Tratamiento quirúrgico por otorrinolaringología en el síndrome de apnea-hipopnea obstructiva del sueño (SAHOS)

El síndrome de apnea-hipopnea obstructiva del sueño (SAHOS) se caracteriza por la obstrucción parcial o el colapso total de la vía aérea superior, de manera intermitente y repetitiva, por lo que, en un principio, se vio el manejo quirúrgico como una alternativa curativa para esta patología. Sin embargo, en la actualidad se reconoce que la cirugía, aun sin lograr tasas de efectividad muy altas de manera consistente, sí mejora la tolerancia y adaptación a la terapia de presión positiva, la cual sigue siendo la primera línea de manejo.Así, el primer paso antes de pensar en cualquier procedimiento quirúrgico es un adecuado diagnóstico topográfico, de modo que siempre se debe realizar una nasofibrolaringoscopia para identificar el o los sitios de obstrucción. Además, se sabe que el 75% de los pacientes presentan obstrucciones en múltiples niveles y que, cuando el abordaje se hace multinivel, se logra corregir el SAHOS hasta en un 95%. Entre los procedimientos vigentes se encuentran cirugías de nariz, paladar blando, amígdalas, base de lengua, estimulación del nervio hipogloso y procedimientos del esqueleto facial, así como procedimientos coadyuvantes, entre los que están radiofrecuencia e implantes de paladar.Obstructive sleep apnea-hypopnea syndrome (OSAHS) is characterized by the partial obstruction or total collapse of the upper airway in an intermittent and repetitive manner; in this scenario, surgical management was initially regarded as an alternative for treating this pathology. Nowadays, surgery is highly recognized because it improves tolerance and adaptation to positive pressure therapy; it remains as the first line of treatment, although high rates of effectiveness are not achieved.The first step before considering any surgical procedure is an adequate topographic diagnosis; therefore, a nasofibrolaryngoscopy should always be performed to identify the obstruction site(s). It is known that 75% of patients have obstructions at multiple levels, so correcting OSAHS by up to 95% is possible when the approach considers all the levels. Current procedures include nasal surgery, soft palate, tonsils, tongue base, hypoglossal nerve stimulator and facial skeletal procedures, as well as adjuvant procedures that include radiofrequency and palate implants

Recommendations from the Asociación Colombiana de Medicina del Sueño for the practice of sleep medicine in Colombia during the COVID-19 pandemic

El lavado de manos frecuente, el uso obligatorio de mascarilla por parte de la población general en sitios públicos, el distanciamiento físico y social, y el confinamiento obligatorio de la mayoría de la población en sus casas son las medidas que hasta el momento han ayudado a frenar la propagación del nuevo coronavirus (SARS-CoV-2), causante de la actual pandemia por COVID-19. Sin embargo, la adopción de algunas de estas medidas ha generado retraso en el diagnóstico y tratamiento de diferentes enfermedades, incluyendo los trastornos del sueño, por lo que es urgente que los especialistas en medicina del sueño y los centros de sueño retomen sus actividades gradualmente, siempre que se implementen estrictos protocolos de bioseguridad que mitiguen el riesgo de contagio. En este contexto, y con el fin de ayudar a los somnólogos a reabrir los centros de sueño y reanudar los procedimientos allí realizados, la Asociación Colombiana de Medicina del Sueño propone en la presente reflexión una serie de recomendaciones para tener en cuenta durante el proceso de reactivación. Estas recomendaciones se basan en las estrategias de mitigación establecidas por las autoridades sanitarias del país, las directrices de la American Academy of Sleep Medicine, y la literatura disponible sobre el tema, la cual fue revisada luego de realizar una búsqueda en las bases de datos PubMed, SciELO y Google Scholar usando los términos “sleep” “sleep medicine” y “COVID-19”.Measures such as frequent handwashing, mandatory use of face masks by the general population in public spaces, social and physical distancing, and mandatory confinement of most people at their homes have contributed to slowing down the spread of the new coronavirus (SARS-CoV-2), which is the source of the current COVID-19 pandemic. However, adopting some of these measures has caused delays in the diagnosis and treatment of various diseases, including sleep disorders. There-fore, it is urgent for sleep specialists and sleep centers to gradually resume activities, as long as strict biosecurity protocols aimed at reducing the risk of contagion are implemented. In this scenario, and in order to help somnologists reopen sleep centers and resume the proce-dures performed there, the Asociación Colombiana de Medicina del Sueño (Colombian Association of Sleep Medicine) proposes through this reflection paper several recommendations that should be considered during the reactivation process. These recommendations are based on the COVID-19 spread mitigation strategies established by the Colombian health authorities, the guidelines issued by the American Academy of Sleep Medicine, and relevant literature on this subject, which was re-viewed after performing a search in the PubMed, SciELO, and Google Scholar databases using the search terms “sleep” “sleep medicine” and “COVID-19

RECOMENDACIONES DE LA ASOCIACION COLOMBIANA DE MEDICINA DE SUEÑO PARA EL EJERCICIO DE LA MEDICINA DEL SUEÑO EN COLOMBIA DURANTE LA CONTINGENCIA PANDEMIA COVID-19.

The Asociación Colombiana de Medicina del Sueño (ACMES) in order to help somnologists evaluate the sleep unit and the procedures carried out on it in response to the outbreak of COVID-19 issues this guide. This is based on the mitigation strategies recommended by the country's health authorities and the bibliographic review of the available medical evidence and current AASM recommendations. Colombia is in the phase of sustained transmission of COVID-19 and frequent hand-washing measures, the use of a mask by the general population in public places, physical distancing and home confinement, supported by local sanitary norms, have helped to stop the spread of the virus. However, the economic crisis associated with this outbreak makes it urgent that the country returns little by little with the implementation of the necessary biosecurity measures to a relative normality. In this current context of the pandemic in Colombia, ACMES has designed this guide so that somnologists and local sleep units have a minimum orientation in their practice during this outbreak and once the public health measures to lower the speed of contagion have been overcome gradually reopen the economy and contain the speed of spread to get back to normal if possible.La Asociación Colombiana de Medicina del Sueño (ACMES) con el fin de ayudar a los somnólogos a evaluar la unidad de sueño y los procedimientos que se llevan a cabo en la misma en respuesta al brote del COVID-19 emite la presente guía. Esta se fundamenta en las estrategias de mitigación recomendadas por las autoridades sanitarias del país y de la revisión bibliográfica de la evidencia médica disponible y recomendaciones actuales AASM.  Colombia se encuentra en la fase de transmisión sostenida del COVID-19 y las medidas de lavado de manos frecuente, de uso de mascarilla por la población general en sitios públicos, de distanciamiento físico y confinamiento en los hogares, respaldada por normas sanitarias locales han ayudado a frenar la propagación del virus. Sin embargo, la crisis económica asociada a este brote hace urgente que el país retorne poco a poco con la implementación de las medidas de bioseguridad necesaria a una relativa normalidad. En este contexto actual de la pandemia en Colombia la ACMES ha diseñado esta guía para que los somnólogos y las unidades de sueño locales tengan una orientación mínima en su práctica durante este brote y una vez superadas las medidas de salud pública para bajar la velocidad del contagio del virus, reabrir poco a poco la economía y contener la velocidad de la propagación para volver a la normalidad en lo posible

Screening in strongly coupled N=2* supersymmetric Yang-Mills plasma

Using gauge-gravity duality, we extend thermodynamic studies and present results for thermal screening masses in strongly coupled N=2* supersymmetric Yang-Mills theory. This non-conformal theory is a mass deformation of maximally supersymmetric N=4 gauge theory. Results are obtained for the entropy density, pressure, specific heat, equation of state, and screening masses, down to previously unexplored low temperatures. The temperature dependence of screening masses in various symmetry channels, which characterize the longest length scales over which thermal fluctuations in the non-Abelian plasma are correlated, is examined and found to be asymptotically linear in the low temperature regime.Comment: 43 pages, 13 figures, typo fixed, published versio

MR fluoroscopy in vascular and cardiac interventions (review)

Vascular and cardiac disease remains a leading cause of morbidity and mortality in developed and emerging countries. Vascular and cardiac interventions require extensive fluoroscopic guidance to navigate endovascular catheters. X-ray fluoroscopy is considered the current modality for real time imaging. It provides excellent spatial and temporal resolution, but is limited by exposure of patients and staff to ionizing radiation, poor soft tissue characterization and lack of quantitative physiologic information. MR fluoroscopy has been introduced with substantial progress during the last decade. Clinical and experimental studies performed under MR fluoroscopy have indicated the suitability of this modality for: delivery of ASD closure, aortic valves, and endovascular stents (aortic, carotid, iliac, renal arteries, inferior vena cava). It aids in performing ablation, creation of hepatic shunts and local delivery of therapies. Development of more MR compatible equipment and devices will widen the applications of MR-guided procedures. At post-intervention, MR imaging aids in assessing the efficacy of therapies, success of interventions. It also provides information on vascular flow and cardiac morphology, function, perfusion and viability. MR fluoroscopy has the potential to form the basis for minimally invasive image–guided surgeries that offer improved patient management and cost effectiveness

A communal catalogue reveals Earth's multiscale microbial diversity

Our growing awareness of the microbial world's importance and diversity contrasts starkly with our limited understanding of its fundamental structure. Despite recent advances in DNA sequencing, a lack of standardized protocols and common analytical frameworks impedes comparisons among studies, hindering the development of global inferences about microbial life on Earth. Here we present a meta-analysis of microbial community samples collected by hundreds of researchers for the Earth Microbiome Project. Coordinated protocols and new analytical methods, particularly the use of exact sequences instead of clustered operational taxonomic units, enable bacterial and archaeal ribosomal RNA gene sequences to be followed across multiple studies and allow us to explore patterns of diversity at an unprecedented scale. The result is both a reference database giving global context to DNA sequence data and a framework for incorporating data from future studies, fostering increasingly complete characterization of Earth's microbial diversity.Peer reviewe

A communal catalogue reveals Earth’s multiscale microbial diversity

Our growing awareness of the microbial world’s importance and diversity contrasts starkly with our limited understanding of its fundamental structure. Despite recent advances in DNA sequencing, a lack of standardized protocols and common analytical frameworks impedes comparisons among studies, hindering the development of global inferences about microbial life on Earth. Here we present a meta-analysis of microbial community samples collected by hundreds of researchers for the Earth Microbiome Project. Coordinated protocols and new analytical methods, particularly the use of exact sequences instead of clustered operational taxonomic units, enable bacterial and archaeal ribosomal RNA gene sequences to be followed across multiple studies and allow us to explore patterns of diversity at an unprecedented scale. The result is both a reference database giving global context to DNA sequence data and a framework for incorporating data from future studies, fostering increasingly complete characterization of Earth’s microbial diversity

Surgical treatment by otorhinolaryngology in obstructive sleep apnea-hypopnea syndrome (OSAHS)

Obstructive sleep apnea-hypopnea syndrome (OSAHS) is characterized by the partial obstruction or total collapse of the upper airway in an intermittent and repetitive manner; in this scenario, surgical management was initially regarded as an alternative for treating this pathology. Nowadays, surgery is highly recognized because it improves tolerance and adaptation to positive pressure therapy; it remains as the first line of treatment, although high rates of effectiveness are not achieved. The first step before considering any surgical procedure is an adequate topographic diagnosis; therefore, a nasofibrolaryngoscopy should always be performed to identify the obstruction site(s). It is known that 75% of patients have obstructions at multiple levels, so correcting OSAHS by up to 95% is possible when the approach considers all the levels. Current procedures include nasal surgery, soft palate, tonsils, tongue base, hypoglossal nerve stimulator and facial skeletal procedures, as well as adjuvant procedures that include radiofrequency and palate implants

Fibronasolaringoscopy in the diagnosis of obstructive sleep apnea-hypopnea syndrome (OSAHS)

In patients diagnosed with sleep-disordered breathing (SDB), no anatomical findings can be associated with the severity of the pathology or the surgical success. Current advances in video technology have allowed a more accurate assessment of airway measurements and a more accurate map of the specific site of obstruction. Fibronasolaryngoscopy is an affordable and economical technique for evaluating the airway in multiple positions during sleep and wakeful periods; this requires a thorough understanding of the anatomy and physiology of the upper airway by the examiner to determine the exact sites of obstruction and patterns of collapse that could lead to a possible surgical management of the condition, making this diagnostic examination a fundamental part of the study of patients with SDB

Fibronasolaringoscopia en el diagnóstico de síndrome de apnea-hipopnea obstructiva del sueño (SAHOS)

En los pacientes con diagnóstico de trastornos respiratorios del sueño (TRS) no se ha podido asociar ningún hallazgo anatómico a la severidad de la patología que el paciente presenta o a su éxito quirúrgico. Los avances actuales en la tecnología de video han permitido evaluar de manera más fidedigna las medidas de la vía aérea (VA) y trazar un mapa más exacto del sitio específico de obstrucción. La fibronasolaringoscopia es una técnica accesible y económica para la evaluación de la VA en múltiples posiciones en períodos de sueño y vigilia; esta requiere un amplio conocimiento por parte del examinador de la anatomía y fisiología de la vía aérea superior para determinar los sitios exactos de obstrucción y los patrones de colapso que podrían determinar la posibilidad del manejo quirúrgico o no, haciendo de este examen diagnóstico parte fundamental en el estudio de los pacientes con TRS.In patients diagnosed with sleep-disordered breathing (SDB), no anatomical findings can be associated with the severity of the pathology or the surgical success. Current advances in video technology have allowed a more accurate assessment of airway measurements and a more accurate map of the specific site of obstruction.Fibronasolaryngoscopy is an affordable and economical technique for evaluating the airway in multiple positions during sleep and wakeful periods; this requires a thorough understanding of the anatomy and physiology of the upper airway by the examiner to determine the exact sites of obstruction and patterns of collapse that could lead to a possible surgical management of the condition, making this diagnostic examination a fundamental part of the study of patients with SDB