Stem cells and the origin of gliomas: A historical reappraisal with molecular advancements.

The biology of both normal and tumor development clearly possesses overlapping and parallel features. Oncogenes and tumor suppressors are relevant not only in tumor biology, but also in physiological developmental regulators of growth and differentiation. Conversely, genes identified as regulators of developmental biology are relevant to tumor biology. This is particularly relevant in the context of brain tumors, where recent evidence is mounting that the origin of brain tumors, specifically gliomas, may represent dysfunctional developmental neurobiology. Neural stem cells are increasingly being investigated as the cell type that originally undergoes malignant transformation - the cell of origin - and the evidence for this is discussed

Dynamics in a supercooled liquid of symmetric dumbbells: Reorientational hopping for small molecular elongations

We present extensive molecular dynamics simulations of a liquid of symmetric dumbbells, for constant packing fraction, as a function of temperature and molecular elongation. For large elongations, translational and rotational degrees of freedom freeze at the same temperature. For small elongations only the even rotational degrees of freedom remain coupled to translational motions and arrest at a finite common temperature. The odd rotational degrees of freedom remain ergodic at all investigated temperature and the temperature dependence of the corresponding characteristic time is well described by an Arrhenius law. Finally, we discuss the evidence in favor of the presence of a type-A transition temperature for the odd rotational degrees of freedom, distinct from the type-B transition associated with the arrest of the translational and even rotational ones, as predicted by the mode-coupling theory for the glass transition.Comment: 4 pages, 3 figure

Nanoindentation Of Si Nanostructures: Buckling And Friction At Nanoscales

A nanoindentation system was employed to characterize mechanical properties of silicon nanolines (SiNLs), which were fabricated by an anisotropic wet etching (AWE) process. The SiNLs had the linewidth ranging from 24 nm to 90 nm, having smooth and vertical sidewalls and the aspect ratio (height/linewidth) from 7 to 18. During indentation, a buckling instability was observed at a critical load, followed by a displacement burst without a load increase, then a full recovery of displacement upon unloading. This phenomenon was explained by two bucking modes. It was also found that the difference in friction at the contact between the indenter and SiNLs directly affected buckling response of these nanolines. The friction coefficient was estimated to be in a range of 0.02 to 0.05. For experiments with large indentation displacements, irrecoverable indentation displacements were observed due to fracture of Si nanolines, with the strain to failure estimated to be from 3.8% to 9.7%. These observations indicated that the buckling behavior of SiNLs depended on the combined effects of load, line geometry, and the friction at contact. This study demonstrated a valuable approach to fabrication of well-defined Si nanoline structures and the application of the nanoindentation method for investigation of their mechanical properties at the nanoscale.Microelectronics Research Cente

A New H I Survey of Active Galaxies

We have conducted a new Arecibo survey for H I emission for 113 galaxies with broad-line (type 1) active galactic nuclei (AGNs) out to recession velocities as high as 35,000 km/s. The primary aim of the study is to obtain sensitive H I spectra for a well-defined, uniformly selected sample of active galaxies that have estimates of their black hole masses in order to investigate correlations between H I properties and the characteristics of the AGNs. H I emission was detected in 66 out of the 101 (65%) objects with spectra uncorrupted by radio frequency interference, among which 45 (68%) have line profiles with adequate signal-to-noise ratio and sufficiently reliable inclination corrections to yield robust deprojected rotational velocities. This paper presents the basic survey products, including an atlas of H I spectra, measurements of H I flux, line width, profile asymmetry, optical images, optical spectroscopic parameters, as well as a summary of a number of derived properties pertaining to the host galaxies. To enlarge our primary sample, we also assemble all previously published H I measurements of type 1 AGNs for which can can estimate black hole masses, which total an additional 53 objects. The final comprehensive compilation of 154 broad-line active galaxies, by far the largest sample ever studied, forms the basis of our companion paper, which uses the H I database to explore a number of properties of the AGN host galaxies.Comment: To appear in ApJS; 31 pages. Preprint will full-resolution figures can be downloaded from http://www.ociw.edu/~lho/preprints/ms1.pd

Posterior Cerebral Artery Angle and the Rupture of Basilar Tip Aneurysms

Since the initial publication of the International Study of Unruptured Intracranial Aneurysms (ISUIA), management of unruptured intracranial aneurysms has been mainly based on the size of the aneurysm. The contribution of morphological characteristics to treatment decisions of unruptured aneurysms has not been well studied in a systematic and location specific manner. We present a large sample of basilar artery tip aneurysms (BTA) that were assessed using a diverse array of morphological variables to determine the parameters associated with ruptured aneurysms. Demographic and clinical risk factors of aneurysm rupture were obtained from chart review. CT angiograms (CTA) were evaluated with Slicer, an open source visualization and image analysis software, to generate 3-D models of the aneurysms and surrounding vascular architecture. Morphological parameters examined in each model included aneurysm volume, aspect ratio, size ratio, aneurysm angle, basilar vessel angle, basilar flow angle, and vessel to vessel angles. Univariate and multivariate analyses were performed to determine statistical significance. From 2008–2013, 54 patients with BTA aneurysms were evaluated in a single institution, and CTAs from 33 patients (15 ruptured, 18 unruptured) were available and analyzed. Aneurysms that underwent reoperation, that were associated with arteriovenous malformations, or that lacked preoperative CTA were excluded. Multivariate logistic regression revealed that a larger angle between the posterior cerebral arteries (P1-P1 angle, p = 0.037) was most strongly associated with aneurysm rupture after adjusting for other morphological variables. In this location specific study of BTA aneurysms, the larger the angle formed between posterior cerebral arteries was found to be a new morphological parameter significantly associated with ruptured BTA aneurysms. This is a physically intuitive parameter that can be measured easily and readily applied in the clinical setting

Pathogenicity of Fusarium species causing head blight in barley

The pathogenicity of eight Fusarium species causing fusarium head blight (FHB) in barley was studied under controlled conditions. Six barley genotypes varying in resistance to FHB were artificially inoculated with six isolates each of F. acuminatum, F. avenaceum, F. crookwellense, F. culmorum, F. equiseti, F. graminearum, F. poae and F. sporotrichioides 10-14 d after heading. Symptoms of FHB were rated as disease severity using a 0-9 scale, 4, 7, 14, 21 and 28 d after inoculation, and as percentage of infected spikelets (IS) after 21 d. All species tested caused head blight symptoms on the barley genotypes, but only F. crookwellense, F. culmorum and F. graminearum resulted in severe disease development (> 65% IS) and were considered highly pathogenic. Fusarium avenaceum had 48% IS, which was significantly lower than those of the three highly pathogenic species and was moderately pathogenic. The remaining species had 65 %) et ont été considérés comme fortement pathogènes. Avec un PÉI de 48 %, qui était significativement inférieur à ceux des trois espèces les plus pathogènes, le Fusarium avenaceum a été considéré comme moyennement pathogène. Les autres espèces ont eu un PÉI de moins de 15 % et ont été considérées comme faiblement pathogènes. Des différences significatives (P < 0,05) ont été observées entre les espèces pour l'agressivité parmi les isolats et pour la sensibilité parmi les génotypes d'orge, ce qui suggère que le tri pour la résistance à la FÉ doit faire appel à des isolats agressifs ou à un mélange de plusieurs isolats. C'est la première fois que le F. crookwellense est signalé comme fortement pathogène et le F. avenaceum comme moyennement pathogène sur l'orge

Ortho-to-Para Ratio Studies of Shocked H2 Gas in the Two Supernova Remnants IC 443 and HB 21

We present near-infrared (2.5-5.0 {\mu}m) spectral studies of shocked H2 gas in the two supernova remnants IC 443 and HB 21, which are well known for their interactions with nearby molecular clouds. The observations were performed with Infrared Camera (IRC) aboard the AKARI satellite. At the energy range 7000 K <= E(v,J) <= 20000 K, the shocked H2 gas in IC 443 shows an ortho-to-para ratio (OPR) of 2.4+0.3-0.2, which is significantly lower than the equilibrium value 3, suggesting the existence of non-equilibrium OPR. The shocked gas in HB 21 also indicates a potential non-equilibrium OPR in the range of 1.8-2.0. The level populations are well described by the power-law thermal admixture model with a single OPR, where the temperature integration range is 1000-4000 K. We conclude that the obtained non-equilibrium OPR probably originates from the reformed H2 gas of dissociative J-shocks, considering several factors such as the shock combination requirement, the line ratios, and the possibility that H2 gas can form on grains with a non-equilibrium OPR. We also investigate C-shocks and partially-dissociative J-shocks for the origin of the non-equilibrium OPR. However, we find that they are incompatible with the observed ionic emission lines for which dissociative J-shocks are required to explain. The difference in the collision energy of H atoms on grain surfaces would make the observed difference between the OPRs of IC 443 and HB 21, if dissociative J-shocks are responsible for the H2 emission. Our study suggests that dissociative J-shocks can make shocked H2 gas with a non-equilibrium OPR.Comment: aastex preprint 12pt, 32 pages, 9 figures, 7 tables, ApJ accepte

Molecular clouds in the center of M81

We investigate the molecular gas content and the excitation and fragmentation properties in the central region of the spiral galaxy Messier 81 in both the ^{12}CO(1-0) and ^{12}CO(2-1) transitions. We have recently observed the two transitions of CO in the M~81 center with A, B, and HERA receivers of the IRAM 30-m telescope. We find no CO emission in the inner $\sim$ 300 pc and a weak molecular gas clump structure at a distance of around 460 pc from the nucleus. Observations of the first two CO transitions allowed us to compute the line ratio, and the average I_{21}/I_{10} ratio is 0.68 for the M~81 center. This low value, atypical both of the galactic nuclei of spiral galaxies and of interacting systems, is probably associated to diffuse gas with molecular hydrogen density that is not high enough to excite the CO molecules. After analyzing the clumping properties of the molecular gas in detail, we identify very massive giant molecular associations (GMAs) in CO(2-1) emission with masses of $\sim$ 10$^{5}$ M$_\odot$ and diameters of $\sim$ 250 pc. The deduced N(H_{2})/I_{CO} ratio for the individually resolved GMAs, assumed to be virialized, is a factor of $\sim$ 15 higher than the \textit{standard} Galactic value, showing - as suspected - that the X ratio departs significantly from the mean for galaxies with an unusual physics of the molecular gas.Comment: 12 pages, 7 figures, 6 tables. Accepted for pubblication in A&