A reaction norm perspective on reproducibility

Reproducibility in biomedical research, and more specifically in preclinical animal research, has been seriously questioned. Several cases of spectacular failures to replicate findings published in the primary scientific literature have led to a perceived reproducibility crisis. Diverse threats to reproducibility have been proposed, including lack of scientific rigour, low statistical power, publication bias, analytical flexibility and fraud. An important aspect that is generally overlooked is the lack of external validity caused by rigorous standardization of both the animals and the environment. Here, we argue that a reaction norm approach to phenotypic variation, acknowledging gene-by-environment interactions, can help us seeing reproducibility of animal experiments in a new light. We illustrate how dominating environmental effects can affect inference and effect size estimates of studies and how elimination of dominant factors through standardization affects the nature of the expected phenotype variation through the reaction norms of small effect. Finally, we discuss the consequences of reaction norms of small effect for statistical analysis, specifically for random effect latent variable models and the random lab model

Pre-schoolers’ images, intergroup attitudes, and liking of refugee peers in Germany

There is extensive research on children’s intergroup attitudes, but their perceptions of refugee children have rarely been studied. We conducted a study with 5- and 6-year-old children (N = 60) in Germany following the arrival of unprecedented large numbers of refugees in 2015 and 2016. Children completed a set of three tasks that measured their perceptions of refugee children (minority group) and German children (majority group): a draw-a-typical-child task (including questions about whether participants wanted to interact with the depicted child), an intergroup attitude task, and a liking task. Results indicate that participants drew similar pictures of and had similar intentions to interact with refugee children and German children. There was mixed evidence for group favouritism: while participants showed similar explicit attitudes towards German and refugee peers, they indicated more liking of German peers. Moreover, children viewed refugee children as a less variable (more homogeneous) group than German children. Opportunities for intergroup contact with refugee peers (i.e., whether participants attended kindergartens with or without refugee children) had no discernible effect on any of the measures. Our findings provide a snapshot of children’s perceptions of refugees in a unique historical context and contribute to research on the development of intergroup attitudes in real-world settings

Fusion de bases propositionnelles : une méthode basée sur les R-ensembles

La prise de décision collective conduit à l'interaction de plusieurs agents afin d'élaborer une décision commune cohérente. D'un point de vue informatique, ce problème peut se ramener à celui de la fusion de différentes sources d'informations. Dans le domaine de la représentation des connaissances pour l'intelligence artificielle, plusieurs approches ont été proposées pour la fusion de bases de croyances propositionnelles, cependant, la plupart d'entre elles l'ont été sur un plan sémantique et sont peu utilisables en pratique. Ce papier propose une nouvelle approche syntaxique pour la fusion de bases de croyances, appelée Fusion par Rensembles (ou RSF). La notion de R-ensemble, initialement définie dans le contexte de la révision de croyances, est étendue à la fusion et la plupart des opérations classiques de fusion sont capturées syntaxiquement par RSF. Afin d'implanter efficacement RSF, ce papier montre comment RSF peut être codé en un programme logique avec sémantique des modèles stables, puis présente une adaptation du système Smodels permettant de calculer efficacement les R-ensembles. Finalement, une étude expérimentale préliminaire montre que la mise en œuvre utilisant la programmation logique avec sémantique des modèles stables semble prometteuse pour réaliser la fusion de bases de croyances sur des applications réelles. Collective decision making leads to interaction between agents in order to elaborate a consistent common decision. From a data-processing point of view, this problem can be brought back to the merging of different sources of information. In knowledge representation for artificial intelligence, several approaches have been proposed for propositional bases fusion, however, most of them are de- paper proposes a new syntactic approach of belief bases fusion, called Removed Sets Fusion (RSF). The notion of removed-set, initially defined in the context of belief revision is extended to fusion and most of the classical fusion operations are syntactically captured by RSF. In order to efficiently implement RSF, the paper shows how RSF can be encoded into a logic program with answer set semantics, then presents an adaptation of the smodels system devoted to efficiently compute the removed sets in order to perform RSF. Finally a preliminary experimental study shows that the answer set programming approach seems promising for performing belief bases fusion on real scale applications

Behavioral Profiles of Genetically Selected Aggressive and Nonaggressive Male Wild House Mice in Two Anxiety Tests

Artificially selected aggressive (SAL) and non-aggressive (LAL) male house mice were tested in a hexagonal tunnel maze and light–dark preference (LD) box to determine if the bidirectional selection for aggressive behavior leads to a coselection for different levels of trait anxiety. The tunnel maze consists of an open, brightly lit central arena surrounded by a complex system of interconnecting tunnels. As in the LD box, animals which spend less time and are less active in the brightly illuminated section of the maze are considered to have higher anxiety levels. In the tunnel maze, the LAL mice showed more exploration and spent more time in the central arena than the SAL animals, but only during the final 2 min of the 6-min test. This reduced preference for the central arena was not due to general inactivity or a failure of the SAL to find the central arena and indicates a higher level of state anxiety in the aggressive animals. In contrast, no “anxiety-like” differences were found in the LD box, either for the percentage of time spent in the light compartment or for the number of crossings. SAL males actually showed higher levels of moving and rearing, and lower levels of freezing, than did LAL males.

Trust in Educational Settings—What It Is and Why It Matters. European Perspectives

This editorial paper introduces the relevance of trust in educational settings. It discusses interdisciplinary approaches to trust, reflects upon the relationships between trust and education and how trust has so far been studied in educational research. In addition, a comprehensive model of trust is introduced as a framework for the individual papers of this special issue that altogether, through different disciplinary and methodological lenses, investigate trust in various realms of education in five European countries

Trust in Educational Settings: Insights and Emerging Research Questions

The theoretical and empirical foundations of research on trust in education are still weak. To contribute to a better understanding of the role of trust in educational systems, this final article of the special issue “Trust in educational settings. European perspectives” highlights the findings from the contributions in this special issue and links them to insights and concepts from interdisciplinary trust research. Furthermore, it identifies and discusses seven avenues for future research on trust in educational settings. Thus, this paper and the special issue as a whole aim to highlight relevant avenues for future research, thereby strengthening research on trust in education

Evaluating the accuracy of facial expressions as emotion indicators across contexts in dogs

Facial expressions potentially serve as indicators of animal emotions if they are consistently present across situations that (likely) elicit the same emotional state. In a previous study, we used the Dog Facial Action Coding System (DogFACS) to identify facial expressions in dogs associated with conditions presumably eliciting positive anticipation (expectation of a food reward) and frustration (prevention of access to the food). Our first aim here was to identify facial expressions of positive anticipation and frustration in dogs that are context-independent (and thus have potential as emotion indicators) and to distinguish them from expressions that are reward-specific (and thus might relate to a motivational state associated with the expected reward). Therefore, we tested a new sample of 28 dogs with a similar set-up designed to induce positive anticipation (positive condition) and frustration (negative condition) in two reward contexts: food and toys. The previous results were replicated: Ears adductor was associated with the positive condition and Ears flattener, Blink, Lips part, Jaw drop, and Nose lick with the negative condition. Four additional facial actions were also more common in the negative condition. All actions except the Upper lip raiser were independent of reward type. Our second aim was to assess basic measures of diagnostic accuracy for the potential emotion indicators. Ears flattener and Ears downward had relatively high sensitivity but low specificity, whereas the opposite was the case for the other negative correlates. Ears adductor had excellent specificity but low sensitivity. If the identified facial expressions were to be used individually as diagnostic indicators, none would allow consistent correct classifications of the associated emotion. Diagnostic accuracy measures are an essential feature for validity assessments of potential indicators of animal emotion. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10071-021-01532-1

The impact of environmental enrichment on the outcome variability and scientific validity of laboratory animal studies.

It has been widely accepted for some time that species-appropriate environmental enrichment is important for the welfare of research animals, but its impact on research data initially received little attention. This has now changed, as the use of enrichment as one element of routine husbandry has expanded. In addition to its use in the care of larger research animals, such as nonhuman primates, it is now being used to improve the environments of small research animals, such as rodents, which are used in significantly greater numbers and in a wide variety of studies. Concern has been expressed that enrichment negatively affects both experimental validity and reproducibility. However, when a concise definition of enrichment is used, with a sound understanding of the biology and behaviour of the animal as well as the research constraints, it becomes clear that the welfare of research animals can be enhanced through environmental enrichment without compromising their purpose. Indeed, it is shown that the converse is true: the provision of suitable enrichment enhances the well-being of the animal, thereby refining the animal model and improving the research data. Thus, the argument is made that both the validity and reproducibility of the research are enhanced when proper consideration is given to the research animal's living environment and the animal's opportunities to express species-typical behaviours

Pre-schoolers’ images, intergroup attitudes, and liking of refugee peers in Germany

There is extensive research on children’s intergroup attitudes, but their perceptions of refugee children have rarely been studied. We conducted a study with 5- and 6-year-old children (N = 60) in Germany following the arrival of unprecedented large numbers of refugees in 2015 and 2016. Children completed a set of three tasks that measured their perceptions of refugee children (minority group) and German children (majority group): a draw-a-typical-child task (including questions about whether participants wanted to interact with the depicted child), an intergroup attitude task, and a liking task. Results indicate that participants drew similar pictures of and had similar intentions to interact with refugee children and German children. There was mixed evidence for group favouritism: while participants showed similar explicit attitudes towards German and refugee peers, they indicated more liking of German peers. Moreover, children viewed refugee children as a less variable (more homogeneous) group than German children. Opportunities for intergroup contact with refugee peers (i.e., whether participants attended kindergartens with or without refugee children) had no discernible effect on any of the measures. Our findings provide a snapshot of children’s perceptions of refugees in a unique historical context and contribute to research on the development of intergroup attitudes in real-world settings

A Semantic Characterization for ASP Base Revision

International audienceThe paper deals with base revision for Answer Set Programming (ASP). Base revision in classical logic is done by the removal of formulas. Exploiting the non-monotonicity of ASP allows one to propose other revision strategies, namely addition strategy or removal and/or addition strategy. These strategies allow one to define families of rule-based revision operators. The paper presents a semantic characterization of these families of revision operators in terms of answer sets. This semantic characterization allows for equivalently considering the evolution of syntactic logic programs and the evolution of their semantic content. It then studies the logical properties of the proposed operators and gives complexity results