Neutrino masses and mixings in non-factorizable geometry

We study bulk fermion fields in the localized gravity model with non-factorizable metric recently proposed by Randall and Sundrum, and Gogberashvili. In addition to a tower of weak-scale Kaluza-Klein states we find a zero mode for any value of the fundamental fermion mass. If the fermion mass is larger than half the curvature of the compact dimension, the zero mode can be localized on the ``hidden'' 3-brane in the Randall-Sundrum model. Identifying this mode with a right-handed neutrino provides a new way for obtaining small Dirac neutrino masses without invoking a see-saw mechanism. Cancellation of the parity anomaly requires introducing an even number of bulk fermions. This naturally leads to a strong hierarchy of neutrino masses and generically large mixing angles.Comment: 15 pages, 1 figure; minor changes, typos corrected, some references added, SLAC preprint number included (version to appear in Physics Letters B

Court Review: Volume 43, Issue 4 – Mental Illness and the Courts: Some Reflections on Judges as Innovators

Issues raised by the influx of defendants with serious mental illnesses are some of the most important that criminal judges confront. Because of the volume of defendants with mental illnesses, the impact goes beyond that of the individual case and extends to jails, police and sheriff departments, the treatment system, and ultimately to the role of the judge. This article suggests some of the ways in which communities have attempted to respond to these issues, and highlights the fact that judges have become significant leaders as well as innovators in such efforts. Not every judge will decide to adopt one or more of these roles, but regardless, it is likely that the issues that mental illness creates for the criminal justice system will exist far into the future

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder