Towards Transformational Creation of Novel Songs

We study transformational computational creativity in the context of writing songs and describe an implemented system that is able to modify its own goals and operation. With this, we contribute to three aspects of computational creativity and song generation: (1) Application-wise, songs are an interesting and challenging target for creativity, as they require the production of complementary music and lyrics. (2) Technically, we approach the problem of creativity and song generation using constraint programming. We show how constraints can be used declaratively to define a search space of songs so that a standard constraint solver can then be used to generate songs. (3) Conceptually, we describe a concrete architecture for transformational creativity where the creative (song writing) system has some responsibility for setting its own search space and goals. In the proposed architecture, a meta-level control component does this transparently by manipulating the constraints at runtime based on self-reflection of the system. Empirical experiments suggest the system is able to create songs according to its own taste.Peer reviewe

KP-LAB Knowledge Practices Laboratory -- Specification of end-user applications

deliverablesThe present deliverable provides a high-level view on the new specifications of end user applications defined in the WPII during the M37-M46 period of the KP-Lab project. This is the last in the series of four deliverables that cover all the tools developed in the project, the previous ones being D6.1, D6.4 and D6.6. This deliverable presents specifications for the new functionalities for supporting the dedicated research studies defined in the latest revision of the KP-Lab research strategy. The tools addressed are: the analytic tools (Data export, Time-line-based analyser, Visual analyser), Clipboard, Search, Versioning of uploadable content items, Visual Model Editor (VME) and Visual Modeling Language Editor (VMLE). The main part of the deliverable provides the summary of tool specifications and the description of the Knowledge Practices Environment architecture, as well as an overview of the revised technical design process, of the tools’ relationship with the research studies, and of the driving objectives and the high-level requirements relevant for the present specifications. The full specifications of tools are provided in the annexes 1-9

Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020

We show the distribution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three genomic nomenclature systems to all sequence data from the World Health Organization European Region available until 10 July 2020. We highlight the importance of real-time sequencing and data dissemination in a pandemic situation, compare the nomenclatures and lay a foundation for future European genomic surveillance of SARS-CoV-2

Genome-wide association study identifies 74 loci associated with educational attainment

Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals1. Here we report the results of a genome-wide association study (GWAS) for educational attainment that extends our earlier discovery sample1,2 of 101,069 individuals to 293,723 individuals, and a replication study in an independent sample of 111,349 individuals from the UK Biobank. We identify 74 genome-wide significant loci associated with the number of years of schooling completed. Single-nucleotide polymorphisms associated with educational attainment are disproportionately found in genomic regions regulating gene expression in the fetal brain. Candidate genes are preferentially expressed in neural tissue, especially during the prenatal period, and enriched for biological pathways involved in neural development. Our findings demonstrate that, even for a behavioural phenotype that is mostly environmentally determined, a well-powered GWAS identifies replicable associated genetic variants that suggest biologically relevant pathways. Because educational attainment is measured in large numbers of individuals, it will continue to be useful as a proxy phenotype in efforts to characterize the genetic influences of related phenotypes, including cognition and neuropsychiatric diseases

An Adaptable Framework for Ontology-based Content Creation on the Semantic Web

Creation of rich, ontology-based metadata is one of the major challenges in developing the Semantic Web. Emerging applications utilizing semantic web techniques, such as semantic portals, cannot be realized if there are no proper tools to provide metadata for them. This paper discusses how to make provision of metadata easier and cost-effective by an annotation framework comprising of annotation editor combined with shared ontology services. We have developed an annotation system Saha supporting distributed collaboration in creating annotations, and hiding the complexity of the annotation schema and the domain ontologies from the annotators. Saha adapts flexibly to different metadata schemas, which makes it suitable for different applications. Support for using ontologies is based on ontology services, such as concept searching and browsing, concept URI fetching, semantic autocompletion and linguistic concept extraction. The system is being tested in various practical semantic portal projects