Combined ion and atom trap for low temperature ion-atom physics

We report an experimental apparatus and technique which simultaneously traps ions and cold atoms with spatial overlap. Such an apparatus is motivated by the study of ion-atom processes at temperatures ranging from hot to ultra-cold. This area is a largely unexplored domain of physics with cold trapped atoms. In this article we discuss the general design considerations for combining these two traps and present our experimental setup. The ion trap and atom traps are characterized independently of each other. The simultaneous operation of both is then described and experimental signatures of the effect of the ions and cold-atoms on each other are presented. In conclusion the use of such an instrument for several problems in physics and chemistry is briefly discussed.Comment: 24 pages, 13 figures. Figures Fixe

Повышение эффективности диагностики и лечения больных с гнойно-воспалительными заболеваниями на основе применения лазерно-флюоресцентной диагностики

In this article the results of using laser-fluorescent diagnostics (LFD) method in patients with purulent diseases are demonstrated. LFD allows making an adequate assessment of the patient's rehabilitation process on the amplitude-spectral objective characteristics; to define dates of convalescence, to reveal complications and to correct an option of drug therapy in time. Such technology permits to prevent complications and reduce the time of treatment for 2-15 days (depends on severity of disease).В статье приведены результаты использования лазерно-флюоресцентной диагностики (ЛФД) в клинике у больных с гнойно-воспалительными заболеваниями. Метод ЛФД основан на объективных амплитудно-спектральных характеристиках, что позволяет проводить адекватную оценку процесса реабилитации больного, определять сроки его выздоровления, выявлять осложнения и своевременно корректировать выбор средств медикаментозной поддержки больных ГВЗ. Применение ЛФД позволяет предотвратить осложнения и сократить сроки лечения больных на 2-15 дней в зависимости от степени тяжести заболевания

Readout technologies for directional WIMP Dark Matter detection

The measurement of the direction of WIMP-induced nuclear recoils is a compelling but technologically challenging strategy to provide an unambiguous signature of the detection of Galactic dark matter. Most directional detectors aim to reconstruct the dark-matter-induced nuclear recoil tracks, either in gas or solid targets. The main challenge with directional detection is the need for high spatial resolution over large volumes, which puts strong requirements on the readout technologies. In this paper we review the various detector readout technologies used by directional detectors. In particular, we summarize the challenges, advantages and drawbacks of each approach, and discuss future prospects for these technologies

Multicast Application Sharing Tool for the Access Grid Toolkit

Multicast Application Sharing Tool (MAST) allows geographically distributed participants to\ud share arbitrary legacy applications. MAST supports scalable group to group collaboration by\ud using multicast. It is being used within the eMinerals project to augment the Access Grid\ud functionality. In this paper we describe MAST and its deployment as an Access Grid node\ud service within the eMinerals Virtual Venue

ВОЗМОЖНОСТИ И ПЕРСПЕКТИВЫ ПРИМЕНЕНИЯ РАМАН-ФЛЮОРЕСЦЕНТНОЙ ДИАГНОСТИКИ В СТОМАТОЛОГИИ

Experimental-theoretic rationale and hardware-software device of application of Raman-fluorescence medical technologies in dentistry were performed. High-sensitive and high-specific express methods of caries and demineralization level of hard tooth tissues diagnostic, species indication of germs and express determination of its sensitivity to medications, verification of medications and drugs, malignant and benign neoplasms express diagnostic were presented. Wide range of method's clinical-diagnostic capabilities and of presented domestic hardware-software complex of Raman fluorescence diagnostic are recommended for clinical application.Представлено экспериментальное обоснование и аппаратно-программное обеспечение применения раман-флюоресцентных медицинских технологий в стоматологии. Предложены высокочувствительные и высокоспецифические экспресс-методики диагностики кариеса, степени деминерализации твёрдых тканей зуба, видовой индикации микробов и экспресс-определения их чувствительности к лекарственным препаратам, верификации лекарственных препаратов и наркотических веществ, экспресс-диагностики доброкачественных и злокачественных новообразований. Широкий диапазон клинико-диагностических возможностей метода и предложенного отечественного аппаратнопрограммного комплекса раман-флюоресцентной диагностики рекомендуется к клиническому применению

ВОЗМОЖНОСТИ И ПЕРСПЕКТИВЫ ПРИМЕНЕНИЯ РАМАН-ФЛЮОРЕСЦЕНТНОЙ ДИАГНОСТИКИ В СТОМАТОЛОГИИ

Experimental-theoretic rationale and hardware-software device of application of Raman-fluorescence medical technologies in dentistry were performed. High-sensitive and high-specific express methods of caries and demineralization level of hard tooth tissues diagnostic, species indication of germs and express determination of its sensitivity to medications, verification of medications and drugs, malignant and benign neoplasms express diagnostic were presented. Wide range of method's clinical-diagnostic capabilities and of presented domestic hardware-software complex of Raman fluorescence diagnostic are recommended for clinical application.Представлено экспериментальное обоснование и аппаратно-программное обеспечение применения раман-флюоресцентных медицинских технологий в стоматологии. Предложены высокочувствительные и высокоспецифические экспресс-методики диагностики кариеса, степени деминерализации твёрдых тканей зуба, видовой индикации микробов и экспресс-определения их чувствительности к лекарственным препаратам, верификации лекарственных препаратов и наркотических веществ, экспресс-диагностики доброкачественных и злокачественных новообразований. Широкий диапазон клинико-диагностических возможностей метода и предложенного отечественного аппаратнопрограммного комплекса раман-флюоресцентной диагностики рекомендуется к клиническому применению

20-year experience with laserofluorescent diagnostics in clinical microbiology

Results of rapid laser-assisted identification of microorganisms for diagnostics of microbial processes based on auto-fluorescence effect in bacteria-containing materials are summarized. It is proposed to use the auto-fluorescence technique for express diagnostics of pyoinflammatory diseases, evaluation of microflora conditions (eubiosis, dysbiosis) and sensitivity to antibiotics, monitoring and prognostication, assessment of the quality of antibiotic therapy. Priority in the development of this medical technology for laserofluorescent diagnostics and its practical application is protected by 15 patents

20-year experience with laserofluorescent diagnostics in clinical microbiology

Results of rapid laser-assisted identification of microorganisms for diagnostics of microbial processes based on auto-fluorescence effect in bacteria-containing materials are summarized. It is proposed to use the auto-fluorescence technique for express diagnostics of pyoinflammatory diseases, evaluation of microflora conditions (eubiosis, dysbiosis) and sensitivity to antibiotics, monitoring and prognostication, assessment of the quality of antibiotic therapy. Priority in the development of this medical technology for laserofluorescent diagnostics and its practical application is protected by 15 patents

A multicenter study of the safety and effectiveness of mechanical thrombectomy for patients with acute ischemic stroke not meeting top-tier evidence criteria

Background While mechanical thrombectomy (MT) has become the standard of care for patients with acute ischemic stroke (AIS) with emergent large-vessel occlusions (ELVO), recently published guidelines appropriately award top-tier evidence to the same selective criteria that were employed in completed clinical trials. We sought to evaluate the safety and effectiveness of MT in patients with AIS with ELVO who do not meet top-tier evidence criteria (TTEC). Methods We conducted an observational study on consecutive patients with AIS with ELVO who underwent MT at six high-volume endovascular centers. Standard safety outcomes (3-month mortality, symptomatic intracranial hemorrhage) and effectiveness outcomes (3-month functional independence: modified Rankin Scale scores of 0–2) were compared between patients meeting and failing TTEC. Results The sample consisted of 349 (60%) controls fulfilling TTEC and 234 (40%) non- TTEC patients. Control patients meeting TTEC for MT tended to have higher functional independence rates at 3 months (47% vs 39%; p=0.055), while the rates of symptomatic intracerebral hemorrhage (sICH) were similar (9%) in both groups (p=0.983). In multivariable logistic regression models, adherence to TTEC for MT was not independently related to any safety outcome (sICH: OR 0.71, 95% CI 0.30 to 1.68, p=0.434; 3-month mortality: OR 1.27, 95% CI 0.69 to 2.33, p=0.448) or effectiveness outcome (3-month functional independence: OR 0.81, 95% CI 0.48 to 1.37, p=0.434; 3-month functional improvement: OR 0.73, 95% CI 0.48 to 1.11, p=0.138) after adjusting for potential confounders. Conclusions Approximately 40% of patients with AIS with ELVO offered MT do not fulfill TTEC for MT. Patients who did not meet TTEC had high rates of good clinical outcome and low complication rates