2,352 research outputs found
SAR-to-Optical Image Translation Based on Conditional Generative Adversarial Networks - Optimization, Opportunities and Limits
Due to its all time capability, synthetic aperture radar (SAR) remote sensing plays an important role in Earth observation. The ability to interpret the data is limited, even for experts, as the human eye is not familiar to the impact of distance-dependent imaging, signal intensities detected in the radar spectrum as well as image characteristics related to speckle or steps of post-processing. This paper is concerned with machine learning for SAR-to-optical image-to-image translation in order to support the interpretation and analysis of original data. A conditional adversarial network is adopted and optimized in order to generate alternative SAR image representations based on the combination of SAR images (starting point) and optical images (reference) for training. Following this strategy, the focus is set on the value of empirical knowledge for initialization, the impact of results on follow-up applications, and the discussion of opportunities/drawbacks related to this application of deep learning. Case study results are shown for high resolution (SAR: TerraSAR-X, optical: ALOS PRISM) and low resolution (Sentinel-1 and -2) data. The properties of the alternative image representation are evaluated based on feedback from experts in SAR remote sensing and the impact on road extraction as an example for follow-up applications. The results provide the basis to explain fundamental limitations affecting the SAR-to-optical image translation idea but also indicate benefits from alternative SAR image representations
A Detection Of H-alpha In An Exoplanetary Exosphere
We report on a search for H-alpha absorption in four exoplanets. Strong
features at H-alpha are observed in the transmission spectra of both HD 189733b
and HD 209458b. We attempt to characterize and remove the effects of stellar
variability in HD 189733b, and along with an empirical Monte Carlo test the
results imply a statistically significant transit-dependent feature of
(-8.72+/-1.48)x10^-4 integrated over a 16 Angstrom band relative to the
adjacent continuum. We interpret this as the first detection of this line in an
exoplanetary atmosphere. A previous detection of Ly-alpha in HD 189733b's
atmosphere allows us to calculate an excitation temperature for hydrogen,
T_exc=2.6x10^4 K. This calculation depends significantly on certain simplifying
assumptions. We explore these assumptions and argue that T_exc is very likely
much greater than the radiative equilibrium temperature (the temperature the
planet is assumed to be at based on stellar radiation and the planetary
distance) of HD 189733b. A large T_exc implies a very low density that is not
in thermodynamic equilibrium the planet's lower atmosphere. We argue that the
n=2 hydrogen required to cause H-alpha absorption in the atmosphere is created
as a result of the greater UV flux at HD 189733b, which has the smallest orbit
and most chromospherically active central star in our sample. Though the
overall integration of HD 209458b's transmission spectrum over a wide band is
consistent with zero, it contains a dramatic, statistically significant feature
in the transmission spectrum with reflectional symmetry. We discuss possible
physical processes that could cause this feature. Our remaining two targets (HD
147506b and HD 149026b) do not show any clear features, so we place upper
limits on their H-alpha absorption levels.Comment: 42 total pages (preprint format), 9 figures, 4 tables. Accepted for
publication in The Astrophysical Journa
The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe
The preponderance of matter over antimatter in the early Universe, the
dynamics of the supernova bursts that produced the heavy elements necessary for
life and whether protons eventually decay --- these mysteries at the forefront
of particle physics and astrophysics are key to understanding the early
evolution of our Universe, its current state and its eventual fate. The
Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed
plan for a world-class experiment dedicated to addressing these questions. LBNE
is conceived around three central components: (1) a new, high-intensity
neutrino source generated from a megawatt-class proton accelerator at Fermi
National Accelerator Laboratory, (2) a near neutrino detector just downstream
of the source, and (3) a massive liquid argon time-projection chamber deployed
as a far detector deep underground at the Sanford Underground Research
Facility. This facility, located at the site of the former Homestake Mine in
Lead, South Dakota, is approximately 1,300 km from the neutrino source at
Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino
charge-parity symmetry violation and mass ordering effects. This ambitious yet
cost-effective design incorporates scalability and flexibility and can
accommodate a variety of upgrades and contributions. With its exceptional
combination of experimental configuration, technical capabilities, and
potential for transformative discoveries, LBNE promises to be a vital facility
for the field of particle physics worldwide, providing physicists from around
the globe with opportunities to collaborate in a twenty to thirty year program
of exciting science. In this document we provide a comprehensive overview of
LBNE's scientific objectives, its place in the landscape of neutrino physics
worldwide, the technologies it will incorporate and the capabilities it will
possess.Comment: Major update of previous version. This is the reference document for
LBNE science program and current status. Chapters 1, 3, and 9 provide a
comprehensive overview of LBNE's scientific objectives, its place in the
landscape of neutrino physics worldwide, the technologies it will incorporate
and the capabilities it will possess. 288 pages, 116 figure
Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis
BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London
Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer
Summary
Patients with blood cancer continue to have a greater risk of inadequate immune responses following three COVID-19 vaccine doses and risk of severe COVID-19 disease. In the context of the CAPTURE study (NCT03226886) we report immune responses in 80 patients with blood cancer who received a fourth dose of BNT162b2. We measured neutralising antibody titres (NAbT) using a live virus microneutralization assay against wild-type (WT), Delta, Omicron BA.1 and BA.2 and T cell responses against WT and Omicron BA.1 using an activation-induced marker (AIM) assay. The proportion of patients with detectable NAb titres and T cell responses after the fourth vaccine dose increases compared to those after the third vaccine dose. Patients who received B cell-depleting therapies within 12 months before vaccination have the greatest risk of not having detectable NAbT. In addition, we report immune responses in 57 patients with breakthrough infections after vaccination
Measured and Parameterized Energy Fluxes Estimated for Atlantic Transects of R/V Polarstern
Are American Homeowners Locked into Their Houses? The Impact of Housing Market Conditions on State-to-State Migration
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