Three-dimensional anatomical atlas of the human body

A thesis submitted in partial fulfillment of the requirements for the degree of Doctor in Information Management, specialization in Geographic Information SystemsAnatomical atlases allow mapping the anatomical structures of the human body. Early versions of these systems consisted of analogic representations with informative text and labelled images of the human body. With the advent of computer systems, digital versions emerged and the third dimension was introduced. Consequently, these systems increased their efficiency, allowing more realistic visualizations with improved interactivity. The development of anatomical atlases in geographic information systems (GIS) environments allows the development of platforms with a high degree of interactivity and with tools to explore and analyze the human body. In this thesis, a prototype for the human body representation is developed. The system includes a 3D GIS topological model, a graphical user interface and functions to explore and analyze the interior and the surface of the anatomical structures of the human body. The GIS approach relies essentially on the topological characteristics of the model and on the kind of available functions, which include measurement, identification, selection and analysis. With the incorporation of these functions, the final system has the ability to replicate the kind of information provided by the conventional anatomical atlases and also provides a higher level of functionality, since some of the atlases limitations are precisely features offered by GIS, namely, interactive capabilities, multilayer management, measurement tools, edition mode, allowing the expansion of the information contained in the system, and spatial analyzes

Quick-Time VRTM: when medical education meets virtual reality

Learning medicine is a difficult process to undertake, partially due to the complexity of the subject and limitations of traditional methods of teaching (lectures, textbooks, laboratory and anatomical dissections). These resources have been effective for decades, even though presenting intrinsic drawbacks. Textbooks are non-interactive education tools and do not provide any three dimensional experience. Cadaver dissection is an invaluable aid to learn anatomy. It provides an immersive, interactive experience allied with an inimitable tactile feedback. However, it has several limitations, including availability of specimens, costs and a substantial time commitment. Computer based virtual reality methods may overcome these drawbacks and provide interesting alternatives for medical training. Technological advances have generated great expectations for the use of computer-based virtual reality technologies in medical education, mainly anatomy and surgery. However, these Virtual Reality tools for general medical education are expensive due to the equipment necessary to create highly detailed, immersive three-dimensional image environments with real time friendly user interactivity. The concepts of Virtual Reality methods that generate immersive environments, as well as those that create simulated objects with interactive viewing features may be contemplated by the QuickTimeTM which is one of the technologies that can be successfully used for interactive, photorealistic displaying of medical images (radiological, anatomical and histological) and interaction on current generation of personal computers at a low and accessible cost. In this paper, the authors provide an overview of the Quick Time Virtual Reality methods aimingLearning medicine is a difficult process to undertake, partially due to the complexity of the subject and limitations of traditional methods of teaching (lectures, textbooks, laboratory and anatomical dissections). These resources have been effective for decades, even though presenting intrinsic drawbacks. Textbooks are non-interactive education tools and do not provide any three dimensional experience. Cadaver dissection is an invaluable aid to learn anatomy. It provides an immersive, interactive experience allied with an inimitable tactile feedback. However, it has several limitations, including availability of specimens, costs and a substantial time commitment. Computer based virtual reality methods may overcome these drawbacks and provide interesting alternatives for medical training. Technological advances have generated great expectations for the use of computer-based virtual reality technologies in medical education, mainly anatomy and surgery. However, these Virtual Reality tools for general medical education are expensive due to the equipment necessary to create highly detailed, immersive three-dimensional image environments with real time friendly user interactivity. The concepts of Virtual Reality methods that generate immersive environments, as well as those that create simulated objects with interactive viewing features may be contemplated by the QuickTimeTM which is one of the technologies that can be successfully used for interactive, photorealistic displaying of medical images (radiological, anatomical and histological) and interaction on current generation of personal computers at a low and accessible cost. In this paper, the authors provide an overview of the Quick Time Virtual Reality methods aiming to introduce them to medical educators and illustrate their application on medical training

Exploring the human body space: A geographical information system based anatomical atlas

Anatomical atlases allow mapping the anatomical structures of the human body. Early versions of these systems consisted of analogical representations with informative text and labeled images of the human body. With computer systems, digital versions emerged and the third and fourth dimensions were introduced. Consequently, these systems increased their efficiency, allowing more realistic visualizations with improved interactivity and functionality. The 4D atlases allow modeling changes over time on the structures represented. The anatomical atlases based on geographic information system (GIS) environments allow the creation of platforms with a high degree of interactivity and new tools to explore and analyze the human body. In this study we expand the functions of a human body representation system by creating new vector data, topology, functions, and an improved user interface. The new prototype emulates a 3D GIS with a topological model of the human body, replicates the information provided by anatomical atlases, and provides a higher level of functionality and interactivity. At this stage, the developed system is intended to be used as an educational tool and integrates into the same interface the typical representations of surface and sectional atlases

Design of CT pictures from 2D to 3D

Volume visualization is one important part of scientific visualization. It has developed basing on absorbing the relative knowledge of computer delineation, computer visualization and computer image disposal. The knowledge of this branch is of much importance in computer application. Since it deals with contents with deeper meaning and it is more theoretic, having more arithmetic means, it generally stands for the level of computer application. The study and application of volume visualization is like a raging fire. My country started comparatively later in this field. This thesis gives systematic representation and discuss in the field of tomography image 3D reconstruction. It mainly discusses after rotation, translation, filtering, interpolation and sharpening a series of 2D CT scanning images, get the boundary data of different object to form 3D volume data and actualize the 3D reconstruction of the object, and at the same time implement the function of display, translation, rotation, scaling and projection the volume data. Basing on the implementation of these functions according to software programming, this thesis gives a sum up to each algorithm of 3D volume visualization processing. The method to actualize the 3D reconstruction of the tomography image is mainly about the image processing, image transformation, the way to actualize 3D reconstruction and image compression, etc. In image processing, it talks about getting the anchor points in the tomography image, the geometrie transformation of the image, getting the boundary of the target, cross section display and the smoothing and sharpening of the image. In the transformation of the image, this thesis deals with the algorithm and implementation principle of the geometric transformation (transition, rotation, and scaling) of the 2D image, the three-dimensionalization of the planar data, construction of the stereo mode, geometric transformation of the 3D graph, curve-fitting, the processing of hidden line and hidden surface, color processing. It also introduces the thoughts of using OpenGL to develop and actualize tomography image 3D reconstruction system, including using OpenGL to transform the coordinate, solid model building, to actualize 3D rotation and projection. Recently, the methods of applying chemotherapy to deal with cancer in hospitals of our country are different. Hospital with great fund takes import software to design while most of the hospitals take domestic software. These kinds of software are designed by DAHENG Company in BeiJing, WEIDA Company in ShenZhen. The programs in the software these two hospitals' doctors use to treat are images fielding in the plane not making radiation design under the mode of omnibearing cubic display. Under this circumstance the judgment of the key part can not remain precise, and this part is the most important part that the doctors need. The above problem is the aim of this project. This thesis mainly deals with the subject that after calibrating and sharpening the series of 2D CT images, extract the boundary data of different bodies to form a 3D volume data and actualize 3D reconstruction and at the same time actualize the function of display, translation, rotation, scaling and projection. Mostly basing on the application of medical area, this thesis aims at making further research on computer graphies, computer vision and computer image processing through the study and application of volume visualization in this field. By the study and development of the volume visualization technology in this project, it can provide simulation and display functions to the observer before the operation and the radiotherapy as well as providing the chance to simulate the real teaching and practicing link to the medical school in the teaching process, and increase the clinic level and teaching level of medical area.\ud ______________________________________________________________________________ \ud MOTS-CLÉS DE L’AUTEUR : volume visualization, volume data, tomography image, 3D reconstruction, anchor point, boundary data, periphery boundary, OpenGL

Polarization fields: dynamic light field display using multi-layer LCDs

We introduce polarization field displays as an optically-efficient design for dynamic light field display using multi-layered LCDs. Such displays consist of a stacked set of liquid crystal panels with a single pair of crossed linear polarizers. Each layer is modeled as a spatially-controllable polarization rotator, as opposed to a conventional spatial light modulator that directly attenuates light. Color display is achieved using field sequential color illumination with monochromatic LCDs, mitigating severe attenuation and moiré occurring with layered color filter arrays. We demonstrate such displays can be controlled, at interactive refresh rates, by adopting the SART algorithm to tomographically solve for the optimal spatially-varying polarization state rotations applied by each layer. We validate our design by constructing a prototype using modified off-the-shelf panels. We demonstrate interactive display using a GPU-based SART implementation supporting both polarization-based and attenuation-based architectures. Experiments characterize the accuracy of our image formation model, verifying polarization field displays achieve increased brightness, higher resolution, and extended depth of field, as compared to existing automultiscopic display methods for dual-layer and multi-layer LCDs.National Science Foundation (U.S.) (Grant IIS-1116452)United States. Defense Advanced Research Projects Agency (Grant HR0011-10-C-0073)Alfred P. Sloan Foundation (Research Fellowship)United States. Defense Advanced Research Projects Agency (Young Faculty Award

Multigradient field-active contour model for multilayer boundary detection of ultrasound rectal wall image

Extraction and reconstruction of rectal wall structures from an ultrasound image is helpful for surgeons in rectal clinical diagnosis and 3-D reconstruction of rectal structures from ultrasound images. The primary task is to extract the boundary of the muscular layers on the rectal wall. However, due to the low SNR from ultrasound imaging and the thin muscular layer structure of the rectum, this boundary detection task remains a challenge. An active contour model is an effective high-level model, which has been used successfully to aid the tasks of object representation and recognition in many image-processing applications. We present a novel multigradient field active contour algorithm with an extended ability for multiple-object detection, which overcomes some limitations of ordinary active contour models—"snakes." The core part in the algorithm is the proposal of multigradient vector fields, which are used to replace image forces in kinetic function for alternative constraints on the deformation of active contour, thereby partially solving the initialization limitation of active contour for rectal wall boundary detection. An adaptive expanding force is also added to the model to help the active contour go through the homogenous region in the image. The efficacy of the model is explained and tested on the boundary detection of a ring-shaped image, a synthetic image, and an ultrasound image. The experimental results show that the proposed multigradient field-active contour is feasible for multilayer boundary detection of rectal wal

From Cleanroom to Desktop: Emerging Micro-Nanofabrication Technology for Biomedical Applications

This review is motivated by the growing demand for low-cost, easy-to-use, compact-size yet powerful micro-nanofabrication technology to address emerging challenges of fundamental biology and translational medicine in regular laboratory settings. Recent advancements in the field benefit considerably from rapidly expanding material selections, ranging from inorganics to organics and from nanoparticles to self-assembled molecules. Meanwhile a great number of novel methodologies, employing off-the-shelf consumer electronics, intriguing interfacial phenomena, bottom-up self-assembly principles, etc., have been implemented to transit micro-nanofabrication from a cleanroom environment to a desktop setup. Furthermore, the latest application of micro-nanofabrication to emerging biomedical research will be presented in detail, which includes point-of-care diagnostics, on-chip cell culture as well as bio-manipulation. While significant progresses have been made in the rapidly growing field, both apparent and unrevealed roadblocks will need to be addressed in the future. We conclude this review by offering our perspectives on the current technical challenges and future research opportunities

Roadmap on 3D integral imaging: Sensing, processing, and display

This Roadmap article on three-dimensional integral imaging provides an overview of some of the research activities in the field of integral imaging. The article discusses various aspects of the field including sensing of 3D scenes, processing of captured information, and 3D display and visualization of information. The paper consists of a series of 15 sections from the experts presenting various aspects of the field on sensing, processing, displays, augmented reality, microscopy, object recognition, and other applications. Each section represents the vision of its author to describe the progress, potential, vision, and challenging issues in this field