138 research outputs found
Time elapsed between the first symptoms, diagnosis and treatment of oral cancer patients in Belo Horizonte, Brazil
Objective: One of the most important objectives of a public health service is early diagnosis of disease, which provides a better prognosis and reduction in treatment cost. We investigated the delay for diagnosis and treatment of oral cancer in a public hospital. Material and methods: One hundred eighty records of patients who attended for their first consultation in the department of head and neck surgery in a public hospital from Belo Horizonte?Brazil, between the period from 1 January 1999 to 31 December 2001 were analysed. The following variables were analyzed: gender, age, evolution time (ET), time elapsed from referral to hospital and first appointment (RT), time elapsed from first appointment and treatment (TT), total time elapsed from first noticing the lesion and starting treatment (TTE), sites and staging. Results: Results for males and females were, respectively: mean age = 57.9 and 60.8 years; ET= 169.4 and 215.4 days; RT = 27.9 and 40.6 days; TT = 40.9 and 44.9days; TTE = 207.9 and 263.8 days. No correlation was observed between age and TTE for either gender. Women presented the highest mean values for ET and TTE (p<0.01). Conclusion: It was concluded that public health policy should be developed to address the excessively long time lapsed between diagnosis and treatment as well as improve public health education programs to promote early oral cancer identification
Frontal fibrosing alopecia development in two patients after botulinum toxin applications: relationship or coincidence?
Frontal fibrous alopecia is a primary lymphocytic scarring alopecia that is difficult to control, with a perifollicular lichenoid infiltrate marking its histology. Since its description in 1994 by Kossard, there has been an increase in cases reported worldwide. This article reports two cases that underwent incisional biopsies with longitudinal and transverse sections in areas presenting higher disease activity and reviews some aspects of this dermatosis. It also addresses the suspicion of a possible relationship with the application of botulinum toxin – a question already raised by other authors but with no established confirmation
Dark Matter and Fundamental Physics with the Cherenkov Telescope Array
The Cherenkov Telescope Array (CTA) is a project for a next-generation
observatory for very high energy (GeV-TeV) ground-based gamma-ray astronomy,
currently in its design phase, and foreseen to be operative a few years from
now. Several tens of telescopes of 2-3 different sizes, distributed over a
large area, will allow for a sensitivity about a factor 10 better than current
instruments such as H.E.S.S, MAGIC and VERITAS, an energy coverage from a few
tens of GeV to several tens of TeV, and a field of view of up to 10 deg. In the
following study, we investigate the prospects for CTA to study several science
questions that influence our current knowledge of fundamental physics. Based on
conservative assumptions for the performance of the different CTA telescope
configurations, we employ a Monte Carlo based approach to evaluate the
prospects for detection. First, we discuss CTA prospects for cold dark matter
searches, following different observational strategies: in dwarf satellite
galaxies of the Milky Way, in the region close to the Galactic Centre, and in
clusters of galaxies. The possible search for spatial signatures, facilitated
by the larger field of view of CTA, is also discussed. Next we consider
searches for axion-like particles which, besides being possible candidates for
dark matter may also explain the unexpectedly low absorption by extragalactic
background light of gamma rays from very distant blazars. Simulated
light-curves of flaring sources are also used to determine the sensitivity to
violations of Lorentz Invariance by detection of the possible delay between the
arrival times of photons at different energies. Finally, we mention searches
for other exotic physics with CTA.Comment: (31 pages, Accepted for publication in Astroparticle Physics
The Fermi Bubble as a Source of Cosmic Rays in the Energy Range > 10E15 eV
The {\it Fermi} Large Area Telescope has recently discovered two giant
gamma-ray bubbles which extend north and south of the Galactic center with
diameters and heights of the order of kpc. We suggest that the
periodic star capture processes by the Galactic supermassive black hole Sgr
A, with a capture rate of
yr and an energy release of erg per capture, can
result in hot plasma injecting into the Galactic halo at a wind velocity of
cm s. The periodic injection of hot plasma can produce a
series of shocks. Energetic protons in the bubble are re-accelerated when they
interact with these shocks. We show that for energy larger than
eV, the acceleration process can be better described by the stochastic
second-order Fermi acceleration.
We propose that hadronic cosmic rays (CRs) within the ``knee'' of the
observed CR spectrum are produced by Galactic supernova remnants distributed in
the Galactic disk. Re-acceleration of these particles in the Fermi Bubble
produces CRs beyond the knee. With a mean CR diffusion coefficient in this
energy range in the bubble cm s, we can
reproduce the spectral index of the spectrum beyond the knee and within. The
conversion efficiency from shock energy of the bubble into CR energy is about
10\%. This model provides a natural explanation of the observed CR flux,
spectral indices, and matching of spectra at the knee.Comment: 43 pages, 8 figues, to be published in the Astrophysical Journal;
version 2, 45 pages, 8 figures, added references and corrected typo
Axion-mediated dark matter and Higgs diphoton signal
We consider axion-mediated dark matter models motivated by Fermi gamma ray
line at 130 GeV, where anomaly interactions of an axion-like scalar mediate a
singlet Dirac fermion dark matter (DM) to electroweak gauge bosons. In these
models, extra vector-like leptons generate anomaly interactions for the axion
and can also couple to the SM Higgs boson to modify the Higgs-to-diphoton rate.
We can distinguish models by the branching fraction of the DM annihilation into
a photon pair, favoring the model with a triplet fermion. From the condition
that the lighter charged extra lepton must be heavier than dark matter for no
tree-level DM annihilations, we also show that the ratio of Higgs-to-diphoton
rate to the SM value is constrained by vacuum stability to 1.4(1.5) for the
cutoff scale of 10(1) TeV.Comment: 29 pages, 6 figures, references adde
Interplay between Fermi gamma-ray lines and collider searches
We explore the interplay between lines in the gamma-ray spectrum and LHC searches involving missing energy and photons. As an example, we consider a singlet Dirac
fermion dark matter with the mediator for Fermi gamma-ray line at 130 GeV. A new chiral or local U(1) symmetry makes weak-scale dark matter natural and provides the axion or
Z 0 gauge boson as the mediator connecting between dark matter and electroweak gauge bosons. In these models, the mediator particle can be produced in association with a
monophoton at colliders and it produces large missing energy through the decays into a DM pair or ZZ; Z with at least one Z decaying into a neutrino pair. We adopt the monophoton searches with large missing energy at the LHC and impose the bounds on the coupling and mass of the mediator field in the models. We show that the parameter space of the Z 0 mediation model is already strongly constrained by the LHC 8TeV data, whereas a certain region of the parameter space away from the resonance in axion-like mediator models are bounded. We foresee the monophoton bounds on the Z 0 and axion mediation models at the LHC 14 TeV
Summary of Lepton Photon 2011
In this lecture, I summarize developments presented at the Lepton Photon 2011
conference and give my perspective on the current situation in high-energy
physics.Comment: 56 pages, 37 figures; v2: minor corrections to reference
Right-handed Sneutrino Dark Matter in Supersymmetric B-L Model
We show that the lightest right-handed sneutrino in TeV scale supersymmetric
B-L model with inverse seesaw mechanism is a viable candidate for cold dark
matter. We find that it accounts for the observed dark matter relic abundance
in a wide range of parameter space. The spin-independent cross section of B-L
right-handed sneutrino is consistent with the recent results CDMS II and XENON
experiments and it is detectable in future direct detection experiments.
Although the B-L right-handed sneutrinos annihilate into leptons, the PAMELA
results can not be explained in this model unless a huge boost factor is
considered. Also the muon flux generated by B-L right-handed sneutrino in the
galactic center is smaller than Super-Kamiokande's upper bound.Comment: 16 pages, 7 figures; version accepted for publication in Journal of
High Energy Physic
MAGIC gamma-ray and multi-frequency observations of flat spectrum radio quasar PKS 1510-089 in early 2012
Aims. Amongst more than fifty blazars detected in very high energy (VHE, E> 100 GeV) γ rays, only three belong to the subclass of flat spectrum radio quasars (FSRQs). The detection of FSRQs in the VHE range is challenging, mainly because of their soft spectra in the GeV-TeV regime. MAGIC observed PKS 1510−089 (z = 0.36) starting 2012 February 3 until April 3 during a high activity state in the high energy (HE, E> 100 MeV) γ-ray band observed by AGILE and Fermi. MAGIC observations result in the detection of a source with significance of 6.0 standard deviations (σ). We study the multi-frequency behaviour of the source at the epoch of MAGIC observation, collecting quasi-simultaneous data at radio and optical (GASP-WEBT and F-Gamma collaborations, REM, Steward, Perkins, Liverpool, OVRO, and VLBA telescopes), X-ray (Swift satellite), and HE γ-ray frequencies.
Methods. We study the VHE γ-ray emission, together with the multi-frequency light curves, 43 GHz radio maps, and spectral energy distribution (SED) of the source. The quasi-simultaneous multi-frequency SED from the millimetre radio band to VHE γ rays is modelled with a one-zone inverse Compton model. We study two different origins of the seed photons for the inverse Compton scattering, namely the infrared torus and a slow sheath surrounding the jet around the Very Long Baseline Array (VLBA) core.
Results. We find that the VHE γ-ray emission detected from PKS 1510−089 in 2012 February-April agrees with the previous VHE observations of the source from 2009 March-April. We find no statistically significant variability during the MAGIC observations on daily, weekly, or monthly time scales, while the other two known VHE FSRQs (3C 279 and PKS 1222+216) have shown daily scale to sub-hour variability. The γ-ray SED combining AGILE, Fermi and MAGIC data joins smoothly and shows no hint of a break. The multi-frequency light curves suggest a common origin for the millimetre radio and HE γ-ray emission, and the HE γ-ray flaring starts when the new component is ejected from the 43 GHz VLBA core and the studied SED models fit the data well. However, the fast HE γ-ray variability requires that within the modelled large emitting region, more compact regions must exist. We suggest that these observed signatures would be most naturally explained by a turbulent plasma flowing at a relativistic speed down the jet and crossing a standing conical shock
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