Bicriteria scheduling of a two-machine flowshop with sequence-dependent setup times

The official published version of the article can be found at the link below.A two-machine flowshop scheduling problem is addressed to minimize setups and makespan where each job is characterized by a pair of attributes that entail setups on each machine. The setup times are sequence-dependent on both machines. It is shown that these objectives conflict, so the Pareto optimization approach is considered. The scheduling problems considering either of these objectives are NP-hard , so exact optimization techniques are impractical for large-sized problems. We propose two multi-objective metaheurisctics based on genetic algorithms (MOGA) and simulated annealing (MOSA) to find approximations of Pareto-optimal sets. The performances of these approaches are compared with lower bounds for small problems. In larger problems, performance of the proposed algorithms are compared with each other. Experimentations revealed that both algorithms perform very similar on small problems. Moreover, it was observed that MOGA outperforms MOSA in terms of the quality of solutions on larger problems.Partial Funding from EPSRC under grant EP/D050863/1

Heuristic algorithms for solving a class of multiobjective zero-one programming problems

Master'sMASTER OF ENGINEERIN

Multi-objective sequence dependent setup times permutation flowshop: A new algorithm and a comprehensive study

The permutation flowshop scheduling problem has been thoroughly studied in recent decades, both from single objective as well as from multi-objective perspectives. To the best of our knowledge, little has been done regarding the multi-objective flowshop with Pareto approach when sequence dependent setup times are considered. As setup times and multi-criteria problems are important in industry, we must focus on this area. We propose a simple, yet powerful algorithm for the sequence dependent setup times flowshop problem with several criteria. The presented method is referred to as Restarted Iterated Pareto Greedy or RIPG and is compared against the best performing approaches from the relevant literature. Comprehensive computational and statistical analyses are carried out in order to demonstrate that the proposed RIPG method clearly outperforms all other algorithms and, as a consequence, it is a state-of- art method for this important and practical scheduling problemThe authors thank the anonymous referees for their careful and detailed comments which have helped improve this manuscript considerably. This work is partially financed by the Spanish Ministry of Science and Innovation, under the projects "SMPA-Advanced Parallel Multiobjective Sequencing: Practical and Theorerical Advances" with reference DPI2008-03511/DPI and "RESULT-Realistic Extended Scheduling Using Light Techniques" with reference DPI2012-36243-C02-01 and by the Small and Medium Industry of the Generalitat Valenciana (IMPIVA) and by the European Union through the European Regional Development Fund (FEDER) inside the R+D program "Ayudas dirigidas a Institutos Tecnologicos de la Red IMPIVA" during the year 2011, with project numbers IMDEEA/2011/142 and IMDEEA/2012/143.Ciavotta, M.; Minella, GG.; Ruiz García, R. (2013). Multi-objective sequence dependent setup times permutation flowshop: A new algorithm and a comprehensive study. European Journal of Operational Research. 227(2):301-313. https://doi.org/10.1016/j.ejor.2012.12.031S301313227

Optimisation du développement de nouveaux produits dans l'industrie pharmaceutique par algorithme génétique multicritère

Le développement de nouveaux produits constitue une priorité stratégique de l'industrie pharmaceutique, en raison de la présence d'incertitudes, de la lourdeur des investissements mis en jeu, de l'interdépendance entre projets, de la disponibilité limitée des ressources, du nombre très élevé de décisions impliquées dû à la longueur des processus (de l'ordre d'une dizaine d'années) et de la nature combinatoire du problème. Formellement, le problème se pose ainsi : sélectionner des projets de Ret D parmi des projets candidats pour satisfaire plusieurs critères (rentabilité économique, temps de mise sur le marché) tout en considérant leur nature incertaine. Plus précisément, les points clés récurrents sont relatifs à la détermination des projets à développer une fois que les molécules cibles sont identifiées, leur ordre de traitement et le niveau de ressources à affecter. Dans ce contexte, une approche basée sur le couplage entre un simulateur à événements discrets stochastique (approche Monte Carlo) pour représenter la dynamique du système et un algorithme d'optimisation multicritère (de type NSGA II) pour choisir les produits est proposée. Un modèle par objets développé précédemment pour la conception et l'ordonnancement d'ateliers discontinus, de réutilisation aisée tant par les aspects de structure que de logique de fonctionnement, a été étendu pour intégrer le cas de la gestion de nouveaux produits. Deux cas d'étude illustrent et valident l'approche. Les résultats de simulation ont mis en évidence l'intérêt de trois critères d'évaluation de performance pour l'aide à la décision : le bénéfice actualisé d'une séquence, le risque associé et le temps de mise sur le marché. Ils ont été utilisés dans la formulation multiobjectif du problème d'optimisation. Dans ce contexte, des algorithmes génétiques sont particulièrement intéressants en raison de leur capacité à conduire directement au front de Pareto et à traiter l'aspect combinatoire. La variante NSGA II a été adaptée au problème pour prendre en compte à la fois le nombre et l'ordre de lancement des produits dans une séquence. A partir d'une analyse bicritère réalisée pour un cas d'étude représentatif sur différentes paires de critères pour l'optimisation bi- et tri-critère, la stratégie d'optimisation s'avère efficace et particulièrement élitiste pour détecter les séquences à considérer par le décideur. Seules quelques séquences sont détectées. Parmi elles, les portefeuilles à nombre élevé de produits provoquent des attentes et des retards au lancement ; ils sont éliminés par la stratégie d'optimistaion bicritère. Les petits portefeuilles qui réduisent les files d'attente et le temps de lancement sont ainsi préférés. Le temps se révèle un critère important à optimiser simultanément, mettant en évidence tout l'intérêt d'une optimisation tricritère. Enfin, l'ordre de lancement des produits est une variable majeure comme pour les problèmes d'ordonnancement d'atelier. ABSTRACT : New Product Development (NPD) constitutes a challenging problem in the pharmaceutical industry, due to the characteristics of the development pipeline, namely, the presence of uncertainty, the high level of the involved capital costs, the interdependency between projects, the limited availability of resources, the overwhelming number of decisions due to the length of the time horizon (about 10 years) and the combinatorial nature of a portfolio. Formally, the NPD problem can be stated as follows: select a set of R and D projects from a pool of candidate projects in order to satisfy several criteria (economic profitability, time to market) while copying with the uncertain nature of the projects. More precisely, the recurrent key issues are to determine the projects to develop once target molecules have been identified, their order and the level of resources to assign. In this context, the proposed approach combines discrete event stochastic simulation (Monte Carlo approach) with multiobjective genetic algorithms (NSGA II type, Non-Sorted Genetic Algorithm II) to optimize the highly combinatorial portfolio management problem. An object-oriented model previously developed for batch plant scheduling and design is then extended to embed the case of new product management, which is particularly adequate for reuse of both structure and logic. Two case studies illustrate and validate the approach. From this simulation study, three performance evaluation criteria must be considered for decision making: the Net Present Value (NPV) of a sequence, its associated risk defined as the number of positive occurrences of NPV among the samples and the time to market. Theyv have been used in the multiobjective optimization formulation of the problem. In that context, Genetic Algorithms (GAs) are particularly attractive for treating this kind of problem, due to their ability to directly lead to the so-called Pareto front and to account for the combinatorial aspect. NSGA II has been adapted to the treated case for taking into account both the number of products in a sequence and the drug release order. From an analysis performed for a representative case study on the different pairs of criteria both for the bi- and tricriteria optimization, the optimization strategy turns out to be efficient and particularly elitist to detect the sequences which can be considered by the decision makers. Only a few sequences are detected. Among theses sequences, large portfolios cause resource queues and delays time to launch and are eliminated by the bicriteria optimization strategy. Small portfolio reduces queuing and time to launch appear as good candidates. The optimization strategy is interesting to detect the sequence candidates. Time is an important criterion to consider simultaneously with NPV and risk criteria. The order in which drugs are released in the pipeline is of great importance as with scheduling problems

Identifying preferred solutions in multiobjective combinatorial optimization problems

We develop an evolutionary algorithm for multiobjective combinatorial optimization problems. The algorithm aims at converging the preferred solutions of a decision-maker. We test the performance of the algorithm on the multiobjective knapsack and multiobjective spanning tree problems. We generate the true nondominated solutions using an exact algorithm and compare the results with those of the evolutionary algorithm. We observe that the evolutionary algorithm works well in approximating the solutions in the preferred regions

Multiobjective optimization of New Product Development in the pharmaceutical industry

New Product Development (NPD) constitutes a challenging problem in the pharmaceutical industry, due to the characteristics of the development pipeline, namely, the presence of uncertainty, the high level of the involved capital costs, the interdependency between projects, the limited availability of resources, the overwhelming number of decisions due to the length of the time horizon (about 10 years) and the combinatorial nature of a portfolio. Formally, the NPD problem can be stated as follows: select a set of R and D projects from a pool of candidate projects in order to satisfy several criteria (economic profitability, time to market) while copying with the uncertain nature of the projects. More precisely, the recurrent key issues are to determine the projects to develop once target molecules have been identified, their order and the level of resources to assign. In this context, the proposed approach combines discrete event stochastic simulation (Monte Carlo approach) with multiobjective genetic algorithms (NSGA II type, Non-Sorted Genetic Algorithm II) to optimize the highly combinatorial portfolio management problem. An object-oriented model previously developed for batch plant scheduling and design is then extended to embed the case of new product management, which is particularly adequate for reuse of both structure and logic. Two case studies illustrate and validate the approach. From this simulation study, three performance evaluation criteria must be considered for decision making: the Net Present Value (NPV) of a sequence, its associated risk defined as the number of positive occurrences of NPV among the samples and the time to market. Theyv have been used in the multiobjective optimization formulation of the problem. In that context, Genetic Algorithms (GAs) are particularly attractive for treating this kind of problem, due to their ability to directly lead to the so-called Pareto front and to account for the combinatorial aspect. NSGA II has been adapted to the treated case for taking into account both the number of products in a sequence and the drug release order. From an analysis performed for a representative case study on the different pairs of criteria both for the bi- and tricriteria optimization, the optimization strategy turns out to be efficient and particularly elitist to detect the sequences which can be considered by the decision makers. Only a few sequences are detected. Among theses sequences, large portfolios cause resource queues and delays time to launch and are eliminated by the bicriteria optimization strategy. Small portfolio reduces queuing and time to launch appear as good candidates. The optimization strategy is interesting to detect the sequence candidates. Time is an important criterion to consider simultaneously with NPV and risk criteria. The order in which drugs are released in the pipeline is of great importance as with scheduling problems

Time/cost trade-offs in machine scheduling with controllable processing times

Ankara : The Department of Industrial Engineering and the Institute of Engineering and Science of Bilkent University, 2008.Thesis (Ph.D.) -- Bilkent University, 2008.Includes bibliographical references leaves 166-175Processing time controllability is a critical aspect in scheduling decisions since most of the scheduling practice in industry allows controlling processing times. A very well known example is the computer numerically controlled (CNC) machines in flexible manufacturing systems. Selected processing times for a given set of jobs determine the manufacturing cost of the jobs and strongly affect their scheduling performance. Hence, when making processing time and scheduling decisions at the same time, one must consider both the manufacturing cost and the scheduling performance objectives. In this thesis, we have studied such bicriteria scheduling problems in various scheduling environments including single, parallel and non-identical parallel machine environments. We have included some regular scheduling performance measures such as total weighted completion time and makespan. We have considered the convex manufacturing cost function of CNC turning operation. We have provided alternative methods to find efficient solutions in each problem. We have particularly focused on the single objective problems to get efficient solutions, called the -constraint approach. We have provided efficient formulations for the problems and shown useful properties which led us to develop fast heuristics to generate set of efficient solutions. In this thesis, taking another point of view, we have also studied a conic quadratic reformulation of a machine-job assignment problem with controllable processing times. We have considered a convex compression cost function for each job and solved a profit maximization problem. The convexity of cost functions is a major source of difficulty in finding optimal integer solutions in this problem, but our strengthened conic reformulation has eliminated this difficulty. Our reformulation approach is sufficiently general so that it can also be applied to other mixed 0-1 optimization problems with separable convex cost functions.Our computational results demonstrate that the proposed conic reformulation is very effective for solving the machine-job assignment problem with controllable processing times to optimality. Finally, in this thesis, we have considered rescheduling with controllable processing times. In particular, we show that in contrast to fixed processing times, if we have the flexibility to control the processing times of the jobs, we can generate alternative reactive schedules in response to a disruption such as machine breakdown. We consider a non-identical parallel machining environment where processing times of the jobs are compressible at a certain cost which is a convex function of the compression on the processing time. When rescheduling, it is critical to catch up the initial schedule as soon as possible by reassigning the jobs to the machines and changing their processing times. On the other hand, one must keep the total cost of the jobs at minimum. We present alternative match-up scheduling problems dealing with this trade-off. We use the strong conic reformulation approach in solving these problems. We further provide fast heuristic algorithms.Gürel, SinanPh.D

Search-Based Software Bugs Localization, Triage and Prioritization

http://deepblue.lib.umich.edu/bitstream/2027.42/170552/1/PhD_Dissertation___Rafi_Almhana__Copy_ (1).pdfSEL