Fibrocytes in health and disease

Fibrocytes, a group of bone marrow-derived mesenchymal progenitor cells, were first described in 1994 as fibroblast-like, peripheral blood cells that migrate to regions of tissue injury. These cells are unique in their expression of extracellular matrix proteins concomitantly with markers of hematopoietic and monocyte lineage. The involvement of fibrocytes and the specific role they play in the process of wound repair has been a focus of study since their initial description. Fibrocytes contribute to the healing repertoire via several mechanisms; they produce a combination of cytokines, chemokines, and growth factors to create a milieu favorable for repair to occur; they serve as antigen presenting cells (APCs); they contribute to wound closure; and, they promote angiogenesis. Furthermore, regulatory pathways involving serum amyloid P, leukocyte-specific protein 1, and adenosine A2A receptors have emphasized the significant role that fibrocytes have in wound healing and fibrosis. The therapeutic targeting of fibrocytes holds promise for the augmentation of wound repair and the treatment of different fibrosing disorders

Centrality evolution of the charged-particle pseudorapidity density over a broad pseudorapidity range in Pb-Pb collisions at root s(NN)=2.76TeV

Peer reviewe

The ALICE Data Quality Monitoring: qualitative and quantitative review of three years of operations

ALICE (A Large Ion Collider Experiment) is a detector designed to study the physics of strongly interacting matter produced in heavy-ion collisions at the CERN Large Hadron Collider (LHC). Due to the complexity of ALICE in terms of number of detectors and performance requirements, Data Quality Monitoring (DQM) plays an essential role in providing online feedback on the data being recorded. It intends to provide shifters with precise and complete information to quickly identify problems, and as a consequence to ensure acquisition of high quality data. This paper presents a review of the ALICE DQM system during the first three years of LHC operations from a quantitative and qualitative point of view. We start by presenting the DQM software and tools before moving on to the various analyses carried out. An overview of the produced monitoring quantities is given, presenting the diversity of usage and flexibility of the DQM. Well-prepared shifters and experts, in addition to a precise organisation, were required to ensure smooth and successful operations. The description of the measures taken to ensure both aspects and an account of the DQM shifters' job are followed by a summary of the evolution of the system. We then give a quantitative review of the final setup of the system used during the whole year 2012. We conclude the paper with use cases where the DQM proved to be very valuable, scalable and efficient and with the plans for the coming years

Inhibition of the symbiotic fungus of leaf-cutting ants by coumarins

Leaf-cutting ants are known to be a serious pest for agriculture due to the high amounts of vegetal matter from crops used by them in order to cultivate a symbiotic fungus on which they rely for food and enzymes. The mutualism between the fungus and the ants is a point to be explored when alternative methods of control are being thought of. Considering that some plants are naturally resistant to phytophagous insects, some natural products (secondary metabolites) should be evaluated with respect to their insecticide and/or fungicide properties. In this paper we isolated eight coumarins from four different plant species and we determined their effect on the development of the symbiotic fungus of the leaf-cutting ant Atta sexdens. With the exception of clausarin, all the other coumarins were inhibitory from 64 μg mL-1 through 80 μg mL-1 and xanthyletin inhibited the fungus at 25 μ mL -1. ©2005 Sociedade Brasileira de Química