The best of both worlds? An exploratory study of human resource management practices in U.S.-based Japanese affiliates

Japanese management practices have received considerable attention and notoriety over the past fifteen years as Westerners have searched for an understanding of Japan's meteoric economic success. As Japan's foreign direct investments have skyrocketed in the last few years attention has shifted from what the Japanese are doing at home to what they are doing overseas. In spite of this, however, relatively little empirical research has actually been conducted on the management of foreign affiliates of Japanese firms. This chapter reports the results of an exploratory study examining the characteristics of human resource management practices and policies in 49 Japanese manufacturing and service affiliates located in the United States. It describes the policies and practices of personnel selection, compensation, appraisal, and development in terms of three archetypal strategies for managing human resources. This chapter also examines the extent to which policies and practices conform to predications for the three HRM strategy types, as well as the degree of consistency found between stated organizational policies and actual practice

Multiple sclerosis in South Africa

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Japanese-style versus American-style human resource management overseas: Examining whether the data support the "facts"

This paper first provides an overview of the existing literature documenting contrasts between human resource management practices in Japanese and Western Firms. Then we present the results of a comparative research study of HRM practices in a sample of Japanese affiliates in the U.S. and American affiliates in Japan

Prospects for radio detection of ultra-high energy cosmic rays and neutrinos

The origin and nature of the highest energy cosmic ray events is currently the subject of intense investigation by giant air shower arrays and fluorescent detectors. These particles reach energies well beyond what can be achieved in ground-based particle accelerators and hence they are fundamental probes for particle physics as well as astrophysics. Because of the scarcity of these high-energy particles, larger and larger ground-based detectors have been built. The new generation of digital radio telescopes may play an important role in this, if properly designed. Radio detection of cosmic ray showers has a long history but was abandoned in the 1970's. Recent experimental developments together with sophisticated air shower simulations incorporating radio emission give a clearer understanding of the relationship between the air shower parameters and the radio signal, and have led to resurgence in its use. Observations of air showers by the SKA could, because of its large collecting area, contribute significantly to measuring the cosmic ray spectrum at the highest energies. Because of the large surface area of the moon, and the expected excellent angular resolution of the SKA, using the SKA to detect radio Cherenkov emission from neutrino-induced cascades in lunar regolith will be potentially the most important technique for investigating cosmic ray origin at energies above the photoproduction cut-off. (abridged)Comment: latex, 26 pages, 17 figures, to appear in: "Science with the Square Kilometer Array," eds. C. Carilli and S. Rawlings, New Astronomy Reviews, (Elsevier: Amsterdam

Urease activity in soybean meal products

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141471/1/aocs0360.pd

Radioelectric Field Features of Extensive Air Showers Observed with CODALEMA

Based on a new approach to the detection of radio transients associated with extensive air showers induced by ultra high energy cosmic rays, the experimental apparatus CODALEMA is in operation, measuring about 1 event per day corresponding to an energy threshold ~ 5. 10^16 eV. Its performance makes possible for the first time the study of radio-signal features on an event-by-event basis. The sampling of the magnitude of the electric field along a 600 meters axis is analyzed. It shows that the electric field lateral spread is around 250 m (FWHM). The possibility to determine with radio both arrival directions and shower core positions is discussed.Comment: Accepted for publication in Astroparticle Physic

The effects of psilocybin on cognitive and emotional functions in healthy participants : Results from a phase 1, randomised, placebo-controlled trial involving simultaneous psilocybin administration and preparation

Background: Psilocybin, a psychoactive serotonin receptor partial agonist, has been reported to acutely reduce clinical symptoms of depressive disorders. Psilocybin's effects on cognitive function have not been widely or systematically studied. Aim: The aim of this study was to explore the safety of simultaneous administration of psilocybin to healthy participants in the largest randomised controlled trial of psilocybin to date. Primary and secondary endpoints assessed the short- and longer-term change in cognitive functioning, as assessed by a Cambridge Neuropsychological Test Automated Battery (CANTAB) Panel, and emotional processing scales. Safety was assessed via endpoints which included cognitive function, assessed by CANTAB global composite score, and treatment-emergent adverse event (TEAE) monitoring. Methods: In this phase 1, randomised, double-blind, placebo-controlled study, healthy participants (n=89; mean age 36.1 years; 41 females, 48 males) were randomised to receive a single oral dose of 10 or 25 mg psilocybin, or placebo, administered simultaneously to up to six participants, with one-to-one psychological support - each participant having an assigned, dedicated therapist available throughout the session. Results: In total, 511 TEAEs were reported, with a median duration of 1.0 day; 67% of all TEAEs started and resolved on the day of administration. There were no serious TEAEs, and none led to study withdrawal. There were no clinically relevant between-group differences in CANTAB global composite score, CANTAB cognitive domain scores, or emotional processing scale scores. Conclusions: These results indicate that 10 mg and 25 mg doses of psilocybin were generally well tolerated when given to up to six participants simultaneously and did not have any detrimental short- or long-term effects on cognitive functioning or emotional processing.Peer reviewe

Recruitment of MBD1 to target genes requires sequence-specific interaction of the MBD domain with methylated DNA

MBD1, a member of the methyl-CpG-binding domain family of proteins, has been reported to repress transcription of methylated and unmethylated promoters. As some MBD1 isoforms contain two DNA-binding domains—an MBD, which recognizes methylated DNA; and a CXXC3 zinc finger, which binds unmethylated CpG—it is unclear whether these two domains function independently of each other or if they cooperate in facilitating recruitment of MBD1 to particular genomic loci. In this report we investigate DNA-binding specificity of MBD and CXXC3 domains in vitro and in vivo. We find that the methyl-CpG-binding domain of MBD1 binds more efficiently to methylated DNA within a specific sequence context. We identify genes that are targeted by MBD1 in human cells and demonstrate that a functional MBD domain is necessary and sufficient for recruitment of MBD1 to specific sites at these loci, while DNA binding by the CXXC3 motif is largely dispensable. In summary, the binding preferences of MBD1, although dependent upon the presence of methylated DNA, are clearly distinct from those of other methyl-CpG-binding proteins, MBD2 and MeCP2