17 research outputs found
Turnover time of fluorescent dissolved organic matter in the dark global ocean
Research articleMarine dissolved organic matter (DOM) is one of the largest reservoirs of reduced carbon on
Earth. In the dark ocean (4200 m), most of this carbon is refractory DOM. This refractory
DOM, largely produced during microbial mineralization of organic matter, includes humic-like
substances generated in situ and detectable by fluorescence spectroscopy. Here we show two
ubiquitous humic-like fluorophores with turnover times of 435±41 and 610±55 years, which
persist significantly longer than the B350 years that the dark global ocean takes to renew. In
parallel, decay of a tyrosine-like fluorophore with a turnover time of 379±103 years is also
detected. We propose the use of DOM fluorescence to study the cycling of resistant DOM
that is preserved at centennial timescales and could represent a mechanism of carbon
sequestration (humic-like fraction) and the decaying DOM injected into the dark global
ocean, where it decreases at centennial timescales (tyrosine-like fraction).Versión del editor10,015
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European Seafood Production under Climate Change: Assessing Economic and Social Consequences
Climate change has been observed to have a significant impact on the distribution of aquatic species and productivity of aquaculture systems across the globe. This affects the level of food production, the livelihoods of communities that depend on fisheries and aquaculture, and the future sustainability of these sectors. As in all other parts of the world, climate change will have inequitable and diverse impacts on economic growth across Europe, creating winners and losers. The European H2020 project ClimeFish investigates the impacts of climate change in aquatic food production at the European and regional scale, for the three main production sectors: marine fisheries, lakes and ponds and marine aquaculture. ClimeFish has developed a process for conducting socio-economic impact assessment by first identifying the effect(s) of climate change on the biological properties of both fish and aquaculture species, and secondly assessing the socio-economic impacts based on these biological forecasts, collecting additional socio-economic data and feedback from relevant stakeholders. Here, we provide an overview of the methods and work conducted in seven different case studies will be provided, focusing on both opportunities and threats within the three sectors and geographical locations around Europe as well as a European wide analysis. Challenges related to the data collection and analysis, as well as potential ways of overcoming them, are discussed
Ofatumumab versus Teriflunomide in Multiple Sclerosis
BACKGROUND: Ofatumumab, a subcutaneous anti-CD20 monoclonal antibody, selectively depletes B cells. Teriflunomide, an oral inhibitor of pyrimidine synthesis, reduces T-cell and B-cell activation. The relative effects of these two drugs in patients with multiple sclerosis are not known. METHODS: In two double-blind, double-dummy, phase 3 trials, we randomly assigned patients with relapsing multiple sclerosis to receive subcutaneous ofatumumab (20 mg every 4 weeks after 20-mg loading doses at days 1, 7, and 14) or oral teriflunomide (14 mg daily) for up to 30 months. The primary end point was the annualized relapse rate. Secondary end points included disability worsening confirmed at 3 months or 6 months, disability improvement confirmed at 6 months, the number of gadolinium-enhancing lesions per T1-weighted magnetic resonance imaging (MRI) scan, the annualized rate of new or enlarging lesions on T2-weighted MRI, serum neurofilament light chain levels at month 3, and change in brain volume. RESULTS: Overall, 946 patients were assigned to receive ofatumumab and 936 to receive teriflunomide; the median follow-up was 1.6 years. The annualized relapse rates in the ofatumumab and teriflunomide groups were 0.11 and 0.22, respectively, in trial 1 (difference, -0.11; 95% confidence interval [CI], -0.16 to -0.06; P<0.001) and 0.10 and 0.25 in trial 2 (difference, -0.15; 95% CI, -0.20 to -0.09; P<0.001). In the pooled trials, the percentage of patients with disability worsening confirmed at 3 months was 10.9% with ofatumumab and 15.0% with teriflunomide (hazard ratio, 0.66; P = 0.002); the percentage with disability worsening confirmed at 6 months was 8.1% and 12.0%, respectively (hazard ratio, 0.68; P = 0.01); and the percentage with disability improvement confirmed at 6 months was 11.0% and 8.1% (hazard ratio, 1.35; P = 0.09). The number of gadolinium-enhancing lesions per T1-weighted MRI scan, the annualized rate of lesions on T2-weighted MRI, and serum neurofilament light chain levels, but not the change in brain volume, were in the same direction as the primary end point. Injection-related reactions occurred in 20.2% in the ofatumumab group and in 15.0% in the teriflunomide group (placebo injections). Serious infections occurred in 2.5% and 1.8% of the patients in the respective groups. CONCLUSIONS: Among patients with multiple sclerosis, ofatumumab was associated with lower annualized relapse rates than teriflunomide. (Funded by Novartis; ASCLEPIOS I and II ClinicalTrials.gov numbers, NCT02792218 and NCT02792231.)
VizieR Online Data Catalog: Gaia DR1 open cluster members (Gaia Collaboration+, 2017)
VizieR On-line Data Catalog: J/A+A/601/A19. Originally published in: 2017A&A...601..A19GWe have determined and examined the astrometric data for 19 open clusters, ranging from the Hyades at just under 47pc to NGC 2422 at nearly 440pc. The clusters are : the Hyades, Coma Berenices, the Pleiades, Praesepe, alpha Per, IC 2391, IC 2602, Blanco 1, NGC 2451, NGC 6475, NGC 7092, NGC 2516, NGC 2232, IC 4665, NGC 6633, Collinder 140, NGC 2422, NGC 3532 and NGC 2547. (2 data files)
VizieR Online Data Catalog: Gaia DR1 open cluster members (Gaia Collaboration+, 2017)
VizieR On-line Data Catalog: J/A+A/601/A19. Originally published in: 2017A&A...601..A19GWe have determined and examined the astrometric data for 19 open clusters, ranging from the Hyades at just under 47pc to NGC 2422 at nearly 440pc. The clusters are : the Hyades, Coma Berenices, the Pleiades, Praesepe, alpha Per, IC 2391, IC 2602, Blanco 1, NGC 2451, NGC 6475, NGC 7092, NGC 2516, NGC 2232, IC 4665, NGC 6633, Collinder 140, NGC 2422, NGC 3532 and NGC 2547. (2 data files)
Correction: Epidemiology and outcomes of early-onset AKI in COVID-19-related ARDS in comparison with non-COVID-19-related ARDS: insights from two prospective global cohort studies (Critical Care, (2023), 27, 1, (3), 10.1186/s13054-022-04294-5)
Following publication of the original article [1], the authors identified that the collaborating authors part of the collaborating author group CCCC Consortium was missing. The collaborating author group is available and included as Additional file 1 in this article
Stroke in critically ill patients with respiratory failure due to COVID-19: Disparities between low-middle and high-income countries
Purpose: We aimed to compare the incidence of stroke in low-and middle-income countries (LMICs) versus high-income countries (HICs) in critically ill patients with COVID-19 and its impact on in-hospital mortality. Methods: International observational study conducted in 43 countries. Stroke and mortality incidence rates and rate ratios (IRR) were calculated per admitted days using Poisson regression. Inverse probability weighting (IPW) was used to address the HICs vs. LMICs imbalance for confounders. Results: 23,738 patients [20,511(86.4 %) HICs vs. 3,227(13.6 %) LMICs] were included. The incidence stroke/1000 admitted-days was 35.7 (95 %CI = 28.4–44.9) LMICs and 17.6 (95 %CI = 15.8–19.7) HICs; ischemic 9.47 (95 %CI = 6.57–13.7) LMICs, 1.97 (95 %CI = 1.53, 2.55) HICs; hemorrhagic, 7.18 (95 %CI = 4.73–10.9) LMICs, and 2.52 (95 %CI = 2.00–3.16) HICs; unspecified stroke type 11.6 (95 %CI = 7.75–17.3) LMICs, 8.99 (95 %CI = 7.70–10.5) HICs. In regression with IPW, LMICs vs. HICs had IRR = 1.78 (95 %CI = 1.31–2.42, p < 0.001). Patients from LMICs were more likely to die than those from HICs [43.6% vs 29.2 %; Relative Risk (RR) = 2.59 (95 %CI = 2.29–2.93), p < 0.001)]. Patients with stroke were more likely to die than those without stroke [RR = 1.43 (95 %CI = 1.19–1.72), p < 0.001)]. Conclusions: Stroke incidence was low in HICs and LMICs although the stroke risk was higher in LMICs. Both LMIC status and stroke increased the risk of death. Improving early diagnosis of stroke and redistribution of healthcare resources should be a priority. Trial registration: ACTRN12620000421932 registered on 30/03/2020
Transverse polarisation measurement of hyperons in Ne collisions at =68.4 GeV with the LHCb detector
A measurement of the transverse polarization of the and hyperons in Ne fixed-target collisions at =68.4 GeV is presented using data collected by the LHCb detector. The polarization is studied using the decay together with its charge conjugated process, the integrated values measured are Furthermore, the results are shown as a function of the Feynman variable, transverse momentum, pseudorapidity and rapidity of the hyperons, and are compared with previous measurements.A measurement of the transverse polarization of the and hyperons in Ne fixed-target collisions at = 68.4 GeV is presented using data collected by the LHCb detector. The polarization is studied using the decay together with its charge conjugated process, the integrated values measured are
Furthermore, the results are shown as a function of the Feynman~~variable, transverse momentum, pseudorapidity and rapidity of the hyperons, and are compared with previous measurements