Geographic range did not confer resilience to extinction in terrestrial vertebrates at the end-Triassic crisis

Rates of extinction vary greatly through geological time, with losses particularly concentrated in mass extinctions. Species duration at other times varies greatly, but the reasons for this are unclear. Geographical range correlates with lineage duration amongst marine invertebrates, but it is less clear how far this generality extends to other groups in other habitats. It is also unclear whether a wide geographical distribution makes groups more likely to survive mass extinctions. Here we test for extinction selectivity amongst terrestrial vertebrates across the end-Triassic event. We demonstrate that terrestrial vertebrate clades with larger geographical ranges were more resilient to extinction than those with smaller ranges throughout the Triassic and Jurassic. However, this relationship weakened with increasing proximity to the end-Triassic mass extinction, breaking down altogether across the event itself. We demonstrate that these findings are not a function of sampling biases; a perennial issue in studies of this kind

Genetics of melanoma progression: the rise and fall of cell senescence.

There are many links between cell senescence and the genetics of melanoma, meaning both familial susceptibility and somatic-genetic changes in sporadic melanoma. For example, CDKN2A, the best-known melanoma susceptibility gene, encodes two effectors of cell senescence, while other familial melanoma genes are related to telomeres and their maintenance. This article aimed to analyze our current knowledge of the genetic or epigenetic driver changes necessary to generate a cutaneous metastatic melanoma, the commonest order in which these occur, and the relation of these changes to the biology and pathology of melanoma progression. Emphasis is laid on the role of cell senescence and the escape from senescence leading to cellular immortality, the ability to divide indefinitely

Varieties of living things: Life at the intersection of lineage and metabolism

publication-status: Publishedtypes: Articl

VITALAS at TRECVID-2009

This paper describes the participation of VITALAS in the TRECVID-2009 evaluation where we submitted runs for the High-Level Feature Extraction (HLFE) and Interactive Search tasks. For the HLFE task, we focus on the evaluation of low-level feature sets and fusion methods. The runs employ multiple low-level features based on all available modalities (visual, audio and text) and the results show that use of such features improves the retrieval eectiveness signicantly. We also use a concept score fusion approach that achieves good results with reduced low-level feature vector dimensionality. Furthermore, a weighting scheme is introduced for cluster assignment in the \bag-of-words" approach. Our runs achieved good performance compared to a baseline run and the submissions of other TRECVID-2009 participants. For the Interactive Search task, we focus on the evaluation of the integrated VITALAS system in order to gain insights into the use and eectiveness of the system's search functionalities on (the combination of) multiple modalities and study the behavior of two user groups: professional archivists and non-professional users. Our analysis indicates that both user groups submit about the same total number of queries and use the search functionalities in a similar way, but professional users save twice as many shots and examine shots deeper in the ranked retrieved list.The agreement between the TRECVID assessors and our users was quite low. In terms of the eectiveness of the dierent search modalities, similarity searches retrieve on average twice as many relevant shots as keyword searches, fused searches three times as many, while concept searches retrieve even up to ve times as many relevant shots, indicating the benets of the use of robust concept detectors in multimodal video retrieval. High-Level Feature Extraction Runs 1. A VITALAS.CERTH-ITI 1: Early fusion of all available low-level features. 2. A VITALAS.CERTH-ITI 2: Concept score fusion for ve low-level features and 100 concepts, text features and bag-of-words with color SIFT descriptor based on dense sampling. 3. A VITALAS.CERTH-ITI 3: Concept score fusion for ve low-level features and 100 concepts combined with text features. 4. A VITALAS.CERTH-ITI 4: Weighting scheme for bag-of-words based on dense sampling of the color SIFT descriptor. 5. A VITALAS.CERTH-ITI 5: Baseline run, bag-of-words based on dense sampling of the color SIFT descriptor. Interactive Search Runs 1. vitalas 1: Interactive run by professional archivists 2. vitalas 2: Interactive run by professional archivists 3. vitalas 3: Interactive run by non-professional users 4. vitalas 4: Interactive run by non-professional user

The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition

Hematopoietic stem cells (HSCs) emerge during development from the vascular wall of the main embryonic arteries. The onset of circulation triggers several processes that provide critical external factors for HSC generation. Nevertheless, it is not fully understood how and when the onset of circulation affects HSC emergence. Here we show that in Ncx1-/- mouse embryos devoid of circulation the HSC lineage develops until the phenotypic pro-HSC stage. However, these cells reside in an abnormal microenvironment, fail to activate the hematopoietic program downstream of Runx1, and are functionally impaired. Single-cell transcriptomics shows that during the endothelial-to-hematopoietic transition, Ncx1-/- cells fail to undergo a glycolysis to oxidative phosphorylation metabolic switch present in wild-type cells. Interestingly, experimental activation of glycolysis results in decreased intraembryonic hematopoiesis. Our results suggest that the onset of circulation triggers metabolic changes that allow HSC generation to proceed

Effect of metal Ions (Ni2+, Cu2+ and Zn2+) and water coordination on the structure of L-phenylalanine, L-tyrosine, L-tryptophan and their zwitterionic forms

Methods of quantum chemistry have been applied to double-charged complexes involving the transition metals Ni2+, Cu2+ and Zn2+ with the aromatic amino acids (AAA) phenylalanine, tyrosine and tryptophan. The effect of hydration on the relative stability and geometry of the individual species studied has been evaluated within the supermolecule approach. The interaction enthalpies, entropies and Gibbs energies of nine complexes Phe•M, Tyr•M, Trp•M, (M = Ni2+, Cu2+ and Zn2+) were determined at the Becke3LYP density functional level of theory. Of the transition metals studied the bivalent copper cation forms the strongest complexes with AAAs. For Ni2+and Cu2+ the most stable species are the NO coordinated cations in the AAA metal complexes, Zn2+cation prefers a binding to the aromatic part of the AAA (complex II). Some complexes energetically unfavored in the gas-phase are stabilized upon microsolvation

Maternal body mass index and post-term birth: a systematic review and meta-analysis

Acknowledgements All authors contributed to the design of the research, acquisition of data and writing of the manuscript. NH and JR obtained funding. NH, RV and LH carried out the analysis. The authors would like to acknowledge Dr Helen Simpson at South Tees Hospitals NHS Foundation Trust and Dr Helene Brandon at Gateshead NHS Foundation Trust for their contribution to the clinical relevance and interpretation of this study. Dr Simpson and Dr Brandon are consultant obstetricians with a special interest in maternal obesity and risk management. This research was part funded by a Medical Research Council and Newcastle University Faculty of Medical Sciences Doctoral Training award for ES. The funders had no role in design and conduct of the study, collection, management, analysis and interpretation of the data and preparation, review or approval of the manuscript.Peer reviewedPublisher PD

Dynamic behaviour of bio-based and recycled materials for indoor environmental comfort

UK construction industry contributes 120 Mt of waste every year. Bio-based building materials may be a solution for this problem, as they combine re-use and recycling abilities together with hygroscopic characteristics, leading to buildings energy savings. For the first time, the dynamic response to hygrothermal changes of bio-based materials is examined in terms of Moisture Buffering Value (MBV), dry/wet thermal conductivity, microstructure, density and latent heat through daily cycles. It is shown that MBV is a useful tool for characterisation but needs to be combined with the shape of the change in mass of the final hygrothermal cycle. Mastering this is required to obtain significant improved indoor environment quality in buildings. Ten samples of bio-based insulation materials and one thermoplastic recycled polymer were analysed (wool, hemp, saw mill residue, wood, straw, cork and polyethylene terephthalate). Saw and wool are the most promising, as materials exhibit dynamic response to hygrothermal changes. Only half the amount of samples revealed equivalent efficient moisture transfer to be able to desorb the adsorbed quantity of water. Latent heat of vaporisation and condensation tests led to the conclusion that samples of wool and saw mill residue can qualify as bio-based materials for ‘green’ panels

Species' geographic distributions through time: Playing catchup with changing climates

This is the author's accepted manuscript.Species’ ranges are often treated as a rather fixed characteristic, rather than a fluid, ever-changing manifestation of their ecological requirements and dispersal abilities. Paleontologists generally have had a more flexible point of view on this issue than neontologists, but each perspective can improve by appreciating the other. Here, we provide an overview of paleontological and neontological perspectives on species’ geographic distributions, focusing on what can be learned about historical variations in distributions. The cross-disciplinary view, we hope, offers some novel perspectives on species-level biogeography