Anastopoulos Christos
- Ancu Lucian Ste
- Andari Nansi
- Andeen Timothy
- Anders Christoph
- Anders Gabriel
- Anders John Kenne
- Anderson Kelby
- Andreazza Attilio
- Andrei George Vic
- Angelidakis Stylianos
- Angelozzi Ivan
- Anger Philipp
- Angerami Aaron
- Anghinolfi Francis
- Anisenkov Alexey
- Anjos Nuno
- Annovi Alberto
- Antonelli Mario
- Antonov Alexey
- Antos Jaroslav
- Anulli Fabio
- Aoki Masato
- Aperio Bella Ludovica
- Arabidze Giorgi
- Arai Yasuo
- Araque Juan Pedro
- Arce Ayana
- Arduh Francisco
- Arguin Jean-Franc
- Argyropoulos Spyridon
- Arik Metin
- Armbruster Aaron Jame
- Arnaez Olivier
- Arnold Hannah
- Arratia Miguel
- Arslan Ozan
- Artamonov Andrei
- Artoni Giacomo
- Asai Shoji
- Asbah Nedaa
- Ashkenazi Adi
- Asquith Lily
- Assamagan Ketevi
- Astalos Robert
- Atkinson Markus
- Atlay Naim Bora
- Augsten Kamil
- Aurousseau Mathieu
- Avolio Giuseppe
- Axen Bradley
- Ayoub Mohamad Ka
- Azuelos Georges
- Baak Max
- Baas Alessandra
- Baca Matthew Jo
- Bacci Cesare
- Bachacou Henri
- Bachas Konstantin
- Backes Moritz
- Backhaus Malte
- Bagiacchi Paolo
- Bagnaia Paolo
- Bai Yu
- Bain Travis
- Baines John
- Baker Oliver Kei
- Baldin Evgenii
- Balek Petr
- Balestri Thomas
- Balli Fabrice
- Balunas William Ke
- Banas Elzbieta
- Banerjee Swagato
- Bannoura Arwa A E
- Barak Liron
- Barberio Elisabetta
- Barberis Dario
- Barbero Marlon
- Barillari Teresa
- Barisonzi Marcello
- Barklow Timothy
- Barlow Nick
- Barnes Sarah Loui
- Barnett Bruce
- Barnett Michael
- Barnovska Zuzana
- Baroncelli Antonio
- Barone Gaetano
- Barr Alan
- Barreiro Guimarães da Costa João
- Barreiro Fernando
- Barros do Vale Maria Alin
- Bartoldus Rainer
- Barton Adam Edwar
- Bartos Pavol
- Basalaev Artem
- Bassalat Ahmed
- Basye Austin
- Bates Richard
- Batista Santiago J
- Batley Richard
- Battaglia Marco
- Bauce Matteo
- Bauer Florian
- Bawa Harinder S
- Beacham James Bake
- Beattie Michael Da
- Beau Tristan
- Beauchemin Pierre-Hug
- Beccherle Roberto
- Bechtle Philip
- Beck Hans Peter
- Becker Kathrin
- Becker Maurice
- Beckingham Matthew
- Becot Cyril
- Beddall Andrew
- Beddall Ayda
- Bednyakov Vadim
- Bee Christophe
- Beemster Lars
- Beermann Thomas
- Begel Michael
- Behr Janna Kath
- Belanger-Champagne Camille
- Bell William
- Bella Gideon
- Bellagamba Lorenzo
- Bellerive Alain
- Bellomo Massimilia
- Belotskiy Konstantin
- Beltramello Olga
- Benary Odette
- Benchekroun Driss
- Bender Michael
- Bendtz Katarina
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- Benhammou Yan
- Benhar Noccioli Eleonora
- Benitez Garcia Jorge-Arma
- Benjamin Douglas
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- Beretta Matteo
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- Bernius Catrin
- Bernlochner Florian Ur
- Berry Tracey
- Berta Peter
- Bertella Claudia
- Bertoli Gabriele
- Bertolucci Federico
- Bertsche Carolyn
- Bertsche David
- Besana Maria Ilar
- Besjes Geert-Jan
- Bessidskaia Bylund Olga
- Bessner Martin Flo
- Besson Nathalie
- Betancourt Christophe
- Bethke Siegfried
- Bevan Adrian Joh
- Bhimji Wahid
- Bianchi Riccardo-M
- Bianchini Louis
- Bianco Michele
- Biebel Otmar
- Biedermann Dustin
- Bieniek Stephen Pa
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- Biglietti Michela
- Bilbao De Mendizabal Javier
- Bilokon Halina
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- Bingul Ahmet
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- Black James
- Black Kevin
- Blackburn Daniel
- Blair Robert
- Blanchard Jean-Bapti
- Blanco Jacobo Eze
- Blazek Tomas
- Bloch Ingo
- Blocker Craig
- Blum Walter
- Blumenschein Ulrike
- Blunier Sylvain
- Bobbink Gerjan
- Bobrovnikov Victor
- Bocchetta Simona Ser
- Bocci Andrea
- Bock Christophe
- Boehler Michael
- Bogaerts Joannes An
- Bogavac Danijela
- Bogdanchikov Alexander
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- Borisov Anatoly
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- Bortfeldt Jonathan
- Bortolotto Valerio
- Bos Kors
- Boscherini Davide
- Bosman Martine
- Boudreau Joseph
- Bouffard Julian
- Bouhova-Thacker Evelina Va
- Boumediene Djamel Edd
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- Bousson Nicolas
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- Breaden Madden William Dm
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- Carlino Gianpaolo
- Carminati Leonardo
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- Carquin Edson
- Carrillo-Montoya German D
- Carter Janet
- Carvalho João
- Casadei Diego
- Casado Maria Pila
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- Chalupkova Ina
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- Chernyatin Valeriy
- Cheu Elliott
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- Chiarella Vitaliano
- Chiarelli Giorgio
- Chiodini Gabriele
- Chisholm Andrew
- Chislett Rebecca Th
- Chitan Adrian
- Chizhov Mihail
- Choi Kyungeon
- Chouridou Sofia
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- Christodoulou Valentinos
- Chromek-Burckhart Doris
- Chudoba Jiri
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- Chwastowski Janusz
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- Ciubancan Mihai
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- Clark Brian Lee
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- Cochran James H
- Coffey Laurel
- Cogan Joshua God
- Colasurdo Luca
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- Cole Stephen
- Colijn Auke-Piete
- Collot Johann
- Colombo Tommaso
- Compostella Gabriele
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- Crispin Ortuzar Mireia
- Cristinziani Markus
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- Cummings Jane
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- Czodrowski Patrick
- Côté David
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- Da Cunha Sargedas De Sousa Mario Jose
- Da Via Cinzia
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- Danninger Matthias
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- Eigen Gerald
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- Weingarten Jens
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- Zanello Lucia
- Zanzi Daniele
- Zeitnitz Christian
- Zeman Martin
- Zemla Andrzej
- Zeng Qi
- Zengel Keith
- Zenin Oleg
- Zerwas Dirk
- Zhang Dongliang
- Zhang Fangzhou
- Zhang Guangyi
- Zhang Huijun
- Zhang Jinlong
- Zhang Lei
- Zhang Ruiqi
- Zhang Xueyao
- Zhang Zhiqing
- Zhao Xiandong
- Zhao Yongke
- Zhao Zhengguo
- Zhemchugov Alexey
- Zhong Jiahang
- Zhou Bing
- Zhou Chen
- Zhou Lei
- Zhou Li
- Zhou Mingliang
- Zhou Ning
- Zhu Cheng Guan
- Zhu Hongbo
- Zhu Junjie
- Zhu Yingchun
- Zhuang Xuai
- Zhukov Konstantin
- Zibell Andre
- Zieminska Daria
- Zimine Nikolai
- Zimmermann Christoph
- Zimmermann Stephanie
- Zinonos Zinonas
- Zinser Markus
- Ziolkowski Michael
- Zobernig Georg
- Zoccoli Antonio
- zur Nedden Martin
- Zurzolo Giovanni
- Zwalinski Lukasz
- Åkesson Torsten Pa
- Åsman Barbro
- Ženiš Tibor
- Živković Lidija
- Άlvarez Piqueras Damián
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 19/02/2016
- Field of study
- …