Atypical eye contact in autism: Models, mechanisms and development

An atypical pattern of eye contact behaviour is one of the most significant symptoms of Autism Spectrum Disorder (ASD). Recent empirical advances have revealed the developmental, cognitive and neural basis of atypical eye contact behaviour in ASD. We review different models and advance a new ‘fast-track modulator model’. Specifically, we propose that atypical eye contact processing in ASD originates in the lack of influence from a subcortical face and eye contact detection route, which is hypothesized to modulate eye contact processing and guide its emergent specialization during development

Larger Error Signals in Major Depression are Associated with Better Avoidance Learning

The medial prefrontal cortex (mPFC) is particularly reactive to signals of error, punishment, and conflict in the service of behavioral adaptation and it is consistently implicated in the etiology of major depressive disorder (MDD). This association makes conceptual sense, given that MDD has been associated with hyper-reactivity in neural systems associated with punishment processing. Yet in practice, depression-related variance in measures of mPFC functioning often fails to relate to performance. For example, neuroelectric reflections of mediofrontal error signals are often found to be larger in MDD, but a deficit in post-error performance suggests that these error signals are not being used to rapidly adapt behavior. Thus, it remains unknown if depression-related variance in error signals reflects a meaningful alteration in the use of error or punishment information. However, larger mediofrontal error signals have also been related to another behavioral tendency: increased accuracy in avoidance learning. The integrity of this error-avoidance system remains untested in MDD. In this study, EEG was recorded as 21 symptomatic, drug-free participants with current or past MDD and 24 control participants performed a probabilistic reinforcement learning task. Depressed participants had larger mid-frontal EEG responses to error feedback than controls. The direct relationship between error signal amplitudes and avoidance learning accuracy was replicated. Crucially, this relationship was stronger in depressed participants for high conflict “lose–lose” situations, demonstrating a selective alteration of avoidance learning. This investigation provided evidence that larger error signal amplitudes in depression are associated with increased avoidance learning, identifying a candidate mechanistic model for hypersensitivity to negative outcomes in depression

Induced Boredom Suppresses the Recall of Positively Valenced Information: A Preliminary Study

The mood-congruence memory (MCM) effect in the case of depressed mood is typically evidenced by enhanced recall of negatively valenced information and/or a corresponding reduction in the recall of positive information. However, the impact of the related affect of boredom on memory has been overlooked. A sample of undergraduate and graduate students (n = 28) were asked to either read an interesting story (Low Boredom condition) or complete a tedious vowel-counting task (High Boredom condition) after studying a list of neutral, negative, and positive words. Following the experimental manipulation, the participants were asked to recall as many words from the list as they could remember. The participants in the low boredom (LB) group reported (i.e., recalled words + misremembered words) significantly more positive words than participants in the high boredom (HB) condition. However, no differences were found between groups in terms of the total number words reported, total number of positive, neutral or negative words recalled, or the overall accuracy of recall. Boredom appears to inhibit the reporting and recall of positively valenced information, but seems to have less influence on the recall and reporting of emotionally negative information than what is typically reported in studies with depressed mood. This finding is consistent with a conception of boredom as an affect state that is more closely tied to the perceived depletion of potential positive reinforcement (e.g., novelty, enjoyment, meaningfulness) than the depletion of negative reinforcement (e.g., escape from suffering, loss, failure). Larger implications of the findings are discussed

Bestial boredom: a biological perspective on animal boredom and suggestions for its scientific investigation

Boredom is likely to have adaptive value in motivating exploration and learning, and many animals may possess the basic neurological mechanisms to support it. Chronic inescapable boredom can be extremely aversive, and understimulation can harm neural, cognitive and behavioural flexibility. Wild and domesticated animals are at particular risk in captivity, which is often spatially and temporally monotonous. Yet biological research into boredom has barely begun, despite having important implications for animal welfare, the evolution of motivation and cognition, and for human dysfunction at individual and societal levels. Here I aim to facilitate hypotheses about how monotony affects behaviour and physiology, so that boredom can be objectively studied by ethologists and other scientists. I cover valence (pleasantness) and arousal (wakefulness) qualities of boredom, because both can be measured, and I suggest boredom includes suboptimal arousal and aversion to monotony. Because the suboptimal arousal during boredom is aversive, individuals will resist low arousal. Thus, behavioural indicators of boredom will, seemingly paradoxically, include signs of increasing drowsiness, alongside bouts of restlessness, avoidance and sensation-seeking behaviour. Valence and arousal are not, however, sufficient to fully describe boredom. For example, human boredom is further characterized by a perception that time ‘drags’, and this effect of monotony on time perception can too be behaviourally assayed in animals. Sleep disruption and some abnormal behaviour may also be caused by boredom. Ethological research into this emotional phenomenon will deepen understanding of its causes, development, function and evolution, and will enable evidence-based interventions to mitigate human and animal boredom

The effects of direct and imaginal stimulation on physiological and self-report measures : a test of the continuity assumption

One of the primary assumptions underlying the "cognitive trend" in behavior therapy and the covert conditioning model of behavior is that imaginal stimuli elicit reactions comparable to those observed with external stimulation. The present study was designed to test the assumption of continuity between external and imaginal stimuli, and to address several procedural questions related to the covert conditioning behavior therapy techniques. Twelve female college undergraduates were exposed to subjectively determined positive, negative, and neutral stimuli in both their real-life (overt) and imaginal (covert) forms. Exposure to each of the stimuli lasted for 90 seconds. Measures of heart rate, skin conductance, and self-reported affective intensity were used to evaluate autonomic and subjective reactivity to each stimulus. Subjects were exposed to the six experimental stimuli in counterbalanced orders to avoid confounds associated with a standardized sequence of stimulus presentations. Additionally, the saliency of the six stimuli was determined to be roughly equivalent by means of image clarity ratings for covert stimulus presentations, and attentional focus ratings for overt stimulus presentations. Results indicated that reactions to real-life and imaginal stimuli were indistinguishable both across and within the three stimulus valence categories on cardiovascular and verbal response measures, and on a measure of absolute change in electrodermal activity