Identifying the willingness to pay for eco-certified wine by South African consumers: a comparison of biodynamic, fair trade and sustainably produced wines

As eco-certified wines are being produced in increasing quantities and varieties, so are the definitions and the labels that accompany them. This has resulted in confusion with regard to what type of eco-certified wines customers prefer and what prices they are prepared to pay for such wines. The purpose of the research is to provide clarity regarding consumer knowledge about eco-certified wines and their preferences for each category as expressed by their willingness to pay (WTP). Specifically, the goal of the research was to identify the willingness to pay for South African eco-certified wine with a focus on three labels: biodynamic, fair trade and sustainable. The methodology used by the study was to identify the willingness to pay for the wines by using contingency valuation modelling. A survey was administered using the Qualtrics platform. It consisted of three sections: the first set of questions included questions about purchasing behaviour and important considerations when buying wine. The second set of questions collected perspectives and opinions about the multiple wine certifications discussed in this article and the third set of questions collected demographic data. The research focused on South African consumers and consisted of 267 respondents. Three WTP models were run separately for biodynamic, fair trade and sustainable wines. The study found that younger individuals with higher incomes, higher levels of education, previous eco-labelled product purchases and better knowledge of eco-certified wines have a positive impact on the WTP. The only exception seems to be the in case of biodynamic wines where previous knowledge of eco-certification has a negative effect on the WTP. The research outcomes provide guidelines to producers, retailers and restaurateurs about their output, marketing and salesefforts towards the ever-growing consumer demand for such wines

Stratégies et trajectoires environnementales des établissements de Poitou-Charentes

L’article propose une analyse dynamique des stratégies environnementales des firmes, en lien avec les types d’innovations environnementales développés. À partir de données originales issues d’entretiens et portant sur près de 400 innovations environnementales adoptées par des établissements de Poitou-Charentes, les résultats mettent en évidence un lien entre la typologie des innovations environnementales, certains déterminants et les caractéristiques structurelles des établissements. L’apport de cet article repose également sur la mise en évidence d’une relation entre le déroulement de la trajectoire environnementale des établissements (types d’innovations environnementales adoptées au cours du temps) et le caractère cumulatif des processus d’apprentissage.This article proposes a dynamic analysis of firms’ environmental strategies in relation to the type of environmental innovations they are implementing. Drawing on original data compiled from interviews concerning approximately 400 environmental innovations adopted by firms in the Poitou-Charentes region, the results highlight an existing link between the type of environmental innovation, the different types of drivers, and the structural characteristics of the firms. The primary contribution of this article is to demonstrate a relationship between the firms’ environmental development path (types of environmental innovations adopted over time) and the cumulative quality of the learning process

Les effets de l’intégration verticale sur les revenus et les performances financières en viticulture française

Cet article a pour objectif de présenter l’impact de l’intégration verticale sur les revenus et les performances financières des exploitations viticoles. Dans ce but, les auteurs ont croisé les données du Réseau d’information comptable agricole (RICA) et du Casier viticole informatisé (CVI) pour établir une typologie des exploitations selon les volumes de raisin livrés à la coopérative, de vin vendu en vrac et de bouteilles produites. Ils présentent l’effet multiplicateur de l’intégration verticale sur la production et les revenus, puis l’impact de l’intégration verticale sur les performances financières moyennes. Leurs résultats sont cohérents avec la tendance des exploitations à abandonner les degrés intermédiaires d’intégration verticale (Traversac et al., 2007), soit en se spécialisant dans l’activité viticole, soit en achevant le processus d’intégration par la mise en marché de vins conditionnés en bouteilles.In this article, the authors present the impact of vertical integration on the incomes and financial performances of wine farms. They mobilize in this aim data resulting from the merging of two databases, the Farm Accountancy Data Network (FADN) and the Casier Viticole Informatisé (CVI), to establish a typology of wine farms according to (i) the volumes of grapes delivered to the cooperative, (ii) the volume of wine sold in bulk and (iii) the volume sold in bottles. They present the multiplying effect of vertical integration on farm incomes, using the farms specialized in grape production as reference points. Then they present the impact of vertical integration on average financial performances. The results  are consistent with the trend to bipolarization of wine farms towards grape production or full vertical integration via the sale of wine in bottles (Traversac et al., 2007)

Identifying the willingness to pay for eco-certified wine by south african consumers: a comparison of biodynamic, fair trade and sustainably produced wines

As eco-certified wines are being produced in increasing quantities and varieties, so are the definitions and the labels that accompany them. This has resulted in confusion with regard to what type of eco-certified wines customers prefer and what prices they are prepared to pay for such wines. The purpose of the research is to provide clarity regarding consumer knowledge about eco-certified wines and their preferences for each category as expressed by their willingness to pay (WTP). Specifically, the goal of the research was to identify the willingness to pay for South African eco-certified wine with a focus on three labels: biodynamic, fair trade and sustainable. The methodology used by the study was to identify the willingness to pay for the wines by using contingency valuation modelling. A survey was administered using the Qualtrics platform. It consisted of three sections: the first set of questions included questions about purchasing behaviour and important considerations when buying wine. The second set of questions collected perspectives and opinions about the multiple wine certifications discussed in this article and the third set of questions collected demographic data. The research focused on South African consumers and consisted of 267 respondents. Three WTP models were run separately for biodynamic, fair trade and sustainable wines. The study found that younger individuals with higher incomes, higher levels of education, previous eco-labelled product purchases and better knowledge of eco-certified wines have a positive impact on the WTP. The only exception seems to be the in case of biodynamic wines where previous knowledge of eco-certification has a negative effect on the WTP. The research outcomes provide guidelines to producers, retailers and restaurateurs about their output, marketing and sales efforts towards the ever-growing consumer demand for such wines

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis

New therapeutic strategies are needed to combat the tuberculosis pandemic and the spread of multidrug-resistant (MDR) and extensively drug-resistant (XDR) forms of the disease, which remain a serious public health challenge worldwide1, 2. The most urgent clinical need is to discover potent agents capable of reducing the duration of MDR and XDR tuberculosis therapy with a success rate comparable to that of current therapies for drug-susceptible tuberculosis. The last decade has seen the discovery of new agent classes for the management of tuberculosis3, 4, 5, several of which are currently in clinical trials6, 7, 8. However, given the high attrition rate of drug candidates during clinical development and the emergence of drug resistance, the discovery of additional clinical candidates is clearly needed. Here, we report on a promising class of imidazopyridine amide (IPA) compounds that block Mycobacterium tuberculosis growth by targeting the respiratory cytochrome bc1 complex. The optimized IPA compound Q203 inhibited the growth of MDR and XDR M. tuberculosis clinical isolates in culture broth medium in the low nanomolar range and was efficacious in a mouse model of tuberculosis at a dose less than 1 mg per kg body weight, which highlights the potency of this compound. In addition, Q203 displays pharmacokinetic and safety profiles compatible with once-daily dosing. Together, our data indicate that Q203 is a promising new clinical candidate for the treatment of tuberculosis

Frontotemporal dementia and its subtypes: a genome-wide association study

SummaryBackground Frontotemporal dementia (FTD) is a complex disorder characterised by a broad range of clinical manifestations, differential pathological signatures, and genetic variability. Mutations in three genes—MAPT, GRN, and C9orf72—have been associated with FTD. We sought to identify novel genetic risk loci associated with the disorder. Methods We did a two-stage genome-wide association study on clinical FTD, analysing samples from 3526 patients with {FTD} and 9402 healthy controls. To reduce genetic heterogeneity, all participants were of European ancestry. In the discovery phase (samples from 2154 patients with {FTD} and 4308 controls), we did separate association analyses for each {FTD} subtype (behavioural variant FTD, semantic dementia, progressive non-fluent aphasia, and {FTD} overlapping with motor neuron disease FTD-MND), followed by a meta-analysis of the entire dataset. We carried forward replication of the novel suggestive loci in an independent sample series (samples from 1372 patients and 5094 controls) and then did joint phase and brain expression and methylation quantitative trait loci analyses for the associated (p<5 × 10−8) single-nucleotide polymorphisms. Findings We identified novel associations exceeding the genome-wide significance threshold (p<5 × 10−8). Combined (joint) analyses of discovery and replication phases showed genome-wide significant association at 6p21.3, \{HLA\} locus (immune system), for rs9268877 (p=1·05 × 10−8; odds ratio=1·204 95% \{CI\} 1·11–1·30), rs9268856 (p=5·51 × 10−9; 0·809 0·76–0·86) and rs1980493 (p value=1·57 × 10−8, 0·775 0·69–0·86) in the entire cohort. We also identified a potential novel locus at 11q14, encompassing RAB38/CTSC (the transcripts of which are related to lysosomal biology), for the behavioural \{FTD\} subtype for which joint analyses showed suggestive association for rs302668 (p=2·44 × 10−7; 0·814 0·71–0·92). Analysis of expression and methylation quantitative trait loci data suggested that these loci might affect expression and methylation in cis. Interpretation Our findings suggest that immune system processes (link to 6p21.3) and possibly lysosomal and autophagy pathways (link to 11q14) are potentially involved in FTD. Our findings need to be replicated to better define the association of the newly identified loci with disease and to shed light on the pathomechanisms contributing to FTD. Funding The National Institute of Neurological Disorders and Stroke and National Institute on Aging, the Wellcome/MRC Centre on Parkinson's disease, Alzheimer's Research UK, and Texas Tech University Health Sciences Center

Photography-based taxonomy is inadequate, unnecessary, and potentially harmful for biological sciences

The question whether taxonomic descriptions naming new animal species without type specimen(s) deposited in collections should be accepted for publication by scientific journals and allowed by the Code has already been discussed in Zootaxa (Dubois & Nemésio 2007; Donegan 2008, 2009; Nemésio 2009a–b; Dubois 2009; Gentile & Snell 2009; Minelli 2009; Cianferoni & Bartolozzi 2016; Amorim et al. 2016). This question was again raised in a letter supported by 35 signatories published in the journal Nature (Pape et al. 2016) on 15 September 2016. On 25 September 2016, the following rebuttal (strictly limited to 300 words as per the editorial rules of Nature) was submitted to Nature, which on 18 October 2016 refused to publish it. As we think this problem is a very important one for zoological taxonomy, this text is published here exactly as submitted to Nature, followed by the list of the 493 taxonomists and collection-based researchers who signed it in the short time span from 20 September to 6 October 2016

Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis

Funder: QingLan Research Project of Jiangsu for Outstanding Young TeachersFunder: Project funded by Postdoctoral Science Foundation of Xuzhou Medical UniversityFunder: Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) for Xuzhou Medical UniversityAbstract: We employed Mendelian randomization (MR) to evaluate the causal relationship between leukocyte telomere length (LTL) and amyotrophic lateral sclerosis (ALS) with summary statistics from genome-wide association studies (n = ~ 38,000 for LTL and ~ 81,000 for ALS in the European population; n = ~ 23,000 for LTL and ~ 4,100 for ALS in the Asian population). We further evaluated mediation roles of lipids in the pathway from LTL to ALS. The odds ratio per standard deviation decrease of LTL on ALS was 1.10 (95% CI 0.93–1.31, p = 0.274) in the European population and 0.75 (95% CI 0.53–1.07, p = 0.116) in the Asian population. This null association was also detected between LTL and frontotemporal dementia in the European population. However, we found that an indirect effect of LTL on ALS might be mediated by low density lipoprotein (LDL) or total cholesterol (TC) in the European population. These results were robust against extensive sensitivity analyses. Overall, our MR study did not support the direct causal association between LTL and the ALS risk in neither population, but provided suggestive evidence for the mediation role of LDL or TC on the influence of LTL and ALS in the European population

An evolutionary approach for pesticide reduction in grape growing

Les atteintes à l’environnement causées par un usage important de pesticides remettent en cause lemodèle productif actuel en viticulture d’appellation. Un cadre d’analyse évolutionniste est mobilisépour comprendre le manque de changement de pratiques phytosanitaires dans ce secteur malgrél’augmentation des pressions réglementaire et sociétale ces dernières années. Après avoir analysé lelock-in des viticulteurs vis-à-vis de l’utilisation des pesticides, nous appréhendons les nouvellespratiques grâce au concept d’innovation environnementale. En nous basant sur une enquête et unmodèle évolutionniste, nous montrons que l’IPM, en tant qu’innovation de processus, permet deréduire de manière significative les quantités de pesticides employées le long de trajectoiresgagnant-gagnant, mais que l’absence de compétences spécifiques dans les exploitations entrave sonadoption. Nous mettons ainsi en évidence l’importance des processus d’apprentissage pour laréduction des pesticides en viticulture. En l’absence de R & D formalisée, les viticulteurs ont besoind’un accompagnement spécifique et d’organismes de conseil agricole structurés localement pourrelever le défi de produire des vins rentables et respectueux de l’environnement. Les politiquespubliques en construction peuvent donc s’appuyer sur ces résultats pour impulser le changementattendu dans un délai raisonnable.The environmental damage caused by the intensive use of pesticides challenges the current production model in appellation wine growing. We mobilize here an evolutionary framework to understand the lack of change in vineyard phytosanitary protection despite increasing regulatory and social pressure in recent years. After analyzing grape growers’ pesticide lock-in, we consider new protection practices via the concept of environmental innovation. Our case analysis and evolutionary model allow us to show that IPM could significantly reduce pesticide use along win-win trajectories, but also that the lack of specific implementation know-how in farms hampers its adoption. We therefore highlight the importance of learning processes for pesticide reduction in grape growing. In the absence of formal R & D, growers need specialized advice and structured extension services to meet the challenge they face: producing profitable and environmentally friendly wines. Public policies can therefore be based on this result to drive the expected change in a reasonable time