PROPUESTA DE GESTIÓN POR COMPETENCIAS PARA MEJORAR EL DESEMPEÑO LABORAL DE LOS COLABORADORES EN LA MUNICIPALIDAD DISTRITAL DE CONCHÁN- PERIODO 2018

La investigación: “Propuesta de gestión por competencias para mejorar el desempeño laboral de loscolaboradores en la Municipalidad Distrital de Conchán- Periodo 2018”, tuvo como objetivo diseñar unapropuesta de un modelo de gestión por competencias para mejorar el desempeño laboral de los colaboradores enla Municipalidad Distrital de Conchán- Periodo 2018. El tipo de estudio: enfoque cuantitativo, de tipo noexperimental –proyectivo, con temática descriptiva, sustantiva; el método fue: hipotético deductivo y con diseñono experimental, descriptivo-proyectivo. La población de 30 colaboradores (los mismos fueron la muestra),muestreo no probabilístico por cuotas. La técnica fue la encuesta y el instrumento fue el cuestionario, conaplicación de la escala de Likert, validado por el juicio de expertos y la confiabilidad con método estadístico.Concluyéndose, que existe un desempeño laboral con nivel medio en los colaboradores en la MunicipalidadDistrital de Conchán – Periodo 2018, identificándose que existe un nivel bajo de motivación en la entidadgubernamental por la labor que desempeñan, debido a que no existen estrategias o planes para superar dichadeficiencia, y que una adecuada y correcta aplicación de la gestión por competencias mejora -sustancialmente- eldesempeño laboral de los colaboradores -administrativos y obreros municipales de la administración pública, cuyaaplicabilidad de la propuesta permitirá brindar un producto de calidad dentro del servicio civil, a través de suconocimiento, habilidad, motivación, actitud y competencias de trabajador, mediante la eficiencia y eficacia en sutrabajo o servicio asignado, logrando un éxito gubernamental en favor de la población

Factores que influyen el registro de calificaciones interno mediante el uso de Carmenta en una institución pública, Ecuador

This research was carried out to know the reality of teachers when recording the grades obtained when a part of the averages of the school year ends, which is why the equivalence between the Carmenta platform and the tables developed internally in each institution are not the same., in the private and fiscal institutions of urban and rural sectors of the Milagro canton, province of Guayas – Ecuador. The objective of this research was to describe the factors and consequences that this tool produces when entering grades in an educational institution. Currently, the records of students' grades have varied in their grades, the Carmenta application causes inconveniences at the end of part of the school year, teachers show a lack of concern and often disinterest when recording. To determine the factors that it produces, the difficulties and errors that can be shown in this activity were taken as a reference, where a survey was carried out on 100 people from fiscal institutions, in which it is made up of closed questions, with the objective of obtaining the information necessary for the development of this research. The results obtained in the survey indicate the causes and consequences of the note recording activity. All these results were obtained by the analytical, descriptive/observation method.Esta investigación se realizó para conocer la realidad de los docentes al momento de registrar las calificaciones obtenidas cuando finaliza una parte de los promedios del año lectivo, motivo que la equivalencia entre la plataforma Carmenta y los cuadros que desarrolla por interno en cada institución no son iguales, en las instituciones particulares y fiscales de sectores urbanos y rurales del cantón Milagro, provincia del Guayas – Ecuador. El objetivo de esta investigación fue describir los factores y consecuencias que produce esta herramienta al ingreso de calificaciones en una institución educativa. En la actualidad, los registros de las notas en los estudiantes han variado en sus calificaciones, la aplicación Carmenta causa inconvenientes al momento de finalizar una parte del año lectivo, los docentes muestran una despreocupación y muchas veces desinterés al momento de registrar. Para determinar los factores que produce, se tomó como referencia las dificultades y errores que puede mostrar en esta actividad, donde se realizó una encuesta a 100 personas de las instituciones fiscales, en el cual está conformada por preguntas cerradas, con el objetivo de obtener la información necesaria para el desarrollo de esta investigación. Los resultados obtenidos en la encuesta, nos indican las causas y consecuencias que presenta la actividad de registro de notas. Todos estos resultados fueron obtenidos por el método analítico, descriptivo/observación

Implementación de un sistema de registros académicos en una institución pública, Ecuador

This research was conducted to know the reality of the management of secretarial activities in the rector's office, in the fiscal institutions of urban and rural sectors of the Milagro canton, province of Guayas - Ecuador. The objective of this research was to describe the current situation of the educational community and the administration of the documents that are delivered by the secretary's office. In these times the records of students of all ages and from different academic periods, are in deterioration, even more in pandemic caused by the COVID-19. To determine the performance of the department, it was taken as a reference the satisfaction and management of the administration, accompanied by scientific documents on the subject, where a survey was made to 200 people of the fiscal institutions, in which it is conformed by closed questions, with the objective of obtaining the necessary information for the development of this investigation. The results obtained in the survey indicate the threats and difficulties presented by the administration at the moment of delivering a document of very previous academic periods. All these results were obtained by the analytical, descriptive/observation method.Esta investigación se realizó para conocer la realidad del manejo de actividades de secretaría en rectorado, en las instituciones fiscales de sectores urbanos y rurales del cantón Milagro, provincia del Guayas – Ecuador. El objetivo de esta investigación fue describir la situación actual de la comunidad educativa y sobre la administración de los documentos que son entregados por secretaría. En estos tiempos los registros de los estudiantes de toda edad y de diferentes periodos académicos, se encuentran en deterioro, más aún en pandemia ocasionado por el COVID-19. Para determinar el rendimiento del departamento, se tomó como referencia la satisfacción y el manejo de la administración, acompañado de documentos científicos sobre el tema, donde se realizó una encuesta a 200 personas de las instituciones fiscales, en el cual está conformada por preguntas cerradas, con el objetivo de obtener la información necesaria para el desarrollo de esta investigación. Los resultados obtenidos en la encuesta, nos indican las amenazas y dificultades que presenta la administración al momento de entregar un documento de periodos académicos muy anteriores. Todos estos resultados fueron obtenidos por el método analítico, descriptivo/observación

Characterization of mutant versions of the R-RAS2/TC21 GTPase found in tumors

The R-RAS2 GTP hydrolase (GTPase) (also known as TC21) has been traditionally considered quite similar to classical RAS proteins at the regulatory and signaling levels. Recently, a long-tail hotspot mutation targeting the R-RAS2/TC21 Gln72 residue (Q72L) was identified as a potent oncogenic driver. Additional point mutations were also found in other tumors at low frequencies. Despite this, little information is available regarding the transforming role of these mutant versions and their relevance for the tumorigenic properties of already-transformed cancer cells. Here, we report that many of the RRAS2 mutations found in human cancers are highly transforming when expressed in immortalized cell lines. Moreover, the expression of endogenous R-RAS2Q72L is important for maintaining optimal levels of PI3K and ERK activities as well as for the adhesion, invasiveness, proliferation, and mitochondrial respiration of ovarian and breast cancer cell lines. Endogenous R-RAS2Q72L also regulates gene expression programs linked to both cell adhesion and inflammatory/immune-related responses. Endogenous R-RAS2Q72L is also quite relevant for the in vivo tumorigenic activity of these cells. This dependency is observed even though these cancer cell lines bear concurrent gain-of-function mutations in genes encoding RAS signaling elements. Finally, we show that endogenous R-RAS2, unlike the case of classical RAS proteins, specifically localizes in focal adhesions. Collectively, these results indicate that gain-of-function mutations of R-RAS2/TC21 play roles in tumor initiation and maintenance that are not fully redundant with those regulated by classical RAS oncoproteins

Una mirada instantánea del mundo: ciudades visibles

En el Número 31 de la Revista (AS) Arquitecturas del Sur aparecerá la primera versión de esta sección, estructurada a partir de fotografías de pequeñas fracciones de distintas ciudades del mundo, todas sacadas el mismo día

Transversalitat en el disseny curricular del Màster Universitari d'Enginyeria en Organització a l'ETSEIAT

Mitjançant aquest projecte hem creat punts de connexió entre diferents assignatures per augmentar la transversalitat dins el pla d'estudis del Màster Universitari en Enginyeria d’Organització. D’aquesta manera, oferim als estudiants/es la possibilitat de tractar problemes propers a les situacions reals de l'exercici de la seva professió, integrant àmbits i metodologies que prèviament es trobaven dispersos en les diferents assignatures. Com a resultat, hem creat una col·lecció de 18 casos transversals que acompanyen els estudiants/es durant més d’una assignatura. Així, poden analitzar una situació complexa amb diferents metodologies tractades al llarg dels seus estudis i integrar-les tot formant un portafoli docent. Els resultats del projecte faciliten que les assignatures deixin de ser contenidors aïllats (propi de la divisió del coneixement en especialitzats o departaments) per convertir-se en un procés continu i interconnectat de coneixements que els estudiants/es han d’aplicar en diferents moments durant els seus estudis. Els materials didàctics desenvolupats conjuntament per l’equip del projecte, són accessibles a cada assignatura involucrada mitjançant la plataforma docent atenea i estaran publicats al dipòsit UPC Commons a partir de febrer de 2013.Peer Reviewe

Epidemiological and clinical characteristics of Streptococcus tigurinus endocarditis

Background: Streptococcus tigurinus was recently described as a new streptococcal species within the viridans group streptococci (VGS). The objectives of the present work were to analyse the clinical and microbiological characteristics of S. tigurinus isolated from patients with bacteraemias, to determine the prevalence of S. tigurinus among VGS endocarditis in Spain, and to compare the clinical characteristics and outcomes of endocarditis caused by S. tigurinus and other VGS. Methods: Retrospective nationwide study, performed between 2008 and 2016 in 9 Spanish hospitals from 7 different provinces comprising 237 cases of infective endocarditis. Streptococcal isolates were identified by sequencing fragments of their 16S rRNA, sodA and groEL genes. Clinical data of patients with streptococcal endocarditis were prospectively collected according to a pre-established protocol. Results: Patients with endocarditis represented 7/9 (77.8%) and 26/86 (30.2%) of the bacteraemias caused by S. tigurinus and other VGS, respectively (p < 0.001), in two of the hospital participants. Among patients with streptococcal endocarditis, 12 different Streptococcus species were recognized being S. oralis, S. tigurinus and S. mitis the three more common. No relevant statistical differences were observed in the clinical characteristics and outcomes of endocarditis caused by the different VGS species. Conclusions: In this multicenter study performed in Spain, S. tigurinus showed a higher predilection for the endocardial endothelium as compared to other VGS. However, clinical characteristics and outcomes of endocarditis caused by S. tigurinus did not significantly differ from endocarditis caused by other oral streptococci.JMM received a personal 80:20 research grant from the Institut d’InvestigacionsBiomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain during 2017–19. Nofunding entity played any role in the design of the study and data collection,analysis, and interpretation of data and in writing the manuscript

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe

Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis

Altres ajuts: Fondo Europeo de Desarrollo Regional (FEDER), "A way of making Europe".Copy number (CN) polymorphisms of complement C4 play distinct roles in many conditions, including immune-mediated diseases. We investigated the association of C4 CN with systemic sclerosis (SSc) risk. Imputed total C4, C4A, C4B, and HERV-K CN were analyzed in 26,633 individuals and validated in an independent cohort. Our results showed that higher C4 CN confers protection to SSc, and deviations from CN parity of C4A and C4B augmented risk. The protection contributed per copy of C4A and C4B differed by sex. Stronger protection was afforded by C4A in men and by C4B in women. C4 CN correlated well with its gene expression and serum protein levels, and less C4 was detected for both in SSc patients. Conditioned analysis suggests that C4 genetics strongly contributes to the SSc association within the major histocompatibility complex locus and highlights classical alleles and amino acid variants of HLA-DRB1 and HLA-DPB1 as C4-independent signals

Novel genes and sex differences in COVID-19 severity

[EN] Here, we describe the results of a genome-wide study conducted in 11 939 coronavirus disease 2019 (COVID-19) positive cases with an extensive clinical information that were recruited from 34 hospitals across Spain (SCOURGE consortium). In sex-disaggregated genome-wide association studies for COVID-19 hospitalization, genome-wide significance (P < 5 × 10−8) was crossed for variants in 3p21.31 and 21q22.11 loci only among males (P = 1.3 × 10−22 and P = 8.1 × 10−12, respectively), and for variants in 9q21.32 near TLE1 only among females (P = 4.4 × 10−8). In a second phase, results were combined with an independent Spanish cohort (1598 COVID-19 cases and 1068 population controls), revealing in the overall analysis two novel risk loci in 9p13.3 and 19q13.12, with fine-mapping prioritized variants functionally associated with AQP3 (P = 2.7 × 10−8) and ARHGAP33 (P = 1.3 × 10−8), respectively. The meta-analysis of both phases with four European studies stratified by sex from the Host Genetics Initiative (HGI) confirmed the association of the 3p21.31 and 21q22.11 loci predominantly in males and replicated a recently reported variant in 11p13 (ELF5, P = 4.1 × 10−8). Six of the COVID-19 HGI discovered loci were replicated and an HGI-based genetic risk score predicted the severity strata in SCOURGE. We also found more SNP-heritability and larger heritability differences by age (<60 or ≥60 years) among males than among females. Parallel genome-wide screening of inbreeding depression in SCOURGE also showed an effect of homozygosity in COVID-19 hospitalization and severity and this effect was stronger among older males. In summary, new candidate genes for COVID-19 severity and evidence supporting genetic disparities among sexes are provided.S