Efficient and facile delivery of gold nanoparticles in vivo using dissolvable microneedles for contrast-enhanced optical coherence tomography

Obtaining sufficient contrast is an indispensable requirement for detecting early stage cancer using optical coherence tomography (OCT), an emerging diagnostic tool that detects abnormal lesions with micrometer resolutions in real time. PEGylated gold nanoparticles (Au NPs; 87 nm in diameter) were formulated in aqueous dissolvable microneedles (dMNs; 200 μm height) for efficient, precisely controlled, and convenient delivery of Au NPs into hamster oral tissue in vivo. The Au NPs were then further briefly dissipated by ultrasound (US). The results showed 33% and 20% increase in average optical scattering intensity (contrast level) in dysplastic and normal tissues, respectively, and pinpointed pathological structures of early stage oral cancer were also identified by the highly convenient and efficient administration of Au NPs in a novel delivery platform

Fractional-Superstring Amplitudes, Multi-Cut Matrix Models and Non-Critical M Theory

Multi-cut two-matrix models are studied in the Z_k symmetry breaking k-cut (\hat p,\hat q) critical points which should correspond to (\hat p,\hat q) minimal k-fractional superstring theory. FZZT-brane or macroscopic loop amplitudes are obtained in all of these critical points and found to have two kinds of solutions in general. Each of these solutions is expressed by hyperbolic cosine or sine functions with proper phase shifts. The algebraic geometries and ZZ-brane disk amplitudes (instanton actions) of these solutions are also studied. In particular, our results suggest that minimal \infty-fractional superstring theory can be viewed as a mother theory which includes all the minimal k-fractional superstring theories (k=1,2,...) as its perturbative vacua in the weak-coupling string landscape. Our results also indicate that, in the strong coupling regime of this fractional superstring theory, there is a three-dimensional theory which would be understood as the non-critical version of M theory in the sense proposed by P. Horava and C. A. Keeler.Comment: 47 pages, 6 figures; references added v

Stokes Phenomena and Quantum Integrability in Non-critical String/M Theory

We study Stokes phenomena of the k \times k isomonodromy systems with an arbitrary Poincar\'e index r, especially which correspond to the fractional-superstring (or parafermionic-string) multi-critical points (\hat p,\hat q)=(1,r-1) in the k-cut two-matrix models. Investigation of this system is important for the purpose of figuring out the non-critical version of M theory which was proposed to be the strong-coupling dual of fractional superstring theory as a two-matrix model with an infinite number of cuts. Surprisingly the multi-cut boundary-condition recursion equations have a universal form among the various multi-cut critical points, and this enables us to show explicit solutions of Stokes multipliers in quite wide classes of (k,r). Although these critical points almost break the intrinsic Z_k symmetry of the multi-cut two-matrix models, this feature makes manifest a connection between the multi-cut boundary-condition recursion equations and the structures of quantum integrable systems. In particular, it is uncovered that the Stokes multipliers satisfy multiple Hirota equations (i.e. multiple T-systems). Therefore our result provides a large extension of the ODE/IM correspondence to the general isomonodromy ODE systems endowed with the multi-cut boundary conditions. We also comment about a possibility that N=2 QFT of Cecotti-Vafa would be "topological series" in non-critical M theory equipped with a single quantum integrability.Comment: 43 pages, 3 figures; v2:references and comments added (footnote 24

Chronic hepatitis B: whom to treat and for how long? Propositions, challenges, and future directions

Recent guidelines of the American Association for the Study of Liver Diseases, the European Association for the Study of the Liver, and the Asian Pacific Association for the Study of the Liver 2008 update of the “Asian-Pacific consensus statement on the management of chronic hepatitis B” offer comprehensive recommendations for the general management of chronic hepatitis B (CHB). These recommendations highlight preferred approaches to the prevention, diagnosis, and treatment of CHB. Nonetheless, the results of recent studies have led to an improved understanding of the disease and a belief that current recommendations on specific therapeutic considerations, including CHB treatment initiation and cessation criteria, particularly in patient populations with special circumstances, can be improved. Twelve experts from the Asia-Pacific region formed the Asia-Pacific Panel Recommendations for the Optimal Management of Chronic Hepatitis B (APPROACH) Working Group to review, challenge, and assess relevant new data and inform future updates of CHB treatment guidelines. The significance of and controversy about reported findings were discussed and debated in an expert meeting of the Working Group in Beijing, China, in November 2008. This review paper attempts to identify areas requiring improved CHB management and provide suggestions for future guideline updates, with special emphasis on treatment initiation and duration

Electroluminescent Characteristics of DBPPV–ZnO Nanocomposite Polymer Light Emitting Devices

We have demonstrated that fabrication and characterization of nanocomposite polymer light emitting devices with metal Zinc Oxide (ZnO) nanoparticles and 2,3-dibutoxy-1,4-poly(phenylenevinylene) (DBPPV). The current and luminance characteristics of devices with ZnO nanoparticles are much better than those of device with pure DBPPV. Optimized maximum luminance efficiencies of DBPPV–ZnO (3:1 wt%) before annealing (1.78 cd/A) and after annealing (2.45 cd/A) having a brightness 643 and 776 cd/m2at a current density of 36.16 and 31.67 mA/cm2are observed, respectively. Current density–voltage and brightness–voltage characteristics indicate that addition of ZnO nanoparticles can facilitate electrical injection and charge transport. The thermal annealing is thought to result in the formation of an interfacial layer between emissive polymer film and cathode

Forecasting Government Bond Spreads with Heuristic Models:Evidence from the Eurozone Periphery

This study investigates the predictability of European long-term government bond spreads through the application of heuristic and metaheuristic support vector regression (SVR) hybrid structures. Genetic, krill herd and sine–cosine algorithms are applied to the parameterization process of the SVR and locally weighted SVR (LSVR) methods. The inputs of the SVR models are selected from a large pool of linear and non-linear individual predictors. The statistical performance of the main models is evaluated against a random walk, an Autoregressive Moving Average, the best individual prediction model and the traditional SVR and LSVR structures. All models are applied to forecast daily and weekly government bond spreads of Greece, Ireland, Italy, Portugal and Spain over the sample period 2000–2017. The results show that the sine–cosine LSVR is outperforming its counterparts in terms of statistical accuracy, while metaheuristic approaches seem to benefit the parameterization process more than the heuristic ones

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

Nurses' perceptions of aids and obstacles to the provision of optimal end of life care in ICU

Contains fulltext : 172380.pdf (publisher's version ) (Open Access

Effectiveness of Non-Contact Dietary Coaching in Adults with Diabetes or Prediabetes Using a Continuous Glucose Monitoring Device: A Randomized Controlled Trial

We aimed to evaluate the effectiveness of dietary coaching and continuous glucose monitoring (CGM) in patients with diabetes or prediabetes to improve their behavioral skills and health outcomes. A randomized controlled study with pre- and post-testing was conducted. Data were collected between November 2020 and April 2021. Forty-five patients with diabetes or prediabetes who used a CGM device were enrolled and analyzed. Dietary education, individual coaching and group coaching were provided to participants in the experimental group for 4 weeks. After the intervention, the thigh circumference in men significantly differed between the two groups (z = −2.02, p = 0.044). For women, participants in the experimental group showed greater improvement in eating self-efficacy compared with those in the control group (z = −2.66, p = 0.008). Insomnia was negatively related to the change in eating self-efficacy (r = −0.35, p = 0.018) and increase in thigh circumference (r = −0.35, p = 0.017). Even if used within a short intervention period, non-contact dietary coaching programs can help enhance behavioral skills, such as eating self-efficacy and health outcomes, such as thigh circumference. Moreover, the changed variables can indirectly improve other health outcomes in patients with diabetes or prediabetes