Starbursts versus Truncated Star Formation in Nearby Clusters of Galaxies

We present long-slit spectroscopy, B and R bandpass imaging, and 21 cm observations of a sample of early-type galaxies in nearby clusters which are known to be either in a star-forming phase or to have had star formation which recently terminated. From the long-slit spectra, obtained with the Blanco 4-m telescope, we find that emission lines in the star-forming cluster galaxies are significantly more centrally concentrated than in a sample of field galaxies. The broadband imaging reveals that two currently star-forming early-type galaxies in the Pegasus I cluster have blue nuclei, again indicating that recent star formation has been concentrated. In contrast, the two galaxies for which star formation has already ended show no central color gradient. The Pegasus I galaxy with the most evident signs of ongoing star formation (NGC7648), exhibits signatures of a tidal encounter. Neutral hydrogen observations of that galaxy with the Arecibo radiotelescope reveal the presence of ~4 x 10^8 solar masses of HI. Arecibo observations of other current or recent star-forming early-type galaxies in Pegasus I indicate smaller amounts of gas in one of them, and only upper limits in others.Comment: to be published in Astronomical Journa

Radial Color Gradients in K+A Galaxies in Distant Clusters of Galaxies

Galaxies in rich clusters with z $\gtrsim$ 0.3 are observed to have a higher fraction of photometrically blue galaxies than their nearby counterparts. This raises the important question of what environmental effects can cause the termination of star formation between z $\approx$ 0.3 and the present. The star formation may be truncated due to ram-pressure stripping, or the gas in the disk may be depleted by an episode of star formation caused by some external perturbation. To help resolve this issue, surface photometry was carried out for a total of 70 early-type galaxies in the cluster Cl1358+62, at z $\sim$ 0.33, using two-color images from the Hubble Archive. The galaxies were divided into two categories based on spectroscopic criteria: 24 are type K+A (e.g., strong Balmer lines, with no visible emission lines), while the remaining 46 are in the control sample with normal spectra. Radial color profiles were produced to see if the K+A galaxies show bluer nuclei in relation to their surrounding disks. Specifically, a linear gradient was fit to the radial color profile of each galaxy. We find that the K+A galaxies on average tend to have slightly bluer gradients towards the center than the normals. A Kolmogorov-Smirnov two-sample test has been applied to the two sets of color gradients. The result of the test indicates that there is only a $\sim$2% probability that the K+A and normal samples are drawn from the same parent distribution. There is a possible complication from a trend in the apparent magnitude vs. color gradient relation, but overall our results favor the centralized star formation scenario as an important process in the evolution of galaxies in dense clusters.Comment: 16 pages, 12 figures, accepted for publication in A

Multicenter Real-World Data of Subsequent Chemotherapy after Progression to PARP Inhibitors in a Maintenance Relapse Setting

Simple Summary Since the irruption of PARPi in the therapeutic armamentarium for ovarian cancer, concerns regarding post-progression treatment outcomes have emerged, owing to known crossed-resistance mechanisms between PARPi and platinum. In this multicentric retrospective series of ovarian cancer patients, we evaluated chemotherapy results upon progression to maintenance with PARPi in the relapsed setting. We further selected the population of platinum-sensitive patients (according to the classical definition) retreated with platinum (n = 74). In this platinum-sensitive population, overall response rate and survival outcomes of platinum rechallenge after PARPi were similar to historical series of the prePARPi era. However, within this group, analysis according to BRCA status showed that BRCA mutant patients (n = 35) presented higher rates of progression and worse survival outcomes under subsequent platinum than BRCA wild type patients (n = 39), with statistically significant differences. This is the largest real-world data series of ovarian cancer patients treated with platinum rechallenge in the post-PARPi scenario. Background: Despite impressive progression-free survival (PFS) results from PARP inhibitors (PARPi) in ovarian cancer, concerns about their effect on post-progression treatment outcomes have recently arisen, particularly when administered in the relapsed setting. Overlapping mechanisms of resistance between PARPi and platinum have been described, and optimal therapies upon progression to PARPi are unknown. We communicate real-world data (RWD) on outcomes of subsequent chemotherapy upon progression to PARPi used as maintenance in ovarian cancer relapses, particularly focusing on platinum rechallenge, according to BRCA status. Methods: Data from high-grade serous or endometrioid ovarian cancer patients who received subsequent chemotherapy after progression to maintenance PARPi in the relapsed setting, in 16 Catalan hospitals between August 2016 and April 2021, and who were followed-up until July 2021, were included. Endpoints were overall response rate (ORR), and PFS and overall survival (OS) measured from the subsequent chemotherapy starting date. Results: 111 patients were included [46 (41.4%) presented pathological BRCA1/2 mutations, 8 (7.5%) in other homologous recombination-related genes]. Sixty-four patients (57.7%) had received two prior chemotherapy lines, including the one immediately prior to PARPi. PARPi were niraparib (n = 60, 54.1%), olaparib (n = 49, 44.1%), and rucaparib (n = 2, 1.8%). A total of 81 patients remained platinum-sensitive (PS population) after progression to PARPi (when progression-free interval [PFI] was >6 months after the last cycle of prior platinum) [median PFI 12.0 months (interquartile range, IQR, 8.8-17.1)]. Of those, 74 were treated with subsequent platinum regimens, with the following results: ORR of 41.9%, median PFS (mPFS) of 6.6 months (95% CI 6-9.2), and median OS (mOS) of 20.6 months (95% CI 13.6-28.9). Analysis of these 74 patients according to BRCA status showed that PFIs for BRCA mutant and non BRCA-mutant patients were 13.6 [IQR11.2-22.2] and 10.3 [IQR 7.4-14.9] months, respectively (p = 0.010); ORR were 40.0% versus 43.6%, respectively; Rates of progression (as best response) to subsequent platinum were 45.7% versus 17.9%, respectively (p = 0.004); mPFS and mOS were 3.5 (95% CI 2.5-8.6) versus 7.5 months (95% CI 6.5-10.1, p = 0.03), and 16.4 (95% CI 9.3-27.5) versus 24.2 months (95% CI 17.2-NR, p = 0.036), respectively. Conclusion: This is the largest series of real-world data on ovarian cancer patients retreated with platinum in the post-PARPi scenario, separately analyzing BRCA mutant and non-mutant patients, to our knowledge. In our platinum-sensitive population, rechallenge with platinum after progression upon PARPi in the 3rd or later lines for ovarian cancer relapses shows relevant ORR and similar PFS outcomes to historical series of the prePARPi era. However, BRCA mutant patients presented significantly higher rates of progression under subsequent platinum and worse survival outcomes associated with subsequent platinum than non-BRCA-mutant patients

Multiple Merging Events in the Double Cluster A3128/A3125

Multi-fiber spectroscopy has been obtained for 335 galaxies in the field of the double cluster A3128/A3125, using the 2dF multi-fiber positioner on the AAT. A total of 532 objects in the double cluster now have known redshifts. We have also obtained a 20 ks Chandra ACIS-I image of A3128 and radio imaging with the MOST and the ATCA. The spatial-kinematic distribution of redshifts in the field of A3128/A3125, when combined with the Chandra image of A3128, reveals a variety of substructures present in the galaxy distribution and in the hot ICM. The most striking large-scale feature in the galaxy distribution is an underpopulated redshift zone ~4000 km/s on either side of the cluster velocity at ~17500 km/s. We attribute this depletion zone to the effect of the extensive Horologium-Reticulum Supercluster (HRS), within which A3128/A3125 is embedded. In addition, numerous smaller groups of galaxies are identified, particularly in the underpopulated region within +-4000 km/s of the cluster redshift. Due to the large gravitational influence of the HRS, these groups arrive at A3128 with a very high (hypersonic) infall velocity. Two of these groups appear as elongated filaments in position-velocity diagrams, indicating that they are tidally distended groups which have been disrupted after a close passage through A3128. We have identified a primary NE-SW merger axis connecting A3128 with A3125, along which the filaments are also oriented. In addition, the Chandra image reveals that the X-ray emission is split into two components, each with very small core radii, that are separated by ~1 Mpc along the NE-SW axis. We propose that the complex X-ray morphology is likely the result of the hypersonic infall of a relatively small group into A3128. The group produces a major disruption in the ICM due to its high infall velocity.Comment: 52 pages, 27 figures, accepted for publication in the Astronomical Journal. A more easily down-loaded version with full resolution figures is available at http://www.physics.unc.edu/~jim/a3128/LANL

CfA3: 185 Type Ia Supernova Light Curves from the CfA

We present multi-band photometry of 185 type-Ia supernovae (SN Ia), with over 11500 observations. These were acquired between 2001 and 2008 at the F. L. Whipple Observatory of the Harvard-Smithsonian Center for Astrophysics (CfA). This sample contains the largest number of homogeneously-observed and reduced nearby SN Ia (z < 0.08) published to date. It more than doubles the nearby sample, bringing SN Ia cosmology to the point where systematic uncertainties dominate. Our natural system photometry has a precision of 0.02 mag or better in BVRIr'i' and roughly 0.04 mag in U for points brighter than 17.5 mag. We also estimate a systematic uncertainty of 0.03 mag in our SN Ia standard system BVRIr'i' photometry and 0.07 mag for U. Comparisons of our standard system photometry with published SN Ia light curves and comparison stars, where available for the same SN, reveal agreement at the level of a few hundredths mag in most cases. We find that 1991bg-like SN Ia are sufficiently distinct from other SN Ia in their color and light-curve-shape/luminosity relation that they should be treated separately in light-curve/distance fitter training samples. The CfA3 sample will contribute to the development of better light-curve/distance fitters, particularly in the few dozen cases where near-infrared photometry has been obtained and, together, can help disentangle host-galaxy reddening from intrinsic supernova color, reducing the systematic uncertainty in SN Ia distances due to dust.Comment: Accepted to the Astrophysical Journal. Minor changes from last version. Light curves, comparison star photometry, and passband tables are available at http://www.cfa.harvard.edu/supernova/CfA3

The psychological science accelerator’s COVID-19 rapid-response dataset

In response to the COVID-19 pandemic, the Psychological Science Accelerator coordinated three large-scale psychological studies to examine the effects of loss-gain framing, cognitive reappraisals, and autonomy framing manipulations on behavioral intentions and affective measures. The data collected (April to October 2020) included specific measures for each experimental study, a general questionnaire examining health prevention behaviors and COVID-19 experience, geographical and cultural context characterization, and demographic information for each participant. Each participant started the study with the same general questions and then was randomized to complete either one longer experiment or two shorter experiments. Data were provided by 73,223 participants with varying completion rates. Participants completed the survey from 111 geopolitical regions in 44 unique languages/dialects. The anonymized dataset described here is provided in both raw and processed formats to facilitate re-use and further analyses. The dataset offers secondary analytic opportunities to explore coping, framing, and self-determination across a diverse, global sample obtained at the onset of the COVID-19 pandemic, which can be merged with other time-sampled or geographic data

Many Labs 2: Investigating Variation in Replicability Across Samples and Settings

We conducted preregistered replications of 28 classic and contemporary published findings, with protocols that were peer reviewed in advance, to examine variation in effect magnitudes across samples and settings. Each protocol was administered to approximately half of 125 samples that comprised 15,305 participants from 36 countries and territories. Using the conventional criterion of statistical significance (p < .05), we found that 15 (54%) of the replications provided evidence of a statistically significant effect in the same direction as the original finding. With a strict significance criterion (p < .0001), 14 (50%) of the replications still provided such evidence, a reflection of the extremely highpowered design. Seven (25%) of the replications yielded effect sizes larger than the original ones, and 21 (75%) yielded effect sizes smaller than the original ones. The median comparable Cohen’s ds were 0.60 for the original findings and 0.15 for the replications. The effect sizes were small (< 0.20) in 16 of the replications (57%), and 9 effects (32%) were in the direction opposite the direction of the original effect. Across settings, the Q statistic indicated significant heterogeneity in 11 (39%) of the replication effects, and most of those were among the findings with the largest overall effect sizes; only 1 effect that was near zero in the aggregate showed significant heterogeneity according to this measure. Only 1 effect had a tau value greater than .20, an indication of moderate heterogeneity. Eight others had tau values near or slightly above .10, an indication of slight heterogeneity. Moderation tests indicated that very little heterogeneity was attributable to the order in which the tasks were performed or whether the tasks were administered in lab versus online. Exploratory comparisons revealed little heterogeneity between Western, educated, industrialized, rich, and democratic (WEIRD) cultures and less WEIRD cultures (i.e., cultures with relatively high and low WEIRDness scores, respectively). Cumulatively, variability in the observed effect sizes was attributable more to the effect being studied than to the sample or setting in which it was studied.UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Sociales::Instituto de Investigaciones Psicológicas (IIP

The Psychological Science Accelerator’s COVID-19 rapid-response dataset

In response to the COVID-19 pandemic, the Psychological Science Accelerator coordinated three large-scale psychological studies to examine the effects of loss-gain framing, cognitive reappraisals, and autonomy framing manipulations on behavioral intentions and affective measures. The data collected (April to October 2020) included specific measures for each experimental study, a general questionnaire examining health prevention behaviors and COVID-19 experience, geographical and cultural context characterization, and demographic information for each participant. Each participant started the study with the same general questions and then was randomized to complete either one longer experiment or two shorter experiments. Data were provided by 73,223 participants with varying completion rates. Participants completed the survey from 111 geopolitical regions in 44 unique languages/dialects. The anonymized dataset described here is provided in both raw and processed formats to facilitate re-use and further analyses. The dataset offers secondary analytic opportunities to explore coping, framing, and self-determination across a diverse, global sample obtained at the onset of the COVID-19 pandemic, which can be merged with other time-sampled or geographic data