Biocatalytic oxidative kinetic resolution of (\ub1)-4-(chlorophenyl)phenylmethanol by Nocardia corallina B-276

Chiral diarylmethanols are versatile building blocks for the preparation of biologically active substances, but they are difficult to obtain in enantiopure form. We used Nocardia corallina B-276 for the oxidative kinetic resolution of (\ub1)-4-(chlorophenyl)phenylmethanol, 1. Two experimental methods were used: 1) Suspension of cells in a phosphate buffer solution and 2) Cells in the culture media, in a 3-L bioreactor. After 36 hrs using the first method, the ketone/alcohol ratio was 56/44 and the unoxidized alcohol had an enantiomeric ratio of 93/7, predominating the R-alcohol

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

New Costa Rican species of Phyllophaga harris (Coleoptera: Melolonthidae: Melolonthinae)

Volume: 102Start Page: 901End Page: 91

Araneofauna urbana (Arachnida: Araneae) de Ciudad Victoria, Tamaulipas, M\ue9xico

Se describe la araneofauna urbana en el área de Ciudad Victoria, Tamaulipas, México y su distribución sobre la mancha urbana. Se realizó un muestreo por conglomerados en tres etapas y se identificaron 59 especies correspondientes a 29 familias. Se encontraron dos nuevos registros para el estado y se presentan los valores de riqueza específica, diversidad y equitatividad, así como los valores desinantropía asociados a las especies. Además se analizó la similitudentre cinco zonas de la ciudad.Se describe la araneofauna urbana en el área de Ciudad Victoria, Tamaulipas, México y su distribución sobre la mancha urbana. Se realizó un muestreo por conglomerados en tres etapas y se identificaron 59 especies correspondientes a 29 familias. Se encontraron dos nuevos registros para el estado y se presentan los valores de riqueza específica, diversidad y equitatividad, así como los valores desinantropía asociados a las especies. Además se analizó la similitudentre cinco zonas de la ciudad

Desarrollo de fruto y semilla en Solanum argentinum (Solanaceae)

Volume: 18Start Page: 47End Page: 5