Dual-mobility socket in challenging total hip arthroplasty : 2-6 years follow-up.

The success of dual-mobility sockets in achieving implant stability in primary hip replacement is already well established. However, stability cannot always be achieved, especially when dealing with more difficult indications. At our department, 104 dual-mobility sockets (92 uncemented and 12 cemented) were implanted for primary total hip arthroplasty in 97 patients between 2009 and 2013. Indications for hip arthroplasty included primary and secondary coxarthrosis, acetabular and subcapital fractures, avascular necrosis, tumor surgery and metastatic fractures. Although no loosenings were observed, 2 dislocations and 1 infection occurred shortly after surgery. In this challenging group of patients no fixation problems or intraprosthetic dislocations have been observed. The design therefore seems to be a valid alternative to constrained implants, especially in high-risk cases, although dislocation cannot be prevented at all times. Although the findings are very promising, long-term survival studies are mandatory to evaluate intraprosthetic stability and fixation longevity of dual-mobility sockets

RTPrimerDB: the portal for real-time PCR primers and probes

RTPrimerDB (http://www.rtprimerdb.org) is a freely accessible database and analysis tool for real-time quantitative PCR assays. RTPrimerDB includes records with user submitted assays that are linked to genome information from reference databases and quality controlled using an in silico assay evaluation system. The primer evaluation tools intended to assess the specificity and to detect features that could negatively affect the amplification efficiency are combined into a pipeline to test custom-designed primer and probe sequences. An improved user feedback system guides users and submitters to enter practical remarks and details about experimental evaluation analyses. The database is linked with reference databases to allow the submission of assays for all genes and organisms officially registered in Entrez Gene and RefSeq. Records in RTPrimerDB are assigned unique and stable identifiers. The content is provided via an interactive web-based search system and is available for download in the recently developed RDML format and as bulk export file. RTPrimerDB is a one-stop portal for high-quality and highly annotated real-time PCR assays

Soft tissue structure modelling for use in orthopaedic applications and musculoskeletal biomechanics

We present our methodology for the three-dimensional anatomical and geometrical description of soft tissues, relevant for orthopaedic surgical applications and musculoskeletal biomechanics. The technique involves the segmentation and geometrical description of muscles and neurovascular structures from high-resolution computer tomography scanning for the reconstruction of generic anatomical models. These models can be used for quantitative interpretation of anatomical and biomechanical aspects of different soft tissue structures. This approach should allow the use of these data in other application fields, such as musculoskeletal modelling, simulations for radiation therapy, and databases for use in minimally invasive, navigated and robotic surgery

Endogent: Centre for Anatomy and Invasive Techniques

The invention of new endoscopical techniques for surgery and interventional radiology demand improved training at postgraduate level. The Endogent Centre for Anatomy and Invasive Techniques support these requirements by establishing hands-on practical training courses by using new procedures for cadaver embalming. Cadavers fixed by conventional procedures using formalin for conservation, are of limited use for practical surgical courses due to the profound changes of colour, strength and fragility of organs and tissues. The new Thiel embalming technique is based on the use of 4-chloro-3- methylenphenol, various salts for fixation, boric acid for disinfecting, and ethylene glycol for preservation of tissue plasticity, while the concentration of formalin is kept to the strict minimum (0.8%). This results in well preserved organs and tissues concerning colour, consistency, flexibility and plasticity. The articular joints remain freely movable and the peritoneal cavity can be inflated for laparoscopic procedures. Up to now this cadaver model was used in our institute for laparoscopic bariatric surgery, colon surgery, arthroscopy and thorax surgery. Another feature is that the lungs can be ventilated during surgical procedures. Preliminary findings seem to indicate that the corpses also serve as a suitable phantom for assessing thorax radiological equipment. Expert clinicians work as tutors and give intensive instructions before the participants start with hands-on surgery. We intend to expose also our undergraduate medical students to demonstrations of surgical approaches on Thiel embalmed corpses, in order to reveal the need for detailed anatomical knowledge in the clinic at an early stage in the medical curriculum

Pixelating Familiar People in the Media: Should Masking Be Taken at Face Value?

This study questions the effectiveness of masking faces by means of pixelation on television or in newspapers. Previous studies have shown that masking just the face leads to unacceptably high recognition levels, making it likely that participants also use other cues for recognition, such as hairstyle or clothes. In the current study we investigate this possibility by means of an identification task in which participants had to identify (partially) masked images of familiar people. To demonstrate that non-facial cues become increasingly important for recognition as faces are masked more strongly, we manipulated the size of the masked area and the degree of pixelation. Confirming our expectations, increasing the size of masked area or its level of deterioration led to lower recognition rates. More importantly, also an interaction effect between the two variables emerged, showing that additional visual information partly compensates the downswing in recognition when masking becomes stronger. Although in some conditions low recognition rates were found, masking was never a hundred percent effective, making it clear that the media should approach this issue with care. Implications of our findings and future directions are considere

Adapting tumor interstitial fluid pressure for intraperitoneal chemotherapy

C

Infants' mu suppression during the observation of real and mimicked goal-directed actions

Since their discovery in the early 1990s, mirror neurons have been proposed to be related to many social-communicative abilities, such as imitation. However, research into the early manifestations of the putative neural mirroring system and its role in early social development is still inconclusive. In the current EEG study, mu suppression, generally thought to reflect activity in neural mirroring systems was investigated in 18- to 30-month-olds during the observation of object manipulations as well as mimicked actions. EEG power data recorded from frontal, central, and parietal electrodes were analysed. As predicted, based on previous research, mu wave suppression was found over central electrodes during action observation and execution. In addition, a similar suppression was found during the observation of intransitive, mimicked hand movements. To a lesser extent, the results also showed mu suppression at parietal electrode sites, over all three conditions. Mu wave suppression during the observation of hand movements and during the execution of actions was significantly correlated with quality of imitation, but not with age or language level