Anévrisme de l’artère splénique rompu dans l’estomac: traitement chirurgical après échec d’une tentative d’embolisation

L'anévrisme de l'artère splénique (AAS) est une entité pathologique rare le plus souvent asymptomatique. Nous rapportons le cas d'un patient âgéde 60 ans, hypertendu qui s'est présenté aux urgences pour un épisode d'hématémèse sans retentissement hémodynamique. Un bilan completcomportant un Angioscanner abdominal a mis en évidence un anévrisme de l'artère splénique refoulant la paroi postérieure de l'estomac en avant.Le diagnostic d'anévrisme de l'artère splénique rompu dans l'estomac a été posé et un traitement endovasculaire à type d'embolisation par coilseffectué. Au 5ème jour post embolisation, le patient nous a été référé pour une persistance de mélénas. Un traitement chirurgical a été décidé. Lamise à plat de l'anévrisme a permis d'évacuer les coils et le thrombus. L'objectif de cette observation est de montrer que l'embolisation d'un AASrompu dans l'estomac a été une cause de retard thérapeutique qui pourrait être fatal pour le patient. Le traitement de référence est la cure chirurgicale de l'AAS par voie conventionnelle sans rétablissement de la continuité  artérielle splénique, sans splénectomie et avec suture de l'orifice digestif

Mise en évidence de téphrites à néphéline syntectoniques dans le bassin cambrien de Sidi Saïd Maâchou (Meseta côtière, Maroc); signification géodynamique

Based on a combined structural, petrographic, and geochemical analysis, a new interpretation of the basic magmatism of Sidi Saïd Maâchou (coastal Meseta) in two stages of emplacement is proposed. The first stage is characterized by transitional pyroclastic flows that have accompanied the opening of the West-Mesetian basin, during the Cambrian; the second stage is made of dykes of basalts, dolerites, and tephrites bearing nepheline. The emplacement of this undersaturated alkaline magma is associated to a sinistral submeridian shear zone which has been activated at the end of the Caledonian orogenesis, by a mantellic advection.Basée sur des critères structuraux, pétrographiques et géochimiques, une réinterprétation du magmatisme basique de Sidi Saîd Maâchou (meseta côtière) en deux stades de mise en place est proposée. Le premier stade est caractérisé par des coulées pyroclastiques transitionnelles accompagnant l’ouverture du bassin ouest mésétien au Cambrien. Le second stade, de nature fissural, comprend des basaltes, dolérites et téphrites à néphéline spécifiques d’un magmatisme alcalin sous-saturé. La mise en place de ce dernier est associée à un couloir de cisaillement senestre subméridien activé à la fin de l’orogenèse calédonienne, engendrant un flux géothermique élevé

PNEUMATOSE KYSTIQUE INTESTINALE ASSOCIEE A UNE STENOSE BULBAIRE SUR ULCERE

Cystic Pneumatosis or pneumatises cystoides of small intestine is a rare affection. Its defined by the existence of gas is found in the digestive tract wall. This affection can be primitive or more often associated to systematic intestinal inflammatory diseases. The signs of this affection are not specific and most of cases are discovered incidentally during surgery or endoscopies. The diagnosis is based on radiological findings. The treatment, however, remains conservative because of the benignity of this disease. The prognosis is conditioned by the underlying disease. We report two cases of cystic Pneumatosis of the small intestine associated to ulcer pyloric stenosis, and we discuss through these cases all diagnosis and therapeutic features of this disease.La Pneumatose kystique intestinale (PKG) est une affection rare, définie par la présence de gaz dans la paroi du tube digestif. Elle peut être primitive ou le plus souvent associée à des maladies inflammatoires systémiques du tube digestif. Symptomatologie non spécifique, parfois de découverte fortuite. Le diagnostic est porté sur la radiologie.  Le traitement est essentiellement  conservateur vu la bénignité de l’affection. Le pronostic étant conditionné par la maladie sous-jacente. Nous rapportons deux cas de pneumatose kystiques intestinale associé à une sténose bulbaire sur ulcère.  A partir de ces deux cas nous avons discuté les éléments du diagnostiques Et l’attitude thérapeutique généralement conservatrice

Current Opinion and Practice on Peritoneal Carcinomatosis Management: The North African Perspective.

The status of peritoneal surface malignancy (PSM) management in North Africa is undetermined. The aim of this study was to assess and compare current practice and knowledge regarding PSM and examine satisfaction with available treatment options and need for alternative therapies in North Africa. This is a qualitative study involving specialists participating in PSM management in North Africa. The survey analyzed demographic characteristics and current knowledge and opinions regarding PSM management in different institutions. We also looked at goals and priorities, satisfaction with treatment modalities and heated intraperitoneal chemotherapy (HIPEC) usefulness according to specialty, country, years of experience, and activity sector. One-hundred and three participants responded to the survey (response rate of 57%), including oncologists and surgeons. 59.2% of respondents had more than 10 years experience and 45.6% treated 20-50 PSM cases annually. Participants satisfaction with PSM treatment modalities was mild for gastric cancer (3/10 [IQR 2-3]) and moderate for colorectal (5/10 [IQR 3-5]), ovarian (5/10 [IQR 3-5]), and pseudomyxoma peritonei (5/10 [IQR 3-5]) type of malignancies. Good quality of life and symptom relief were rated as main priorities for treatment and the need for new treatment modalities was rated 9/10 [IQR 8-9]. The perceived usefulness of systemic chemotherapy in first intention was described as high by 42.7 and 39.8% of respondents for PSM of colorectal and gastric origins, while HIPEC was described as highly useful for ovarian (49.5%) and PMP (73.8) malignancies. The management of PSM in the North African region has distinct differences in knowledge, treatments availability and priorities. Disparities are also noted according to specialty, country, years of expertise, and activity sector. The creation of referral structures and PSM networks could be a step forward to standardized PSM management in the region

Miniature curved artificial compound eyes.

International audienceIn most animal species, vision is mediated by compound eyes, which offer lower resolution than vertebrate single-lens eyes, but significantly larger fields of view with negligible distortion and spherical aberration, as well as high temporal resolution in a tiny package. Compound eyes are ideally suited for fast panoramic motion perception. Engineering a miniature artificial compound eye is challenging because it requires accurate alignment of photoreceptive and optical components on a curved surface. Here, we describe a unique design method for biomimetic compound eyes featuring a panoramic, undistorted field of view in a very thin package. The design consists of three planar layers of separately produced arrays, namely, a microlens array, a neuromorphic photodetector array, and a flexible printed circuit board that are stacked, cut, and curved to produce a mechanically flexible imager. Following this method, we have prototyped and characterized an artificial compound eye bearing a hemispherical field of view with embedded and programmable low-power signal processing, high temporal resolution, and local adaptation to illumination. The prototyped artificial compound eye possesses several characteristics similar to the eye of the fruit fly Drosophila and other arthropod species. This design method opens up additional vistas for a broad range of applications in which wide field motion detection is at a premium, such as collision-free navigation of terrestrial and aerospace vehicles, and for the experimental testing of insect vision theories

LYMPHOME NON HODGKINIEN PRIMITIF DU FOIE : A PROPOS D’UN CAS ET REVUE DE LA LITTERATURE

The invasion secondary liver is common during the evolution of systemic lymphoma, primary lymphoma of the liver are very rare estimated at 1% of all extranodal lymphomas. We report a patient of 37 years, without previous medical history especially, who consulted for isolated pain in the right hypochondrium lasting for five months in a conservation context of general condition, abdominal ultrasound revealed a mass of malignant appearance of the left liver, confirmed by an abdominal CT scan. A liver biopsy was performed, showing the histology associated with immunohistochemistry; non-Hodgkin lymphoma, diffuse large B cells expressing CD20, the rest of the staging did not reveal any other location, including not of lymph node involvement. The patient received chemotherapy: RCHOP: rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone, eight treatments, with good clinical and radiological response and good tolerance, with a decline in 4 months.L’envahissement secondaire du foie est fréquent au cours de l’évolution des lymphomes systémiques. Les lymphomes primitifs du foie sont très rares estimés à 1% de tous les lymphomes extraganglionnaire [1,2]. Nous rapportons l’observation d’une patiente de 37 ans, sans antécédents pathologiques particuliers, qui a consulté pour des douleurs isolées de l’hypochondre droit, évoluant depuis 5 mois dans un contexte de conservation de l’état général, l’échographie abdominale et la tomodensitométrie abdominale ont révélé ; une masse du foie gauche d’allure maligne. Une biopsie du foie a été réalisée, montrant à l’étude histologique associée à l’immunohistochimie ; un lymphome non hodgkinien type B diffus à grandes cellules exprimant CD20, le reste du bilan d’extension n’a révélé aucune autre localisation, notamment pas d’atteinte ganglionnaire. La patiente a reçu une chimiothérapie de type RCHOP : rituximab, cyclophosphamide, doxorubicine, vincristine et prednisone, huit cures, avec une bonne réponse clinique et radiologique et une bonne tolérance, avec un recule de 4 mois

Predictive model of biliocystic communication in liver hydatid cysts using classification and regression tree analysis

<p>Abstract</p> <p>Background</p> <p>Incidence of liver hydatid cyst (LHC) rupture ranged 15%-40% of all cases and most of them concern the bile duct tree. Patients with biliocystic communication (BCC) had specific clinic and therapeutic aspect. The purpose of this study was to determine witch patients with LHC may develop BCC using classification and regression tree (CART) analysis</p> <p>Methods</p> <p>A retrospective study of 672 patients with liver hydatid cyst treated at the surgery department "A" at Ibn Sina University Hospital, Rabat Morocco. Four-teen risk factors for BCC occurrence were entered into CART analysis to build an algorithm that can predict at the best way the occurrence of BCC.</p> <p>Results</p> <p><b>I</b>ncidence of BCC was 24.5%. Subgroups with high risk were patients with jaundice and thick pericyst risk at 73.2% and patients with thick pericyst, with no jaundice 36.5 years and younger with no past history of LHC risk at 40.5%. Our developed CART model has sensitivity at 39.6%, specificity at 93.3%, positive predictive value at 65.6%, a negative predictive value at 82.6% and accuracy of good classification at 80.1%. Discriminating ability of the model was good 82%.</p> <p>Conclusion</p> <p>we developed a simple classification tool to identify LHC patients with high risk BCC during a routine clinic visit (only on clinical history and examination followed by an ultrasonography). Predictive factors were based on pericyst aspect, jaundice, age, past history of liver hydatidosis and morphological Gharbi cyst aspect. We think that this classification can be useful with efficacy to direct patients at appropriated medical struct's.</p

Week 48 resistance analyses of the once-daily, single-tablet regimen darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) in adults living with HIV-1 from the Phase III Randomized AMBER and EMERALD Trials

Darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) 800/150/200/10 mg is being investigated in two Phase III trials, AMBER (NCT02431247; treatment-naive adults) and EMERALD (NCT02269917; treatment-experienced, virologically suppressed adults). Week 48 AMBER and EMERALD resistance analyses are presented. Postbaseline samples for genotyping/phenotyping were analyzed from protocol-defined virologic failures (PDVFs) with viral load (VL) >= 400 copies/mL at failure/later time points. Post hoc analyses were deep sequencing in AMBER, and HIV-1 proviral DNA from baseline samples (VL = 3 thymidine analog-associated mutations (24% not fully susceptible to tenofovir) detected at screening. All achieved VL <50 copies/mL at week 48 or prior discontinuation. D/C/F/TAF has a high genetic barrier to resistance; no darunavir, primary PI, or tenofovir RAMs were observed through 48 weeks in AMBER and EMERALD. Only one postbaseline M184I/V RAM was observed in HIV-1 of an AMBER participant. In EMERALD, baseline archived RAMs to darunavir, emtricitabine, and tenofovir in participants with prior VF did not preclude virologic response

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p&lt;0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p&lt;0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised

Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks