Characterization and formation of melt layers in polar snow : observations and experiments from West Antarctica

Author Posting. © International Glaciological Society, 2005. This article is posted here by permission of International Glaciological Society for personal use, not for redistribution. The definitive version was published in Journal of Glaciology 51 (2005): 307-312, doi:10.3189/172756505781829395.Surface melting rarely occurs across most of the Antarctic ice sheet, away from the warmer coastal regions. Nonetheless, isolated melt features are preserved in the firn and ice in response to infrequent and short-lived melting events. An understanding of the formation and occurrence of these melt layers will help us to interpret records of past melt occurrences from polar ice cores such as the Siple Dome ice-core record from West Antarctica. A search in the near-surface firn in West Antarctica found that melt features are extremely rare, and consist of horizontal, laterally continuous, one to a few millimeter thick, ice layers with few air bubbles. The melt layers found date from the 1992/93 and 1991/92 summers. Field experiments to investigate changes in stratigraphy taking place during melt events reproduced melt features as seen in the natural stratigraphy. Melting conditions of varying intensity were created by passively heating the near-surface air for varying lengths of time inside a clear plastic hotbox. Melt layers formed due entirely to preferential flow and subsequent refreezing of meltwater from the surface into near-surface, fine-grained, crust layers. Continuous melt layers were formed experimentally when positive-degree-day values exceeded 18C-day, a value corresponding well with air-temperature records from automatic weather station sites where melt layers formed in the recent past.This research was supported by NASA grant NAG5-7776 and by US National Science Foundation grant OPP-9814485 to The Pennsylvania State University, and by a NASA Earth System Science Fellowship to S.B. Das

Aspirations for Higher Education among Newcomer Refugee Youth in Toronto: Expectations, Challenges, and Strategies

A large percentage of refugees have low levels of education and official language fluency upon arrival in Canada. Thi spaper discusses educational goals of newcomer refugee youth from three communities in Toronto (Afghan, Karen, and Sudanese), and explores how these are linked to premigration and post-migration determinants. Guided by community-based research principles, we collaborated with eight refugee youth peer researchers and conducted ten focus groups and thirteen interviews with refugee youth. Results show that newcomer refugee youth develop strong aspirations for higher education in Canada as a proactive response to overcome pre-migration experiences of forced migration and educational disruptions. We then discuss how these youth negotiate educational goals in post-migration context in relation to shifts in family responsibilities and everyday encounter with multiple systemic barriers in Canada. In doing this, we examine the thin line between vulnerability and empowerment that refugee youth straddle and reveal policy gaps and contradictions in the depoliticized humanitarianism within refugee resettlement in Canada.Un grand pourcentage de réfugiés a un faible niveau d’ éducation et une faible connaissance des langues officielles à leur arrivée au Canada. Cet article présente les buts éducationnels des nouveaux jeunes réfugiés de trois communautés de Toronto (afghane, karen et soudanaise) et examine en quoi ceux-ci sont liés à des déterminants pré et postmigration. Suivant des principes de recherche communautaire, nous avons travaillé de concert avec huit jeunes chercheurs de ces communautés, avons tenu dix groupes de discussion et réalisé treize entrevues avec des réfugiés. Les résultats montrent que les nouveaux jeunes réfugiés aspirent fortement à une éducation supérieure au Canada en tant que réponse proactive aux expériences prémigration d’un déplacement forcé et aux interruptions dans leur éducation . Nous examinons ensuite les façons dont les jeunes concilient leurs buts éducationnels dans un contexte postmigration par rapport aux changements dans les responsabilités familiales et aux obstacles systémiques au Canada qui font partie de leur quotidien. Ce faisant, nous étudions la mince ligne entre la vulnérabilité et l’autonomisation que chevauchent ces jeunes et mettons au jour les manques dans les politiques et les contradictions dans l’humanitarisme dépolitisé de la réinstallation des réfugiés au Canada

Rise in frequency of surface melting at Siple Dome through the Holocene : evidence for increasing marine influence on the climate of West Antarctica

Author Posting. © American Geophysical Union, 2008. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research 113 (2008): D02112, doi:10.1029/2007JD008790.A new melt layer history from Siple Dome, West Antarctica, indicates notable late-Holocene summertime warming. Visual stratigraphic analyses of the 1004-m ice core identified 62 years with melt layers. Melting events began around 11.7 ka, followed by a period of no melting from 8.8–6.6 ka. Melt layer frequency increased from 6.6 ka to the present, with the 1000-year-average melt layer frequency reaching a maximum of 2% at 0.8 ka. We use our millennial-scale archive of melt events as a unique seasonal paleothermometer to elucidate changes in West Antarctic Holocene summer climate. Our calibration suggests the change in melt frequency from 0% to 2% may represent a summer temperature increase of ≥2°C from the middle to late Holocene. This temperature change cannot be explained entirely by local change in ice elevation or summer insolation and is in contrast to East Antarctic climate records, which show peak warmth in the early Holocene followed by stable or decreasing temperature. We interpret the rise in melt frequency as evidence of an increasing marine influence on the Ross Sea sector of West Antarctica. Although the surface elevation of Siple Dome has not changed greatly, the continued lateral retreat of the West Antarctic ice sheet from its Last Glacial Maximum configuration (across the outer continental shelf), and the delayed drawdown in ice thickness from the adjacent coastal Marie Byrd Land region, in conjunction with periods of increased cyclogenesis, perhaps related to variations in ENSO, would allow a moderated maritime climate to more easily reach West Antarctica.This research was supported by NSF grant OPP-9814485 and NASA grant NAG5-7776 to Penn State University and by a NASA Earth System Science Graduate Fellowship and a WHOI Postdoctoral Scholar Fellowship to S. Das. Additional support to R. Alley at PSU is from NSF grants 0440899, 0440447, and 0424589 and the Comer Science and Education Foundation

Continued deceleration of Whillans Ice Stream, West Antarctica

Author Posting. © American Geophysical Union, 2005. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geophysical Research Letters 32 (2005): L22501, doi:10.1029/2005GL024319.Earlier observations indicated that Whillans Ice Stream slowed from 1973 to 1997. We collected new GPS observations of the ice stream's speed in 2003 and 2004. These data show that the ice stream is continuing to decelerate at rates of about 0.6%/yr2, with faster rates near the grounding line. Our data also indicate that the deceleration extends over the full width of the ice plain. Extrapolation of the deceleration trend suggests the ice stream could stagnate sometime between the middle of the 21st and 22nd Centuries.This work was supported by the National Science Foundation (NSF-OPP-0229659). IJ’s contribution was supported by the Cryospheric Sciences Program of NASA’s Earth Science Enterprise

CONFIRM: a double-blind, placebo controlled phase III clinical trial investigating the effect of nivolumab in patients with relapsed mesothelioma: study protocol for a randomised controlled trial

Background: Mesothelioma is an incurable, apoptosis-resistant cancer caused in most cases by previous exposure to asbestos and is increasing in incidence. It represents a growing health burden but remains under-researched, with limited treatment options. Early promising signals of activity relating to both PD-L1- and PD-1-targeted treatment in mesothelioma implicate a dependency of mesothelioma on this immune checkpoint. There is a need to evaluate checkpoint inhibitors in patients with relapsed mesothelioma where treatment options are limited. Methods: The addition of 12 months of nivolumab (anti-PD1 antibody) to standard practice will be conducted in the UK using a randomised, placebo-controlled phase III trial (the Cancer Research UK CONFIRM trial). A total of 336 patients with pleural or peritoneal mesothelioma who have received at least two prior lines of therapy will be recruited from UK secondary care sites. Patients will be randomised 2:1 (nivolumab:placebo), stratified according to epithelioid/non-epithelioid, to receive either 240 mg nivolumab monotherapy or saline placebo as a 30-min intravenous infusion. Treatment will be for up to 12 months. We will determine whether the use of nivolumab increases overall survival (the primary efficacy endpoint). Secondary endpoints will include progression-free survival, objective response rate, toxicity, quality of life and cost-effectiveness. Analysis will be performed according to the intention-to-treat principle using a Cox regression analysis for the primary endpoint (and for other time-to-event endpoints). Discussion: The outcome of this trial will provide evidence of the potential benefit of the use of nivolumab in the treatment of relapsed mesothelioma. If found to be clinically effective, safe and cost-effective it is likely to become the new standard of care in the UK

Climate Science Special Report: Fourth National Climate Assessment (NCA4), Volume I

New observations and new research have increased our understanding of past, current, and future climate change since the Third U.S. National Climate Assessment (NCA3) was published in May 2014. This Climate Science Special Report (CSSR) is designed to capture that new information and build on the existing body of science in order to summarize the current state of knowledge and provide the scientific foundation for the Fourth National Climate Assessment (NCA4)

Eastern Mediterranean hydroclimate over the late glacial and Holocene, reconstructed from the sediments of Nar lake, central Turkey, using stable isotopes and carbonate mineralogy

There is a lack of high-resolution records of hydroclimate variability in the Eastern Mediterranean from the late glacial and early Holocene. More knowledge of the speed of climate shifts and the degree to which they were synchronous with changes in the North Atlantic or elsewhere is required to understand better the controls on Eastern Mediterranean climate. Using endogenic carbonate from a sediment sequence from Nar Gölü, a maar lake in central Turkey, dated by varve counting and uranium-thorium methods, we present high-resolution (∼25 years) oxygen (δ18O) and carbon isotope records, supported by carbonate mineralogy data, spanning the late glacial and Holocene. δ18Ocarbonate at Nar Gölü has been shown previously to be a strong proxy for regional water balance. After a dry period (i.e. evaporation far exceeding precipitation) in the Younger Dryas, the data show a transition into the relatively wetter early Holocene. In the early Holocene there are two drier periods that appear to peak at ∼9.3 ka and ∼8.2 ka, coincident with cooling ‘events’ seen in North Atlantic records. After this, and as seen in other records from the Eastern Mediterranean, there is a millennial-scale drying trend through the Mid Holocene Transition. The relatively dry late Holocene is punctuated by centennial-scale drought intervals, at the times of 4.2 ka ‘event’ and Late Bronze Age societal ‘collapse’. Overall, we show that central Turkey is drier when the North Atlantic is cooler, throughout this record and at multiple timescales, thought to be due to a weakening of the westerly storm track resulting from reduced cyclogenesis in the North Atlantic. However, some features, such as the Mid Holocene Transition and the fact the early Holocene dry episodes at Nar Gölü are of a longer duration than the more discrete ‘events’ seen in North Atlantic records, imply there are additional controls on Eastern Mediterranean hydroclimate

Luciano Floridi and contemporary art practice

This article examines how the thinking of Luciano Floridi, especially his emphasis on information, could affect the way we approach art practice. It aims to situate art practice in relation to contemporary informational theories and suggests that the way we view contemporary art practice needs to move beyond existing theories. Key components to Floridi’s philosophy are introduced with relevance to art practice, followed by an analysis of these concepts with examples from the history of art. It is hoped that, by clarifying some of the more complex terms and concepts, readers will form a better understanding of the connections and potential synergy between art practice and the sciences of information, through the philosophy of Floridi

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Music therapy and pediatric chronic pain: A scoping review

Chronic pain in the pediatric population is a complex and multi-faceted condition. Prevalent types of chronic pain reported in childhood include headaches, visceral pain and musculoskeletal pain. The purpose of this scoping review was to discover what is known from current literature about the effectiveness of music therapy used as a therapeutic intervention for children with chronic pain. The Arksey & O’Malley scoping review methodological framework and the guidance for conducting systematic scoping reviews provided by the Joanna Briggs Institute were followed to conduct this review. A total of five publications were included. Music therapy interventions and their current geographical locations where music therapy is incorporated into integrative medicine and rehabilitation programs for pediatric chronic pain are presented. The common threads of music therapy interventions incorporated refer to the use of receptive, active and interactive music therapy through individual sessions only. Specific interventions highlight the success in utilizing song singing, song writing techniques and the musical role play of negative everyday scenarios associated with pain. All studies encourage further research within the area. Several gaps have been outlined that indicate the need for further research of music therapy and/or music medicine for pediatric chronic pain internationally, and the effectiveness of group music therapy as an intervention for pediatric chronic pain. (PsycInfo Database Record (c) 2023 APA, all rights reserved